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Joo Heung Lee

Sungkyunkwan University · Medicine

About the Lab

Professor Joo Heung Lee's research lab focuses on translational biomedical research spanning oral tissue biomechanics, cancer signaling pathways, and inflammatory skin disorders. The lab investigates the mechanical behavior of dental hard tissues, the role of AKT isoforms in non-small cell lung cancer, and the clinical and immunological distinctions between intrinsic and extrinsic atopic dermatitis. Additionally, the lab explores dermatological conditions such as vitiligo and acne, with an emphasis on developing clinically relevant grading systems and treatment prediction tools for Asian populations. These diverse yet interconnected research directions highlight a strong commitment to improving diagnostic accuracy and therapeutic outcomes in dermatology and oral medicine.

dental biomechanicsAKT signalingatopic dermatitisvitiligoacne grading

Research Overview

Papers
133
Total Citations
2,106
Papers (5y)
8
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
8total
2020
2021
2022
2023
2025
Citations per year (5y)
38total
20202021202220232025

Selected Papers

15
1
Article|390 citations·2015
Tofacitinib versus etanercept or placebo in moderate-to-severe chronic plaque psoriasis: a phase 3 randomised non-inferiority trial
H. Bachelez, P.C.M. van de Kerkhof, Robert Strohal, А. А. Кубанов, Fernando Valenzuela, Joo‐Heung Lee, V. V. Yakusevich, Sergio Chimenti, Jocelyne Papacharalambous, James Proulx, Pankaj Gupta, Huaming Tan
SJR Q1The LancetOA
ImmunologyImmunology and Microbiology
2
Article|235 citations·2014
Comparison of mechanical property and role between enamel and dentin in the human teeth
Keyoungjin Chun, Hanshin Choi, Joo‐Heung Lee
Journal of Dental BiomechanicsOA

The mechanical properties of enamel and dentin were studied using test specimens having the same shape and dimensions because these properties might vary with the experimental conditions and specimen shapes and dimensions. Healthy human teeth were used as specimens for mechanical tests. The stress (MPa), strain (%), and elastic modulus (E, MPa) of the specimens were obtained from compression tests. The maximum stresses of the enamel, dentin, and enamel-dentin specimens were 62.2 ± 23.8, 193.7 ±

OrthodonticsDentistry
3
Article|212 citations·2015
Mutations in DDX58, which Encodes RIG-I, Cause Atypical Singleton-Merten Syndrome
Mi‐Ae Jang, Eun Kyoung Kim, Hesung Now, Nhung Nguyen, Woo Jong Kim, Joo‐Yeon Yoo, Jinhyuk Lee, Yun‐Mi Jeong, Cheol‐Hee Kim, Ok‐Hwa Kim, Seongsoo Sohn, Seong-Hyeuk Nam
SJR Q1The American Journal of Human GeneticsOA
Molecular BiologyBiochemistry, Genetics and Molecular Biology
4
Article|68 citations·2003
Comparison of Transepidermal Water Loss, Capacitance and pH Values in the Skin between Intrinsic and Extrinsic Atopic Dermatitis Patients
Suk Jin Choi, Mingyu Song, Whan-Tae Sung, Dong‐Youn Lee, Joo‐Heung Lee, Eil-Soo Lee, Jun‐Mo Yang
SJR Q2Journal of Korean Medical ScienceOA

Atopic dermatitis (AD), with the prevalence rate of around 10 to 15%, is characterized by an intensely pruritic skin lesions with typical distribution and morphology. Recently, AD is divided into extrinsic type (ADe) and intrinsic type (ADi) according to the laboratory findings and associated diseases. ADe is well-known for high IgE level, positive response to food- or aero-allergens, whereas ADi has clinically similar skin lesions and distribution patterns of AD with normal serum IgE levels, ne

DermatologyMedicine
5
Article|66 citations·2011
The incidence of leukotrichia in segmental vitiligo: implication of poor response to medical treatment
Dong‐Youn Lee, Cho‐Rok Kim, Ji‐Hye Park, Joo‐Heung Lee
SJR Q1International Journal of Dermatology

BACKGROUND: In vitiligo, the melanocyte of the hair follicle is one of the major sources for repigmentation. Segmental vitiligo seems to be often associated with white hairs. However, in the case of small vellus hairs, it is often difficult or impossible to detect hair color. Thus, the real incidence of leukotrichia in segmental vitiligo has not been known. MATERIALS AND METHODS: In this study, we investigated the existence of white hairs in the lesional skin of 82 patients with segmental vitili

Cell BiologyBiochemistry, Genetics and Molecular Biology
6
Article|51 citations·2004
한국형 여드름 중증도 시스템
성경제, 노영석, 최응호, 오정준, 이주흥, 김선우, 김낙인

Background: A good acne grading system should reflect epidemiological and clinical features of a particular patient group. Current Korean acne grading systems are mostly based on the skin colors, epidemiology, and clinical features of Western countries, which make them less than being ideal for Korean acne patients. Objective: We tried to devise an acne grading system based on clinical and epidemiological characteristics of Korean acne patients. This system is intended for use in primary care se

