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Jeon Seung-hyun

Kyung Hee University · Medicine

About the Lab

Professor Jeon Seung-hyun's research lab specializes in urological oncology and minimally invasive surgical techniques, with a strong focus on renal and bladder cancers. The lab investigates molecular mechanisms underlying cancer progression, particularly the role of antioxidant enzymes in bladder cancer, and explores innovative surgical approaches such as the use of V-Loc sutures in partial nephrectomy to reduce ischemia time. Additionally, the lab examines therapeutic strategies, including adjuvant immunotherapy in renal cell carcinoma, and evaluates long-term renal function outcomes in both kidney donors and cancer patients. Their work bridges clinical urology, molecular pathology, and surgical innovation to improve patient outcomes in genitourinary malignancies.

urological oncologyminimally invasive surgeryrenal cancerantioxidant enzymessurgical innovation

Research Overview

Papers
168
Total Citations
1,205
Papers (5y)
24
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
24total
2021
2022
2023
2024
2025
Citations per year (5y)
158total
20212022202320242025

Selected Papers

15
1
Article|68 citations·2009
Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction
Tae‐Hwan Kim, Seung Hyun Jeon, Eun-Joo Hahn, Kee‐Yoeup Paek, Jong Kwan Park, Nae Young Youn, Hyung-Lae Lee
SJR Q1Asian Journal of AndrologyOA

Korean ginseng and mountain ginseng (Panax ginseng CA Meyer) are important traditional herbal plants whose ginsenosides are generally accepted as serving to improve sexual functions, such as penile erection. We investigated the effects of tissue-cultured mountain ginseng extract (TMGE) on male patients with erectile dysfunction (ED). A double-blind, placebo-controlled study was conducted with 143 patients experiencing ED. Over the course of 8 weeks, one group took 1 000 mg of TMGE twice a day, a

Psychiatry and Mental healthMedicine
2
Article|59 citations·2010
Comparison of laparoscopic versus open radical nephrectomy for large renal tumors: a retrospective analysis of multi‐center results
Seung Hyun Jeon, Tae Gyun Kwon, Koon Ho Rha, Gyung Tak Sung, Wan Lee, Jae Sung Lim, Young Beom Jeong, Sung‐Hoo Hong, Hyeon Hoe Kim, Seok‐Soo Byun
SJR Q1British Journal of UrologyOA

Study Type – Therapy (case series) Level of Evidence 4 What’s known on the subject? and What does the study add? While laparoscopic radical nephrectomy (LRN) has been confirmed in various studies to be at least as efficacious as open radical nephrectomy (ORN) in terms of oncological control and more advantageous from the perspective of minimal invasiveness, very few studies have examined its feasibility and efficacy when applied to renal masses exceeding 7 cm in size, and even fewer involved res

Pulmonary and Respiratory MedicineMedicine
3
Article|32 citations·2005
Prednisolone suppresses cyclosporin A-induced apoptosis but not cell cycle arrest in MDCK cells
Seung Hyun Jeon, Yu Ji Piao, Kyu Jin Choi, Feng Hong, Haeng Woon Baek, Insug Kang, Joohun Ha, Sung Soo Kim, Sung‐Goo Chang
SJR Q1Archives of Biochemistry and Biophysics
SurgeryMedicine
4
Article|26 citations·2013
The Unidirectional Barbed Suture for Renorrhaphy During Laparoscopic Partial Nephrectomy: Stanford Experience
Seung Hyun Jeon, Saebin Jung, Hee Seo Son, Simon Kimm, Benjamin I. Chung
SJR Q2Journal of Laparoendoscopic & Advanced Surgical Techniques

The use of V-Loc sutures for renorrhaphy during LPN is safe and feasible and, in our series, significantly reduces WIT. Further studies are needed to corroborate these findings, but these results indicate a promising development in reducing WIT during minimally invasive partial nephrectomy.

Pulmonary and Respiratory MedicineMedicine
5
Article|23 citations·2007
Expression of Antioxidant Enzymes (Catalase, Superoxide Dismutase, and Glutathione Peroxidase) in Human Bladder Cancer
Seung Hyun Jeon, Jae‐Hoon Park, Sung‐Goo Chang
Korean Journal of UrologyOA

Purpose: Intrinsic antioxidant enzymes (AOE) are essential for protection against potential cellular damage by reactive oxygen species (ROS), which affect many biological processes including carcinogenesis. The aim of the present study was to characterize the expression of antioxidant enzymes in human bladder cancer tissue and to evaluate the relationship with histopathological characteristics. Materials and Methods: Immunohistochemical stainingfor catalase, superoxide dismutase (SOD), and gluta

Molecular BiologyBiochemistry, Genetics and Molecular Biology
6
Article|16 citations·2000
The role of adjuvant immunotherapy after radical nephrectomy and prognostic factors in pT3N0M0 renal cell carcinoma.
Seung Hyun Jeon, Shin-Chun Chang, Jin Il Kim
PubMed

Five-year overall survival after radical nephrectomy in pT3N0M0 renal cell carcinoma is 35-50%. In light of immunotherapy, which has shown some activity in advanced diseases with increasing efficacy in limited metastatic invasion, we decided to explore the theoretical advantage of adjuvant immunotherapy in radically resected stage pT3N0M0 renal cell carcinoma. We studied several factors including tumor size, nuclear grade, mean nuclear area and expression of p53 protein to find out which factor

Pulmonary and Respiratory MedicineMedicine
7
Article|15 citations·2015
Comparison of postoperative estimated glomerular filtration rate between kidney donors and radical nephrectomy patients, and risk factors for postoperative chronic kidney disease
Sang Hyub Lee, Dong Soo Kim, Seok Cho, Sang Jin Kim, Seok Ho Kang, Jinsung Park, Sung Yul Park, Sung‐Goo Chang, Seung Hyun Jeon
SJR Q2International Journal of Urology

