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Jeong-Kuk Seo

Hanyang University · Medicine

About the Lab

Professor Jeong-Kuk Seo's research lab specializes in vascular pharmacology and anesthesiology, focusing on the protective mechanisms of various drugs against oxidative stress in the endothelasm. The lab investigates how medications such as captopril, enalapril, lidocaine, procaine, remifentanil, ketorolac, and diclofenac preserve endothelial function by scavenging reactive oxygen species (ROS), particularly superoxide anions and hydrogen peroxide. A key research direction involves evaluating neuromuscular blocking agents like mivacurium and rocuronium under conditions of prolonged immobilization, such as in plaster casts, to understand altered drug responses. The lab also examines the effects of corticosteroids like methylprednisolone and hydrocortisone on endothelial reactivity during ischemia-reperfusion injury.

endothelial protectionreactive oxygen speciesvasorelaxationanesthetic agentsoxidative stress

Research Overview

Papers
118
Total Citations
158
Papers (5y)
31
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
31total
2008
2009
2010
2012
2013
Citations per year (5y)
110total
20082009201020122013

Selected Papers

15
1
Article|36 citations·2013
Antioxidant Effect of Captopril and Enalapril on Reactive Oxygen Species-Induced Endothelial Dysfunction in the Rabbit Abdominal Aorta
Ji Hoon Kim, Hyuck Kim, Young Hak Kim, Won-Sang Chung, Jung Kook Suh, Sung Jin Kim
The Korean Journal of Thoracic and Cardiovascular SurgeryOA

Both captopril and enalapril protect endothelium against ROS in a dose-dependent fashion in isolated rabbit abdominal aortas. This protective effect is related to superoxide anion scavenging.

PhysiologyMedicine
2
Article|24 citations·2010
Antioxidant effect of lidocaine and procaine on reactive oxygen species-induced endothelial dysfunction in the rabbit abdominal aorta
Jae Myeong Lee, Jung Kook Suh, Ji Seon Jeong, Sang Yun Cho, Dong‐Won Kim
SJR Q1Korean journal of anesthesiologyOA

These findings suggest that lidocaine and procaine dose-dependently preserve endothelium-dependent vasorelaxation against ROS attack, potentially via hydrogen peroxide scavenging.

Pathology and Forensic MedicineMedicine
3
Article|12 citations·2009
The Use of Remifentanil to Facilitate the Insertion of the Cobra Perilaryngeal Airway
Woo Jae Jeon, Kyoung Hun Kim, Jung Kook Suh, Sang Yun Cho
SJR Q1Anesthesia & Analgesia

An effect-site concentration of remifentanil of 2 ng/mL provides excellent conditions for insertion of the CobraPLA on the first attempt with minimal hemodynamic perturbations and a shorter duration of apnea.

Anesthesiology and Pain MedicineMedicine
4
Article|10 citations·2010
Effect of ketorolac and diclofenac on the impairment of endothelium-dependent relaxation induced by reactive oxygen species in rabbit abdominal aorta
Seung Yoon Lee, Jung Kook Suh, Jin Hwa Choi, Woo Jae Jeon, Mi Ae Cheong
SJR Q1Korean journal of anesthesiologyOA

These findings suggest that ketorlac and diclofenac preserve the endothelium-dependent vasorelaxation against the attack of ROS, in a concentration-related manner. One of the endothelial protection mechanisms of ketorolac may be hydrogen peroxide scavenging.

PharmacologyMedicine
5
Article|9 citations·2003
The Duration of Immobilization Causes the Changing Pharmacodynamics of Mivacurium and Rocuronium in Rabbits
Kyo Sang Kim, Jeong W. Jeon, Myoung Soo Koh, Jae Hang Shim, Sang Y. Cho, Jung Kook Suh
SJR Q1Anesthesia & Analgesia

In the clinical setting, in patients with a cast, it is not known whether the monitoring of the neuromuscular paralysis induced by either mivacurium or rocuronium in the contralateral limb is the correct interpretation. We compared the dose-response relationships and the neuromuscular blocking effects of mivacurium and rocuronium in 56 anesthetized rabbits immobilized in a plaster cast for 2, 4, and 6 wk. Train-of-four stimuli were simultaneously applied every 10 s to both common peroneal nerves

NeurologyMedicine
6
Article|7 citations·2013
Antioxidant effects of methylprednisolone and hydrocortisone on the impairment of endothelium dependent relaxation induced by reactive oxygen species in rabbit abdominal aorta
Hee Jong Lee, Jung Kook Suh, Hyun Hoo Song, Mi Ae Jeong, Jong Hoon Yeom, Dong Won Kim
SJR Q1Korean journal of anesthesiologyOA

BACKGROUND: The reperfusion following ischemia produces reactive oxygen species (ROS). We studied the influences of methylprednisolone (MPD) and hydrocortisone (CRT) on ROS effects using the endothelium of rabbit abdominal aorta. METHODS: Isolated rabbit aortic rings were suspended in an organ bath filled with Krebs-Henseleit (K-H) solution. After precontraction with norepinephrine, changes in arterial tension were recorded following the cumulative administration of acetylcholine (ACh). The perc

