In-Kyun Lee
Seoul National University · Biochemistry, Genetics and Molecular Biology
About the Lab
Professor In-Kyun Lee's research lab specializes in structural biology and biochemistry, with a primary focus on understanding the structure and function of novel and hypothetical proteins from pathogenic bacteria, particularly Staphylococcus aureus. The lab employs advanced nuclear magnetic resonance (NMR) spectroscopy to determine high-resolution three-dimensional structures and dynamics of these proteins, aiming to elucidate their roles in bacterial stress response and pathogenesis. A key research direction involves characterizing ribosome-associated chaperones and their involvement in ribosomal quality control mechanisms.
Research Overview
Research Output Trend
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Selected Papers
1SAV0506 is an 87 residue hypothetical protein from Staphylococcus aureus strain Mu50 and also predicted to have similar function to ribosome associated heat shock protein, Hsp 15. Hsp15 is thought to be involved in the repair mechanism of erroneously produced 50S ribosome subunit. In this report, we present the sequence specific backbone resonance assignment of SAV0506. About 82.5% of all resonances could be assigned unambiguously. By analyzing deviations of the <TEX>$C{\alpha}$</TEX> and <TEX>$
Research Areas
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