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Jun Hwa Lee

Sungkyunkwan University · Medicine

About the Lab

Professor Jun Hwa Lee's research lab specializes in clinical metabolomics and biomarker discovery, focusing on the identification of low-mass ions (LMIs) and metabolic profiles using mass spectrometry for early disease detection, particularly in cancer and neurological disorders. The lab integrates MALDI-TOF and triple-TOF mass spectrometry to develop discriminant models like LOME for non-invasive screening, with applications in ovarian cancer, colorectal cancer, and pediatric neurological conditions such as febrile seizures and acute necrotizing encephalopathy. The team also investigates trace element imbalances, such as zinc deficiency, in pediatric neurological diseases, and explores the utility of neuroimaging and SPECT in diagnosing rare syndromes like Dyke-Davidoff-Masson. Their work bridges metabolomics, clinical neurology, and preventive healthcare, especially in vulnerable populations like rural elderly and children.

metabolomicsbiomarker discoverymass spectrometryneurological disorderscancer screening

Research Overview

Papers
142
Total Citations
1,538
Papers (5y)
28
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
28total
2020
2021
2022
2024
2025
Citations per year (5y)
181total
20202021202220242025

Selected Papers

15
1
Article|35 citations·2013
Iodine status in Korean preschool children as determined by urinary iodine excretion
Jeehhun Lee, Jeong Hyun Kim, Soo‐Youn Lee, Jun Hwa Lee, Jun Hwa Lee, Jun Hwa Lee
SJR Q1European Journal of Nutrition
Endocrinology, Diabetes and MetabolismMedicine
2
Article|35 citations·2012
Comparison of Serum Zinc Levels Measured by Inductively Coupled Plasma Mass Spectrometry in Preschool Children with Febrile and Afebrile Seizures
Jun Hwa Lee, Jeong Hyun Kim
SJR Q2Annals of Laboratory MedicineOA

Zinc levels in children with febrile seizure were significantly lower than those in children with afebrile seizure.

Nutrition and DieteticsNursing
3
Article|27 citations·2016
The association of weather on pediatric emergency department visits in Changwon, Korea (2005–2014)
Hae Jeong Lee, Mi Hyeon Jin, Jun Hwa Lee
SJR Q1The Science of The Total Environment
Health, Toxicology and MutagenesisEnvironmental Science
4
Article|26 citations·2017
The effects of weather on pediatric seizure: A single-center retrospective study (2005–2015)
Sung Hoon Kim, Joon Soo Kim, Mi Hyeon Jin, Jun Hwa Lee
SJR Q1The Science of The Total Environment
Health, Toxicology and MutagenesisEnvironmental Science
5
Article|20 citations·2008
Nonlinear frequency responses of quarter vehicle models with amplitude-sensitive engine mounts
Jun Hwa Lee, Rajendra Singh
SJR Q1Journal of Sound and Vibration
Automotive EngineeringEngineering
6
Article|19 citations·2013
Low‐mass‐ion discriminant equation: A new concept for colorectal cancer screening
Jun Hwa Lee, Kyung‐Hee Kim, Ji Won Park, Hee Jin Chang, Byung Chang Kim, Sun Young Kim, Kwang Gi Kim, Kyu Eun Lee, Dae Yong Kim, Jae Hwan Oh, Byong Chul Yoo, In‐Hoo Kim
SJR Q1International Journal of CancerOA

Blood metabolites can be detected as low-mass ions (LMIs) by mass spectrometry (MS). These LMIs may reflect the pathological changes in metabolism that occur as part of a disease state, such as cancer. We constructed a LMI discriminant equation (LOME) to investigate whether systematic LMI profiling might be applied to cancer screening. LMI information including m/z and mass peak intensity was obtained by five independent MALDI-MS analyses, using 1,127 sera collected from healthy individuals and

Molecular BiologyBiochemistry, Genetics and Molecular Biology
7
Article|15 citations·2017
Profiling of Serum Metabolites Using MALDI-TOF and Triple-TOF Mass Spectrometry to Develop a Screen for Ovarian Cancer
Jun Hwa Lee, Yun Hwan Kim, Kyung‐Hee Kim, Jae Youl Cho, Sang Myung Woo, Byong Chul Yoo, Seung Cheol Kim
SJR Q1Cancer Research and TreatmentOA

MALDI-TOF-based OVC LOMEs combined with triple-TOF-based OVC metabolic biomarkers allow reliable OVC screening; the techniques are mutually complementary both quantitatively and qualitatively.

Molecular BiologyBiochemistry, Genetics and Molecular Biology
8
Article|15 citations·2006
A case of Dyke-Davidoff-Masson syndrome in Korea
Jun Hwa Lee, Zee Ihn Lee, Ho Kyun Kim, Soonhak Kwon
Korean Journal of PediatricsOA

Dyke-Davidoff-Masson Syndrome (DDMS) is a rare condition characterized by asymmetry of cerebral hemispheric growth with atrophy on one side, ipsilateral compensatory osseous hypertrophy, and contralateral hemiparesis. We experienced a 17 month-old male who presented with left focal clonic or tonic-clonic seizures accompanied by left hemiparesis and developmental delay. Brain MRIs demonstrated progressive atrophy of the right cerebral hemisphere with dilatation of the lateral ventricle, expansion

Endocrinology, Diabetes and MetabolismMedicine
9
Article|14 citations·2007
The Effects of an Education Program for Safe Drug Use in the Rural Elderly
Jun Hwa Lee, Myonghwa Park
Daehan ganho haghoeji

This study suggests that the education for safe drug use is effective in promoting knowledge and behavior for safe drug use of the rural elderly.

