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Joo-Won Jeong

Yonsei University · Medicine

About the Lab

Professor Joo-Won Jeong's research lab specializes in identifying and characterizing natural compounds with anti-angiogenic, anti-cancer, and neuroprotective properties. The lab focuses on elucidating the molecular mechanisms underlying the therapeutic effects of bioactive phytochemicals such as melatonin, p-coumaric acid, glycyrrhizic acid, cinnamaldehyde, and zingerone in cancer and neurodegenerative diseases. Key research directions include tumor angiogenesis inhibition, regulation of hypoxia-inducible factor-1α (HIF-1α), modulation of signaling pathways (e.g., AKT, ERK, JNK), and induction of autophagy in neurodegenerative models. The lab integrates in vitro cell culture studies with in vivo animal models to validate the translational potential of natural compounds in disease therapy.

anti-angiogenesisnatural compoundscancer therapyneuroprotectionsignaling pathways

Research Overview

Papers
56
Total Citations
813
Papers (5y)
23
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
23total
2021
2022
2023
2024
2025
Citations per year (5y)
245total
20212022202320242025

Selected Papers

15
1
Article|32 citations·2010
Development and Validation of a Novel Prognostic Scoring Model for Ischemic Colitis
Joo Won Chung, Jae Hee Cheon, Jae Jun Park, Eun Suk Jung, Eun Hee Choi, Hannah Kim
SJR Q2Diseases of the Colon & RectumOA

Endoscopic findings and instability of vital signs were associated with the disease course of ischemic colitis. A novel scoring model based on presence of tachycardia, shock within 24 hours after admission, and endoscopic evidence of ulceration provides a method of assessing patient prognosis and should be further validated.

SurgeryMedicine
2
Article|31 citations·2012
Clinicopathologic Features and Outcomes of Pancreatic Cysts During a 12-Year Period
Joo Won Chung, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Si Young Song, Jae Bock Chung, Seung Woo Park
SJR Q2PancreasOA

Most lesions with low or indeterminate risk did not changed in size during follow-up period, but one fifth of high-risk lesions were identified as borderline or malignant after surgery. Surgical resection should be performed in patients with high-risk cysts considering their clinical condition, and radiological follow-up of nonsurgically managed cysts should be continued for more than 6 years.

OncologyMedicine
3
Article|24 citations·2011
Endoscopic Papillary Balloon Dilation for Removal of Choledocholithiasis: Indications, Advantages, Complications, and Long-Term Follow-Up Results
Joo Won Chung, Jae Bock Chung
SJR Q1Gut and LiverOA

Endoscopic papillary balloon dilation (EPBD) is an alternative method of endoscopic sphincterotomy (EST). Although concerns regarding post-procedure pancreatitis have been expressed, EPBD has come to be recognized as an effective and safe method for stone removal in specific cases. To analyze the proper indications, ideal methods, complications, and long-term follow-up results for EPBD, we reviewed articles about EPBD located through a search of the PubMed data base. We analyzed the ballooning m

Pulmonary and Respiratory MedicineMedicine
4
Article|22 citations·2022
Prediction of oxygen requirement in patients with COVID-19 using a pre-trained chest radiograph xAI model: efficient development of auditable risk prediction models via a fine-tuning approach
Joo Won Chung, Doyun Kim, Jongmun Choi, Sehyo Yune, Kyoung Doo Song, Seonkyoung Kim, Michelle Chua, Marc D. Succi, John Conklin, Maria Gabriela Figueiró Longo, Jeanne B. Ackman, Milena Petranović
SJR Q1Scientific ReportsOA

Risk prediction requires comprehensive integration of clinical information and concurrent radiological findings. We present an upgraded chest radiograph (CXR) explainable artificial intelligence (xAI) model, which was trained on 241,723 well-annotated CXRs obtained prior to the onset of the COVID-19 pandemic. Mean area under the receiver operating characteristic curve (AUROC) for detection of 20 radiographic features was 0.955 (95% CI 0.938-0.955) on PA view and 0.909 (95% CI 0.890-0.925) on AP

Radiology, Nuclear Medicine and ImagingMedicine
5
Article|22 citations·2012
Clinical Implications and Risk Factors of Acute Pancreatitis after Cardiac Valve Surgery
Joo Won Chung, Sung Ho Ryu, Jung Hyun Jo, Jeong Youp Park, Sak Lee, Seung Woo Park, Si Young Song, Jae Bock Chung
SJR Q2Yonsei Medical JournalOA

We found that acute pancreatitis after cardiac valve surgery requires longer hospitalization and increases the in-hospital mortality rate. Clinicians should be aware that patients could develop pancreatitis after cardiac valve surgery, especially in patients with hypertension and chronic kidney disease treated with norepinephrine.

