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Hyun-Jung Lee

Ewha Womans University · Medicine

About the Lab

Professor Hyun-Jung Lee's research lab specializes in biomedical materials and clinical anesthesiology, focusing on the development of stimuli-responsive polymers for targeted drug delivery and tissue engineering, as well as improving perioperative outcomes in surgical patients. The lab investigates disease-responsive biomaterials—such as ROS-sensitive degradable polymers—and explores innovative anesthetic techniques to manage postoperative pain and reduce complications. Additionally, the lab contributes to maternal-fetal medicine by studying high-risk obstetric conditions, including placenta previa and postpartum hemorrhage, to enhance clinical management strategies.

biomaterialspostoperative painpostpartum hemorrhagestimuli-responsive polymersperioperative care

Research Overview

Papers
79
Total Citations
1,379
Papers (5y)
28
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
28total
2022
2023
2024
2025
2026
Citations per year (5y)
157total
20222023202420252026

Selected Papers

15
1
Article|41 citations·2019
ROS‐Sensitive Degradable PEG–PCL–PEG Micellar Thermogel
Hyun Jung Lee, Byeongmoon Jeong
SJR Q1Small

Abstract A reactive oxygen species (ROS)‐sensitive degradable polymer would be a promising material in designing a disease‐responsive system or accelerating degradation of polymers with slow hydrolysis kinetics. Here, a thermogelling poly(ethylene glycol)–polycaprolactone–poly(ethylene glycol) (PEG–PCL–PEG or EG 12 –CL 20 –EG 12 ) triblock copolymer with an oxalate group at the middle of the polymer is reported. The polymers form micelles with an average size of 100 nm in water. Thermogelation i

Molecular MedicineBiochemistry, Genetics and Molecular Biology
2
Article|21 citations·2020
<p>Risk Factors for Perioperative Respiratory Adverse Events in Children with Recent Upper Respiratory Tract Infection: A Single-Center-Based Retrospective Study</p>
Hyun Jung Lee, Jae Hee Woo, Sooyoung Cho, Hye‐Won Oh, Hyunyoung Joo, Hee Jung Baik
SJR Q1Therapeutics and Clinical Risk ManagementOA

For pediatric patients who require surgery and have a recent history of URI, procedures should be performed after a URI symptom-free period of at least 1-2 weeks. Confirming the absence of abnormalities in preoperative chest images can reduce the incidence of perioperative RAEs.

Anesthesiology and Pain MedicineMedicine
3
Article|21 citations·2023
Intravenous Versus Perineural Dexamethasone for Reducing Rebound Pain After Interscalene Brachial Plexus Block: A Randomized Controlled Trial
Hyun Jung Lee, Jae Hee Woo, Ji Seon Chae, Youn Jin Kim, Sang-Jin Shin
SJR Q2Journal of Korean Medical ScienceOA

Background: Interscalene brachial plexus block (ISB) is a common regional technique to manage acute postoperative pain for arthroscopic rotator cuff tear repair.However, rebound pain may compromise its overall benefit.Our aim was to investigate the primary hypothesis that perineural and intravenous dexamethasone have different effects on rebound pain after resolution of ISB for arthroscopic rotator cuff tear repair.Methods: Patients aged 20 years scheduled for elective arthroscopic rotator cuff

SurgeryMedicine
4
Article|18 citations·2017
Risk factors for massive postpartum bleeding in pregnancies in which incomplete placenta previa are located on the posterior uterine wall
Hyun Jung Lee, Young Jai Lee, Eun Hee Ahn, Hyeon Chul Kim, Sang Hee Jung, Sung Woon Chang, Ji Yeon Lee
SJR Q2Obstetrics & Gynecology ScienceOA

This is the first study of cases with incomplete placenta previa located on the posterior uterine wall, which were complicated by massive PPH. Our findings might be helpful to guide obstetric management and provide useful information for prediction of massive PPH in pregnancies with incomplete placenta previa located on the posterior uterine wall.

