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Jae Yoon Song

Korea University · Medicine

About the Lab

Professor Jae Yoon Song's research lab focuses on advancing gynecological oncology through innovative diagnostic and surgical approaches. The lab investigates the application of artificial intelligence in improving colposcopic diagnosis of cervical lesions, explores the molecular and immunohistochemical characteristics of aggressive endometrial cancers such as clear cell carcinoma, and examines surgical proficiency and learning curves in minimally invasive gynecologic oncology. The lab also conducts proteomic studies to identify biomarkers like osteopontin associated with cervical carcinogenesis and progression.

cervical cancerartificial intelligenceendometrial cancersurgical proficiencybiomarker discovery

Research Overview

Papers
168
Total Citations
1,716
Papers (5y)
74
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
74total
2022
2023
2024
2025
2026
Citations per year (5y)
237total
20222023202420252026

Selected Papers

15
1
Article|132 citations·2013
Detection of MicroRNA as Novel Biomarkers of Epithelial Ovarian Cancer From the Serum of Ovarian Cancer Patient
Ye-Won Chung, Hyo-Sook Bae, Jae Yun Song, Jae Kwan Lee, Nak Woo Lee, Tak Kim, Kyu-Wan Lee
SJR Q1International Journal of Gynecological Cancer
Cancer ResearchBiochemistry, Genetics and Molecular Biology
2
Article|46 citations·2022
Role of Artificial Intelligence Interpretation of Colposcopic Images in Cervical Cancer Screening
Seongmin Kim, Hwajung Lee, Sanghoon Lee, Jae Yun Song, Jae Kwan Lee, Nak-Woo Lee
SJR Q2HealthcareOA

The accuracy of colposcopic diagnosis depends on the skill and proficiency of physicians. This study evaluated the feasibility of interpreting colposcopic images with the assistance of artificial intelligence (AI) for the diagnosis of high-grade cervical intraepithelial lesions. This study included female patients who underwent colposcopy-guided biopsy in 2020 at two institutions in the Republic of Korea. Two experienced colposcopists reviewed all images separately. The Cerviray AI® system (AIDO

EpidemiologyMedicine
3
Article|41 citations·2014
Should Endometrial Clear Cell Carcinoma be Classified as Type II Endometrial Carcinoma?
Hyo Sook Bae, Hye‐Sun Kim, Sun Young Kwon, Kyu-Rae Kim, Jae Yun Song, Insun Kim
SJR Q2International Journal of Gynecological PathologyOA

Endometrial clear cell carcinomas (ECCCs) are considered to be Type II endometrial carcinomas, like uterine serous adenocarcinoma (SCA), and therefore aggressive clinical management is indicated. However, according to the limited clinical, immunohistochemical, and molecular data available in the literature, ECCCs show overlapping features of SCA and endometrioid adenocarcinomas. Therefore, questions regarding their designation as the Type II carcinomas have been raised. We performed immunohistoc

Obstetrics and GynecologyMedicine
4
Article|40 citations·2020
Learning curve could affect oncologic outcome of minimally invasive radical hysterectomy for cervical cancer
Seongmin Kim, Kyung‐Jin Min, Sang‐Hoon Lee, Jin Hwa Hong, Jae Yun Song, Jae Kwan Lee, Nak Woo Lee
SJR Q2Asian Journal of SurgeryOA

Surgical proficiency could significantly affect the oncologic outcome in MIS. A prospective study regarding sufficient surgical competence is necessary for elaborate analysis of the feasibility of minimally invasive radical hysterectomy.

Obstetrics and GynecologyMedicine
5
Article|36 citations·2012
The appropriate cone depth to avoid endocervical margin involvement is dependent on age and disease severity
Hyo Sook Bae, Ye Won Chung, Tak Kim, Kyu Wan Lee, Jae Yun Song
SJR Q1Acta Obstetricia Et Gynecologica Scandinavica

OBJECTIVE: To analyse factors associated with endocervical cone margin involvement and suggest appropriate cone depth for the conization procedure. DESIGN: Retrospective cohort study. SETTING: Gynecological oncology center. POPULATION: One thousand two hundred and twenty women undergoing conization for cervical intraepithelial neoplasia (CIN) II or III or stage IA1 microinvasive cervical carcinoma. METHODS: The following factors were analysed: age, parity, gravida, conization type, margin status

