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Jihee Seong

Sungkyunkwan University · Medicine

About the Lab

Professor Jihee Seong's research lab focuses on maternal-fetal medicine and reproductive health, with a strong emphasis on prenatal diagnostics, preterm birth prevention, and the management of complications such as preterm premature rupture of membranes (PPROM). The lab investigates the impact of pharmacological agents—particularly NSAIDs—on early pregnancy outcomes, as well as the microbiological and immunological factors influencing gastric and intra-amniotic infections. Their work also extends to rare gynecologic malignancies, such as hepatoid carcinoma of the ovary, combining clinical, pathological, and molecular approaches to improve diagnostic accuracy and patient outcomes.

preterm birthamniopatchgastric microbiotaintra-amniotic infectionNSAIDs in pregnancy

Research Overview

Papers
167
Total Citations
2,215
Papers (5y)
67
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
67total
2022
2023
2024
2025
2026
Citations per year (5y)
255total
20222023202420252026

Selected Papers

15
1
Article|70 citations·2016
Comparison of Gastric Microbiota Between Gastric Juice and Mucosa by Next Generation Sequencing Method
Ji‐Hee Sung, Nayoung Kim, Jaeyeon Kim, Hyun Jin Jo, Ji Hyun Park, Ryoung Hee Nam, Yeong‐Jae Seok, Yeon-Ran Kim, Dong Ho Lee, Hyun Chae Jung
Journal of Cancer PreventionOA

Even though these samples were small, gastric mucosa could be more effective than gastric fluid in the detection of meaningful gastric microbiota by pyrosequencing.

SurgeryMedicine
2
Article|41 citations·2019
Peripartum Management of Gestational Diabetes Using a Digital Health Care Service: A Pilot, Randomized Controlled Study
Ji‐Hee Sung, Da Young Lee, Kyoung Pil Min, Cheol‐Young Park
SJR Q1Clinical Therapeutics
Obstetrics and GynecologyMedicine
3
Article|38 citations·2017
Associations among Gastric Juice pH, Atrophic Gastritis, Intestinal Metaplasia andHelicobacter pyloriInfection
Ji‐Hee Sung, Nayoung Kim, Jongchan Lee, Young‐Jae Hwang, Hyung Woo Kim, Jung Wha Chung, Jin‐Wook Kim, Dong Ho Lee
SJR Q1Gut and LiverOA

There is a relationship between chronic <i>H. pylori</i> infection and gastric juice pH ≥3, which may originate from AG and IM in the body.

SurgeryMedicine
4
Review|31 citations·2019
Should the diagnostic criteria for suspected clinical chorioamnionitis be changed?
Ji‐Hee Sung, Suk‐Joo Choi, Soo‐Young Oh, Cheong‐Rae Roh
SJR Q2The Journal of Maternal-Fetal & Neonatal Medicine

<b>Purpose of review:</b> The criteria for the diagnosis of intra-amniotic infection (IAI) were derived from a study of women at term in labor but is currently used as the main diagnostic tool for clinical chorioamnionitis. Regarding the inconsistent usage of the term, the diagnostic utility of clinical chorioamnionitis needs to be revisited. In this review, we addressed the critical issues on why the diagnostic criteria of suspected clinical chorioamnionitis should be changed.<b>Recent findings

EpidemiologyMedicine
5
Article|25 citations·2023
Neonatal and maternal adverse outcomes and exposure to nonsteroidal anti-inflammatory drugs during early pregnancy in South Korea: A nationwide cohort study
Eun‐Young Choi, Han Eol Jeong, Yunha Noh, Ahhyung Choi, Dong Keon Yon, Jung Yeol Han, Ji‐Hee Sung, Seung‐Ah Choe, Ju‐Young Shin
SJR Q1PLoS MedicineOA

BACKGROUND: Existing data on the use of nonsteroidal anti-inflammatory drugs (NSAIDs) during late pregnancy is well established, providing assurance. However, the use of NSAIDs during early pregnancy remains inconclusive owing to conflicting findings on adverse neonatal outcomes as well as the limited data on adverse maternal outcomes. Therefore, we sought to investigate whether early prenatal exposure to NSAIDs was associated with neonatal and maternal adverse outcomes. METHODS AND FINDINGS: We

