Jeon, Sang-Hak

in glia is essential for the development and maintenance of brain function. We propose a mechanism that underlies these neurodegenerative phenotypes triggered by defective PS metabolism.

In Drosophila, the spatially restricted expression of the homeotic genes is controlled by Polycomb group (PcG) repression. PcG proteins appear to form different complexes to repress this gene expression. Although the pleiohomeotic gene (pho) shares mutational phenotypes with other PcG mutations, which demonstrates that PHO binds directly with a Polycomb (Pc)-containing complex, the genetic interactions of pho with other PcG genes have not been examined in detail. Here we investigated whether pho

An important step in Drosophila neurogenesis is to establish the neural dorsoventral (DV) patterning. Here we describe how dpp loss-of- and gain-of-function mutation affects the homeobox-containing neural DV patterning genes expressed in the ventral neuroectoderm. Ventral nervous system defective (vnd), intermediate neuroblast defective (ind), muscle-specific homeobox (msh), and orthodenticle (otd) genes participate in development of the central nervous system and peripheral nervous system, and

Maintenance of appropriate muscle mass is crucial for physical activity and metabolism. Aging and various pathological conditions can cause sarcopenia, a condition characterized by muscle mass decline. Although sarcopenia has been actively studied, the mechanisms underlying muscle atrophy are not well understood. Thus, we aimed to investigate the role of Phosphatidylserine synthase (Pss) in muscle development and homeostasis in Drosophila. The results showed that muscle-specific Pss knockdown de

Biological sciences have been dramatically changed since the discovery of DNA structure and now biological engineering is expected to be a key industrial area in the twenty-first century. Among several biological areas, "reproduction and development" become more interesting as they are directly related to the maintenance of human beings and recent technological success on these areas. Cloned animals produced by nuclear transplantation and artificial insemination are such cases. In this paper, it

The ventral nerve cord (VNC) of Drosophila exhibits significant segmental-specific characteristics during embryonic development. Homeotic genes are expressed over long periods of time and confer identity to the different segments. castor (cas) is one of the genes which are expressed in neuroblasts along the VNC. However, at late embryonic stages, cas transcripts are found only in head and thoracic segments and terminal abdominal segments, while Cas protein lasts longer in all segments. In this s

Nervous system development takes place after positional information has been established along the dorsal-ventral (D/V) axis. The initial subdivision provided by a gradient of nuclear dorsal protein is maintained by the zygotic genes expressed along the D/V axis. In this study, an investigation was conducted to determine the range of Dpp function in repressing the expression of eagle (eg) that is present in intermediate neuroblasts defective (ind) and muscle specific homeobox (msh) gene domain.

Different proliferation of neuroblast 6-4 (NB6-4) in the thorax and abdomen produces segmental specific expression pattern of several neuroblast marker genes. NB6-4 is divided to form four medialmost cell body glia (MM-CBG) per segment in thorax and two MM-CBG per segment in abdomen. As homeotic genes determine the identities of embryonic segments along theA/P axis, we investigated if temporal and specific expression of homeotic genes affects MM-CBG patterns in thorax and abdomen. A Ubx loss-of-

This study examines the growth of an innovative pre-service science teachers’ (PST) community over a period of three years in a voluntary and informal setting for teaching science to high school students. The objective of this study is to understand the traits and conditions necessary for the learning and development that occurred in the PST group. We describe the growth of the PST group with a focus on the group’s endeavor to move from simple laboratory work to a more inquiry-based approach to

과학 탐구 활동의 중요성이 끊임없이 강조되고 있음에도 불구하고, 교육 현장에 과학 탐구를 활성화 시킬 방안에 관한 연구는 미흡한 실정이다. 본 연구에서는 초등학교 6학년 과학 교과서에 실려 있는 식물 세포 관찰 탐구 활동을 보완하기 위해 설탕 용액과 스마트폰 현미경 어댑터를 활용하는 방안을 제시하고, 각 방법이 학생들의 관찰 활동에 미치는 영향에 대해 분석하였다. 기존 관찰 탐구 활동을 접목한 수업에선 식물 세포의 세포벽과 세포막이 서로 붙어있었기 때문에 그 둘을 구별하여 관찰한 학생이 없었다. 하지만 20% 설탕 용액을 활용하여 식물 세포의 세포벽에서 세포막을 분리해낸 결과, 세포막, 세포벽, 핵을 모두 관찰한 학생의 수가 증가하였다. 또한, 스마트폰 현미경 어댑터를 활용한 결과, 식물 세포를 자세하고 정확히 관찰한 학생들의 수가 비교집단에 비해 더 큰 폭으로 늘어난 것을 확인하였다. 본 연구는 설탕 용액을 기존 식물 세포 관찰 수업에 추가적으로 활용하는 것에 대한 교육적 가치와,