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Hyun‐Sik Kang

Sungkyunkwan University · Medicine

About the Lab

Professor Hyun-Sik Kang's research lab focuses on metabolic and musculoskeletal health in aging and pediatric populations, with a strong emphasis on insulin resistance, sarcopenia, osteoporosis, and cardiovascular risk factors. The lab investigates the interplay between lifestyle factors, genetic markers (such as ACTN3 polymorphism), and metabolic syndrome in Korean adults and adolescents. Key research directions include identifying early biomarkers for metabolic and musculoskeletal disorders, evaluating the impact of physical activity and muscle strength on mortality, and exploring the role of insulin resistance in childhood obesity and metabolic syndrome. The lab employs clinical, genetic, and epidemiological approaches using large-scale population data and advanced imaging techniques like dual-energy X-ray absorptiometry (DXA).

insulin resistancesarcopeniametabolic syndromemuscle strengthosteoporosis

Research Overview

Papers
379
Total Citations
3,064
Papers (5y)
80
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
80total
2021
2022
2023
2024
2025
Citations per year (5y)
204total
20212022202320242025

Selected Papers

15
1
Article|215 citations·2002
Physical training improves insulin resistance syndrome markers in obese adolescents
Hyun‐Sik Kang, Bernard Gutin, Paule Barbeau, Scott Owens, Christian R. Lemmon, Jerry D. Allison, Mark S. Litaker, Ngoc‐Anh Le
SJR Q1Medicine & Science in Sports & Exercise

PT, especially high-intensity PT, had a favorable effect on several IRS markers in obese adolescents.

Public Health, Environmental and Occupational HealthMedicine
2
Article|99 citations·2010
Preinterventional Clopidogrel Response Variability for Coil Embolization of Intracranial Aneurysms: Clinical Implications
Hyun‐Sik Kang, B.J. Kwon, Jeong Eun Kim, Moon Hee Han
SJR Q1American Journal of NeuroradiologyOA

Procedure-related thromboembolic events occurred more frequently in patients in the upper quartile with higher PRU, especially in the fourth quartile. Further study including a large number of patients is expected to confirm this finding.

Cardiology and Cardiovascular MedicineMedicine
3
Article|77 citations·2019
Protective effect of exercise training against the progression of Alzheimer’s disease in 3xTg-AD mice
Donghyun Kim, Jinkyung Cho, Hyun‐Sik Kang
SJR Q2Behavioural Brain Research
PhysiologyMedicine
4
Article|48 citations·2017
Insulin Resistance and Its Association with Metabolic Syndrome in Korean Children
Jinkyung Cho, Haeryun Hong, Soohyun Park, Shinuk Kim, Hyun‐Sik Kang
SJR Q2BioMed Research InternationalOA

Background . This study investigated the association between insulin resistance (IR) and metabolic syndrome (MetS) in children. Methods . A cross-sectional study involving 1036 healthy children aged between 7 and 13 years was conducted. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as an index of IR. Participants were classified according to the HOMA-IR quartiles. Results . Incremental, linear trends were found in age (<mml:math xmlns:mml="http://www.w3.org/1998/Mat

Endocrinology, Diabetes and MetabolismMedicine
5
Article|48 citations·2009
Combined effects of body mass index and cardio/respiratory fitness on serum vaspin concentrations in Korean young men
Jinkyung Cho, Tae‐Kyung Han, Hyun‐Sik Kang
SJR Q1European Journal of Applied Physiology
EpidemiologyMedicine
6
Article|44 citations·2019
Handgrip strength, depression, and all-cause mortality in Korean older adults
Soohyun Park, Jinkyung Cho, Donghyun Kim, Youngyun Jin, Inhwan Lee, Haeryun Hong, Hyun‐Sik Kang
SJR Q1BMC GeriatricsOA

BACKGROUND: Decreased muscle strength and/or depression with aging are emerging as important public health concerns in both developed and developing countries. This study investigated the effects of low handgrip strength (HGS) and depression on the risk of all-cause mortality in Korean older adults. METHODS: Data from 13,901 Korean adults (57% women) who participated in the 2008 baseline survey and completed the 2011 follow-up assessments were used. RESULTS: In total, the current findings showed

PhysiologyMedicine
7
Article|38 citations·2017
ACTN3 Gene and Susceptibility to Sarcopenia and Osteoporotic Status in Older Korean Adults
Jinkyung Cho, Inhwan Lee, Hyun‐Sik Kang
SJR Q2BioMed Research InternationalOA

Background . Little information is available about molecular markers for sarcopenia and osteoporosis in Asian populations. Objective . This study investigated the association of the ACTN3 polymorphism with sarcopenia and osteoporotic status in older Korean adults. Methods . Older Korean 62 men and 270 women (mean age 73.7 ± 6.6 years) participated in this study. Body mass index, percent body fatness, appendicular skeletal muscle mass, and bone mineral density of the lumbar spine, femur, and tota

GeneticsBiochemistry, Genetics and Molecular Biology
8
Article|38 citations·2019
Lifestyle Risk Factors and All-Cause and Cardiovascular Disease Mortality: Data from the Korean Longitudinal Study of Aging
Inhwan Lee, Shinuk Kim, Hyun‐Sik Kang
SJR Q2International Journal of Environmental Research and Public HealthOA

