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Jung Kwon Lee

Sungkyunkwan University · Medicine

About the Lab

Professor Jung Kwon Lee's research lab focuses on preventive and population health, with a strong emphasis on chronic disease prevention, mental health, and lifestyle-related risk factors across diverse populations. The lab investigates the interplay between behavioral factors—such as substance use, diet, and stress—and long-term health outcomes, including cardiovascular disease, renal impairment, and cancer-related psychological distress. A significant portion of the work also explores bioactive compounds and their potential therapeutic applications in neurodegenerative diseases like Alzheimer’s, particularly through the development of novel phenolic acid-conjugated chitooligosaccharides. The lab integrates epidemiological, behavioral, and biochemical approaches to promote holistic health and wellness across the lifespan.

chronic disease preventionmental healthlifestyle factorsAlzheimer’s diseasebiomarker development

Research Overview

Papers
83
Total Citations
1,036
Papers (5y)
12
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
12total
2021
2022
2023
2024
2025
Citations per year (5y)
107total
20212022202320242025

Selected Papers

15
1
Article|232 citations·2001
Students’ perception of medical school stress and their evaluation of a wellness elective
Jungkwon Lee, Antonnette V. Graham
SJR Q1Medical Education

CONTEXT: Because medical education is known to be demanding and stressful, Case Western Reserve University developed a programme which included a wellness elective which focused on stress reduction and personal wellness. OBJECTIVES: The purpose of this study was to explore students' perceptions of medical school stress and to assess their perspective on the wellness elective. SUBJECTS: The essays of 60 medical students enrolled in the wellness elective were used. METHODS: The essays were analyse

General Health ProfessionsHealth Professions
2
Article|100 citations·2013
Associations between the Risk of Internet Addiction and Problem Behaviors among Korean Adolescents
Jisun Sung, Jungkwon Lee, Hye‐Mi Noh, Yong Soon Park, Eun Ju Ahn
SJR Q2Korean Journal of Family MedicineOA

The risk of internet addiction was associated with cigarette smoking, alcohol drinking, drug abuse, and sexual intercourse experience among Korean adolescents.

Sociology and Political ScienceSocial Sciences
3
Article|67 citations·2015
Health-Related Quality of Life and Cardiovascular Disease Risk in Korean Adults
Hyeonyoung Ko, Jungkwon Lee, Jinyoung Shin, Eun-I Jo
SJR Q2Korean Journal of Family MedicineOA

A high CVD risk is associated with impaired HRQoL. After adjustment for demographic and clinical factors, a 10-year CVD risk ≥20.0% is an independent predictor of impaired HRQoL in the general population; in particular, of mobility problems in men, and of mobility, self-care, and usual activity problems in women.

Economics and EconometricsEconomics, Econometrics and Finance
4
Article|41 citations·2012
β-secretase inhibitory activity of phenolic acid conjugated chitooligosaccharides
Tae-Kil Eom, BoMi Ryu, Jungkwon Lee, Hee‐Guk Byun, Sunjoo Park, Se‐Kwon Kim
SJR Q2Journal of Enzyme Inhibition and Medicinal ChemistryOA

Eight kinds of phenolic acid conjugated chitooligosaccharides (COSs) were synthesized using hydroxyl benzoic acid and hydroxyl cinnamic acid. These phenolic acid conjugated-COSs with different substitution groups, including p-hydroxyl, 3,4-dihydroxyl, 3-methoxyl-4-hydroxyl and 3,5-dimethoxyl-4-hydroxy groups, were evaluated for their inhibitory activities against β-site amyloid precursor protein (APP)-cleaving enzyme (BACE) and inhibited BACE with a ratio of 50.8%, 74.8%, 62.1%, 64.8% and 42.6%,

PhysiologyMedicine
5
Article|40 citations·2011
Purification and characterization of angiotensin I-converting enzyme inhibitory peptide from enzymatic hydrolysates of Styela clava flesh tissue
Seok‐Chun Ko, Jungkwon Lee, Hee‐Guk Byun, Seung‐Cheol Lee, You‐Jin Jeon
SJR Q2Process Biochemistry
Molecular BiologyBiochemistry, Genetics and Molecular Biology
6
Article|39 citations·2011
Effect of angiotensin I-converting enzyme (ACE) inhibitory peptide purified from enzymatic hydrolysates of Styela plicata
Seok‐Chun Ko, Min Kang, Jungkwon Lee, Hee‐Guk Byun, Se‐Kwon Kim, Seung‐Cheol Lee, Byong-Tae Jeon, Pyo‐Jam Park, Won‐Kyo Jung, You‐Jin Jeon
SJR Q1European Food Research and Technology
Molecular BiologyBiochemistry, Genetics and Molecular Biology
7
Article|37 citations·2012
Nitric oxide-mediated vasorelaxation effects of anti-angiotensin I-converting enzyme (ACE) peptide from Styela clava flesh tissue and its anti-hypertensive effect in spontaneously hypertensive rats
Seok‐Chun Ko, Dong Geon Kim, Chang‐Hoon Han, Young Jae Lee, Jungkwon Lee, Hee‐Guk Byun, Seung‐Cheol Lee, Sunjoo Park, Dae-Ho Lee, You‐Jin Jeon
SJR Q1Food Chemistry
Molecular BiologyBiochemistry, Genetics and Molecular Biology
8
Article|36 citations·2013
Association between Coffee Consumption and Renal Impairment in Korean Women with and without Diabetes: Analysis of the Fourth Korea National Health and Nutrition Examination Survey in 2008
Bo Ha Kim, Yong Soon Park, Hye‐Mi Noh, Jisun Sung, Jung Kwon Lee
SJR Q2Korean Journal of Family MedicineOA

