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Hyun Jin Ryu

Seoul National University · Medicine

About the Lab

Professor Hyun Jin Ryu's research lab specializes in nephrology and chronic kidney disease (CKD) outcomes, with a strong focus on nutritional status, cardiovascular complications, and transplant outcomes in CKD populations. The lab investigates the interplay between organomegaly, body composition, and disease progression in polycystic kidney disease (ADPKD), while also examining cardiovascular and mortality risks across different CKD etiologies. A key emphasis is placed on clinical phenotyping using advanced tools like bioimpedance analysis and on optimizing immunosuppression strategies post-kidney transplantation.

chronic kidney diseasenutritional statuscardiovascular diseasetransplant outcomesbioimpedance analysis

Research Overview

Papers
113
Total Citations
1,427
Papers (5y)
41
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
41total
2022
2023
2024
2025
2026
Citations per year (5y)
234total
20222023202420252026

Selected Papers

15
1
Article|28 citations·2017
Total kidney and liver volume is a major risk factor for malnutrition in ambulatory patients with autosomal dominant polycystic kidney disease
Hyunjin Ryu, Hyosang Kim, Hayne Cho Park, Hyunsuk Kim, Eun Jin Cho, Kyu‐Beck Lee, Wookyung Chung, Kook‐Hwan Oh, Jeong Yeon Cho, Young‐Hwan Hwang, Curie Ahn
SJR Q2BMC NephrologyOA

Nutritional risk was detected in 30% of ambulatory ADPKD patients with relatively good renal function. Intra-abdominal organomegaly was related to nutritional status independently from renal function deterioration.

GeneticsBiochemistry, Genetics and Molecular Biology
2
Article|25 citations·2021
Incidence of cardiovascular events and mortality in Korean patients with chronic kidney disease
Hyunjin Ryu, Jayoun Kim, Eunjeong Kang, Yeji Hong, Dong‐Wan Chae, Kyu Hun Choi, Seung Hyeok Han, Tae‐Hyun Yoo, Kyu‐Beck Lee, Yong‐Soo Kim, Wookyung Chung, Yun Kyu Oh
SJR Q1Scientific ReportsOA

Few studies have investigated the incidence of cardiovascular disease (CVD) in the Asian chronic kidney disease (CKD) population. This study assessed the incidence of CVD, death, and a composite outcome of CVD and death in a prospective Korean predialysis CKD cohort. From a total of 2179 patients, incidence rates were analyzed, and competing risk analyses were conducted according to CKD stage. Additionally, incidence was compared to the general population. During a median 4.1 years of follow-up,

NephrologyMedicine
3
Article|18 citations·2019
Bioelectrical impedance analysis as a nutritional assessment tool in Autosomal Dominant Polycystic Kidney Disease
Hyunjin Ryu, Hayne Cho Park, Hyunsuk Kim, Jongho Heo, Eunjung Kang, Young‐Hwan Hwang, Jeong Yeon Cho, Kyu‐Beck Lee, Yun Kyu Oh, Kook‐Hwan Oh, Curie Ahn
SJR Q1PLoS ONEOA

These results demonstrated that segmental BIA parameters of ECW/TBWWB, ECW/TBWTR, ECW/TBWLE and PhALE provide useful information on nutritional status including the impact of organomegaly in ADPKD.

PhysiologyMedicine
4
Article|17 citations·2020
Weaning Immunosuppressant in Patients with Failing Kidney Grafts and The Outcomes: A Single-Center Retrospective Cohort Study
Hyunjin Ryu, Yong Chul Kim, Jong Joo Moon, Eun Young Song, Sangil Min, Jongwon Ha, Kwon Wook Joo, Yon Su Kim, Curie Ahn, Hajeong Lee
SJR Q1Scientific ReportsOA

An immunosuppressant weaning protocol in failing allografts has not yet been established. Maintaining immunosuppressants would preserve residual renal function (RRF) and prevent graft intolerance syndrome and sensitization but would increase the risks of infection and malignancy. In this study, graft failure cases after kidney transplantation in a single center were reviewed retrospectively. The outcome differences in all-cause mortality, infection-related hospitalization, cancer, graft intolera

TransplantationMedicine
5
Article|14 citations·2015
A case of gemcitabine-induced thrombotic microangiopathy in a urothelial tumor patient with a single kidney
Hyunjin Ryu, Eunjeong Kang, Seokwoo Park, Sehoon Park, Kyoungbun Lee, Kwon Wook Joo, Hajeong Lee
SJR Q1Kidney Research and Clinical PracticeOA

