Hyun-Sung Yu

We report on an approach to exploit multiple light scattering by shaping the incident wavefront in optical coherence tomography (OCT). Most of the reflected signal from biological tissue consists of multiply scattered light, which is regarded as noise in OCT. A digital mirror device (DMD) is utilized to shape the incident wavefront such that the maximal energy is focused at a specific depth in a highly scattering sample using a coherence-gated reflectance signal as feedback. The proof-of-concept

Holography is one of the most prominent approaches to realize true-to-life reconstructions of objects. However, owing to the limited resolution of spatial light modulators compared to static holograms, reconstructed objects exhibit various coherent properties, such as content-dependent defocus blur and interference-induced noise. The coherent properties severely distort depth perception, the core of holographic displays to realize 3D scenes beyond 2D displays. Here, we propose a hologram that im

We present a wide-field quantitative label-free imaging of mouse brain tissue slices with sub-micrometre resolution, employing holographic microscopy and an automated scanning platform. From the measured light field images, scattering coefficients and anisotropies are quantitatively retrieved by using the modified the scattering-phase theorem, which enables access to structural information about brain tissues. As a proof of principle, we demonstrate that these scattering parameters enable us to

We propose and demonstrate a system for wavefront shaping, which generates optical foci through complex disordered media and achieves an enhancement factor of greater than 100,000. To exploit the 1 megapixel capacity of a digital micro-mirror device and its fast frame rate, we developed a fast and efficient method to handle the heavy matrix algebra computation involved in optimizing the focus. We achieved an average enhancement factor of 101,391 within an optimization time of 73 minutes with amp

This report provides an update on development of a pre-conceptual design for the Small Secure Transportable Autonomous Reactor (SSTAR) Lead-Cooled Fast Reactor (LFR) plant concept and supporting research and development activities. SSTAR is a small, 20 MWe (45 MWt), natural circulation, fast reactor plant for international deployment concept incorporating proliferation resistance for deployment in non-fuel cycle states and developing nations, fissile self-sufficiency for efficient utilization of

We introduce a non-invasive approach for optogenetic regulation in biological cells through highly scattering skull tissue using wavefront shaping. The wavefront of the incident light was systematically controlled using a spatial light modulator in order to overcome multiple light-scattering in a mouse skull layer and to focus light on the target cells. We demonstrate that illumination with shaped waves enables spatiotemporal regulation of intracellular Ca(2+) level at the individual-cell level.

While recent research has shown that holographic displays can represent photorealistic 3D holograms in real time, the difficulty in acquiring high-quality real-world holograms has limited the realization of holographic streaming systems. Incoherent holographic cameras, which record holograms under daylight conditions, are suitable candidates for real-world acquisition, as they prevent the safety issues associated with the use of lasers; however, these cameras are hindered by severe noise due to

The identification and quantification of specific molecules are crucial for studying the pathophysiology of cells, tissues, and organs as well as diagnosis and treatment of diseases. Recent advances in holographic microspectroscopy, based on quantitative phase imaging or optical coherence tomography techniques, show promise for label-free noninvasive optical detection and quantification of specific molecules in living cells and tissues (e.g., hemoglobin protein). To provide important insight int

We present measurements of the full Jones matrix of individual pixels in a liquid-crystal display (LCD) panel. Employing a polarization-sensitive digital holographic microscopy based on Mach-Zehnder interferometry, the complex amplitudes of the light passing through individual LCD pixels are precisely measured with respect to orthogonal bases of polarization states, from which the full Jones matrix components of individual pixels are obtained. We also measure the changes in the Jones matrix of i

Multi-focal plane and multi-layered light-field displays are promising solutions for addressing all visual cues observed in the real world. Unfortunately, these devices usually require expensive optimizations to compute a suitable decomposition of the input light field or focal stack to drive individual display layers. Although these methods provide near-correct image reconstruction, a significant computational cost prevents real-time applications. A simple alternative is a linear blending strat

Digital holography has high potentials for future 3D imaging and display technology. Due to the capability of recording and projecting realistic 3D images, holography has been extensively studied for decades. However, the requirement of a reference beam in interferometric systems and a limited number of pixels in existing spatial light modulators have been major obstacles for the practical applications of 3D holography technology. Recently, the field of wavefront shaping, or the study of control

Developing an efficient strategy for light focusing through scattering media is an important topic in the study of multiple light scattering. The enhancement factor of the light focusing, defined as the ratio between the optimized intensity and the background intensity is proportional to the number of controlling modes in a spatial light modulator (SLM). The demonstrated enhancement factors in previous studies are typically less than 1,000 due to several limiting factors, such as the slow refres

In digital 3D holographic displays, the generation of realistic 3D images has been hindered by limited viewing angle and image size. Here we demonstrate a digital 3D holographic display using volume speckle fields produced by scattering layers in which both the viewing angle and the image size are greatly enhanced. Although volume speckle fields exhibit random distributions, the transmitted speckle fields have a linear and deterministic relationship with the input field. By modulating the incide