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Kyungryul Seo

Yonsei University · Medicine

About the Lab

Professor Kyungryul Seo's research lab specializes in anterior segment ophthalmology, with a focus on corneal biomechanics, ocular surface health, and the impact of medical devices and medications on the eye. The lab investigates corneal thickness, endothelial cell morphology, and intraocular pressure changes in various clinical conditions, including diabetes and contact lens use. It also explores novel ocular drug delivery systems and immunogenic responses to vaccine candidates using exosomes, particularly in the context of infectious diseases like toxoplasmosis. The lab employs advanced imaging technologies such as OCT, pachymetry, and Scheimpflug imaging to assess ocular parameters with high precision.

corneal biomechanicsocular surfacecontact lens effectsexosome immunologyintraocular pressure

Research Overview

Papers
91
Total Citations
215
Papers (5y)
19
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
19total
2020
2021
2022
2023
2024
Citations per year (5y)
23total
20202021202220232024

Selected Papers

15
1
Article|24 citations·2011
Central Corneal Thickness and Corneal Endothelial Cell Changes Caused by Contact Lens Use in Diabetic Patients
임현성, Ki Cheul Shin, 이군자, 김응권, 서경률
http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0311120110520020322

Purpose: To analyze the effects of soft contact lenses on central corneal thickness and morphologic characteristics of the corneal endothelium in diabetic patients. Materials and Methods: Ultrasound pachymetry and noncontact specular microscopy were performed on 26 diabetic patients who regularly use soft contact lenses (group 1), 27 diabetic patients who do not use soft contact lenses (group 2) and 30 normal subjects (group 3). We compared the values in each group using the Mann-Whitney test. R

2
Article|21 citations·2007
The Effect of Swimming Goggles on Intraocular Pressure and Blood Flow within the Optic Nerve Head
마경탁, 정우석, 서경률, 성공제, 김찬윤
http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0311120070480050807

Purpose: Goggles are frequently worn in the sport of swimming and are designed to form a seal around the periorbital tissue orbit. The resultant pressure on the eye may have the potential to affect intraocular pressure and blood flow of the optic nerve head. This study evaluates the influence of wearing swimming goggles on intraocular pressure (IOP) and blood flow of the ocular nerve head (ONH) in normal subjects. Materials and Methods: Thirty healthy participants took part in this study. The IO

3
Article|14 citations·2015
The Effects of Two Non-Steroidal Anti-Inflammatory Drugs, Bromfenac 0.1% and Ketorolac 0.45%, on Cataract Surgery
정지원, 김태임, 정병훈, 김응권, 서경률
http://ymj.kr/DOIx.php?id=10.3349/ymj.2015.56.6.1671

Purpose: To compare the additive effects of two types of non-steroidal anti-inflammatory drugs (NSAIDs), bromfenac 0.1% or ketorolac0.45%, relative to topical steroid alone in cataract surgery. Materials and Methods: A total 91 subjects scheduled to undergo cataract operation were randomized into three groups: Group 1, pre/postoperative bromfenac 0.1%; Group 2, pre/postoperative preservative-free ketorolac 0.45%; and Group 3, postoperative steroid only, as a control. Outcome measures included in

4
Article|12 citations·2012
Reliability of RTVue, Visante, and Slit-Lamp Adapted Ultrasonic Pachymetry for Central Corneal Thickness Measurement
홍진표, 김응권, 남상민, 김태임, 서경률, 이상엽, Alessandro Meduri
http://www.eymj.org/DOIx.php?id=10.3349/ymj.2012.53.3.634

Purpose: To evaluate reliability of Fourier-domain optical coherence tomography (OCT) (RTVue), time-domain OCT (Visante), and slit-lamp adapted ultrasonic pachymetry (SL-US) in the measurement of central corneal thickness (CCT). Materials and Methods: Thirty healthy volunteers visited our clinic 3 times and fifty eyes were measured by one physician. RTVue and Visante were randomly performed, and then SL-US, in which the ultrasound probe was inserted into the Goldmann tonometry mount, was done. D

5
Article|11 citations·2020
Immunogenicity of Exosomes from Dendritic Cells Stimulated with Toxoplasma gondii Lysates in Ocularly Immunized Mice
정봉광, 김은도, 송혜미, 채종일, 서경률

