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Jae-Hoon Jeong

Yonsei University · Engineering

About the Lab

Professor Jae-Hoon Jeong's research lab specializes in interdisciplinary studies at the intersection of neuroscience, materials science, and organic chemistry. The lab investigates synaptic transmission mechanisms using advanced electron microscopy techniques, particularly electron tomography, to understand the structural basis of neurotransmitter release and long-term potentiation. It also explores functional materials, such as diamond-like carbon coatings on field emission arrays, for enhanced electron emission properties. Additionally, the lab engages in synthetic organic chemistry, focusing on complex natural product synthesis through selective cyclization strategies. These diverse research directions reflect a strong emphasis on structural biology, neurophysiological mechanisms, and innovative materials development.

synaptic transmissionelectron tomographyfield emissionnatural product synthesisnanomaterials

Research Overview

Papers
137
Total Citations
1,183
Papers (5y)
17
Primary Field
Engineering

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
17total
2022
2023
2024
2025
2026
Citations per year (5y)
45total
20222023202420252026

Selected Papers

15
1
Article|46 citations·2016
Variable priming of a docked synaptic vesicle
Jae Hoon Jung, Joseph A. Szule, Robert M. Marshall, U.J. McMahan
SJR Q1Proceedings of the National Academy of SciencesOA

The priming of a docked synaptic vesicle determines the probability of its membrane (VM) fusing with the presynaptic membrane (PM) when a nerve impulse arrives. To gain insight into the nature of priming, we searched by electron tomography for structural relationships correlated with fusion probability at active zones of axon terminals at frog neuromuscular junctions. For terminals fixed at rest, the contact area between the VM of docked vesicles and PM varied >10-fold with a normal distribution

Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
Article|39 citations·1997
Enhancement of electron emission efficiency and stability of molybdenum-tip field emitter array by diamond like carbon coating
Jae Hoon Jung, Byeoung Kwon Ja, Yun Hi Lee, Jin Jang, Myung Hwan Oh
SJR Q1IEEE Electron Device Letters

The effect of diamond like carbon (DLC) films, coated by a layer-by-layer technique using PECVD (plasma enhanced chemical vapor deposition) on the electron emission characteristics of molybdenum (Mo)-tip field emitter array (FEA) is examined. The turn-on voltage was lowered from 80 V for the Mo-tip to 65 V for the DLC-coated Mo-tip FEA while the maximum emission current was increased from 140 μA for the Mo-tip to 320 μA for the DLC-coated Mo-tip FEA composed of 900 emitters. For an anode current

Materials ChemistryMaterials Science
3
Article|36 citations·2003
Becker's Nevus with Ipsilateral Breast Hypoplasia: Improvement with Spironolactone
Jae Hoon Jung, You Chan Kim, Hyang-Joon Park, Yong Woo Cinn
SJR Q1The Journal of Dermatology

Ipsilateral breast hypoplasia is a rare abnormality in Becker's nevus. The pathogenesis of the breast hypoplasia is not understood, but an increased level of androgenic receptor in the affected area may play a role. We report a case of Becker's nevus with ipsilateral breast hypoplasia. Spironolactone, an anti-androgenic agent, was tried for treatment of the hypoplasia, and, one month later, breast enlargement was seen in only the hypoplastic breast with Becker's nevus. This finding supports the

GeneticsBiochemistry, Genetics and Molecular Biology
4
Article|36 citations·2021
Shortened tethering filaments stabilize presynaptic vesicles in support of elevated release probability during LTP in rat hippocampus
Jae Hoon Jung, Lyndsey M. Kirk, Jennifer N. Bourne, Kristen M. Harris
SJR Q1Proceedings of the National Academy of SciencesOA

Long-term potentiation (LTP) is a cellular mechanism of learning and memory that results in a sustained increase in the probability of vesicular release of neurotransmitter. However, previous work in hippocampal area CA1 of the adult rat revealed that the total number of vesicles per synapse decreases following LTP, seemingly inconsistent with the elevated release probability. Here, electron-microscopic tomography (EMT) was used to assess whether changes in vesicle density or structure of vesicl

Cellular and Molecular NeuroscienceNeuroscience
5
Article|32 citations·2009
Expedient Synthesis of (−)‐Amphidinolide X
Jae Hoon Jung, Eun Lee
SJR Q1Angewandte Chemie International Edition

Specific cyclizations: The total synthesis of (−)-amphidinolide X was accomplished by employing a SmI2-mediated 5-exo cyclization of an aldehydo β-alkoxyvinyl sulfoxide and a ring-closing metathesis reaction (see scheme; Tol: tolyl).