This study examined the association between lifestyle risk factors and all-cause and cardiovascular disease (CVD) mortality in 9945 Korea adults (56% women) aged 45 years and older. Smoking, heavy alcohol intake, underweight or obesity, physical inactivity, and unintentional weight loss (UWL) were included as risk factors. During 9.6 ± 2.0 years of follow-up, there were a total of 1530 cases of death from all causes, of which 365 cases were from CVD. Compared to a zero risk factor (hazard ratio,

Public Health, Environmental and Occupational HealthMedicine
9
Article|36 citations·2019
Exercise training modifies gut microbiota with attenuated host responses to sepsis in wild‐type mice
Donghyun Kim, Hyun‐Sik Kang
SJR Q1The FASEB Journal

This study investigated the effects of exercise preconditioning-induced modification in gut microbiota composition and host responses to cecal ligation and puncture (CLP)-induced sepsis. Four-week-old C57BL/6N male mice were randomly assigned to either CLP ( n = 30) or CLP-exercise (CLP+Exe; n = 30) groups. Prior to CLP-induced sepsis, the CLP+Exe mice were subjected to 8 wk of treadmill running. Fecal samples were collected and analyzed by 16S rRNA amplification sequencing to assess gut microbi

Molecular BiologyBiochemistry, Genetics and Molecular Biology
10
Article|29 citations·2018
Association between Obesity and Carotid Intima-Media Thickness in Korean Office Workers: The Mediating Effect of Physical Activity
Youngyun Jin, Donghyun Kim, Jinkyung Cho, Inhwan Lee, Kyu-Hwan Choi, Hyun‐Sik Kang
SJR Q2BioMed Research InternationalOA

BACKGROUND: Obesity and physical inactivity are associated with higher prevalence of cardiovascular disease (CVD). OBJECTIVE: This study investigated the association between obesity and carotid intima-media thickness (CIMT) stratified by physical activity (PA) in Korean office workers. METHODS: Data obtained from 914 office workers aged 21-60 years (347 women) were used. Resting blood pressures, body mass index (BMI), and waist-to-height ratio (WHtR) were measured. PA was assessed using the inte

Cardiology and Cardiovascular MedicineMedicine
11
Article|24 citations·2015
Poor physical fitness is independently associated with mild cognitive impairment in elderly Koreans
Shinho Lee, Jinhee Han, Young-Un Jin, Inhan Lee, Haeryun Hong, Hyun‐Sik Kang
SJR Q1Biology of SportOA

The purpose of this study was to investigate the association between physical fitness and mild cognitive impairment (MCI) in elderly Koreans. This was a cross-sectional study that involved 134 men and 299 women aged 65 to 88 years. Six senior fitness tests were used as independent variables: 30 s chair stand for lower body strength, arm curl for upper body strength, chair-sit-and-reach for lower body flexibility, back scratch for upper body flexibility, 8-ft up-and-go for agility/dynamic balance

PhysiologyMedicine
12
Article|23 citations·2021
Eating Speed, Physical Activity, and Cardiorespiratory Fitness Are Independent Predictors of Metabolic Syndrome in Korean University Students
Minjeong Kang, Mingyu Joo, Haeryun Hong, Hyun‐Sik Kang
SJR Q1NutrientsOA

Background: Little is known regarding the role of eating quickly, physical inactivity, and poor cardiorespiratory fitness (CRF) in assessing the onset of metabolic syndrome (Mets) in Korean young adults. Objectives: This study examined the association between the three risk factors and Mets in 1891 Korean university students (30% female) aged 18–29 years. Methods: Eating speed (slow vs. fast) and physical activity (active vs. inactive) were assessed with a standardized questionnaire. Maximal oxy

Endocrinology, Diabetes and MetabolismMedicine
13
Article|22 citations·2006
남자대학생의 심폐체력과 비만 및 대사증후군지표의 상관관계
강현식, 이상화, 이은혜

n a prospective way, we studied 226 college male students who were apparently healthy and not taking any medications affecting blood pressure, blood lipids, and blood glucose. Following an overnight fasting, 20 ㎖ of venous blood was drawn from an antecubital vein into heparin-treated collection tubes for fasting lipids and glucose assays. Resting blood pressures were also measured in duplicate, of which mean values were used for data analysis. cardiorespiratory(CR) fitness was quantified as minu

14
Article|21 citations·2018
Physical activity and all-cause mortality in Korean older adults
Jinkyung Cho, Inhwan Lee, Soo Hyun Park, Youngyun Jin, Donghyun Kim, Shinuk Kim, Hyun‐Sik Kang
SJR Q3Annals of Human BiologyOA

PA was inversely and independently associated with all-cause mortality in Korean older adults.

PhysiologyMedicine
15
Article|18 citations·2016
Adiponectin mediates the additive effects of combining daily exercise with caloric restriction for treatment of non-alcoholic fatty liver
J Cho, Yeojung Koh, Ji Min Han, D Kim, T Kim, Hyun‐Sik Kang
SJR Q1International Journal of Obesity
EpidemiologyMedicine

Research Areas

PhysiologyEpidemiologyAerospace EngineeringGeneral Health ProfessionsPublic Health, Environmental and Occupational HealthCardiology and Cardiovascular Medicine

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