Public Health, Environmental and Occupational HealthMedicine
6
Article|21 citations·2017
Amniopatch treatment for preterm premature rupture of membranes before 23 weeks' gestation and factors associated with its success
Ji‐Hee Sung, Jin-Yi Kuk, Hyun‐Hwa Cha, Suk‐Joo Choi, Soo‐Young Oh, Cheong‐Rae Roh, Jong-Hwa Kim
SJR Q3Taiwanese Journal of Obstetrics and GynecologyOA

OBJECTIVE: The purpose of this study is to investigate the factors associated with successful amniopatch treatment in patients with iatrogenic preterm premature rupture of membranes (iPPROM) or spontaneous PPROM (sPPROM) before 23 weeks' gestation. MATERIALS AND METHODS: This cohort study included 28 women who received amniopatch treatment due to iPPROM or sPPROM at 15-23 weeks' gestation. Patients' clinical characteristics before performing the amniopatch, factors associated with the procedure,

EpidemiologyMedicine
7
Article|20 citations·2013
Hepatoid carcinoma of the ovary without staining for alpha-fetoprotein
Ji‐Hee Sung, Tae Hyun Kim, Hyang Gi Park, Min Ji Kim, Byoung‐Gie Kim, Tae‐Joong Kim, Duk‐Soo Bae
SJR Q2Obstetrics & Gynecology ScienceOA

Primary hepatoid carcinoma of the ovary (HCO) is a rare type of ovarian tumor that resembles hepatocellular carcinoma both histologically and immunohistochemically in its staining for alpha-fetoprotein (AFP). We describe a 51-year-old woman who presented to our hospital complaining of abdominal pain. Computed tomography scan revealed a large tumor in the pelvis. She underwent total hysterectomy and bilateral salpingo-oophorectomy with tumorectomy. A right ovarian mass measuring 9×8×6 cm was foun

Reproductive MedicineMedicine
8
Article|19 citations·2016
Neonatal outcomes of twin pregnancies delivered at late-preterm versus term gestation based on chorionicity and indication for delivery
Ji‐Hee Sung, Soo Hyun Kim, Yoo‐Min Kim, Jihye Kim, Min‐A Kim, Hye Ran Lee, Hyejung Lee, Eunjung Lee, Suk‐Joo Choi, Soo‐Young Oh, Cheong‐Rae Roh, Jong-Hwa Kim
SJR Q2Journal of Perinatal Medicine

OBJECTIVE: To investigate the neonatal outcomes of twin pregnancies delivered at late-preterm versus term gestation based on chorionicity and indication for delivery. STUDY DESIGN: This is a retrospective cohort study of women with twin pregnancies delivered at ≥34 weeks of gestation from 1995 to 2014. Subjects were categorized into two groups according to gestational age at delivery: late-preterm group (34-36 weeks) and term group (≥37 weeks). Neonatal outcome measures including neonatal intens

Pediatrics, Perinatology and Child HealthMedicine
9
Article|18 citations·2021
A case–control study of clinical characteristics and risk factors of symptomatic postpartum pubic symphysis diastasis
Ji‐Hee Sung, Min‐A Kang, Seung‐Jae Lim, Suk‐Joo Choi, Soo‐Young Oh, Cheong‐Rae Roh
SJR Q1Scientific ReportsOA

Postpartum pubic symphysis diastasis (PPSD) refers to the separation of pubic symphysis after delivery. It is typically diagnosed based on clinical symptoms and radiologic findings. This study tried to assess clinical characteristics and risk factors of PPSD. This was a nested case-control study matched for year of delivery and gestational age at delivery using a retrospective cohort of women who delivered vaginally at a single institution. The incidence of PPSD was 0.156% (33/21,131). The incid

Public Health, Environmental and Occupational HealthMedicine
10
Article|13 citations·2017
Rifabutin-based Fourth and Fifth-line Rescue Therapy in Patients with forHelicobacter pyloriEradication Failure
Ji‐Hee Sung, Nayoung Kim, Yo‐Han Park, Young Jae Hwang, Soohoon Kwon, Gyeongjae Na, Joon Young Choi, Jae Bin Kang, Hye Rang Kim, Jin‐Wook Kim, Dong Ho Lee
SJR Q3Korean Journal of GastroenterologyOA

BACKGROUND/AIMS: ) eradication. Hence, we aimed to evaluate the efficacy of rifabutin-based rescue therapy, at least after three eradication failures. METHODS: eradication at least three times, were consecutively enrolled between 2007 and 2015 at Seoul National University Bundang Hospital. The rifabutin-based rescue regimen was consisted of proton pump inhibitor (PPI), rifabutin (150 mg b.i.d.), and amoxicillin (1 g b.i.d.), given for 7 or 14 days. MIC concentration test by the agar dilution met

