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Hyun-Ju Shin

Yonsei University · Medicine

About the Lab

Professor Hyun-Ju Shin's research lab specializes in medical imaging and artificial intelligence, focusing on improving diagnostic accuracy and efficiency in radiology through AI integration. The lab investigates the impact of AI on radiologists' workflow, particularly in interpreting pediatric and adult chest radiographs, while also exploring the biological mechanisms underlying neurological injury, such as hippocampal cell death following seizures. A key research direction involves understanding the role of biomarkers like lipocalin-2 in neuroinflammation and blood-brain barrier disruption. Additionally, the lab contributes to radiation dose optimization in pediatric CT and ultrasound/MRI-based diagnosis of congenital biliary atresia.

artificial intelligence in radiologypediatric medical imagingneuroinflammationradiation dose optimizationbiomarker discovery

Research Overview

Papers
168
Total Citations
3,129
Papers (5y)
50
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
50total
2022
2023
2024
2025
2026
Citations per year (5y)
585total
20222023202420252026

Selected Papers

15
1
Article|127 citations·2016
Comparison of shear wave velocities on ultrasound elastography between different machines, transducers, and acquisition depths: a phantom study
Hyun Joo Shin, Myung‐Joon Kim, Ha Yan Kim, Yun Ho Roh, Mi‐Jung Lee
SJR Q1European RadiologyOA
Radiology, Nuclear Medicine and ImagingMedicine
2
Article|96 citations·2007
Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice
Hyun Joo Shin, Jiyeong Lee, Eunyung Son, Dong Hun Lee, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Gu Seob Roh
SJR Q2Neuroscience Letters
NeurologyNeuroscience
3
Article|81 citations·2023
The impact of artificial intelligence on the reading times of radiologists for chest radiographs
Hyun Joo Shin, Kyunghwa Han, Leeha Ryu, Eun‐Kyung Kim
SJR Q1npj Digital MedicineOA

Whether the utilization of artificial intelligence (AI) during the interpretation of chest radiographs (CXRs) would affect the radiologists' workload is of particular interest. Therefore, this prospective observational study aimed to observe how AI affected the reading times of radiologists in the daily interpretation of CXRs. Radiologists who agreed to have the reading times of their CXR interpretations collected from September to December 2021 were recruited. Reading time was defined as the du

Health InformaticsMedicine
4
Article|57 citations·2015
Superb microvascular imaging for the detection of parenchymal perfusion in normal and undescended testes in young children
Yong Seung Lee, Myung‐Joon Kim, Sang Won Han, Hye Sun Lee, Young-Jae Im, Hyun Joo Shin, Mi‐Jung Lee
SJR Q1European Journal of RadiologyOA
SurgeryMedicine
5
Article|46 citations·2021
Lipocalin-2 Deficiency Reduces Oxidative Stress and Neuroinflammation and Results in Attenuation of Kainic Acid-Induced Hippocampal Cell Death
Hyun Joo Shin, Ju‐Hong Jeon, Jong Youl Lee, Hyeong Seok An, Hye Min Jang, Yu Jeong Ahn, Jae Woong Lee, Kyung Eun Kim, Gu Seob Roh
SJR Q1AntioxidantsOA

The hippocampal cell death that follows kainic acid (KA)-induced seizures is associated with blood-brain barrier (BBB) leakage and oxidative stress. Lipocalin-2 (LCN2) is an iron-trafficking protein which contributes to both oxidative stress and inflammation. However, LCN2's role in KA-induced hippocampal cell death is not clear. Here, we examine the effect of blocking LCN2 genetically on neuroinflammation and oxidative stress in KA-induced neuronal death. LCN2 deficiency reduced neuronal cell d

Molecular BiologyBiochemistry, Genetics and Molecular Biology
6
Article|44 citations·2022
Diagnostic performance of artificial intelligence approved for adults for the interpretation of pediatric chest radiographs
Hyun Joo Shin, Nak‐Hoon Son, Min Jung Kim, Eun‐Kyung Kim
SJR Q1Scientific ReportsOA

Artificial intelligence (AI) applied to pediatric chest radiographs are yet scarce. This study evaluated whether AI-based software developed for adult chest radiographs can be used for pediatric chest radiographs. Pediatric patients (≤ 18 years old) who underwent chest radiographs from March to May 2021 were included retrospectively. An AI-based lesion detection software assessed the presence of nodules, consolidation, fibrosis, atelectasis, cardiomegaly, pleural effusion, pneumothorax, and pneu

Radiology, Nuclear Medicine and ImagingMedicine
7
Article|38 citations·2013
Radiation Dose Reduction via Sinogram Affirmed Iterative Reconstruction and Automatic Tube Voltage Modulation (CARE kV) in Abdominal CT
Hyun Joo Shin, Yong Eun Chung, Young Han Lee, Jin‐Young Choi, Mi‐Suk Park, Myeong‐Jin Kim, Ki Whang Kim
SJR Q1Korean Journal of RadiologyOA

Combining CARE kV, reduction of mAs from 240 to 170 mAs and noise reduction by applying SAFIRE strength 3 or 4 reduced the radiation dose by 41.3% without increasing image noise compared with the standard-dose FBP images.