PhysiologyMedicine
7
Article|3 citations·2000
The Effects of Etomidate on the Isolated Porcine Coronary Artery
Jung Kook Suh, Woo Jong Shin, Jon Hoon Yeom, Sang Yoon Cho, Jong Hun Jun, Kyoung Hun Kim, Jae Chul Shim
SJR Q1Korean Journal of AnesthesiologyOA
Endocrinology, Diabetes and MetabolismMedicine
8
Article|3 citations·2008
The Assessment of Postoperative Nausea and Vomiting (PONV) using Rhodes Index in PONV High Risk Group
Jung Kook Suh, Dong Jun Bae, Sang Yun Cho, Woo Jae Jeon
SJR Q1Korean Journal of AnesthesiologyOA

The Rhodes index of nausea, vomiting and retching (RINVR) is a reliable and valid instrument to assess PONV. The purpose of this study was to investigate the incidence of PONV in high risk group with using RINVR.

SurgeryMedicine
9
Article|2 citations·2008
수술 후 오심과 구토의 고 위험군에서 Rhodes Index를 이용한 수술 후 오심과 구토의 측정
서정국, 배동준, 조상윤, 전우재

The Rhodes index of nausea, vomiting and retching (RINVR) is a reliable and valid instrument to assess PONV. The purpose of this study was to investigate the incidence of PONV in high risk group with using RINVR. Methods:Patients scheduled for elective surgery under general anesthesia were classified in three groups (group I:two risk factors, group II:three risk factors, group III:four risk factors) by using a simplified risk score.We investigated the incidences of PONV in each group. Results:T

10
Article|1 citations·2008
Randomized Study Comparing the Sniffing Position with the Neutral Position for Lightwand Intubation
Jung Kook Suh, Nam Woo Kim, Woo Jae Jeon, Jong Hoon Yeom, Woo Jong Shin, Kyoung Hun Kim, Sang Yun Cho
SJR Q1Korean Journal of AnesthesiologyOA

The sniffing position is recommended for optimal glottic visualization under direct laryngoscopy. However, there is no study assessing whether sniffing position is superior to a neutral position during lightwand-guided intubation. This prospective, randomized study was performed to compare facilitation of lightwand-guided intubation between the sniffing and neutral positions.

Anesthesiology and Pain MedicineMedicine
11
Article|1 citations·1984
Effects of Manually Controlled Ventilation on Gas Exchange during General Anesthesia
Jung Kook Suh, Seo Il Sook, Heung Dae Kim
Yeungnam University Journal of MedicineOA

In the beginning of anesthetic training, one of the clinical practices that anesthetists have to learn is manually controlled ventilatory techniques. The popularity of manually controlled ventilatory techniques has been gradually decreased with increased use for anesthetic ventilators. However it is important and basic for the anesthetists to master manually controlled ventilatory techniques skillfully. Recently, we analyzed the arterial blood gas in 30 cases before and during general anesthesia

Anesthesiology and Pain MedicineMedicine
12
Article|0 citations·1995
The Effect of Thiopental on the Isolated Rabbit Abdominal Aorta
Jung Kook Suh, Woo Jong Shin, Se Ung Chon
SJR Q1Korean Journal of AnesthesiologyOA
Developmental NeuroscienceNeuroscience
13
Article|0 citations·1997
Effects of Ketamine on the Ca(2+) Channel and K(+) Channel of the Porcine Coronary Artery
Jung Kook Suh, Kyung Hyun Kim, Woo Jong Shin, Jong Hoon Yeom, Kyo Sang Kim, Hee Koo Yoo, Kyoung Hun Kim
SJR Q1Korean Journal of AnesthesiologyOA
Pathology and Forensic MedicineMedicine
14
Article|0 citations·2004
Effect of Thiopental and Ketamine on Endothelium-Dependent Relaxation Induced by Reactive Oxygen Species in Rabbit Thoracic Aorta
Mi Young􀀁 Choi, Jung Kook Suh, Jong Won Lee, Sang Yoon Cho
SJR Q1Korean Journal of AnesthesiologyOA

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Pathology and Forensic MedicineMedicine
15
Article|0 citations·2002
A New Landmark Using the Clavicular Head of the Sternocleidomastoid Muscle for Infraclavicular Subclavian Vein Catheterization
Jung Kook Suh, Mi Ae Cheong, Jeong Woo Jeon, Woo Jong Shin, Dong‐Won Kim, Kyoung Hun Kim, Kyo Sang Kim
SJR Q1Korean Journal of AnesthesiologyOA

Background: Invasive central venous catheterization is necessary in critically ill patients for hemodynamic monitoring and for administration of hypertonic fluids, drugs, and parenteral nutrition. Common access sites are the internal jugular veins, subclavian veins, and femoral veins. Yoffa's percutaneous supraclavicular subclavian vein catheterization technique has some disadvantages and difficulties which include dislodgement of the puncture needle and difficult enhancement of the guide wire.

Emergency Medical ServicesHealth Professions

Research Areas

Anesthesiology and Pain MedicineCardiology and Cardiovascular MedicinePhysiologySurgeryPulmonary and Respiratory MedicinePathology and Forensic Medicine

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