Immunogenicity of dendritic cell-derived exosomes stimulated with Toxoplasma gondii lysates (TLA exo), mixed with cholera toxin as an adjuvant, was investigated in mice immunized via 2 mucosal routes (ocular vs intranasal). BALB/c mice were injected 3 times with TLA exo vaccine at 2 week interval, and the levels of IgG in serum and IgA in tear, saliva, feces, and vaginal wash were measured. To observe the expression of T. gondii-specific B1 gene, mice infected with ME49 T. gondii cysts were immu

6
Article|10 citations·2018
Biomechanical Properties of the Cornea Using a Dynamic Scheimpflug Analyzer in Healthy Eyes
이훈, David Sung Yong Kang, 하병진, 최진영, 김응권, 서경률, 김태임
https://www.eymj.org/DOIx.php?id=10.3349/ymj.2018.59.9.1115

Purpose: To investigate biomechanical properties of the cornea using a dynamic Scheimpflug analyzer according to age. Materials and Methods: In this prospective, cross-sectional, observational study, participants underwent ophthalmic investigationsincluding corneal biomechanical properties, keratometric values, intraocular pressure (IOP), and manifest refraction sphericalequivalent (MRSE). We determined the relationship of biomechanical parameters and ocular/systemic variables (participant’sage,

7
Article|9 citations·2013
Comparison of Preoperative and Postoperative Ocular Biometry in Eyes with Phakic Intraocular Lens Implantations
신주연, 이재범, 서경률, 김응권, 김태임
http://www.eymj.org/Synapse/Data/PDFData/0069YMJ/ymj-54-1259.pdf

Purpose: To compare preoperative and postoperative ocular biometry in patients with iris-fixated phakic intraocular lens (pIOLs): Artisan and Artiflex. Materials and Methods: This study included 40 eyes with Artisan and 36 eyes with Artiflex pIOL implants. Anterior chamber depth (ACD) and axial length (AL) were measured by applanation ultrasonography (A-scan) and partial coherence interferometry (IOLMaster) preoperatively and 3 months after pIOL implantation. Results: ACD measurements after Arti

8
Article|8 citations·2021
Accuracy of the Kane Formula for Intraocular Lens Power Calculation in Comparison with Existing Formulas: A Retrospective Review
류소영, 전익현, 김태임, 김응권, 서경률
https://www.eymj.org/DOIx.php?id=10.3349/ymj.2021.62.12.1117

Purpose: To evaluate the accuracy of the Kane formula for intraocular lens (IOL) power calculation in comparison with existing formulas by incorporating optional variables into calculation. Materials and Methods: This retrospective review consisted of 78 eyes of patients who had undergone uneventful phacoemulsification with intraocular implantation at Severance Hospital in Seoul, Korea between February 2020 and January 2021. The Kane formula was compared with six of the existing IOL formulas (SR

9
Article|7 citations·2002
단초점과 다초점 인공수정체안의 광학수차와 대비감도의 비교
이준모, 서경률, 김응권
10
Article|7 citations·2005
익상편수술시 결막소판술과 자가결막이식술의 재발률 비교
조정우, 정소향, 서경률, 김응권

목적 : 익상편 수술에 있어 결막소판술(conjunctival mini-flap technique)과 자가결막이식술의 재발률을 비교하고, 재발에 관여하는 인자를 알아보고자 하였다. 대상과 방법 : 2001년 3월부터 2004년 2월까지 본원에서 익상편으로 결막소판술을 시행받은 환자 49명 49안과 자가결막이식술을 받은 환자 41명 41안을 대상으로 재발률과 재발에 관여하는 인자를 후향적으로 조사하였다. 결과 : 결막소판술로 수술받은 환자들의 경우 평균 8.79±3.9개월의 추적관찰기간동안 3명 3안(7.1%)에서 재발을 보였고, 자가결막이식술을 받은 환자들의 경우 평균 12.7±6.5개월의 추적관찰기간동안 9명 9안(21.9%)에서 재발을 하였다. 각 수술방법에 있어 연령이나 성별, 재수술여부와 재발과는 유의한 연관성이 없었다. 결론 : 익상편수술에 있어 결막소판술이 자가결막이식술보다도 낮은 재발률을 보이면서 심각한 합병증을 유발하지 않는 효과적이고 안전한 수술방법임을 확인할 수 있

11
Article|7 citations·2007
The Change of Corneal Sensitivity and Recovery of Corneal Nerve after Cataract Surgery
Yong Min Kim, Sun Woong Kim, Tae‐im Kim, Eung Kweon Kim, Kyung Ryul Seo
SJR Q4Journal of the Korean Ophthalmological Society