Radiology, Nuclear Medicine and ImagingMedicine
8
Article|35 citations·2016
Optimal Acquisition Number for Hepatic Shear Wave Velocity Measurements in Children
Hyun Joo Shin, Myung‐Joon Kim, Ha Yan Kim, Yun Ho Roh, Mi‐Jung Lee
SJR Q1PLoS ONEOA

Three acquisitions can be enough for hepatic SWVs in children more than 6 years old regardless of breathing status or hepatic pathology. More acquisitions are recommended for children under the age of 5 years during FB.

EpidemiologyMedicine
9
Article|30 citations·2014
Tonicity-responsive enhancer binding protein haplodeficiency attenuates seizure severity and NF-κB-mediated neuroinflammation in kainic acid-induced seizures
Hyun Joo Shin, H Kim, Rok-Won Heo, H J Kim, Wan Sung Choi, Hyug Moo Kwon, Gu Seob Roh
SJR Q1Cell Death and DifferentiationOA
Cell BiologyBiochemistry, Genetics and Molecular Biology
10
Article|27 citations·2020
Key imaging features for differentiating cystic biliary atresia from choledochal cyst: prenatal ultrasonography and postnatal ultrasonography and MRI
Hyun Joo Shin, Haesung Yoon, Seok Joo Han, Kyong Ihn, Hong Koh, Ja‐Young Kwon, Mi‐Jung Lee
SJR Q1ULTRASONOGRAPHYOA

Small cyst size (<1 cm) on prenatal US, triangular cord thickening (≥4 mm) and gallbladder mucosal irregularity on postnatal US, and small cyst size (≤2.2 cm) and an invisible distal common bile duct on MRI can discriminate cBA from CC type Ia/b in infancy.

SurgeryMedicine
11
Article|25 citations·2019
Performance of deep learning-based algorithm for detection of ileocolic intussusception on abdominal radiographs of young children
Sung‐Won Kim, Haesung Yoon, Mi‐Jung Lee, Myung‐Joon Kim, Kyunghwa Han, Ja Kyung Yoon, Hyung Cheol Kim, Jaeseung Shin, Hyun Joo Shin
SJR Q1Scientific ReportsOA

The purpose of this study was to develop and test the performance of a deep learning-based algorithm to detect ileocolic intussusception using abdominal radiographs of young children. For the training set, children (≤5 years old) who underwent abdominal radiograph and ultrasonography (US) for suspicion of intussusception from March 2005 to December 2017 were retrospectively included and divided into control and intussusception groups according to the US results. A YOLOv3-based algorithm was deve

SurgeryMedicine
12
Article|25 citations·2018
Liver intravoxel incoherent motion diffusion-weighted imaging for the assessment of hepatic steatosis and fibrosis in children
Hyun Joo Shin, Haesung Yoon, Myung‐Joon Kim, Seok Joo Han, Hong Koh, Seung Kim, Mi‐Jung Lee
SJR Q1World Journal of GastroenterologyOA

In liver IVIM DWI with multiple <i>b</i>-values in children, there was a positive correlation between hepatic fat and blood volume, and a negative correlation between hepatic stiffness and endovascular blood flow velocity, while diffusion-related parameters were not affected.

Radiology, Nuclear Medicine and ImagingMedicine
13
Article|24 citations·2013
Can increased tumoral vascularity be a quantitative predicting factor of lymph node metastasis in papillary thyroid microcarcinoma?
Hyun Joo Shin, Eun‐Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Kyunghwa Han, Jin Young Kwak
SJR Q2EndocrineOA
Endocrinology, Diabetes and MetabolismMedicine
14
Article|22 citations·2023
Incidentally found resectable lung cancer with the usage of artificial intelligence on chest radiographs
Se Hyun Kwak, Eun‐Kyung Kim, Myung Hyun Kim, Eun Hye Lee, Hyun Joo Shin
SJR Q1PLoS ONEOA

PURPOSE: Detection of early lung cancer using chest radiograph remains challenging. We aimed to highlight the benefit of using artificial intelligence (AI) in chest radiograph with regard to its role in the unexpected detection of resectable early lung cancer. MATERIALS AND METHODS: Patients with pathologically proven resectable lung cancer from March 2020 to February 2022 were retrospectively analyzed. Among them, we included patients with incidentally detected resectable lung cancer. Because c

Pulmonary and Respiratory MedicineMedicine
15
Article|22 citations·2015
A Study on Serum Antithyroglobulin Antibodies Interference in Thyroglobulin Measurement in Fine-Needle Aspiration for Diagnosing Lymph Node Metastasis in Postoperative Patients
Hyun Joo Shin, Hye Sun Lee, Eun‐Kyung Kim, Hee Jung Moon, Ji Hye Lee, Jin Young Kwak
SJR Q1PLoS ONEOA

Serum TgAbs may interfere with FNA-Tg studies and caution is advised while analyzing FNA-Tg for detection of LNM in patients with PTC.

Endocrinology, Diabetes and MetabolismMedicine

Research Areas

Radiology, Nuclear Medicine and ImagingEpidemiologySurgeryPhysiologyMolecular BiologyEndocrinology, Diabetes and Metabolism

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