Jang-hyun Lee
Hanyang University · Medicine
About the Lab
Professor Jang-hyun Lee's research lab specializes in clinical and translational studies focused on soft tissue reconstruction, dermatologic oncology, and oral and maxillofacial surgery. The lab investigates molecular mechanisms underlying skin cancers—particularly malignant melanoma, squamous cell carcinoma, and basal cell carcinoma—by analyzing key signaling molecules such as Src family kinases and TC21. It also explores innovative surgical techniques, including dermal fillers for facial rejuvenation and local flap reconstruction for midface defects, emphasizing functional and aesthetic outcomes. The lab integrates molecular pathology with clinical innovation to improve patient outcomes in reconstructive and oncologic surgery.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Calcium hydroxylapatite filler is a popular dermal filler, as it provides long-lasting results. However, it sometimes undergoes unexpected early volume loss, due to rapid gel absorption before neocollagenesis. To compensate for this phenomenon, hyaluronic acid filler was added to calcium hydroxylapatite filler for injection as a mixture. Twenty-five patients who scored 1 or 2 on the Merz 5-point scale for the nasolabial fold and jawline were injected with 3.0 mL of the mixture. The mixture was p
BACKGROUND: Src family kinases (SFKs) play an important role in cancer proliferation, survival, motility, invasiveness, metastasis, and angiogenesis. Among the SFKs, c-Src and c-Yes are particularly over-expressed or hyper-activated in many human epithelial cancers. However, only a few studies have attempted to define the expression and role of c-Src and c-Yes in cutaneous carcinomas. OBJECTIVES: To investigate the expression of c-Src and c-Yes in cutaneous carcinomas to include malignant melano
BACKGROUND: Many novel approaches to mandibular condyle fracture have been reported, but there is a relative lack of reports on the Risdon approach. In this study, the feasibility of the Risdon approach for condylar neck and subcondylar fractures of the mandible is demonstrated. METHODS: A review of patients with mandibular condylar neck and subcondylar fractures was performed from March 2008 to June 2012. A total of 25 patients, 19 males and 6 females, had 14 condylar neck fractures and 11 subc
BACKGROUND: The goal of salvage surgery in the diabetic foot is maximal preservation of the limb, but it is also important to resect unviable tissue sufficiently to avoid reamputation. This study aims to provide information on determining the optimal amputation level that allows preservation of as much limb length as possible without the risk of further reamputation by analyzing several predictive factors. METHODS: Between April 2004 and July 2013, 154 patients underwent limb salvage surgery for
BACKGROUND: TC21 plays an important role in highly aggressive tumor formation, and it was overexpressed in several human cancers, including breast cancer, oral squamous cell carcinoma (SCC), and esophageal SCC. In light of this, we explored the expression of TC21 in overall skin cancers in order to evaluate the relationship between TC21 and malignant skin tumors. METHODS: We examined six normal skin tissues and 18 malignant skin tumor tissues, including six malignant melanomas (MM), six SCCs, an
BACKGROUND: Local flap surgery is commonly performed to cover defects with appropriate skin color and texture match. The purpose of this study was to present an algorithm for choosing an appropriate flap when reconstructing a midface defect using a local flap. METHODS: Between February 2013 and February 2019, 38 patients with midface defects underwent local flap surgery. All defects larger than 3 cm in diameter were reconstructed with perforator-based transposition flaps. Defects smaller than 3
Diabetic foot is a debilitating disease arising from multifactorial process. As its management is complex, a comprehensive but accessible treatment algorithm is needed for successful results. For this reason, the appropriate algorithm for diabetic foot management introduced in this study is significant.
Patient-oriented research is research that makes the patient the subject. While that definition is very broad, it is commonly defined as research conducted with human subjects. Among the topics of patient-oriented research are the usefulness of new technologies, understanding the mechanisms of a disease, therapeutic interventions, and clinical trials. One of the main goals of patient-oriented research is for patients to receive useful benefits from the clinical research findings [1]. Recently, a
A 48-year-old man who had received a bioresorbable plate fixation for a zygomatic bone fracture 13 months earlier visited our clinic complaining of sudden facial swelling. The facial computed tomographic scan showed the soft tissue swelling without any bony abnormality, and the symptoms did not improve after 1 week of antibacterial therapy. The patient had a diagnosis of a late infection caused by unresorbed plates, and exploratory surgery was performed. Partially resorbed plates and screws were
The glabellar rhytid has not only dynamic but also static cause, which is usually achieved by injection of filler. Deep glabellar rhytides, however, are difficult to correct with filler. Therefore, the authors introduce a novel method of inserting a small strip of acellular dermal matrix (ADM) underneath the wrinkle line. From May 2009 to March 2012, 30 patients were treated for deep glabellar wrinkles with ADM augmentation by the senior author. The surgical outcomes were evaluated by the physic
BACKGROUND: Orbitotemporal neurofibromatosis is a challenging disease for orbital surgeons. Ptosis correction may be needed following correction of orbital dystopia. CASE PRESENTATION: A 34-year-old man, who underwent excision of a neurofibroma on the right eyelid in our clinic, returned to our clinic four years later complaining of dystopia and bulkiness of the protruding mass in the right eyelid and eyebrow. Computed tomographic imaging showed dysplasia and deformity in the sphenoid bone and o
To the Editor: A 49-year-old woman visited our department due to painful bilateral trigger thumbs, which were characteristically locked in flexion (Fig. 1A). Both thumbs showed passively correctable locking and the patient did not perform an extension of both thumbs because it was very painful. There were no palpable nodules in either thumb. The patient had no history of previous trauma or familial history. Laboratory tests were normal, including blood sugar, erythrocyte sedimentation rate, C
All manuscripts submitted to the Archives of Plastic Surgery are run through CrossCheck using the software powered by iThenticate to compare their similarity with previously published papers [1]. The editors use the results of this comparison for reference in manuscript screening. The results include the similarity index, which represents the overall similarity of a submitted manuscript to previously published papers.
A functional superficial parotidectomy can maintain salivary function by preserving the Stensen duct. However, this technique still brings the possibility of salivary leakage, because major branches of the parotid duct from the resected site do not get ligated. To reduce this complication, this study introduces a modified technique with major branch ligation. From December 2008 to February 2015, 14 patients who underwent superficial parotidectomy were divided into 2 groups. Group A was treated w
BACKGROUND: As the lip contains ample blood supply, hemangiomas often occur in this area. When surgical excision is performed, wound closure is important. To prevent infection from saliva and food, watertight wound closure is needed. The purpose of this study is to demonstrate the usefulness of Dermabond for wound closure after hemangioma excision on the lip. METHODS: Between December 2015 and August 2017, 11 patients with lip hemangioma underwent surgical excision. When closing the wound, Derma
Research Areas
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