Jae‐Hoon Ko
Sungkyunkwan University · Medicine
About the Lab
Professor Jae-Hoon Ko's research lab focuses on viral immunology, particularly host immune responses to emerging infectious diseases such as SARS-CoV-2 and human adenovirus (HAdV). The lab investigates humoral and cellular immunity, including neutralizing antibody production and T cell responses against SARS-CoV-2 variants, with an emphasis on breakthrough infections and vaccine-induced immunity. Additionally, the lab explores clinical diagnostics and epidemiological surveillance of viral outbreaks, including rapid serological testing and pathogen strain monitoring in outbreak settings.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Objectives: To investigate antibody production in asymptomatic and mild COVID-19 patients. Methods: Sera from asymptomatic to severe COVID-19 patients were collected. Microneutralization (MN), fluorescence immunoassay (FIA), and enzyme-linked immunosorbent assay (ELISA) were performed. Results: A total of 70 laboratory-confirmed COVID-19 patients were evaluated, including 15 asymptomatic/anosmia, 49 mild symptomatic, and 6 pneumonia patients. The production of the neutralizing antibody was obser
Steroid use and RBC transfusion within 1 month of the diagnosis of colitis were independent risk factors for development of CMV colitis in immunocompetent hosts.
With the recent advances in NeRF-based 3D aware GANs quality, projecting an image into the latent space of these 3D-aware GANs has a natural advantage over 2D GAN inversion: not only does it allow multi-view consistent editing of the projected image, but it also enables 3D reconstruction and novel view synthesis when given only a single image. However, the explicit viewpoint control acts as a main hindrance in the 3D GAN inversion process, as both camera pose and latent code have to be optimized
A large HAdV outbreak is currently ongoing in the Korean military, with a trend away from seasonality, and HAdV-55 is likely the predominant strain. Persistent efforts to control the outbreak, HAdV type-specific surveillance, and vaccine development are required.
Here, we examine peripheral blood memory T cell responses against the SARS-CoV-2 BA.4/BA.5 variant spike among vaccinated individuals with or without Omicron breakthrough infections. We provide evidence supporting a lack of original antigenic sin in CD8 + T cell responses targeting the spike. We show that BNT162b2-induced memory T cells respond to the BA.4/BA.5 spike. Among individuals with BA.1/BA.2 breakthrough infections, IFN-γ–producing CD8 + T cell responses against the BA.4/BA.5 spike incr
Research Areas
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