SurgeryMedicine
6
Article|22 citations·2012
Safety of Capsule Endoscopy Using Human Body Communication in Patients with Cardiac Devices
Joo Won Chung, Hye Jin Hwang, Moon Jae Chung, Jeong Youp Park, Hui‐Nam Pak, Si Young Song
SJR Q2Digestive Diseases and Sciences
GastroenterologyMedicine
7
Article|14 citations·2013
Folfox4 as a rescue chemotherapy for gemcitabine-refractory pancreatic cancer.
Joo Won Chung, Hui Won Jang, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Jae Bock Chung, Si Young Song, Seungmin Bang
PubMed

BACKGROUND/AIMS: This phase II study assessed the efficacy and safety of FOLFOX4 as a rescue therapy in patients with gemcitabine-refractory pancreatic cancer. METHODOLOGY: The study included patients with advanced pancreatic cancer who had failed gemcitabine-based chemotherapy. FOLFOX4 was administered biweekly as follows: oxaliplatin, 85 mg/m² as a 2-hour infusion (day 1); leucovorin, 200 mg/m²/day as a 2-hour infusion (days 1 and 2); 5-fluorouracil, bolus 400 mg/m²/day and 600 mg/m²/day as a

OncologyMedicine
8
Article|13 citations·2017
Assessment of the Risk of Colorectal Cancer Survivors Developing a Second Primary Pancreatic Cancer
Joo Won Chung, Moon Jae Chung, Seungmin Bang, Seung Woo Park, Si Young Song, Jae Bock Chung, Jeong Youp Park
SJR Q1Gut and LiverOA

The risk of a second primary PC was higher in patients with CRC. Further studies are needed to identify the risk factors and generate a screening strategy for cancer survivors.

OncologyMedicine
9
Article|10 citations·2023
Automatic Classification of GI Organs in Wireless Capsule Endoscopy Using a No-Code Platform-Based Deep Learning Model
Joo Won Chung, Dong Jun Oh, Junseok Park, Su Hwan Kim, Yun Jeong Lim
SJR Q2DiagnosticsOA

The first step in reading a capsule endoscopy (CE) is determining the gastrointestinal (GI) organ. Because CE produces too many inappropriate and repetitive images, automatic organ classification cannot be directly applied to CE videos. In this study, we developed a deep learning algorithm to classify GI organs (the esophagus, stomach, small bowel, and colon) using a no-code platform, applied it to CE videos, and proposed a novel method to visualize the transitional area of each GI organ. We use

GastroenterologyMedicine
10
Article|8 citations·2015
유아의 마음이론과 도덕적 판단의 관계
정주원, 강민주

본 연구에서는 만 4세 유아의 마음이론과 도덕적 판단의 발달 수준에 대해 살펴보고 마음이론과 도덕적 판단의 관계에 대해 알아보고자 하였다. 이를 위해 만 4세 유아 117명을 대상으로 내용교체 과제와 위치이동 과제를 실시하였고, 과실, 거짓말, 훔치기 항목에 대한 도덕적 판단을 근거로 한 의도성 판단 지수를 사용하여 유아의 도덕적 판단 능력을 측정하였다. 본 연구의 결과를 요약하면 다음과 같다. 첫째, 과반수의 만 4세 유아들이 마음이론 두 과제의 개념을 이해하는 것으로 나타났다. 만 4세 유아는 자신의 틀린 믿음에 대한 표상을 타인의 틀린 믿음에 대한 표상보다 잘 하는 것으로 나타났으며, 타인의 틀린 믿음에 대한 표상을 타인의 후속행동에 대한 예측보다 잘 하는 것으로 나타났다. 둘째, 만 4세 유아들은 도덕적 판단을 할 때 의도와 결과를 같은 비중으로 중요하게 고려하는 것으로 나타났다. 셋째, 유아의 마음이론과 도덕적 판단은 정적 상관이 있었다. 즉, 틀린 믿음 표상능력이 높을수록