Purpose: To compare corneal sensitivity and recovery of corneal innervations after a temporal clear corneal incision in cataract surgery. Methods: We measured changes to corneal sensitivity using Cochet-Bonnet esthesiometer in 25 eyes of 20 patients and analyzed corneal nerve density with confocal microscopy in 20 eyes of 20 patients who had undergone cataract surgery. The parameters were measured before, and at 1 week, 1 month, and 3 months after cataract surgery. Results: The mean preoperative

Public Health, Environmental and Occupational HealthMedicine
12
Article|6 citations·2007
Comparison of Higher-Order Aberration and Contrast Sensitivity in Monofocal and Multifocal Intraocular Lenses
김창염, 정소향, 김태임, 조영재, 윤근영, 서경률
http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0311120070480040627

Purpose: The visual performance of pseudophakic eyes depends on the type of intraocular lenses (IOLs) that are implanted. Aspherical and multifocal IOLs have recently been developed to improve visual quality after cataract surgery, but multifocal IOLs can be associated with decreased contrast sensitivity (CS), halos, and glare. This study compares the visual performance of monofocal and multifocal IOLs by measurement of higher-order aberrations (HOAs) and CS values. Materials and Methods: HOAs a

13
Article|6 citations·2013
두 종류 비구면 인공수정체 삽입 후 Double-pass 원리를 이용한 시력의 질 비교
곽애영, 최문정, 서경률, 안지민
http://dx.doi.org/10.3341/jkos.2013.54.12.1818

목적: 두 종류의 일체형 비구면 인공수정체를 삽입한 백내장 수술 환자를 대상으로 Double pass 원리를 적용한 분석기를 이용하여임상결과를 비교하고자 하였다. 대상과 방법: 본원에서 2009년 10월에서 2011년 2월까지 백내장 수술을 시행 받은 25안의 Tecnis® ZCB00 (AMO, Inc., Santa Ana,CA, USA) 삽입 군과 16안의 Acrysof® IQ SN60WF (Alcon, Inc., Fort Worth, TX, USA) 삽입 군을 대상으로 술 후 6개월째 나안시력및 최대교정시력, 구면 대응치를 측정하고 Double pass 원리를 적용한 Optical quality analysis system (OQAS, Visiometrics SL,Spain)을 이용하여 변조전달기능(MTF cutoff), Strehl 비율(Strehl ratio), 객관적 산란지수(OSI) 값을 측정하고 차이를 비교해 보았다. 결과: ZCB00 삽입 군과 SN60WF삽입 군에서의

14
Article|6 citations·2015
Comparison of the Astigmatic Power of Toric Intraocular Lenses Using Three Toric Calculators
박현주, 김태임, 이훈, 우영재, 김응권, 서경률, 김하얀
http://ymj.kr/DOIx.php?id=10.3349/ymj.2015.56.4.1097

Purpose: To compare the astigmatic power of toric intraocular lenses (IOLs) obtainedfrom the AcrySof, TECNIS, and iTrace toric calculator in patients with preoperativewith-the-rule (WTR) or against-the-rule (ATR) corneal astigmatism. Materialsand Methods: Fifty eyes with cataract and corneal astigmatism greater than 0.75 diopters were enrolled in each group (WTR and ATR). Keratometric values were measured using autokeratometry, an IOLMaster, and an iTrace, which incorporatedcorneal topography an

15
Article|5 citations·2016
Effect of Co-Implantation of a Capsular Tension Ring on Clinical Outcomes after Cataract Surgery with Monofocal Intraocular Lens Implantation
김태임, 박현주, 이훈, 김도욱, 김응권, 서경률
http://ymj.kr/DOIx.php?id=10.3349/ymj.2016.57.5.1236

Purpose: The objective was to evaluate the effect of co-implantation of a preloaded capsular tension ring (CTR) and aberration-free monofocal intraocular lens (IOL) on clinical outcomes and visual quality after cataract surgery. Materials and Methods: Patients who underwent cataract surgery were randomized into two groups that were implanted with a CTR and IOL (group 1, 26 eyes) or an IOL only (group 2, 26 eyes). At 1 and 3 months after surgery, visual acuity, refractive errors, refractive predi

Research Areas

Public Health, Environmental and Occupational HealthRadiology, Nuclear Medicine and ImagingEpidemiology

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