Pediatrics, Perinatology and Child HealthMedicine
5
Article|17 citations·2023
Preoperative Frailty Is an Independent Risk Factor for Postinduction Hypotension in Older Patients Undergoing Noncardiac Surgery: A Retrospective Cohort Study
Hyun Jung Lee, Youn Jin Kim, Jae Hee Woo, Hye‐Won Oh
SJR Q1The Journals of Gerontology Series AOA

BACKGROUND: Intraoperative hypotension is a risk factor for perioperative adverse outcomes and is highly prevalent in older patients. Frailty has been associated with hemodynamic instability but its impact on postinduction hypotension is unclear. Therefore, we assessed the association between frailty and postinduction hypotension in older patients. METHODS: We retrospectively evaluated electronic medical records of patients aged ≥65 years who were assessed for preoperative frailty and underwent

Cardiology and Cardiovascular MedicineMedicine
6
Article|15 citations·2019
Uterine artery embolization versus cesarean hysterectomy in the management of postpartum hemorrhage
Hyun Jung Lee, Hee Young Cho, Min Joo Peck, Hyo Jin Ki, Myoung Jin Moon, Hyeon Chul Kim, Sung Woon Jang, Young Ran Kim
SJR Q2Minimally Invasive Therapy & Allied Technologies

<b>Objective:</b> The purpose of this study was to compare the efficacy and complications between cesarean hysterectomy and uterine artery embolization (UAE) in the management of postpartum bleeding.<b>Material and methods:</b> We analyzed the outcomes of 48 patients who underwent cesarean hysterectomy from October 2007 to January 2017, and 333 patients who underwent UAE for postpartum bleeding which was unresponsive to conservative management. We reviewed all medical records retrospectively, an

Pediatrics, Perinatology and Child HealthMedicine
7
Article|11 citations·2023
Transcutaneous Carbon Dioxide Monitoring More Accurately Detects Hypercapnia than End-Tidal Carbon Dioxide Monitoring during Non-Intubated Video-Assisted Thoracic Surgery: A Retrospective Cohort Study
Hyun Jung Lee, Jae Hee Woo, Sooyoung Cho, Sunyoung Moon, Sook Whan Sung
SJR Q1Journal of Clinical MedicineOA

Transcutaneous carbon dioxide (PtcCO2) monitoring is known to be effective at estimating the arterial partial pressure of carbon dioxide (PaCO2) in patients with sedation-induced respiratory depression. We aimed to investigate the accuracy of PtcCO2 monitoring to measure PaCO2 and its sensitivity to detect hypercapnia (PaCO2 &gt; 60 mmHg) compared to nasal end-tidal carbon dioxide (PetCO2) monitoring during non-intubated video-assisted thoracoscopic surgery (VATS). This retrospective study inclu

Pulmonary and Respiratory MedicineMedicine
8
Article|7 citations·2020
Transcatheter Arterial Embolization in the Management of Postpartum Hemorrhage due to Genital Tract Injury after Vaginal Delivery
Hyun Jung Lee, Migang Kim, B H Lim, Young Ran Kim, Gyeong Sik Jeon, Sang Hee Jung
SJR Q2Journal of Vascular and Interventional Radiology
Pediatrics, Perinatology and Child HealthMedicine
9
Article|5 citations·2019
Massive Broad Ligament Hematoma Caused by Spontaneous Uterine Artery Rupture after Uncomplicated Vaginal Delivery
Hyun Jung Lee, Eun Duc Na, Hyeon Chul Kim, Mi Sun Kim, Myoung Jin Moon
SJR Q2Journal of Minimally Invasive Gynecology
Pediatrics, Perinatology and Child HealthMedicine
10
Article|3 citations·2022
Strategy to Reduce Hypercapnia in Robot-Assisted Radical Prostatectomy Using Transcutaneous Carbon Dioxide Monitoring: A Prospective Observational Study
Hyun Jung Lee, Ji Seon Chae, Sang-Mee An, Hye‐Won Oh, Youn Jin Kim, Jae Hee Woo
Dove Medical Press (Taylor and Francis Group)OA

