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Kyoung Suk Lee

Seoul National University · Medicine

About the Lab

Professor Kyoung Suk Lee's research lab focuses on cardiovascular and respiratory health, with a strong emphasis on heart failure management, symptom clusters, and their impact on clinical outcomes. The lab investigates patient-reported outcomes, self-care behaviors, and sleep quality as key determinants of disease progression and survival. It also explores molecular mechanisms in airway diseases, particularly the interplay between VEGF and TGF-beta(1) in airway remodeling. Overall, the lab integrates clinical, psychosocial, and translational research to improve patient-centered care and outcomes.

heart failuresymptom clustersself-care managementsleep qualityairway remodeling

Research Overview

Papers
110
Total Citations
2,089
Papers (5y)
25
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
25total
2022
2023
2024
2025
2026
Citations per year (5y)
147total
20222023202420252026

Selected Papers

15
1
Article|109 citations·2010
Symptom Clusters in Men and Women With Heart Failure and Their Impact on Cardiac Event-Free Survival
Kyoung Suk Lee, Eun Kyeung Song, Terry A. Lennie, Susan K. Frazier, Misook L. Chung, Seongkum Heo, Jia-Rong Wu, Mary Kay Rayens, Bárbara Riegel, Debra K. Moser
SJR Q1The Journal of Cardiovascular Nursing

Although distress for individual symptoms may differ between men and women, they both experienced identical symptom clusters. Only the emotional/cognitive cluster predicted a higher risk for a cardiac event. These results suggested that interventions should be developed that consider symptom clusters. Targeting patients who have high distress from emotional/cognitive symptoms may be particularly important as they may be most vulnerable for adverse outcomes.

Cardiology and Cardiovascular MedicineMedicine
2
Article|88 citations·2007
Inhibition of VEGF blocks TGF-β1production through a PI3K/Akt signalling pathway
Kyoung Suk Lee, S. J. Park, S. R. Kim, Kyung Hoon Min, K. Y. Lee, Yeong Hun Choe, Shengqian Hong, Y. R. Lee, J. S. Kim, Soo‐Jong Hong, Yi‐Chao Lee
SJR Q1European Respiratory JournalOA

Vascular endothelial growth factor (VEGF) is a mediator of airway inflammation and remodelling in asthma. Transforming growth factor (TGF)-beta(1) plays pivotal roles in diverse biological processes, including tissue remodelling and repair in a number of chronic lung diseases. However, there are few studies elucidating the interactions between VEGF and TGF-beta(1) in allergic airway disease. A murine model of allergic airway disease was used to define the mechanism by which VEGF induces subepith

OncologyMedicine
3
Article|59 citations·2016
Prognostic Importance of Sleep Quality in Patients With Heart Failure
Kyoung Suk Lee, Terry A. Lennie, Seongkum Heo, Eun Kyeung Song, Debra K. Moser
SJR Q1American Journal of Critical Care

BACKGROUND: Poor sleep quality is common and is associated with poor quality of life and health status in patients with heart failure. However, few investigators have focused on the impact of impaired sleep quality on survival in heart failure. OBJECTIVE: To examine whether self-reported sleep quality is associated with prognosis in patients with heart failure. METHODS: The study sample consisted of 204 patients with heart failure. Sleep quality was measured with the Pittsburgh Sleep Quality Ind

Experimental and Cognitive PsychologyPsychology
4
Article|51 citations·2014
The Association Between Regular Symptom Monitoring and Self-care Management in Patients With Heart Failure
Kyoung Suk Lee, Terry A. Lennie, Sandra B. Dunbar, Susan J. Pressler, Seongkum Heo, Eun Kyeung Song, Martha Biddle, Debra K. Moser
SJR Q1The Journal of Cardiovascular NursingOA

Adequacy of self-care management was predicted by adherence to symptom monitoring behaviors. This finding suggests that regular symptom monitoring facilitates performance of adequate self-care management, which may contribute to a decrease in preventable hospitalizations in HF.