Thrombotic microangiopathy (TMA) is a rare complication of gemcitabine treatment. A 55-year-old man with a history of urothelial cancer underwent right ureteronephrectomy and palliative chemotherapy. The patient presented with dyspnea, generalized edema with foamy urine, and new-onset hypertension with acute kidney injury (AKI). Although AKI with oliguria was evident, thrombocytopenia and hemolytic anemia were not overt. To determine the cause of rapidly progressive azotemia, kidney biopsy was p

ImmunologyImmunology and Microbiology
6
Article|12 citations·2023
Comparison of outcomes of chronic kidney disease based on etiology: a prospective cohort study from KNOW-CKD
Hyunjin Ryu, Yeji Hong, Eunjeong Kang, Minjung Kang, Jayoun Kim, Hayne Cho Park, Yun Kyu Oh, Ho Jun Chin, Sue K. Park, Ji Yong Jung, Young Youl Hyun, Su Ah Sung
SJR Q1Scientific ReportsOA

Abstract The causes of chronic kidney disease (CKD) affects its outcomes. However, the relative risks for adverse outcomes according to specific causes of CKD is not well established. In a prospective cohort study from KNOW-CKD, a cohort was analyzed using overlap propensity score weighting methods. Patients were grouped into four categories according to the cause of CKD: glomerulonephritis (GN), diabetic nephropathy (DN), hypertensive nephropathy (HTN), or polycystic kidney disease (PKD). From

NephrologyMedicine
7
Article|10 citations·2021
Rapid Weight Change Over Time Is a Risk Factor for Adverse Outcomes in Patients With Predialysis Chronic Kidney Disease: A Prospective Cohort Study
Hyunjin Ryu, Yeji Hong, Eunjeong Kang, Minjung Kang, Jayoun Kim, Yun Kyu Oh, Soo Jin Yang, Yun Yang, Sue K. Park, Wookyung Chung, Dong‐Wan Chae, Su Ah Sung
SJR Q2Journal of Renal Nutrition
NephrologyMedicine
8
Article|7 citations·2020
RAPID-ADPKD (Retrospective epidemiological study of Asia-Pacific patients with rapId Disease progression of Autosomal Dominant Polycystic Kidney Disease): study protocol for a multinational, retrospective cohort study
Hyunjin Ryu, Hayne C. Park, Yun Kyu Oh, Irene Sangadi, Annette Wong, Changlin Mei, Tevfik Ecder, Angela Yee‐Moon Wang, Tze-Wah Kao, Jenq‐Wen Huang, Gopala K. Rangan, Curie Ahn
SJR Q1BMJ OpenOA

Introduction Patients with autosomal dominant polycystic kidney disease (ADPKD) reach end-stage renal disease in their fifth decade on average. For effective treatment and early intervention, identifying subgroups with rapid disease progression is important in ADPKD. However, there are no epidemiological data on the clinical manifestations and disease progression of patients with ADPKD from the Asia-Pacific region. Methods and analysis The RAPID-ADPKD ( R etrospective epidemiological study of A

GeneticsBiochemistry, Genetics and Molecular Biology
9
Article|6 citations·2021
Greater adherence to the dietary approaches to stop hypertension dietary pattern is associated with preserved muscle strength in patients with autosomal dominant polycystic kidney disease: a single-center cross-sectional study
Hyunjin Ryu, Yun Yang, Eunjeong Kang, Curie Ahn, Soo Jin Yang, Kook‐Hwan Oh
SJR Q1Nutrition Research
GeneticsBiochemistry, Genetics and Molecular Biology
10
Article|6 citations·2020
Cancer development and mortality differences in patients with glomerulonephritis after renal biopsy: a single center retrospective cohort study
Hyunjin Ryu, Kipyo Kim, Jiwon Ryu, Hyung Eun Son, Ji Young Ryu, Sejoong Kim, Ki Ryang Na, Dong‐Wan Chae, Ho Jun Chin, Korean GlomeruloNephritis Study Group
SJR Q2BMC NephrologyOA

BACKGROUND: The association between glomerulonephritis (GN) and cancer has been well known for decades. However, studies evaluating long-term de novo cancer development in patients with GN are limited. This study aimed to evaluate the incidence of cancer development among patients with renal biopsy-proven GN during post-biopsy follow-up and the differences in outcomes according to cancer occurrence. METHODS: We conducted a retrospective cohort study of adult patients who underwent renal biopsy a