Hyun Jung Lee,1 Ji Seon Chae,2 Sang-Mee An,2 Hye-Won Oh,1 Youn Jin Kim,1 Jae Hee Woo1 1Department of Anesthesiology and Pain Medicine, College of Medicine, Ewha Womans University, Seoul, South Korea; 2Department of Anesthesiology and Pain Medicine, Ewha Womans University Seoul Hospital, Seoul, South KoreaCorrespondence: Jae Hee Woo, Department of Anesthesiology and Pain Medicine, College of Medicine, Ewha Womans University, 260 Gonghangdaero, Gangseo-gu, Seoul, 07804, South Korea, Tel +82-2-6986

SurgeryMedicine
11
Article|3 citations·2009
Indicators for Externalizing Behaviors of Adolescents with Asperger Syndrome
이효정, Myles, Brenda Smith, Tien, Kai-Chien

Externalizing behavior has been recognized as a problem area for individuals with Asperger Syndrome for several reasons, such as their poor social cognition and ability to adjust and regulate their responses to the environment. However, due to a lack of empirical studies and information about AS, our understanding of these challenges is still limited In this study, externalizing behavior, including aggression, hyperactivity, and conduct problems, was investigated in an effort to identify predict

12
Article|2 citations·2024
Predictive Value of Ultrasound-Measured Quadriceps Depth and Frailty Status for Hypotension in Older Patients Undergoing Reverse Total Shoulder Arthroplasty in the Beach Chair Position under General Anesthesia
Sang-Mee An, Hyun Jung Lee, Jae Hee Woo, Ji Seon Chae, Sangjin Shin
SJR Q2Journal of Personalized MedicineOA

The beach chair position (BCP) is widely used in shoulder surgery; however, it frequently leads to hypotension. Hypotension in BCP is prevalent among older patients who are at risk of secondary complications such as ischemic injuries. Therefore, this prospective study aimed to investigate the association and predictive value of frailty, as assessed by ultrasound-measured quadriceps depth and questionnaire, in patients aged ≥65 years undergoing elective shoulder surgery under general anesthesia.

SurgeryMedicine
13
Article|2 citations·2023
Potential Risk of Choline Alfoscerate on Isoflurane-Induced Toxicity in Primary Human Astrocytes
Hyun Jung Lee, Hye Rim Cho, Minji Bang, Yeo Song Lee, Youn Jin Kim, Kyuha Chong
SJR Q2Journal of Korean Neurosurgical SocietyOA

OBJECTIVE: Isoflurane, a widely used common inhalational anesthetic agent, can induce brain toxicity. The challenge lies in protecting neurologically compromised patients from neurotoxic anesthetics. Choline alfoscerate (L-α-Glycerophosphorylcholine, α-GPC) is recognized for its neuroprotective properties against oxidative stress and inflammation, but its optimal therapeutic window and indications are still under investigation. This study explores the impact of α-GPC on human astrocytes, the mos

Developmental NeuroscienceNeuroscience
14
Article|2 citations·2015
Pediatricians and Emergency Physicians’ Recognition and Training Regarding Child Abuse
Hyun Jung Lee, Hye Young Jang, Jong Beon Byeon, Jin Hee Jung, Jeong‐Min Ryu, Young Ho Kwak, June Dong Park
Pediatric Emergency Medicine JournalOA

Purpose: To explore the recognition levels and educational experiences of child abuse among physicians.

Pediatrics, Perinatology and Child HealthMedicine
15
Article|1 citations·2024
Comparing pronunciation challenges in South Korean preschoolers with unilateral single-sided deafness due to cochlear nerve deficiency to a norm-referenced standard
Goun Choe, Jong Woo Lim, Hyun Jung Lee, Seung Hyun Kim, Marge Carandang, Bong Jik Kim, Byung Yoon Choi
SJR Q1PLoS ONEOA

This study aimed to compare the development of pronunciation in South Korean preschoolers with unilateral cochlear nerve deficiency (CND) to that of age-matched preschoolers with normal hearing, a topic that has not been explored previously. In a retrospective analysis, 25 preschoolers with unilateral CND who had undergone a speech evaluation battery, including a pronunciation and vocabulary test, were enrolled. Utilizing the Urimal Test of Articulation and Phonation and customized language abil

Cognitive NeuroscienceNeuroscience

Research Areas

SurgeryPediatrics, Perinatology and Child HealthMolecular MedicineAnesthesiology and Pain MedicineDevelopmental NeuroscienceCardiology and Cardiovascular Medicine

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