Ji Yeon Lee

BACKGROUND: Oncogenic KRAS mutation, the most frequent mutation in non-small cell lung cancer (NSCLC), is an aggressiveness risk factor and leads to the metabolic reprogramming of cancer cells by promoting glucose, glutamine, and fatty acid absorption and glycolysis. Lately, sotorasib was approved by the FDA as a first-in-class KRAS-G12C inhibitor. However, sotorasib still has a derivative barrier, which is not effective for other KRAS mutation types, except for G12C. Additionally, resistance to

Pure subtelomeric deletion of the long arm of chromosome 6 is rare. The frequency of this deletion accounts for approximately 0.05% of subjects with intellectual disability and developmental delay with or without dysmorphic features. Common phenotypes associated with this deletion include intellectual disability, developmental delay, dysmorphic features, seizure, hypotonia, microcephaly and hypoplasia of the corpus callosum. The smallest overlapped region is approximately 0.4 Mb, and contains th

Potassium chlorate (KClO3) has been widely used to evaluate the divergence in nitrogen use efficiency (NUE) between indica and japonica rice subspecies. This study investigated the transcriptional regulation of major genes involved in the NUE in rice treated with KClO3, which acts as an inhibitor of the reducing activity of nitrate reductase (NR) in higher plants. A set of two KClO3 sensitive nitrate reductase (NR) and two nitrate transporter (NRT) introgression rice lines (BC2F7), carrying the

이 논문은 제 18대, 19대 국회의원들이 제출한 대표발의안을 토대로 국회내부의 국회의원, 상임위원회 간에 형성된 네트워크 분석을 통해 개별 국회의원과 정당, 상임위원회의 입법활동을 평가하는데 활용함을 목적으로 한다. 본 연구는 이원모드 네트워크 프로젝션(Bipartite Network Projection)의 방법으로 의원들이 상임위원회에 제출한 대표발의안을 토대로 어느 위원회가 중심적인 역할을 하는지와 위원회간의 관계를 파악한다. 두 번째는 같은 방법으로 국회의원들 중 대표발의안을 다양한 위원회에 제출하여 다른 의원들과의 활동 위원회의 교집합이 큰 의원을 찾을 수 있다. 제 18대, 19대 국회의원 중 여당과 제1야당을 분석대상으로 삼아 비교하였다. 본 연구를 통해 국회의원들의 발의안 제출 영역을 통한 협업 평가의 기준으로 활용이 가능함을 보인다.

경력열망은 조직에서 자신이 관리자로서 능력을 발휘할 수 있다고 믿으며, 현재보다 더 높은 수준의 지위로 이동하고자 하는 의지다. 여성의 경력열망은 남성의 경력열망보다 낮은 것으로 보고된다. 기업조직의 성불평등 메커니즘으로 인해 자신이 이룬 성취에 적절한 인정을 받지 못하기 때문이다. 연구는 여성의 경력열망에 영향을 미치는 구조적 요인을 분석해 일반화된 함의를 도출하고자한다. 자료는 6차(2016년), 7차(2018년) 여성관리자패널을 이용하고, 676명의 여성관리자와 181 개의 기업을 대상으로 한다. 주요 결과는 다음과 같다. 첫째, 멘토는 여성의 경력열망에 긍정적인영향을 미친다. 여성관리자에게 멘토는 고위 관리직 및 동료들에게 접근할 수 있는 기회이며, 신뢰와 지원을 얻을 수 있는 수단으로 작용해 경력열망을 높인다. 둘째, 조직에서 여성관리자의 비율이높을수록 여성의 경력열망은 떨어진다. 여성관리자들은 다른 여성관리자의 존재를 경쟁자로 인식하며, 여성 상사의 높은 기대감은 심리적인

Colon cancer has been well studied using a variety of molecular techniques, including whole genome sequencing. However, genetic markers that could be used to predict lymph node (LN) involvement, which is the most important prognostic factor for colon cancer, have not been identified. In the present study, we compared LN(+) and LN(-) colon cancer patients using differential gene expression and network analysis. Colon cancer gene expression data were obtained from the Cancer Genome Atlas and divid

The progression of colorectal cancer (CRC) has been well studied and understood with the development of molecular and genetic techniques. However, specific marker(s) that could be used to predict lymph node (LN) involvement, which is the most important prognostic factor for CRC, have not been identified so far. Our previous study, in which network analysis of LN(+) and LN(-) CRC gene expression was carried out with data obtained from the Cancer Genome Atlas, led to the identification of AHA1. AH

Shoot branching is considered as an important trait for the architecture of plants and contributes to their growth and productivity. In cereal crops, such as rice, shoot branching is controlled by many factors, including phytohormones signaling networks, operating either in synergy or antagonizing each other. In rice, shoot branching indicates the ability to produce more tillers that are essential for achieving high productivity and yield potential. In the present study, we evaluated the growth

This study evaluated the synergistic effect of curcumin (diferuloylmethane) and hinokitiol (β-thujaplicin), natural product derived phytochemicals, on gefitinib (Iressa) resistant non-small cell lung cancer (NSCLC) cells. Gefitinib, a tyrosine kinase inhibitor targeting epidermal growth factor receptor (EGFR), is widely used for lung cancer treatment. However, gefitinib resistance is easily acquired by NSCLC and followed by the development of progressive disease. Curcumin and hinokitiol are well

Many Korean English teachers usually assess learners’ writing according to their subjective judgement without using any rating scale in the writing class. The validity of assessment has been the main issue in the language testing field. This study aims to examine the validity of the assessment categories in their subjective holistic scoring of their EFL students’ English writing. For this purpose, three English teachers at various high schools participated as raters. When assessing given writing

Cancer stem cells, a small subpopulation of cells with stem cell-like characteristics found within most solid tumors, are widely reported to be responsible for the malignancy of aggressive cancer cells, and targeting these cells presents a sound therapeutic strategy for reducing the risk of tumor relapse. In the present study, we examined the effects of an extract of Saccharina japonica (ESJ) on glioblastoma stem cells (GSCs). Saccharina japonica is a member of the Phaeophyceae (brown algae) fam

The purpose of this study is to analyze the test items for the Secondary School English Teachers’ Employment Examination (SETEE) conducted between the years 2016 to 2017. To achieve this purpose, this study investigated the SETEE with respect to pedagogical content knowledge, test usefulness, corpus and readability. This study yielded four significant results. First, the percentage of test items regarding English education was slightly higher in 2016 than the standard set by the Korea Institute