7
letter|50 citations·2006
Treatment of extensive and recalcitrant viral warts with acitretin
YUN-LIM CHOI, KWANG-JUN LEE, Won‐Serk Kim, DONG-YOUN LEE, Joo‐Heung Lee, Eil‐Soo Lee, Jun‐Mo Yang
SJR Q1International Journal of Dermatology
EpidemiologyMedicine
8
Article|46 citations·2012
World Health Organization–European Organization for Research and Treatment of Cancer classification of cutaneous lymphoma in Korea: A retrospective study at a single tertiary institution
Ji‐Hye Park, Hyun‐Tae Shin, Dong‐Youn Lee, Joo‐Heung Lee, Jun‐Mo Yang, Kee‐Taek Jang, Young Hyeh Ko
SJR Q1Journal of the American Academy of Dermatology
DermatologyMedicine
9
letter|38 citations·2006
CD10, a marker for specialized mesenchymal cells (onychofibroblasts) in the nail unit
Kwangjun Lee, Won‐Serk Kim, Joo‐Heung Lee, Jun‐Mo Yang, Eil-Soo Lee, Goo‐Hyun Mun, Kee‐Taek Jang, Dong‐Youn Lee
SJR Q1Journal of Dermatological Science
EpidemiologyMedicine
10
letter|36 citations·2006
Identification of the Target Genes of Atopic Dermatitis by Real-Time PCR
Eun–Young Seo, Geon Tae Park, Kyu-Mi Lee, Jung‐Ah Kim, Joo‐Heung Lee, Jun‐Mo Yang
SJR Q1Journal of Investigative DermatologyOA
DermatologyMedicine
11
Article|34 citations·2006
Case of childhood granulomatous periorificial dermatitis in a Korean boy treated by oral erythromycin
Yun‐Lim CHOI, Kwang‐Jun LEE, Hye‐Jin CHO, Won‐Serk Kim, Joo‐Heung Lee, Jun‐Mo Yang, Eil‐Soo LEE, Dong‐Youn Lee
SJR Q1The Journal of Dermatology

Childhood granulomatous periorificial dermatitis (CGPD) is a disease presenting most commonly in prepubertal children as yellow-brown papules limited to the perioral, perinasal and periocular regions. The condition is benign, self-limiting and is not associated with systemic involvement. We herein report a case of an 11-year-old Korean boy with multiple, asymptomatic, monomorphic, red-to-yellow-colored papular eruptions on the perioral areas of 7-month duration. Histopathological examination rev

DermatologyMedicine
12
Article|30 citations·2017
The Clinical Profile of Patients with Psoriasis in Korea: A Nationwide Cross-Sectional Study (EPI-PSODE)
송해준, 박철종, 김태윤, 최용범, 이석종, 김낙인, 조재위, 전지현, 장민수, 윤재일, 김명화, 박준수

Background: Psoriasis is an immune-mediated, chronic inflammatory disease affecting multiple aspects of patients’ lives. Its epidemiology varies regionally; however, nationwide epidemiologic data on psoriasis depicting profile of Korean patients has not been available to date. Objective: To understand nationwide epidemiologic characteristics and clinical features of adult patients with psoriasis visited university hospitals in Korea. Methods: This multicenter, non-interventional, cross-sectional

13
Article|30 citations·2001
Novel Mutations of the Transglutaminase 1 Gene in Lamellar Ichthyosis
Jun-Mo Yang, Kwang-Sung Ahn, Mi-Ook Cho, Kozo Yoneda, Cha-Hui Lee, Joo‐Heung Lee, Eil-Soo Lee, Eleonora Candi, Gerry Melino, Bijan Ahvazi, Peter M. Steinert
SJR Q1Journal of Investigative DermatologyOA
Cell BiologyBiochemistry, Genetics and Molecular Biology
14
Article|29 citations·2013
The effectiveness of early treatment in segmental vitiligo: retrospective study according to disease duration
Ji‐Hye Park, Se Won Park, Dong‐Youn Lee, Joo‐Heung Lee, Jun‐Mo Yang
SJR Q2Photodermatology Photoimmunology & Photomedicine

Segmental vitiligo (SV) is usually characterized by a unilateral-dermatomal distribution, earlier onset and rapid progression followed by stabilization. The response to phototherapy in patients with SV is limited. We evaluated the treatment response in 39 cases of SV according to disease duration. Ten cases (50.0%) of Group 1 (duration ≤ 5 months) and five cases (26.3%) of Group 2 (duration > 5 months) showed more than 50% repigmentation. Contrary to previous reports, patients in our study respo

Cell BiologyBiochemistry, Genetics and Molecular Biology
15
Article|29 citations·2016
A multicenter, randomized, open-label pilot trial assessing the efficacy and safety of etanercept 50 mg twice weekly followed by etanercept 25 mg twice weekly, the combination of etanercept 25 mg twice weekly and acitretin, and acitretin alone in patients with moderate to severe psoriasis
Joo‐Heung Lee, Jai‐Il Youn, Tae‐Yoon Kim, Jee Ho Choi, Chul Jong Park, Yong-Beom Choe, Hae-Jun Song, Nack-In Kim, Kwang Joong Kim, Jeung‐Hoon Lee, Hyun–Jeong Yoo
BMC DermatologyOA

This study was registered on July 7, 2009 at ClinicalTrials.gov, NCT00936065 .

ImmunologyImmunology and Microbiology

Research Areas

Cell BiologyImmunologyDermatologyEpidemiologySurgeryOncology

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