SurgeryMedicine
11
Article|7 citations·2023
A randomized clinical trial of antibiotic treatment duration in preterm pre-labor rupture of membranes: 7 days vs until delivery
Ji‐Hee Sung, Jin-Ha Kim, Yejin KIM, Yun-Sun Choi, Siryeon Hong, Suk‐Joo Choi, Jung-Sun Kim, Cheong‐Rae Roh, Soo‐Young Oh
SJR Q1American Journal of Obstetrics & Gynecology MFM
EpidemiologyMedicine
12
Article|6 citations·2022
Diagnostic Accuracy of Loop-Mediated Isothermal Amplification Assay for Group B Streptococcus Detection in Recto-Vaginal Swab: Comparison with Polymerase Chain Reaction Test and Conventional Culture
Ji‐Hee Sung, Hyun‐Hwa Cha, Nan-Young Lee, Won‐Ki Lee, Yeseul Choi, Hyung Soo Han, Yoo-Young Lee, Gun Oh Chong, Won-Joon Seong
SJR Q2DiagnosticsOA

A rapid method for obtaining group B streptococcus (GBS) screening results has been required in the obstetric field. We aimed to determine the diagnostic performance of the Loop-Mediated Isothermal Amplification (LAMP) assay is acceptable compared to the existing polymerase chain reaction (PCR) assay. The study involved 527 pregnant women aged 19 to 44 years. Rectovaginal swabs were collected between 35 and 37 weeks of gestation or prior to impending preterm births or term labor without GBS scre

Public Health, Environmental and Occupational HealthMedicine
13
Article|6 citations·2015
A Case of Pulmonary Cryptococcosis in an Immunocompetent Male Patient Diagnosed by a Percutaneous Supraclavicular Lymph Node Biopsy
Ji Hee Sung, Do Hoon Kim, Mi-Jung Oh, Kyoung Ju Lee, Young A Bae, Kye Won Kwon, Seung Min Lee, Ho Joon Kang, Jin-Young Choi
SJR Q2Tuberculosis & respiratory diseasesOA

Cryptococcal pneumonia usually occurs in immunocompromised patients with malignancy, acquired immune deficiency syndrome, organ transplantations, immunosuppressive chemotherapies, catheter insertion, or dialysis. It can be diagnosed by gaining tissues in lung parenchyma or detecting antigen in blood or bronchoalveolar lavage fluid. Here we report an immunocompetent 32-year-old male patient with diabetes mellitus diagnosed with cryptococcal pneumonia after a ultrasound-guided percutaneous supracl

EpidemiologyMedicine
14
Article|3 citations·2022
Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes?
Il-Yeo Jang, Hye-Ji Jung, Ji‐Hee Sung, Suk‐Joo Choi, Soo‐Young Oh, Jung‐Sun Kim, Cheong‐Rae Roh
SJR Q2DiagnosticsOA

Objective: To investigate the severity of histologic chorioamnionitis /funisitis according to the indication for preterm delivery and their corresponding neonatal outcomes. Method: This study included 411 singleton women who delivered between 21+0 and 31+6 week of gestation due to preterm labor (PTL, n = 165), preterm premature rupture of membranes (PPROM, n = 202), or incompetent internal os of the cervix (IIOC, n = 44). The primary outcome measure was the rate of severe histological chorioamni

EpidemiologyMedicine
15
Article|3 citations·2024
Association of Uterine Leiomyoma with Type 2 Diabetes Mellitus in Young Women: A Population-Based Cohort Study
Ji‐Hee Sung, Kyung‐Soo Kim, Kyungdo Han, Cheol‐Young Park
SJR Q1Diabetes & Metabolism JournalOA

BACKGRUOUND: We investigated the association between uterine leiomyoma (UL) and incident type 2 diabetes mellitus (T2DM) in young women. METHODS: A nationwide population-based cohort study of 2,541,550 women aged between 20 and 40 years was performed using the National Health Information Database. Cox proportional hazards models were used to analyze the risk of incident T2DM according to the presence of UL and myomectomy. RESULTS: The mean age was 29.70 years, and mean body mass index was 21.31

Obstetrics and GynecologyMedicine

Research Areas

Obstetrics and GynecologyEpidemiologyPediatrics, Perinatology and Child HealthPublic Health, Environmental and Occupational HealthSurgeryMolecular Biology

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