Organic ChemistryChemistry
6
Article|26 citations·2014
Prognostic Significance of Vestibulospinal Abnormalities in Patients With Vestibular Migraine
Jae Hoon Jung, Myung Hoon Yoo, Chan Il Song, Jae Ryung Lee, Hong Ju Park
SJR Q1Otology & Neurotology

2b Individual retrospective cohort study.

NeurologyNeuroscience
7
Article|23 citations·2007
Efficient Chirality Transfer in the SmI2-Mediated Cyclization of Aldehydo β-Alkoxyvinyl Sulfoxides: Asymmetric Synthesis of 3-Hydroxyoxanes
Jae Hoon Jung, Yong Wook Kim, Min Ah Kim, Soo Young Choi, Young Keun Chung, Tae‐Rae Kim, Seokmin Shin, Eun Lee
SJR Q1Organic Letters

Stereoselective syntheses of 3-hydroxyoxanes were achieved via efficient chirality transfer in the SmI2-mediated cyclization reactions of aldehydo beta-alkoxyvinyl sulfoxides.

Organic ChemistryChemistry
8
Article|22 citations·2007
Vascular development in plants: specification of xylem and phloem tissues
Jae Hoon Jung, Chung Mo Park
SJR Q2Journal of Plant Biology
Plant ScienceAgricultural and Biological Sciences
9
Article|18 citations·2010
kNN 알고리즘과 계절별 Landsat TM 위성영상을 이용한 단양군 지역의 지상부 바이오매스 탄소저장량 추정
정재훈, 허준, 유수홍, 김경민, 이정빈
대한공간정보학회지

원격탐사 자료와 현장 자료를 이용한 산림 바이오매스 탄소량 추정은 전 세계적으로 각광을 받고 있으며, 국내의 경우 2010년 국립산림과학원에서 개발한 수종별 탄소배출계수를 통해 보다 정확한 탄소량 추정이 가능하게 되었다. 본 연구에서는 2006년부터 2009년까지 구축된 제5차 국가산림자원조사(National Forest Inventory, NFI) 자료를 기반으로 k-Nearest Neighbor(kNN) 알고리즘을 이용하여 충청북도 단양군의 지상부 바이오매스 탄소량을 추정하였다. 원격탐사 자료로는 계절 변화가 뚜렷한 한반도의 기후가 산림 지역의 분광 특성 및 이에 따른 탄소량 추정에 미치는 영향을 조사하기 위해 2004년부터 2005년까지 계절별로 취득된 Landsat TM 위성영상을 이용하였다. 분석결과 단양군 지역의 지상부 바이오매스 총 탄소량은 최대 3542768.49tonC에서 최소 3329037.51tonC 사이로 추정되었으나, 계절에 따른 특정 경향은 발견되지 않았다.

10
Article|17 citations·2018
Active Zone Material-Directed Orientation, Docking, and Fusion of Dense Core Vesicles Alongside Synaptic Vesicles at Neuromuscular Junctions
Jae Hoon Jung, Joseph A. Szule, Kylee Stouder, Robert M. Marshall, U.J. McMahan
SJR Q1Frontiers in NeuroanatomyOA

Active zone material is an organelle that is common to active zones along the presynaptic membrane of chemical synapses. Electron tomography on active zones at frog neuromuscular junctions has provided evidence that active zone material directs the docking of synaptic vesicles (SVs) on the presynaptic membrane at this synapse. Certain active zone material macromolecules connect to stereotypically arranged macromolecules in the membrane of undocked SVs, stably orienting a predetermined fusion dom

