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Minchul Cho

Seoul National University · Medicine

About the Lab

Professor Minchul Cho's research lab specializes in biomedical engineering and urological interventions, with a primary focus on improving surgical outcomes for benign prostatic hyperplasia (BPH) through advanced laser therapies such as photovaporization (PVP) and holmium laser enucleation (HoLEP). The lab investigates long-term urological outcomes, including lower urinary tract symptoms (LUTS) improvement, quality of life, and the impact of preoperative factors like detrusor underactivity. Additionally, the lab explores molecular mechanisms in urogenital function, particularly the role of LIM kinases and actin cytoskeleton regulation in smooth muscle contraction and cellular dynamics. The integration of clinical urology with molecular biology and surgical innovation defines the lab’s interdisciplinary approach.

benign prostatic hyperplasialaser surgerydetrusor underactivityurological outcomesLIM kinase signaling

Research Overview

Papers
120
Total Citations
1,435
Papers (5y)
31
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
31total
2022
2023
2024
2025
2026
Citations per year (5y)
101total
20222023202420252026

Selected Papers

15
1
Article|86 citations·2019
BlueConnect: Decomposing all-reduce for deep learning on heterogeneous network hierarchy
Min Chul Cho, Ulrich Finkler, Maurício Serrano, David S. Kung, Hillery C. Hunter
IBM Journal of Research and Development

As deep neural networks get more complex and input datasets get larger, it can take days or even weeks to train a deep neural network to the desired accuracy. Therefore, enabling distributed deep learning at a massive scale is critical since it offers the potential to reduce the training time from weeks to hours. In this article, we present BlueConnect, an efficient communication library for distributed deep learning that is highly optimized for popular GPU-based platforms. BlueConnect decompose

Computer Vision and Pattern RecognitionComputer Science
3
Article|33 citations·2003
Investigation of Ozone Reaction in River Waters Causing Instantaneous Ozone Demand
Min Chul Cho, Haeshim Kim, Soon Haeng Cho, Jeyong Yoon
SJR Q2Ozone Science and Engineering

Abstract Ozone consumption by water can be characterized by the instantaneous ozone demand (IOD) and a pseudo first order decay constant. Utilizing the flow injection analytical system for measuring IOD, the instantaneous ozone demand characteristics of two river waters (Korea) were investigated, utilizing a •OH probe compound and •OH scavenger, and were compared with those of two commercial humic acids (the Suwannee River humic acid and Aldrich humic acid). The major findings were as follows; (

Environmental EngineeringEnvironmental Science
4
Article|26 citations·2018
Effect of preoperative detrusor underactivity on long‐term surgical outcomes of photovaporization and holmium laser enucleation in men with benign prostatic hyperplasia: a lesson from 5‐year serial follow‐up data
Min Chul Cho, Sangjun Yoo, Juhyun Park, Sung Yong Cho, Hwancheol Son, Seung‐June Oh, Jae‐Seung Paick
SJR Q1British Journal of Urology

Objectives To investigate the impact of preoperative detrusor underactivity (DU) on serial treatment outcomes over the course of 5 years after photovaporization (PV) or holmium laser enucleation (HoLEP) in patients with benign prostatic hyperplasia (BPH), to compare its impact after PV vs HoLEP, and to identify predictors of long‐term lower urinary tract symptoms (LUTS) improvement. Materials and Methods This study involved 245 patients with BPH who had complete 5‐year follow‐up data (PV using 1

UrologyMedicine
5
Article|23 citations·2019
Quality of life after photo-selective vaporization and holmium-laser enucleation of the prostate: 5-year outcomes
Inyoung Sun, Sangjun Yoo, Juhyun Park, Sung Yong Cho, Hyeon Jeong, Hwancheol Son, Seung‐June Oh, Jae‐Seung Paick, Min Chul Cho
SJR Q1Scientific ReportsOA

