Jihye Park

BACKGROUND: Pain is the most prominent non-motor symptom observed in patients with Parkinson's disease (PD). However, the mechanisms underlying the generation of pain in PD have not been well studied. We used a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD to analyze the relationship between pain sensory abnormalities and the degeneration of dopaminergic neurons. RESULTS: The latency to fall off the rotarod and the total distance traveled in round chamber were sig

Context: Thyroid cancer survivors are at high risk of developing multiple cardiac and vascular conditions as consequence of cancer diagnosis and treatment. However, it is still unclear how the baseline and prognostic factors, as well as cancer treatments, play a role in increasing cardiac and vascular disease risk among thyroid cancer survivors. Objective: To investigate the association between potential risk factors, treatment effects, and cardiovascular disease (CVD) outcomes in thyroid cancer

Abstract Introduction: In multiple myeloma (MM), despite well-characterized precursor states such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM), there is a lack of sufficient biomarkers to predict mechanisms of disease progression. Most genomic analyses have sought biomarkers by study of the malignant plasma cells, however, cancers form a complex ecosystem with the immune and stromal microenvironment. Thus, to characterize the cellular composi

Abstract Background This study aimed to determine the benefit of early therapeutic intervention with the combination of elotuzumab, Lenalidomide, and Dexamethasone in patients with high-risk smoldering multiple myeloma (SMM). ClinicalTrials.gov Identifier: NCT02279394. Aims The overarching objective of this trial is to determine progression free survival to symptomatic multiple myeloma (MM). Furthermore, the study examined whether genomic studies can help in determining patients who would benefi

A trimeric glycoprotein complex on the surface of human cytomegalovirus (HCMV) binds to platelet-derived growth factor (PDGF) receptor α (PDGFRα) to mediate host cell recognition and fusion of the viral and cellular membranes. Soluble PDGFRα potently neutralizes HCMV in tissue culture, and its potential use as an antiviral therapeutic has the benefit that any escape mutants will likely be attenuated. However, PDGFRα binds multiple PDGF ligands in the human body as part of developmental programs

Hypomorphic mutations in the nonhomologous end-joining (NHEJ) DNA repair protein DNA ligase IV (LIG4) lead to immunodeficiency with varying severity. In this study, using a murine knock-in model, we investigated the mechanisms underlying abnormalities in class switch recombination (CSR) associated with the human homozygous Lig4 R278H mutation. Previously, we found that despite the near absence of Lig4 end-ligation activity and severely reduced mature B cell numbers, Lig4(R278H/R278H) (Lig4(R/R))

본 연구는 여대생의 사회지향성과 폭식행동의 관계를 정서조절곤란과 그의 하위변인들이 조절하는 지를 알아보고자 하였다. 주요 변인들 간에는 모두 유의미한 정적 상관이 발견되었으며, 폭식행동에 대한 사회지향성과 정서조절곤란의 하위차원들의 설명력을 알아본 결과 사회지향성은 폭식행동을 유의미하게 설명하였다. 정서조절곤란의 하위차원 중 충동통제곤란, 정서에 대한 주의와 자각 부족, 정서에 대한 비수용성, 정서조절 전략에 대한 접근제한은 폭식행동에 유의미한 영향을 미치는 것으로 나타난 반면, 정서적 명료성의 부족과 목표지향 행동 수행의 어려움은 유의미한 설명력을 가지지 않는 것으로 나타났다. 마지막으로 정서조절곤란은 사회지향성과 폭식행동 관계를 조절하는 것으로 검증되었으며 정서조절곤란의 하위차원 중에서는 충동통제곤란과 정서적 명료성의 부족이 폭식행동에 대한 사회지향성의 영향력을 조절하는 것으로 나타났다.

Abstract Introduction: Multiple Myeloma (MM) is a clonal plasma cell malignancy, accounting for 10% of all hematological malignancies. Genetic analyses of large populations revealed that blood-specific somatic mutations in hematopoietic stem cells (HSCs) are commonly acquired during aging, a new entity labeled: clonal hematopoiesis of indeterminate potential (CHIP). We sought to determine the role of CHIP on survival of MM patients, specifically those receiving immunomodulator (IMiD) maintenance

Abstract Introduction Multiple myeloma is an incurable plasma cell malignancy with a strikingly heterogeneous genomic landscape. Other than IgH translocations and hyperdiploidy, only a few alterations are observed in large enough numbers. Amplification of the long arm of chromosome 1 (1q) is among the most common copy number alterations encountered, with a confirmed adverse effect on survival. Gene expression profiling has identified a minimal common amplified region between 1q21 and 1q23 as a p

Abstract Introduction. Multiple myeloma (MM) is a complex and heterogeneous malignancy of plasma cells that has two precursor states: monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). MGUS and SMM are asymptomatic states that eventually give rise to overt MM, with some patients progressing, while others do not. Recent studies in MM pathobiology have highlighted epigenetic alterations that contribute to the onset, progression and heterogeneity of MM.

Abstract Background: Whole genome sequencing has recently shown the presence of recurrent mutations, such as MYD88, CXCR4 and ARID1A, in patients with Waldenstrom's Macroglobulinemia (WM) at diagnosis. Nevertheless, the contribution of each genomic aberration within the clonal evolution of the tumor during WM progression has not been reported. We therefore aimed to investigate whether sequential genomic events sustain WM disease progression by using whole exome sequencing (WES) and targeted sequ

Notre étude est pour but d’examiner le rapport entre l’État et l’éducation sous le régime de Vichy à travers la politique de Jeunesse. Cette dernière était impliquée dans la politique éducative de la troisième République française. Elle était developpée au niveau de la structure administrative dans le gouvernement de Vichy. Ce dernier a voulu profiter de la politique de jeunesse pour convaincrer aux jeunes sa légitimité du pouvoir et pour leur propager son idéologie politique, «Révolution nation

국방 무기체계에서의 소프트웨어 비중이 증가하고 있으며 구조도 점차 복잡해지고 있어, 이에 따른 신뢰성 검증이 매우 중요하다. 특히 무기체계 시스템을 구성하는 소프트웨어 구성 요소 들의 상호 작용에 따라 발생하는 결함은 정적 시험 및 코드 실행률 점검 수준의 동적 시험만으로는예방하기가 어렵다. 본 논문에서는 소프트웨어의 동적 결함 유형을 분류 개발한다. 미 국방부 무기체계에 사용하는 오픈 소스 소프트웨어(OSS)에서 보고된 이슈 분석을 통하여 본 논문에서 분류한 동적 결함이 실제로 발생하며, 이들은 대체로 통합 이후 발생하는 결함이며, 재현이 어렵고, 결함 원인 파악이 어려웠음을 보인다. 이 분석 결과를 기반으로 무기체계 신뢰성 검증을 위하여 소프트웨어 통합 시험 개선의 중요성을 도출한다.