Molecular BiologyBiochemistry, Genetics and Molecular Biology
11
Article|12 citations·1998
Effect of N doping on the electron emission properties of diamondlike carbon film on a 2-in. Mo field emitter array panel
Jae Hoon Jung, Byeong‐Kwon Ju, Hoon Kim, Myung Hwan Oh, Suk Jae Chung, Jin Jang
Journal of Vacuum Science & Technology B Microelectronics and Nanometer Structures Processing Measurement and Phenomena

We have studied the enhancement of field-emission characteristics by hydrogen-free nitrogen-doped diamondlike carbon (DLC) coating on Mo-tip field emitter arrays by a layer-by-layer technique using plasma-enhanced chemical vapor deposition. The Spindt-type molybdenum tip is used as an emission source without a resistive layer on the silicon substrate. The maximum emission current for each pixel was increased from 160 to 1520 μA by a 20 nm N-doped DLC coating. Furthermore, the emission current fr

Materials ChemistryMaterials Science
12
Article|12 citations·2019
Terminal Schwann cell and vacant site mediated synapse elimination at developing neuromuscular junctions
Jae Hoon Jung, Ian W. M. Smith, Michelle Mikesh
SJR Q1Scientific ReportsOA

Synapses undergo transition from polyinnervation by multiple axons to single innervation a few weeks after birth. Synaptic activity of axons and interaxonal competition are thought to drive this developmental synapse elimination and tested as key parameters in quantitative models for further understanding. Recent studies of muscle synapses (endplates) show that there are also terminal Schwann cells (tSCs), glial cells associated with motor neurons and their functions, and vacant sites (or vacanc

Cellular and Molecular NeuroscienceNeuroscience
13
Article|10 citations·2023
Cryo-EM tomography and automatic segmentation delineate modular structures in the postsynaptic density
Jae Hoon Jung, Xiaobing Chen, Thomas S. Reese
SJR Q1Frontiers in Synaptic NeuroscienceOA

Postsynaptic densities (PSDs) are large protein complexes associated with the postsynaptic membrane of excitatory synapses important for synaptic function including plasticity. Conventional electron microscopy (EM) typically depicts PSDs as compact disk-like structures of hundreds of nanometers in size. Biochemically isolated PSDs were also similar in dimension revealing a predominance of proteins with the ability to polymerize into an extensive scaffold; several EM studies noted their irregular

Molecular BiologyBiochemistry, Genetics and Molecular Biology
14
Article|9 citations·2023
17‐5: Enhancement of Luminance Efficiency of 3,000ppi OLED Micro‐display using RGB Direct Patterning
Jae Hoon Jung, Myong Hwan Choi, Mun‐Sik Kang, O Eun Kwon, Chi‐Woo Kim, Kiro Jung
SID Symposium Digest of Technical Papers

We have successfully developed the ultra‐high resolution 3,000ppi RGB direct patterning of OLED Micro‐display with high device performance. To fabricate this 3,000ppi RGB OLED Micro‐ display, FMM by UV Laser process was used and this FMM is manufactured by our unique Laser Patterning process. And red, green, and blue pixels were direct patterned by organic evaporation system with high precious alignment between Si substrate and FMM. To improve the device life time, very thin multi films of SiN/C

Electrical and Electronic EngineeringEngineering
15
Article|9 citations·1999
Emission stability of a diamond-like carbon coated metal-tip field emitter array
Jae Hoon Jung, Byeong‐Kwon Ju, Yun Hi Lee, Jin Jang, Myung Hwan Oh
Journal of Vacuum Science & Technology B Microelectronics and Nanometer Structures Processing Measurement and Phenomena

The emission stability of Mo-tip field emitter arrays (FEAs) has been improved. The effect of diamond-like carbon (DLC) films deposited using a layer-by-layer technique using plasma enhanced chemical vapor deposition on the electron emission characteristics of Mo-tip FEAs was examined. The turn-on voltage was lowered from 80 V for Mo-tip FEAs to 65 V for DLC-coated Mo-tip FEAs, and the maximum emission current increased from 140 μA for Mo-tip FEAs to 320 μA for DLC-coated Mo-tip FEAs composed of

Materials ChemistryMaterials Science

Research Areas

Electrical and Electronic EngineeringOrganic ChemistryAerospace EngineeringMolecular BiologyMaterials ChemistryCellular and Molecular Neuroscience

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