EpidemiologyMedicine
6
Article|35 citations·2020
Learning curve for sentinel lymph node mapping in gynecologic malignancies
Seongmin Kim, Ki Jin Ryu, Kyung‐Jin Min, Sang‐Hoon Lee, Un Suk Jung, Jin Hwa Hong, Jae Yun Song, Jae Kwan Lee, Nak Woo Lee
SJR Q1Journal of Surgical Oncology

BACKGROUND AND OBJECTIVES: Only a few studies have reported the learning curve for sentinel lymph node (SLN) detection in gynecologic malignancies. We investigated the learning curve for SLN detection during robot-assisted laparoscopic surgery for endometrial and cervical carcinomas. METHODS: This retrospective analysis included patients with stage IA to IIA1 cervical cancer or stage I to III endometrial cancer who underwent SLN mapping using indocyanine green during robot-assisted laparoscopic

Obstetrics and GynecologyMedicine
7
Article|30 citations·2012
Candidates for Tumor Markers of Cervical Cancer Discovered by Proteomic Analysis
Jae Yun Song, Hyo Sook Bae, Do Hyoung Koo, Jae Kwan Lee, Hak Hyun Jung, Kyu Wan Lee, Nak Woo Lee
SJR Q2Journal of Korean Medical ScienceOA

Cervical cancer is the second most common gynecological cancer among Korean women. While nationwide screening program has developed, the pathogenesis of cervical cancer is unknown. The aim of this study was to compare the protein expression profiles between cervical squamous carcinomas and normal cervical tissues in order to identify proteins that are related to the cancer. Three cervical cancer tissue samples and three normal cervical tissue samples were obtained and protein expression was comp

Molecular BiologyBiochemistry, Genetics and Molecular Biology
8
Article|21 citations·2009
Osteopontin expression correlates with invasiveness in cervical cancer
Jae Yun Song, Jae Kwan Lee, Nak Woo Lee, Bom Woo Yeom, Sun Haeng Kim, Kyu Wan Lee
SJR Q2Australian and New Zealand Journal of Obstetrics and Gynaecology

AIM: Osteopontin is a secreted, integrin-binding glycophosphoprotein that is overexpressed in many types of cancers and appears to be involved in carcinogenesis and cancer progression. To understand the role of osteopontin in carcinogenesis of cervical cancer, this study was designed to determine whether osteopontin is expressed in cervical cancer and carcinoma in situ (CIS) tissue as well as in normal cervical tissue. METHODS: The expression of osteopontin was immunohistochemically analysed fro

RheumatologyMedicine
9
Article|17 citations·2023
Comparison of Surgical Outcomes between Single-Port Laparoscopic Surgery and Da Vinci Single-Port Robotic Surgery
Jeong‐Min Kim, Seon‐Mi Lee, Aeran Seol, Jae Yun Song, Ki-Jin Ryu, Sanghoon Lee, Hyuntae Park, Hyun‐Woong Cho, Kyung‐Jin Min, Jin Hwa Hong, Jae Kwan Lee, Nak-Woo Lee
SJR Q2Journal of Personalized MedicineOA

Background: The aim of this study is to compare the surgical outcomes of single-port laparoscopic surgery (SPLS) and single-port robotic surgery (SPRS). Methods: We retrospectively analyzed patients who underwent a hysterectomy, ovarian cystectomy, or myomectomy with SPLS or SPRS from January 2020 to July 2022. Statistical analyses were performed using the SPSS chi-square test and student’s t-test. Results: A total of 566 surgeries including single-port laparoscopic hysterectomy (SPLH; n = 148),

SurgeryMedicine
10
Article|15 citations·2012
Candidates for Tumor Markers of Cervical Cancer Discovered by Proteomic Analysis
송재윤, 배효숙, Do Hyoung Koo, 이재관, 정학현, Kyu Wan Lee, 이낙우
Journal of Korean Medical Science