NephrologyMedicine
11
Article|4 citations·2021
Author Correction: Incidence of cardiovascular events and mortality in Korean patients with chronic kidney disease
Hyunjin Ryu, Jayoun Kim, Eunjeong Kang, Yeji Hong, Dong‐Wan Chae, Kyu Hun Choi, Seung Hyeok Han, Tae‐Hyun Yoo, Kyu‐Beck Lee, Yong‐Soo Kim, Wookyung Chung, Yun Kyu Oh
SJR Q1Scientific ReportsOA

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Pulmonary and Respiratory MedicineMedicine
12
Article|1 citations·2019
Association between vitamin D level and hematuria from a dipstick test in a large scale population based study: Korean National Health and nutrition examination survey
Hyunjin Ryu, Hyunjeong Cho, Yun Kyu Oh, Kwon Wook Joo, Yon Su Kim, Curie Ahn, Seung Seok Han
SJR Q2BMC NephrologyOA

BACKGROUND: Vitamin D deficiency is an important health concern because it is related to several comorbidities and mortality. However, its relationship with the risk of hematuria remains undetermined in the general population. In this study, we analyzed the association between vitamin D deficiency and hematuria. METHODS: We conducted cross-sectional analysis using data of participants from the Korean National Health and Nutrition Examination Survey (KNHANES) 2010-2014. A total of 20,240 particip

Pathology and Forensic MedicineMedicine
13
erratum|1 citations·2023
Author Correction: Comparison of outcomes of chronic kidney disease based on etiology: a prospective cohort study from KNOW-CKD
Hyunjin Ryu, Yeji Hong, Eunjeong Kang, Minjung Kang, Jayoun Kim, Hayne Cho Park, Yun Kyu Oh, Ho Jun Chin, Sue K. Park, Ji Yong Jung, Young Youl Hyun, Su Ah Sung
SJR Q1Scientific ReportsOA

“This work was supported by the Research Program funded by the Korea Centers for Disease Control and Prevention (2011E3300300, 2012E3301100, 2013E3301600, 2013E3301601, 2013E3301602, 2016E3300200, 2016E3300201, 2016E3300202, 2019E320100, 2019E320101, 2019E320102, and 2022-11-007) and the Bio & Medical Technology Development Program of the National Research Foundation (NRF) & funded by the Korean government (MSIT) (No. 2017M3A9E4044649).”

EpidemiologyMedicine
14
Article|0 citations·2020
P0795OUTCOME COMPARISON STUDY ACCORDING TO THE CAUSE OF CHRONIC KIDNEY DISEASE: RESULTS FROM KNOW-CKD STUDY
Hyunjin Ryu, Yeji Hong, Jayoun Kim, Curie Ahn, Yun Kyu Oh, Kook‐Hwan Oh
SJR Q1Nephrology Dialysis TransplantationOA

Abstract Background and Aims The cause of chronic kidney disease (CKD) is one of important factors for predicting the outcome. However, relative risks for the adverse outcomes according to the specific causes of CKD is unknown. Method Using the longitudinal data of prospective cohort of Korean predialysis CKD, KNOW-CKD cohort, the relative risk of end-stage renal disease (ESRD), composite of ESRD development or creatinine doubling, and composite of cardiovascular disease (CVD) and all-cause mort

RheumatologyMedicine
15
Preprint|0 citations·2021
Comparison of Outcomes of Chronic Kidney Disease Based on Etiology: A Prospective Cohort Study
Hyunjin Ryu, Yeji Hong, Eunjeong Kang, Minjung Kang, Jayoun Kim, Hayne Cho Park, Yun Kyu Oh, Ho Jun Chin, Sue K. Park, Ji Yong Jung, Young Youl Hyun, Su Ah Sung
Research SquareOA

Abstract Background and objectivesThe cause of chronic kidney disease (CKD) affects outcomes. However, relative risks for adverse outcomes according to specific causes of CKD are not well studied.Design, setting, participants and measurementsProspective cohort study from KNOW-CKD cohort were analyzed using overlap propensity score weighting methods. Patients were grouped into four categories according to the cause of CKD: glomerulonephritis (GN), diabetic nephropathy (DN), hypertensive nephropat

NephrologyMedicine

Research Areas

GeneticsNephrologyPulmonary and Respiratory MedicineCardiology and Cardiovascular MedicineOncologyPublic Health, Environmental and Occupational Health

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