OBJECTIVES: To compare post-nephrectomy renal function between kidney donors and renal cell carcinoma patients, to evaluate trends in recovery, and to identify factors relevant to renal failure. METHODS: Patients who had radical or donor nephrectomy from four different institutions between 2003 and 2012 were reviewed. Propensity score matching was carried out and 79 patients were selected for each group. The estimated glomerular filtration rate was calculated using the Modification of Diet in Re

Pulmonary and Respiratory MedicineMedicine
8
Article|15 citations·2009
How Many Cases Are Necessary to Develop Competence for Laparoscopic Radical Nephrectomy?
Seung Hyun Jeon, Kyungsik Han, Koo Han Yoo, Bong‐Keun Choe, Ill Young Seo, Jae Sung Lim, Yoshinari Ono
SJR Q1Journal of Endourology

Our results suggest that 15 cases are needed for a novice surgeon to achieve competence in LRN. Surgical outcomes and morbidity can be improved once this learning curve has been overcome.

Pulmonary and Respiratory MedicineMedicine
9
Article|12 citations·2012
Predictive value of obstructive voiding symptoms and objective bladder emptying tests for urinary retention
Seung Hyun Jeon, Eun‐Hee Yoo
SJR Q3Journal of Obstetrics and Gynaecology

The prevalence of voiding dysfunction was 47.4% by the question of "do you usually experience a feeling of incomplete bladder emptying" from Korean version of PFDI (pelvic floor distress inventory), 33.7% by the value of less than 10th centile of peak flow rate of uroflowmetry by Liverpool nomogram, 20.2% by the cutoff values of less than 12 ml per second of maximum flow rate and greater than 25 cmH20 of detrusor pressure at maximum flow rate in the pressure flow study and 11.6% by the elevated

RheumatologyMedicine
10
Review|12 citations·2022
Outcomes of Retzius-sparing versus conventional robot-assisted radical prostatectomy: A KSER update series systematic review and meta-analysis
Doo Yong Chung, Hae Do Jung, Do Kyung Kim, Min Ho Lee, Sin Woo Lee, Sunghyun Paick, Joo Yong Lee, Seung Hyun Jeon
SJR Q1PLoS ONEOA

BACKGROUND: Robotic-assisted radical prostatectomy(RARP) is widely used to surgically treat of localized prostate cancer. Among RARP, retzius-sparing techniques(RS-RARP) are implemented through douglas pouch, not the existing conventional approach(C-RARP). We conducted an updated systematic review and meta-analysis including recent published papers. MATERIALS & METHODS: Systematic review was performed following the PRISMA guideline. PubMed, EMBASE, and Cochrane Library were searched up to August

Pulmonary and Respiratory MedicineMedicine
11
Review|10 citations·2022
Comparison of Ultra-Mini Percutaneous Nephrolithotomy and Retrograde Intrarenal Surgery for Renal Stones: A Systematic Review and Meta-Analysis from the KSER Update Series
Hae Do Jung, Doo Yong Chung, Do Kyung Kim, Min Ho Lee, Sin Woo Lee, Sunghyun Paick, Seung Hyun Jeon, Joo Yong Lee
SJR Q1Journal of Clinical MedicineOA

Miniaturized percutaneous nephrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS) for renal stones have been developed to overcome the invasive disadvantages of PCNL. We aimed to compare the therapeutic effect and safety of ultra-mini percutaneous nephrolithotomy (UMPCNL) and RIRS for renal stones using an updated systematic review and meta-analysis. We searched clinical trials comparing UMPCNL and RIRS for renal stones using the PubMed, EMBASE, Cochrane Library, and Google Scholar datab

Pulmonary and Respiratory MedicineMedicine
12
Article|6 citations·2007
Laparoscopic Treatment of Isolated Renal Hydatid Cyst
Seung Hyun Jeon, Tae-Hwan Kim, Hyung-Lae Lee
Korean Journal of Urology

An isolated unilocular renal hydatid cyst is very rare and to the best of our knowledge, no such case has been reported in the Korean literature. A 56 year old woman, who liked eating raw vegetables fertilized by dog feces, visited our department because of an incidentally found renal cyst. Ultrasonography and the computed tomography (CT) scan showed a ty-pical daughter cyst within the 6cm sized mother cyst. We performed retroperitoneal laparoscopic cyst marsupilaization after aspiration of the

Pathology and Forensic MedicineMedicine
13
Article|4 citations·2005
Clinical Prognostic Factors for Radical Cystectomy in Bladder Cancer
Seung Hyun Jeon, Sung-Hyun Jeon, Sung‐Goo Chang
SJR Q1Cancer Research and TreatmentOA

PURPOSE: We investigated the effects of radical cystectomy and the prognostic factors that affect the survival of bladder cancer patients. MATERIALS AND METHODS: From 1979 to 2002, 59 patients with long-term follow up results of at least 2 years were enrolled in this study. Indications for surgery included muscle invasive bladder cancer and high-risk superficial bladder cancer. The cancer specific and recurrence free survival rates with respect to the possible prognostic factors were determined

SurgeryMedicine
14
Article|3 citations·2007
신장에 발생한 원발성 포충낭종에 대한 복강경적 치료
전승현, 김태환, 이형래
http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0358320070480050555
15
Article|1 citations·2007
인체 방광암 조직에서 항산화효소의 면역조직 특성에 관한 연구
전승현, 박재훈, 장성구
http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0358320070480090921

Research Areas

Pulmonary and Respiratory MedicineSurgeryUrologyAerospace EngineeringOncologyEpidemiology

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