Cardiology and Cardiovascular MedicineMedicine
5
Article|47 citations·2017
Relationship between self-care and comprehensive understanding of heart failure and its signs and symptoms
Kyoung Suk Lee, Debra K. Moser, Kathleen Dracup
SJR Q1European Journal of Cardiovascular Nursing

BACKGROUND: Although incomplete understanding of heart failure and its signs and symptoms appears to be a barrier to successful self-care, there are few studies examining the relationship between self-care and levels of comprehensive understanding of heart failure and its signs and symptoms. AIM: To determine whether incomplete understanding of heart failure and its signs and symptoms is associated with self-care in heart failure patients who were recently discharged from the hospital due to hea

Cardiology and Cardiovascular MedicineMedicine
6
Article|46 citations·2014
Psychometric testing of the Duke Activity Status Index in patients with heart failure
Xiuzhen Fan, Kyoung Suk Lee, Susan K. Frazier, Terry A. Lennie, Debra K. Moser
SJR Q1European Journal of Cardiovascular NursingOA

Our data support the psychometric properties of the DASI as a measure of functional status in patients with HF. This instrument can be used to evaluate functional status and enhance health care provider understanding of functional status related to daily living from the patient perspective.

Cardiology and Cardiovascular MedicineMedicine
7
Review|42 citations·2023
Relationship between comorbidity and health outcomes in patients with heart failure: a systematic review and meta-analysis
Kyoung Suk Lee, Da-In Park, Jihyang Lee, Oonjee Oh, Nayoung Kim, G. Nam
SJR Q2BMC Cardiovascular DisordersOA

BACKGROUND: The prevalence of heart failure (HF) is expected to rise due to increased survivorship and life expectancy of patients with acute heart conditions. Patients with HF and other multiple comorbid conditions are likely to have poor health outcomes. This study aimed to assimilate the current body of knowledge and to provide the pooled effect of HF patients' comorbid conditions on health outcomes. METHODS: statistics. RESULTS: A total of 42 studies were included in this review, and a meta-

Cardiology and Cardiovascular MedicineMedicine
8
Article|36 citations·2016
Self-care in rural residents with heart failure: What we are missing
Kyoung Suk Lee, Debra K. Moser, Michele M. Pelter, Thomas S. Nesbitt, Kathleen Dracup
SJR Q1European Journal of Cardiovascular Nursing

The variables included in the model did not sufficiently explain self-care among rural dwellers with HF. Given that all variables in the model were intrapersonal-level factors, more investigations that incorporate interpersonal factors (e.g. cultural beliefs and access to care) are needed in order to improve our understanding of self-care in HF patients living in rural areas.

Cardiology and Cardiovascular MedicineMedicine
9
Article|36 citations·2019
<p>The relationship between psychological states and health perception in individuals at risk for cardiovascular disease</p>
Kyoung Suk Lee, Frances J. Feltner, Alison Bailey, Terry A. Lennie, Misook L. Chung, Brittany L. Smalls, Donna L. Schuman, Debra K. Moser
SJR Q2Psychology Research and Behavior ManagementOA

<b>Backgrounds:</b> Perceptions of health are important to motivate people to change behaviors. Non-adherence to healthy behaviors that prevent cardiovascular disease may result from inadequate health perceptions. However, there are few studies investigating relationships between health perceptions and psychological states. <b>Objective:</b> To determine whether psychological states (ie, depressive symptoms and anxiety) are associated with the congruency between health perception and estimated r

Applied PsychologyPsychology
10
Article|33 citations·2013
A Comprehensive Symptom Diary Intervention to Improve Outcomes in Patients With HF: A Pilot Study
Kyoung Suk Lee, Terry A. Lennie, Sherry Warden, Joy M. Jacobs‐Lawson, Debra K. Moser
SJR Q1Journal of Cardiac Failure
Cardiology and Cardiovascular MedicineMedicine
11
Review|32 citations·2024
Treatment burden in multimorbidity: an integrative review
Ji Eun Lee, Jihyang Lee, Rooheui Shin, Oonjee Oh, Kyoung Suk Lee
SJR Q1BMC Primary CareOA

