Jiyeong Han
Hanyang University · Medicine
About the Lab
Professor Jiyeong Han's research lab specializes in biomaterials and tissue engineering, with a focus on developing advanced materials and clinical strategies for regenerative dentistry and oral health. The lab investigates innovative surface modifications for medical membranes, particularly using nanostructured titanium dioxide to enhance fouling resistance in water desalination, while also exploring bone regeneration techniques in periodontal and oral implantology. Key research directions include the application of bioactive materials in ridge augmentation, guided bone regeneration, and the optimization of implant survival through careful assessment of anatomical and biological factors such as residual bone height and membrane integrity. The lab integrates preclinical models with clinical outcomes to bridge materials science and patient-centered dental care.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15We present a nonconventional membrane surface modification approach that utilizes surface topography to manipulate the tribology of foulant accumulation on water desalination membranes via imprinting of submicron titanium dioxide (TiO 2 ) pillar patterns onto the molecularly structured, flat membrane surface. This versatile approach overcomes the constraint of the conventional approach relying on interfacial polymerization that inevitably leads to the formation of ill-defined surface topography.
There are limited data, however, to suggest that anti-TNF-α agents can reduce local production of inflammatory cytokines and periodontal inflammation in RA patients with periodontitis.
After orthodontic treatment, clinical parameters were improved in the FA and CAT groups with meticulous oral hygiene education and plaque control. Regarding plaque index and gingival index, no significant differences were found between these two groups. We suggest that combined periodontal and orthodontic treatment can improve patients' periodontal health irrespective of orthodontic techniques.
OBJECTIVES: To evaluate the long-term influence of residual bone height (RBH), sinus membrane perforation and the presence of voids on the survival of implants placed simultaneously with lateral maxillary sinus floor augmentation (MSFA). MATERIALS AND METHODS: A total of 207 patients (613 implants) who underwent MSFA from 1999 to 2003 and followed up until 2018 were included in this study. RBH and marginal bone loss were assessed using a series of panoramic and periapical radiographs. Cumulative
Abstract Objectives: This study was designed to evaluate the effect of bone graft materials and collagen membranes in ridge splitting procedures with immediate implant placement using a dog model. Materials and methods: Mandibular premolars were extracted in five beagle dogs. After 3 months, ridge splitting and placement of three OsseoSpeed ™ implants were performed bilaterally. The gaps between the implants were allocated according to the following eight treatment modalities; Group 1(no graft),
PURPOSE: The aim of this study is to evaluate the buccal and lingual bone thickness in the anterior teeth and the relationship between bone thickness and the tissue biotype. METHODS: Three male and two female human cadaver heads (mean age, 55.4 years) were used in this study. First, the biotype of periodontium was evaluated and categorized into a thick or a thin group. Next, full thickness reflections of the mandible and the maxilla to expose the underlying bone for accurate measurements in the
The failure to trigger mitophagy is implicated in the pathogenesis of familial Parkinson disease that is caused by PINK1 or Parkin mutations. According to the prevailing PINK1-Parkin signaling model, mitophagy is promoted by the mitochondrial translocation of Parkin, an essential PINK1-dependent step that occurs via a previously unknown mechanism. Here we determined that critical concentrations of NO was sufficient to induce the mitochondrial translocation of Parkin even in PINK1 deficiency, wit
Although fixed retainers were bonded in periodontitis patients, periodontal health was well maintained if supportive periodontal treatment with repeated oral hygiene education was provided. Nonetheless, fixed retainer failure occurred more frequently in patients who had stage III (grade B or C) periodontitis or a CI ≥1 at 12-month follow-up after bonding of fixed retainers.
Mitochondria are small organelles that produce the majority of cellular energy as ATP. Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), and rare familial forms of PD provide valuable insight into the pathogenic mechanism underlying mitochondrial impairment, even though the majority of PD cases are sporadic. The regulation of mitochondria is crucial for the maintenance of energy-demanding neuronal functions in the brain. Mitochondrial biogenesis and m
Purpose: Anti-rheumatic agents target common molecular pathways of inflammation in rheumatoid arthritis (RA) and periodontitis. The purpose of this study was to determine the relative effect of anti-rheumatic agents on the levels of inflammatory biomarkers and periodontal inflammation in RA patients with periodontitis. Methods: A systematic review and meta-analysis were conducted of studies comparing periodontal parameters of inflammation, such as bleeding on probing, and biomarkers of inflammat
BACKGROUND: There is limited information about inferior meatus pneumatization in terms of implant treatment for the posterior maxilla. PURPOSE: To demonstrate the clinical, radiologic, and nasal endoscopic outcomes of implants accidentally protruding into the nasal cavities with inferior meatus pneumatization in the posterior maxilla. MATERIALS AND METHODS: A total of 560 implants (324 patients) with transcrestal sinus augmentation in the posterior maxilla were screened. On panoramic radiographs
The purpose of this study was to determine whether ATP-sensitive potassium channel (K(ATP) channel) activation generates oxygen free radicals in the rabbit heart. We assayed malondialdehyde (MDA) in rabbit heart slices in vitro as an indicator of oxygen free radical generation. The K(ATP) channel openers, pinacidil and cromakalim, significantly increased MDA production in a concentration-dependent manner. MDA formation also increased linearly with incubation time in the presence of K(ATP) channe
BACKGROUND: There is a little comparative data on implants placed transcrestally with/without sinus membrane (SM) perforation. PURPOSE: To compare the clinical and radiological outcomes of implants with maxillary sinus perforation and those without SM perforation. MATERIALS AND METHODS: Among 560 transcrestally placed implants in 324 patients, the patients who underwent cone-beam computed tomographic radiography (CBCT) were included. The following groups were established: implants with SM perfor
Purpose: The aim of this study is to evaluate the buccal and lingual bone thickness in the anterior teeth and the relationship between bone thickness and the tissue biotype. Methods: Three male and two female human cadaver heads (mean age, 55.4 years) were used in this study. First, the biotype of periodontium was evaluated and categorized into a thick or a thin group. Next, full thickness reflections of the mandible and the maxilla to expose the underlying bone for accurate measurements in the
Research Areas
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