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Juhyeon Lim

Seoul National University · Medicine

About the Lab

Professor Juhyeon Lim's research lab focuses on gastrointestinal and metabolic diseases, with a strong emphasis on gastric cancer, Helicobacter pylori infection, and their long-term health implications. The lab investigates the molecular mechanisms linking H. pylori to gastric carcinogenesis, particularly through epigenetic changes such as miRNA methylation, and explores the role of aging and obesity in gastric cancer progression. Using large-scale national health databases, the lab conducts epidemiological and clinical studies to evaluate risk factors, treatment outcomes, and long-term survival in elderly and high-risk populations.

gastric cancerH. pyloriepigeneticsobesity and cancerinsomnia and cancer

Research Overview

Papers
108
Total Citations
1,703
Papers (5y)
34
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
34total
2021
2022
2023
2024
2025
Citations per year (5y)
324total
20212022202320242025

Selected Papers

15
1
Article|105 citations·2012
Do antiplatelets increase the risk of bleeding after endoscopic submucosal dissection of gastric neoplasms?
Joo Hyun Lim, Sang Gyun Kim, Ji Won Kim, Yoon Jin Choi, Jieun Kwon, Ji Yeon Kim, Yun Bin Lee, Jeongmin Choi, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung, In Sung Song
SJR Q1Gastrointestinal Endoscopy
Pulmonary and Respiratory MedicineMedicine
2
Article|48 citations·2014
Risk factors for synchronous or metachronous tumor development after endoscopic resection of gastric neoplasms
Joo Hyun Lim, Sang Gyun Kim, Jeongmin Choi, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung
SJR Q1Gastric CancerOA
Pulmonary and Respiratory MedicineMedicine
3
Review|45 citations·2016
Thirty-day mortality after percutaneous gastrostomy by endoscopic versus radiologic placement: a systematic review and meta-analysis
Joo Hyun Lim, Seung Ho Choi, Changhyun Lee, Ji Yeon Seo, Hae Yeon Kang, Jong In Yang, Su Jin Chung, Joo Sung Kim
SJR Q2Intestinal ResearchOA

BACKGROUND/AIMS: A percutaneous gastrostomy can be placed either endoscopically (percutaneous endoscopic gastrostomy, PEG) or radiologically (radiologically-inserted gastrostomy, RIG). However, there is no consistent evidence of the safety and efficacy of PEG compared to RIG. Recently, 30-day mortality has become considered as the most important surrogate index for evaluating the safety and efficacy of percutaneous gastrostomy. The aim of this meta-analysis was to compare the 30-day mortality ra

Nutrition and DieteticsNursing
4
Article|37 citations·2015
Risk factors of delayed ulcer healing after gastric endoscopic submucosal dissection
Joo Hyun Lim, Sang Gyun Kim, Jeongmin Choi, Jong Pil Im, Joo Sung Kim, Hyun Chae Jung
SJR Q1Surgical Endoscopy
Pulmonary and Respiratory MedicineMedicine
5
Article|36 citations·2019
Long-term clinical outcomes of endoscopic vs. surgical resection for early gastric cancer with undifferentiated histology
Joo Hyun Lim, Jung Kim, Sang Gyun Kim, Hyunsoo Chung
SJR Q1Surgical Endoscopy
Pulmonary and Respiratory MedicineMedicine
6
Article|33 citations·2016
Inverse Relationship Between Helicobacter Pylori Infection and Asthma Among Adults Younger than 40 Years
Joo Hyun Lim, Nayoung Kim, Seon Hee Lim, Jin‐Won Kwon, Cheol Min Shin, Yoon‐Seok Chang, Joo Sung Kim, Hyun Chae Jung, Sang‐Heon Cho
SJR Q3MedicineOA

Recent studies have suggested that Helicobacter pylori could prevent allergic disease, particularly in children. However, whether this is true in adults is controversial. The aim of this study was to investigate whether there is negative association between H. pylori infection and asthma among adults in an area with a high prevalence of H. pylori.This was a cross-sectional study using 2011 health surveillance data. Blood samples were taken from all participants to measure serum H. pylori IgG sta

SurgeryMedicine
7
Article|29 citations·2014
Clinicopathological Features and Surgical Safety of Gastric Cancer in Elderly Patients
Joo Hyun Lim, Dong Ho Lee, Cheol Min Shin, Nayoung Kim, Young Soo Park, Hyun Chae Jung, In Sung Song
SJR Q2Journal of Korean Medical ScienceOA

Gastric cancer is one of the most common cancers, especially among the elderly. However little is known about gastric cancer in elderly patients. This study was designed to evaluate the specific features of gastric cancer in elderly patients. Medical records of 1,107 patients who had radical gastrectomy for gastric cancer between June 2005 and December 2009 were reviewed. They were divided into young (<65 yr, n=676), young-old (65-74 yr, n=332), and old-old age group (≥75 yr, n=99). Increased CA

Pulmonary and Respiratory MedicineMedicine
8
Article|25 citations·2023
Risk of cancer in patients with insomnia: Nationwide retrospective cohort study (2009–2018)
Kichul Yoon, Cheol Min Shin, Kyungdo Han, Jin‐Hyung Jung, Eun Hyo Jin, Joo Hyun Lim, Seung Joo Kang, Yoon Jin Choi, Dong Ho Lee
SJR Q1PLoS ONEOA