BACKGROUND: People living with multimorbidity experience increased treatment burden, which can result in poor health outcomes. Despite previous efforts to grasp the concept of treatment burden, the treatment burden of people living with multimorbidity has not been thoroughly explored, which may limit our understanding of treatment burden in this population. This study aimed to identify the components, contributing factors, and health outcomes of treatment burden in people with multiple diseases

EpidemiologyMedicine
12
Review|26 citations·2020
An Integrative Review of the Symptom Perception Process in Heart Failure
Kyoung Suk Lee, Seieun Oh
SJR Q1The Journal of Cardiovascular Nursing

BACKGROUND: Accurate symptom perception is a fundamentally essential component of self-care for patients with heart failure (HF) so they can make appropriate decisions about their symptoms. OBJECTIVE: The purpose of this integrative review was to describe the pathways of the symptom perception process and its contributing factors in patients with HF. METHODS: A comprehensive literature search was conducted using PubMed, EMBASE, and PsycINFO databases to identify studies describing the symptom pe

Cardiology and Cardiovascular MedicineMedicine
13
Article|25 citations·2004
Imbalance between matrix metalloproteinase‐9 and tissue inhibitor of metalloproteinase‐1 in toluene diisocyanate‐induced asthma
Kyoung Suk Lee, Sun Jin, Hyun Lee, Gary Lee
SJR Q1Clinical & Experimental Allergy

BACKGROUND: Toluene diisocyanate (TDI)-induced asthma is an inflammatory disease of the airways characterized by airway remodelling due, at least in part, to an excess of extracellular matrix deposition in the airway wall. The ratio of matrix metalloproteinase-9 (MMP-9) and its inhibitor, tissue inhibitor of metalloproteinase-1 (TIMP-1) may be a marker of the balance between airway tissue destruction and repair. OBJECTIVE: We determined whether an imbalance of the MMP-9 : TIMP-1 molar ratio is p

Public Health, Environmental and Occupational HealthMedicine
14
Article|25 citations·2016
Living Arrangements Modify the Relationship Between Depressive Symptoms and Self-care in Patients With Heart Failure
Kyoung Suk Lee, Terry A. Lennie, Ju Young Yoon, Jia-Rong Wu, Debra K. Moser
SJR Q1The Journal of Cardiovascular Nursing

BACKGROUND: Depressive symptoms hinder heart failure patients' engagement in self-care. As social support helps improve self-care and decrease depressive symptoms, it is possible that social support buffers the negative impact of depressive symptoms on self-care. OBJECTIVE: The purpose of this study is to examine the effect of living arrangements as an indicator of social support on the relationship between depressive symptoms and self-care in heart failure patients. METHODS: Stable heart failur

Cardiology and Cardiovascular MedicineMedicine
15
Article|25 citations·2019
Distinct Factors Associated With Better Self-care in Heart Failure Patients With and Without Mild Cognitive Impairment
Kyoung Suk Lee, Jin‐Oh Choi, Eun‐Seok Jeon, Jae‐Hyeong Park, Mi Sook Jung, Zian Lee, Hyeong Suk Lee, Hye Jin Yoo
SJR Q1The Journal of Cardiovascular Nursing

BACKGROUND: A decline in cognition may limit patients' ability to effectively engage in self-care in those with heart failure (HF). However, several studies have shown no difference in self-care between HF patients with and without cognitive impairment. This may indicate that there are more salient factors associated with self-care in HF patients with cognitive impairment compared with those without cognitive impairment. OBJECTIVE: The aim of this study was to explore which factors are related t

Cardiology and Cardiovascular MedicineMedicine

Research Areas

Cardiology and Cardiovascular MedicineEpidemiologyGeneral Health ProfessionsEndocrinology, Diabetes and MetabolismSurgeryOncology

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