11
Article|3 citations·2018
Gastrointestinal cancer risk in patients with a family history of gastrointestinal cancer
Joo Won Chung, Jae Jun Park, Yun Jeong Lim, Jun Lee, Sun Moon Kim, Joung‐Ho Han, Seong Ran Jeon, Hong Sub Lee, Yong Sung Kim, Si Young Song
SJR Q3Korean Journal of GastroenterologyOA

GI cancer patients tended to have a first relative with a history of concordant GI cancer. Personal factors (old age and male) and lifestyle (smoking) contribute to the development of GI cancer, independently. Individuals with high risk for GI cancers may be advised to undergo screening at an earlier age.

Pathology and Forensic MedicineMedicine
12
Article|3 citations·2017
Assessment of the Risk of Colorectal Cancer Survivors Developing a Second Primary Pancreatic Cancer
정주원, 정문재, 방승민, 박승우, 송시영, 정재복, 박정엽

Background/Aims: We aimed to investigate the incidence of second primary pancreatic cancer (PC) after colorectal cancer (CRC) and to identify risk factors associated with subsequent PC. Methods: The observed incidence of a subsequent PC in patients with CRC was standardized using a population with CRC from the Korean Central Cancer Registry (KCCR). The expected incidence rate of PC was obtained by assuming that the select group experienced the same cancer incidence as the corresponding general p

13
Article|2 citations·2010
Aplastic Anemia with Trisomy 8 and Trisomy 9 in Intestinal Behçet's Disease
Joo Won Chung, Jae Hee Cheon, Kyong Joo Lee, Jin Seok Kim, Seon-Jung Jang, Woo Ick Yang, Tae Il Kim, Won Ho Kim
SJR Q3Korean Journal of GastroenterologyOA

Behcets disease is a multisystemic inflammatory disease characterized with recurrent oral ulcer, genital ulcer, and multiple organ involvement. Aplastic anemia is one of the rarest complications of Behcets disease. There were only several reports about Behcets disease associated myelodysplatic syndrome worldwide. Moreover, aplastic anemia in intestinal Behcets disease was rarely reported. Here, we present a case of aplastic anemia with trisomy 8 and trisomy 9 in intestinal Behcets disease and a

OphthalmologyMedicine
14
Preprint|1 citations·2022
Prediction of oxygen requirement in patients with COVID-19 using a pre-trained chest radiograph xAI model: Efficient development of auditable risk prediction models via a fine-tuning approach
Joo Won Chung, Doyun Kim, Jongmun Choi, Sehyo Yune, Kyungdoo Song, Seonkyoung Kim, Michelle Chua, Marc D. Succi, John Conklin, Maria Gabriela Figueiró Longo, Jeanne B. Ackman, Milena Petranović
Research SquareOA

Abstract Clinical risk prediction requires comprehensive integration of clinical information and concurrent radiological findings. We present an upgraded chest radiograph (CXR) explainable artificial intelligence (xAI) model, which was trained on 241,723 well-annotated CXRs obtained prior to the onset of the COVID-19 pandemic. Mean area under the receiver operating characteristic curve (AUROC) for detection of 20 radiographic features was 0.955 (95% CI 0.938-0.955) on PA view and 0.909 (95% CI 0

Radiology, Nuclear Medicine and ImagingMedicine
15
Article|1 citations·2008
[A case of giant Brunner's gland hyperplasia combined with adenomyomatous hyperplasia].
Joo Won Chung, Joo Hee Seo, Seung Woo Park, Si Young Song, Jae Bock Chung, Sang Kyum Kim, Ho Keun Kim, Seungmin Bang
PubMed

Brunner's gland hyperplasia is a rare tumor of the duodenum and might also be an unusual cause of gastrointestinal bleeding. In symptomatic patients, treatment requires either surgical resection or endoscopic polypectomy. We report a case of upper gastrointestinal bleeding from a pedunculated Brunner's gland hyperplasia in the duodenal bulb. Endoscopic resection using the detachable snare and hemoclipping was instituted to remove a large pedunculated polyp. The pathologic diagnosis was Brunner's

GastroenterologyMedicine

Research Areas

Radiology, Nuclear Medicine and ImagingOncologyGastroenterologyPulmonary and Respiratory MedicineInfectious DiseasesSurgery

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