Kyungmin Joo

Periodontal ligament stem cells (PDLSCs) are multipotent stem cells derived from periodontium and have mesenchymal stem cell (MSC)-like characteristics. Recently, the perivascular region was recognized as the developmental origin of MSCs, which suggests the in vivo angiogenic potential of PDLSCs. In this study, we investigated whether PDLSCs could be a potential source of perivascular cells, which could contribute to in vivo angiogenesis. PDLSCs exhibited typical MSC-like charac-teristics such a

Radiation is the most useful treatment modality for cancer patients. It initiates a series of signal cascades such as DNA damage response (DDR) signaling for repairing damaged DNA, arresting the cell cycle, and inducing cell death. Until now, few genes have been found to be regulated by radiation, which explains the molecular mechanisms of cellular responses to radiation. Although the transcriptional changes caused by radiation have been widely investigated, little is known about the direct evid

Corticotropin releasing factor (CRF) is known to be involved in the stress response and in some degenerative brain disorders. In addition, CRF has a role as a neuro-modulator in adult cerebellar circuits. Data from developmental studies suggest a putative role for CRF as a trophic factor during cerebellar development. In this study, we investigated the trophic role for CRF family of peptides by culturing cerebellar neurons in the presence of CRF, urocortin or urocortin II. Primary cell cultures

Background: Misuse of anabolic-androgenic steroids (AAS), especially through “stacking” multiple substances, poses significant health risks. This study leverages data from the FDA’s Adverse Event Reporting System (FAERS) to assess these risks and identify factors predicting severe outcomes. Methods: We analyzed 286 FAERS reports of intentional AAS misuse. After removing duplicates, the final dataset included 218 unique cases involving men, 7 involving women, and 14 cases with unspecified sex. Dr

심장은 복잡한 과정을 거쳐 발생하기 때문에 그에 대한 공간적 이해가 매우 어렵다. 서울대학교 의과대학에서는 심장발생 과정의 이해를 촉진하고자 발생 과정에 대한 모델링 실습을 고안하고 2011년부터 의학과 1학년을 대상으로 이를 시행해 오고 있다. 본 실습의 타당성을 알아보고, 각 의과대학에 이 과정의 시행을 제안하고자 이 연구를 시행하였다. 실습에는 시중에서 판매되는 어린이용 합성수지 점토를 이용하였다. 실습 첫날에는 유출로, 오른심실, 왼심실을 한 단위로, 공통심방을 한 단위로 각각 만든 후 이 두 단위를 이어 붙여 발생 30일 또는 35일의 심장을만들도록 하였다. 2~3일 동안 모형이 마르게 둔 후에 제작된 심장을 유출로, 오른심실, 왼심실을 관통하는 관상단면을 따라 절단한 후 속 모습을 교과서의 모습과 비교하고 성찰하도록 하였다. 이후 색이 다른 점토를 이용하여 방실관, 심실사이구멍, 유출로 등에 심장속막방석이 자라는 모습을 재현하여 심장의 4개 방, 대동맥, 허파동맥이 분할되

Abstract Objective: Ionizing irradiation causes cell death but also birth and migration of new neurons within sites of cerebral damage. The cellular environment that induces neuronal regeneration and migration after irradiation has not been defined yet. The aim of this study was to evaluate the neuronal response after irradiation injury induced by gamma knife radiosurgery. Methods: We used a model of long-distance migration of newly transplanted neural stem cells from the subependymal zone on th

Glioblastoma multiforme (GBM) is the most malignant World Health Organization grade IV brain tumor. GBM patients have a poor prognosis because of its resistance to standard therapies, such as chemotherapy and radiation. Since stem-like cells have been associated with the treatment resistance of GBM, novel therapies targeting the cancer stem cell (CSC) population is critically required. However, GBM CSCs share molecular and functional characteristics with normal neural stem cells (NSCs). To eluci

Nitric oxide (NO) modulates the activities of various channels and receptors to participate in the regulation of neuronal intracellular Ca2+ levels. Ca2+ binding protein (CaBP) expression may also be altered by NO. Accordingly, we examined expression changes in calbindin-D28k, calretinin, and parvalbumin in the cerebral cortex and hippocampal region of neuronal NO synthase knockout(−/−) (nNOS−/−) mice using immunohistochemistry. For the fi rst time, we demonstrate that the expression of CaBPs is

Spinal cord injury (SCI) is a devastating central nervous system injury that leads to severe disabilities in motor and sensory functions, causing significant deterioration in patients’ quality of life. Owing to the complexity of SCI pathophysiology, there has been no effective treatment for reversing neural tissue damage and recovering neurological functions. Several novel therapies targeting different stages of pathophysiological mechanisms of SCI have been developed. Among these, treatments us