PURPOSE: To investigate the association between insomnia and the risk of various cancers using the Korean National Health Insurance Service database. MATERIALS AND METHODS: Patients who underwent a national health examination in 2009 were followed-up until 2018. Newly-diagnosed cancers were collected one year after the baseline. Insomnia was defined as having a diagnosis of F510 or G470 within one year prior to enrollment. The incidence of various cancers was compared between patients with and w

Experimental and Cognitive PsychologyPsychology
9
Article|25 citations·2021
Nationwide cohort study: cholesterol level is inversely related with the risk of gastric cancer among postmenopausal women
Joo Hyun Lim, Cheol Min Shin, Kyungdo Han, Juhwan Yoo, Eun Hyo Jin, Yoon Jin Choi, Dong Ho Lee
SJR Q1Gastric CancerOA
Cancer ResearchBiochemistry, Genetics and Molecular Biology
10
Article|22 citations·2017
Helicobacter pylori Is Associated with miR-133a Expression through Promoter Methylation in Gastric Carcinogenesis
Joo Hyun Lim, Sang Gyun Kim, Ji Min Choi, Hyo‐Joon Yang, Joo Sung Kim, Hyun Chae Jung
SJR Q1Gut and LiverOA

This result suggests <i>H. pylori</i> eradication could reverse methylation-silencing of <i>miR-133a</i> which is involved in <i>H. pylori</i>-induced gastric carcinogenesis.

Cancer ResearchBiochemistry, Genetics and Molecular Biology
11
Article|20 citations·2012
Precise Size-control of Silica Nanoparticles via Alkoxy Exchange Equilibrium of Tetraethyl Orthosilicate (TEOS) in the Mixed Alcohol Solution
임주현, 하신우, 이진규
http://journal.kcsnet.or.kr/main/j_search/j_abstract_view.htm?code=B120351&qpage=j_search&spage=b_bkcs&dpage=ar
12
Article|19 citations·2021
Association between the Persistence of Obesity and the Risk of Gastric Cancer: A Nationwide Population-Based Study
Joo Hyun Lim, Cheol Min Shin, Kyungdo Han, Seung Woo Lee, Eun Hyo Jin, Yoon Jin Choi, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee
SJR Q1Cancer Research and TreatmentOA

PURPOSE: There remains controversy about relationship between obesity and gastric cancer. We aimed to examine the association using obesity-persistence. MATERIALS AND METHODS: We analyzed a nationwide population-based cohort which underwent health check-up between 2009 and 2012. Among them, those who had annual examinations during the last 5 years were selected. Gastric cancer risk was compared between those without obesity during the 5 years (never-obesity group) and those with obesity diagnosi

OncologyMedicine
13
Article|18 citations·2016
Efficacy of Levofloxacin-Based Third-Line Therapy for the Eradication of Helicobacter pylori in Peptic Ulcer Disease
Joo Hyun Lim, Sang Gyun Kim, Ji Hyun Song, Jae Jin Hwang, Dong Ho Lee, Jae Pil Han, Su Jin Hong, Ji Hyun Kim, Seong Woo Jeon, Gwang Ha Kim, Ki‐Nam Shim, Woon Geon Shin
SJR Q1Gut and LiverOA

Levofloxacin-based third-line <i>H. pylori</i> eradication showed efficacy similar to that of previously reported first/second-line therapies.

SurgeryMedicine
14
Article|9 citations·2020
Dietary pattern and its association with right‐colonic diverticulosis
Joo Hyun Lim, Young Sun Kim, Jung Eun Lee, Jiyoung Youn, Goh Eun Chung, Ji Hyun Song, Sun Young Yang, Joo Sung Kim
SJR Q1Journal of Gastroenterology and Hepatology

BACKGROUND AND AIM: In East Asia, colonic diverticulosis develops most commonly in the right colon and is known to have different characteristics compared with left-sided one. This study was designed to investigate whether right-colonic diverticulosis is associated with posteriori dietary patterns. METHODS: We retrospectively reviewed medical records of prospectively collected cohort that received health check-up in Korea between May 2011 and January 2012. Their anthropometric data, biochemical

SurgeryMedicine
15
Article|8 citations·2013
A Case of Common Bile Duct Cancer That Completely Responded to Combination Chemotherapy of Gemcitabine and TS-1
Joo Hyun Lim, Ji Kon Ryu, Yoon Jin Choi, Jieun Kwon, Ji Yeon Kim, Yun Bin Lee, Jae Hwan Kim, Won Jae Yoon, Yong Tae Kim, Yong Bum Yoon
SJR Q1Gut and LiverOA

Common bile duct (CBD) cancer is a relatively rare malignancy that arises from the biliary epithelium and is associated with a poor prognosis. Here, we report a case of advanced metastatic CBD cancer successfully treated by chemotherapy with gemcitabine combined with S-1 (tegafur+gimeracil+oteracil). A 65-year-old male presented with pyogenic liver abscess. After antibiotic therapy and percutaneous drainage, follow-up computed tomography (CT) showed an enhanced nodule in the CBD. Biopsy was perf

SurgeryMedicine

Research Areas

Pulmonary and Respiratory MedicineSurgeryOncologyCancer ResearchEpidemiologyNutrition and Dietetics

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