In a representative sample of Korean women, coffee consumption was significantly associated with a decreased risk of renal impairment especially in middle and elderly-aged diabetic women.

PharmacologyMedicine
9
Article|36 citations·2007
Dose-specific or dose-dependent effect of growth hormone treatment on the proliferation and differentiation of cultured neuronal cells
Esther Lyuh, Hyunjung Kim, Manho Kim, Jungkwon Lee, Kyong Soo Park, Keun‐Young Yoo, Kwang‐Woo Lee, Yoon‐Ok Ahn
SJR Q3Growth Hormone & IGF Research
Endocrinology, Diabetes and MetabolismMedicine
10
Article|33 citations·2022
Exploring socio-demographic, physical, psychological, and quality of life-related factors related with fear of cancer recurrence in stomach cancer survivors: a cross-sectional study
Jinyoung Shin, Dong Wook Shin, Jungkwon Lee, Ji‐Hye Hwang, Ji Eun Lee, Belong Cho, Yun‐Mi Song
SJR Q2BMC CancerOA

BACKGROUND: Stomach cancer is one the most common neoplasms with high mortality. However, fear of cancer recurrence (FCR) in stomach cancer survivors has been scarcely evaluated. Thus, the aim of this study was to evaluate FCR and factors related to FCR in Korean stomach cancer survivors. METHODS: A total of 363 stomach cancer survivors who had completed primary treatment and had no metastasis or recurrence were recruited between September 2014 and March 2017 regardless of time lapse after the i

OncologyMedicine
11
Article|26 citations·2015
Management of cancer survivors in Korea
Dong Wook Shin, Sung Sunwoo, Jungkwon Lee
SJR Q4Journal of Korean Medical AssociationOA

With the early detection of cancer and advances in cancer treatment, the number of cancer survivors is increasing dramatically and is currently over 1 million. Many cancer survivors face lifetime risks associated with their cancer therapy, with a significant proportion at risk for serious morbidity and premature mortality. The long-term physical and psychosocial effects of cancer treatment on cancer survivors and their families are increasingly being recognized as emerging problems from both cli

OncologyMedicine
12
Article|23 citations·2016
Association between Smoking and Periodontal Disease in Korean Adults: The Fifth Korea National Health and Nutrition Examination Survey (2010 and 2012)
Ah-Young Jang, Jungkwon Lee, Jinyoung Shin, Hae‐Young Lee
SJR Q2Korean Journal of Family MedicineOA

Periodontal disease is significantly associated with smoking status in Korean adults.

PeriodonticsDentistry
13
Article|22 citations·2013
The effectiveness of an educational intervention on proper analgesic use for dysmenorrhea
Hyun Suk Jung, Jungkwon Lee
SJR Q2European Journal of Obstetrics & Gynecology and Reproductive Biology
Public Health, Environmental and Occupational HealthMedicine
14
Article|21 citations·2018
Association between Female Urinary Incontinence and Geriatric Health Problems: Results from Korean Longitudinal Study of Ageing (2006)
Kyungjin Sohn, Chang Ki Lee, Jinyoung Shin, Jungkwon Lee
SJR Q2Korean Journal of Family MedicineOA

Cerebrovascular disease, arthritis, and especially fear of falls were significantly associated with UI in elderly Korean women.

RheumatologyMedicine
15
Article|17 citations·2021
d,l-Methadone causes leukemic cell apoptosis via an OPRM1-triggered increase in IP3R-mediated ER Ca2+ release and decrease in Ca2+ efflux, elevating [Ca2+]i
Jungkwon Lee, Jesusa L. Rosales, Hee‐Guk Byun, Ki‐Young Lee
SJR Q1Scientific ReportsOA

Abstract The search continues for improved therapy for acute lymphoblastic leukemia ( a LL), the most common malignancy in children. Recently, d , l -methadone was put forth as sensitizer for a LL chemotherapy. However, the specific target of d , l -methadone in leukemic cells and the mechanism by which it induces leukemic cell apoptosis remain to be defined. Here, we demonstrate that d , l -methadone induces leukemic cell apoptosis through activation of the mu1 subtype of opioid receptors (OPRM

NeurologyMedicine

Research Areas

OncologyMolecular BiologyGeneral Health ProfessionsPublic Health, Environmental and Occupational HealthPulmonary and Respiratory MedicinePhysiology

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