Cervical cancer is the second most common gynecological cancer among Korean women. While nationwide screening program has developed, the pathogenesis of cervical cancer is unknown. The aim of this study was to compare the protein expression profiles between cervical squamous carcinomas and normal cervical tissues in order to identify proteins that are related to the cancer. Three cervical cancer tissue samples and three normal cervical tissue samples were obtained and protein expression was comp

11
Article|13 citations·2023
Pivotal Clinical Study to Evaluate the Efficacy and Safety of Assistive Artificial Intelligence-Based Software for Cervical Cancer Diagnosis
Seongmin Kim, Hyonggin An, Hyun‐Woong Cho, Kyung‐Jin Min, Jin Hwa Hong, Sanghoon Lee, Jae Yun Song, Jae Kwan Lee, Nak-Woo Lee
SJR Q1Journal of Clinical MedicineOA

Colposcopy is the gold standard diagnostic tool for identifying cervical lesions. However, the accuracy of colposcopies depends on the proficiency of the colposcopist. Machine learning algorithms using an artificial intelligence (AI) system can quickly process large amounts of data and have been successfully applied in several clinical situations. This study evaluated the feasibility of an AI system as an assistive tool for diagnosing high-grade cervical intraepithelial neoplasia lesions compare

EpidemiologyMedicine
12
Article|11 citations·2016
Management of atypical squamous cells of undetermined significance or low‐grade squamous intraepithelial lesions of the uterine cervix with human papilloma virus infection among young women aged less than 25 years
Ki‐Jin Ryu, Sanghoon Lee, Kyung‐Jin Min, Jin Hwa Hong, Jae Yun Song, Jae Kwan Lee, Nak Woo Lee
SJR Q3Diagnostic Cytopathology

Current ASCCP guidelines recommend repeat cytology 12 months after HPV-positive results in women aged 21-24 years with either atypical squamous cells of undetermined significance (ASCUS) or a low-grade squamous intraepithelial lesion (LSIL). The purpose of this study was to validate an algorithm in such women with ASCUS or LSIL. A multicenter cross-sectional study was carried out at three academic hospitals involving 40,847 Korean women who underwent cervical cancer screening with cytology and H

EpidemiologyMedicine
13
Article|10 citations·2013
Assessment of cervical cancer screening policy in Korea for women over age 65
Sanghoon Lee, Hyun Tae Park, Jin Hwa Hong, Jae Yun Song, Jae Kwan Lee, Nak Woo Lee, Tak Kim, Kyu Wan Lee
SJR Q1Journal of Geriatric Oncology
EpidemiologyMedicine
14
Article|9 citations·2023
Depressed Mood as a Significant Risk Factor for Gynecological Cancer Aggravation
Seon‐Mi Lee, Jae Yun Song, Aeran Seol, Sanghoon Lee, Hyun‐Woong Cho, Kyung‐Jin Min, Jin Hwa Hong, Jae Kwan Lee, Nak-Woo Lee
SJR Q2International Journal of Environmental Research and Public HealthOA

Background: The aim of this study was to evaluate the relationship between depressed mood and gynecological cancer outcomes, identifying risk factors for cancer aggravation. Methods: This study was a retrospective analysis of gynecological cancer patients (January 2020–August 2022) at Korea University Anam Hospital using Patient Health Questionnaire-9 (PHQ-9). Patients were classified into non-depressed mood (NDM)- and depressed mood (DM)-based scores. Statistical analysis was performed using St

OncologyMedicine
15
Article|4 citations·2023
A Rare Case Report of Successful Laparoscopy-Guided Reduction of Non-Puerperal Uterine Inversion
Seongmin Kim, Sanghoon Lee, Jae Yun Song
SJR Q2MedicinaOA

Non-puerperal uterine inversion is an extremely rare and potentially dangerous condition. Cases are poorly described in the literature, and their actual incidence is unknown. A 34-year-old nulliparous female patient visited the emergency department following a loss of consciousness. She had experienced continuous vaginal bleeding over the preceding two months, with a two-day history of worsening symptoms. The patient showed signs of hypovolemic shock secondary to unceasing vaginal bleeding. Ultr

Pediatrics, Perinatology and Child HealthMedicine

Research Areas

Reproductive MedicineObstetrics and GynecologyEpidemiologySurgeryOncologyPublic Health, Environmental and Occupational Health

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