Information SystemsComputer Science
10
Article|13 citations·2012
Recurrent Acute Necrotizing Encephalopathy in a Korean Child
Jun Hwa Lee, Jun Hwa Lee, Munhyang Lee, Jeehun Lee, Jeehun Lee
SJR Q2Journal of Child Neurology

Acute necrotizing encephalopathy is characterized by fever, seizures, acute encephalopathy, and rapid progression to coma. It is usually associated with viral illness and shows characteristic brain magnetic resonance imaging features, including symmetrical involvement of bilateral thalami, brain stem, white matter, and cerebellum. After the first report of recurrent or familial cases in 2003, similar cases were found exclusively in American and European regions. The association with Ran-binding

Infectious DiseasesMedicine
11
Article|11 citations·2018
Individualized metabolic profiling stratifies pancreatic and biliary tract cancer: a useful tool for innovative screening programs and predictive strategies in healthcare
Jun Hwa Lee, Seung Eun Yu, Kyung‐Hee Kim, Myung Hyun Yu, Inhye Jeong, Jae Youl Cho, Sang‐Jae Park, Woo Jin Lee, Sung‐Sik Han, Tae Hyun Kim, Eun Kyung Hong, Sang Myung Woo
SJR Q1The EPMA JournalOA

BACKGROUND: Pancreatic cancer (PC) and biliary tract cancer (BTC) are highly aggressive cancers, characterized by their rarity, difficulty in diagnosis, and overall poor prognosis. Diagnosis of PC and BTC is complex and is made using a combination of appropriate clinical suspicion, imaging and endoscopic techniques, and cytopathological examination. However, the late-stage detection and poor prognosis of this tumor have led to an urgent need for biomarkers for early and/or predictive diagnosis a

Molecular BiologyBiochemistry, Genetics and Molecular Biology
12
Article|11 citations·2014
A Korean Case of β-Ureidopropionase Deficiency Presenting with Intractable Seizure, Global Developmental Delay, and Microcephaly
Jun Hwa Lee, André B. P. Kuilenburg, N. G. G. M. Abeling, Valeria Vasta, Si Houn Hahn
SJR Q2JIMD ReportsOA
Molecular BiologyBiochemistry, Genetics and Molecular Biology
13
Article|10 citations·2019
Are there effects of lunar cycle on pediatric febrile seizure?: A single-center retrospective study (2005–2018)
Sung Hoon Kim, Haeng Seon Shim, Su Mynn Kang, Hyunho Park, Mi Hyeon Jin, Jun Hwa Lee
SJR Q1The Science of The Total Environment
Social PsychologyPsychology
14
Article|10 citations·2016
Low-mass-ion discriminant equation (LOME) for ovarian cancer screening
Jun Hwa Lee, Byong Chul Yoo, Yun Hwan Kim, Sun-A Ahn, Seung‐Gu Yeo, Jae Youl Cho, Kyung‐Hee Kim, Seung Cheol Kim
SJR Q1BioData MiningOA

A low-mass-ion discriminant equation (LOME) was constructed to investigate whether systematic low-mass-ion (LMI) profiling could be applied to ovarian cancer (OVC) screening. Matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry was performed to obtain mass spectral data on metabolites detected as LMIs up to a mass-to-charge ratio ( m/z ) of 2500 for 1184 serum samples collected from healthy individuals and patients with OVC, other types of cancer, or several t

Molecular BiologyBiochemistry, Genetics and Molecular Biology
15
Article|8 citations·2019
The Relative Risk Ratio of Recognition of Responses for the Sports Accidents by Experience in Sports Activities, Participating in Sports Safety Education, and Buying Insurance(Mutual-Aid)
Jun Hwa Lee, Young‐Shin Won, Hyu-Kyoung Park
Korean Society for the Sociology of Sport

본 연구는 스포츠활동 경험, 스포츠안전교육 참여, 보험 또는 공제 가입에 따른 안전사고 조치법 인지의 상대적 위험률을 규명하여 안전한 스포츠활동 참여를 확산시키기 위한 기초자료를 제공하기 위해 실시되었다. 이 연구의 분석을 위한 자료는 2015 스포츠안전사고 실태기초조사의 원자료이며, 모집단은 만 19세 이상의 일반 국민 3,031명을 대상으로 연구의 가설을 검증하기 위한 상대적 위험률을 산출하였다. 연구 결과 첫째, 스포츠활동 미경험자는 심폐소생술을 인지하고 있지 않을 확률이 약 0.4배, 지혈방법을 인지하고 있지 않을 확률이 약 2배, 기도확보 방법을 인지하고 있지 않을 확률이 약 3배, 골절 조치 방법을 인지하고 있지 않을 확률이 약 2배, 제세동기 사용 방법을 인지하고 있지 않을 확률이 약 1.9배, 쇼크 대처 방법을 인지하고 있지 않을 확률이 약 1.3배 높다. 둘째, 스포츠안전교육 미참여자는 심폐소생술을 인지하고 있지 않을 확률이 약 2배, 지혈방법 미인지는 약 4.5배

Safety ResearchSocial Sciences

Research Areas

Molecular BiologyPsychiatry and Mental healthEpidemiologyPulmonary and Respiratory MedicinePublic Health, Environmental and Occupational HealthPhysiology

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