Jinyeop Lee

During the COVID-19 pandemic, face masks have become limited in stock. Most of sterilization methods are not applicable for eliminating virus from face masks without compromising the filtration efficiency of the masks. In this study, using a human coronavirus (HCoV-229E) as a surrogate for SARS-CoV-2 contamination on KF94 face masks, we show that the virus loses its infectivity with a 4 log reduction when exposed for 10 s to 120 ppm ozone gas produced by a dielectric barrier discharge plasma gen

Micromechanics-based homogenization has been employed extensively to predict the effective properties of technologically important composites. In this review article, we address its application to various physical phenomena, including elasticity, thermal and electrical conduction, electric, and magnetic polarization, as well as multi-physics phenomena governed by coupled equations such as piezoelectricity and thermoelectricity. Especially, for this special issue, we introduce several research wo

Influenza A viruses are often present in environmental and clinical samples at concentrations below the limit of detection (LOD) of molecular diagnostics. Here we report an integrated microfluidic preconcentration and nucleic amplification system (μFPNAS) which enables both preconcentration of influenza A virus H1N1 (H1N1) and amplification of its viral RNA, thereby lowering LOD for H1N1. H1N1 virus particles were first magnetically preconcentrated using magnetic nanoparticles conjugated with an

Molecular detection of pathogens in clinical samples often requires pretreatment techniques, including immunomagnetic separation and magnetic silica-bead-based DNA purification to obtain the purified DNA of pathogens. These two techniques usually rely on handling small tubes containing a few millilitres of the sample and manual operation, implying that an automated system encompassing both techniques is needed for larger quantities of the samples. Here, we report a three-dimensional (3D)-printed

Abstract Background Sepsis is caused mainly by infection in the blood with a broad range of bacterial species. It can be diagnosed by molecular diagnostics once compounds in the blood that interfere with molecular diagnostics are removed. However, this removal relies on ultracentrifugation. Immunomagnetic separation (IMS), which typically uses antibody-conjugated silica-coated magnetic nanoparticles (Ab-SiO 2 -MNPs), has been widely applied to isolate specific pathogens in various types of sampl

Abstract Face masks are one of the currently available options for preventing the transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has caused the 2019 pandemic. However, with the increasing demand for protection, face masks are becoming limited in stock, and the concerned individuals and healthcare workers from many countries are now facing the issue of the reuse of potentially contaminated masks. Although various technologies already exist for the steriliz

We consider a system of p species of bosons, each of which consists of N1, N2, …, Np particles. The bosons are in three dimensions with interactions via an interaction potential V such that V ≤ D(1 − Δ), which includes the Coulomb interaction. We set the initial condition to describe a mixture condensate, i.e., a tensor product of factorized states. We show that the difference between the many-body Schrödinger evolution in the mean-field regime and the corresponding p particle dynamics due to a

Abstract Bacterial contamination of blood products is a major problem in transfusion medicine, in terms of both morbidity and mortality. Platelets (PLTs) are stored at room temperature (under constant agitation) for more than 5 days, and bacteria can thus grow significantly from a low level to high titers. However, conventional methods like blood culture and lateral flow assay have disadvantages such as long detection time, low sensitivity, and the need for a large volume of blood components. We

Sepsis, a leading cause of mortality, requires rapid and accurate pathogen identification to ensure effective treatment. Current diagnostic methods such as blood cultures are time-consuming, whereas molecular diagnostic techniques represent a promising alternative for faster pathogen detection. Therefore, the aim of this study was to evaluate different DNA extraction methods for the improved detection of infectious pathogens in the bloodstream. Specifically, we compared one column-based DNA extr

Abstract Fragmented Bose–Einstein condensates are large systems of identical bosons displaying multiple macroscopic occupations of one-body states, in a suitable sense. The quest for an effective dynamics of the fragmented condensate at the leading order in the number of particles, in analogy to the much more controlled scenario for complete condensation in one single state, is deceptive both because characterising fragmentation solely in terms of reduced density matrices is unsatisfactory and a

Abstract We re-examine the combined semi-classical and mean-field limit in the N -body fermionic Schrödinger equation with pure state initial data using the Husimi measure framework. The Husimi measure equation involves three residue types: kinetic, semiclassical, and mean-field. The main result of this paper is to provide better estimates for the kinetic and mean-field residue than those in Chen et al. (J Stat Phys 182(2):1–41, http://arxiv.org/abs/1910.09892v4 , 2021). Especially, the estimate

In this paper, we investigate the dynamics of a system of $N$ weakly interacting bosons with singular three-body interactions in three dimensions. By assuming factorized initial data $Ψ_{N,0}=φ_{0}^{\otimes N}$ and triple collisions, we prove that in the many-particle limit, its mean-field approximation converges to quintic Hartree dynamics. Moreover, we prove that the rate of convergence towards the mean-field quintic Hartree evolution is of $O(N^{-(1+4a)/(3+2a)})$ for $φ_{0}\in H^{(3/2)+a}(\ma

Abstract Clinical samples contain various biological substances, such as proteins and lipids, which can inhibit molecular detection of pathogens, often present at concentrations below the limit of detection (LOD). While existing sample preparation techniques can remove inhibitors and enrich pathogens, they are generally labor-intensive, manual processes that increase the risk of exposure. We present a fully automated sample treatment system that integrates immunomagnetic separation (IMS) and DNA