This study was aimed to compare serial long-term postoperative changes in quality-of-life (QoL) between photoselective-vaporization (PVP) using 120W-High-Performance-System and holmium-laser-enucleation (HoLEP) in benign-prostatic-hyperplasia (BPH) patients and to identify factors influencing the QoL improvement at the short-term, mid-term and long-term follow-up visits after surgery. We analyzed 1,193 patients with a baseline QoL-index ≥2 who underwent PVP (n = 439) or HoLEP (n = 754). Surgical

UrologyMedicine
6
Article|23 citations·2017
Can preoperative detrusor underactivity influence surgical outcomes of 120 W HPS vaporization of the prostate (PVP) or holmium laser enucleation of the prostate (HoLEP)? A serial 3‐year follow‐up study
Min Chul Cho, Juhyun Park, Jung Kwon Kim, Sung Yong Cho, Hyeon Jeong, Seung‐June Oh, Jae‐Seung Paick, Hwancheol Son
SJR Q1Neurourology and Urodynamics

AIMS: To determine the influence of preoperative detrusor underactivity (DU) on serial long-term outcomes of HPS/PVP or HoLEP for LUTS/BPH, and to compare the influence between the two surgeries. METHODS: A total of 382 men, who underwent 120W-HPS/PVP or HoLEP for LUTS/BPH and for whom 36-month follow-up data were available, were classified into four groups: HPS with DU (n = 145), HPS without DU (n = 44), HoLEP with DU (n = 105), and HoLEP without DU (n = 88). DU was defined as bladder contracti

UrologyMedicine
7
Review|20 citations·2021
The Role of LIM Kinase in the Male Urogenital System
Juhyun Park, Soo Woong Kim, Min Chul Cho
SJR Q1CellsOA

The LIM kinases (LIMK1 and LIMK2), known as downstream effectors, and the Rho-associated protein kinase (ROCK), a regulator of actin dynamics, have effects on a diverse set of cellular functions. The LIM kinases are involved in the function of the male urogenital system by smooth muscle contraction via phosphorylation of cofilin and subsequent actin cytoskeleton reorganization. Although LIMK1 and LIMK2 share sequence similarities as serine protein kinases, different tissue distribution patterns

UrologyMedicine
8
Article|20 citations·2017
Inhibition of Jun N-terminal Kinase Improves Erectile Function by Alleviation of Cavernosal Apoptosis in a Rat Model of Cavernous Nerve Injury
Juhyun Park, Ji Sun Chai, Soo Woong Kim, Jae‐Seung Paick, Min Chul Cho
SJR Q2Urology
PharmacologyPharmacology, Toxicology and Pharmaceutics
9
Article|19 citations·2018
Impact of serum 25‐OH vitamin D level on lower urinary tract symptoms in men: a step towards reducing overactive bladder
Sangjun Yoo, Sohee Oh, Hyung Suk Kim, Han Seok Choi, Juhyun Park, Sung Yong Cho, Hwancheol Son, Hyeon Jeong, Hae Won Lee, Min Chul Cho
SJR Q1British Journal of Urology

Objectives To evaluate the impact of serum vitamin D level on male lower urinary tract symptoms (LUTS). Patients and Methods Men with LUTS who visited the outpatient clinic of the urology department at one of two hospitals between March 2014 and April 2017 were eligible for inclusion in the study. The impact of vitamin D on LUTS was evaluated using multivariate analysis to adjust for age, body mass index, prostate‐specific antigen, testosterone, glycated haemoglobin, physical activity and prosta

Pathology and Forensic MedicineMedicine
10
Article|17 citations·2008
α-Blocker Plus Diuretic Combination Therapy as Second-line Treatment for Nocturia in Men With LUTS: A Pilot Study
Min Chul Cho, Ja Hyeon Ku, Jae‐Seung Paick
SJR Q2Urology
UrologyMedicine
11
Article|13 citations·2018
Long-Term Outcomes of Laser Prostatectomy for Storage Symptoms: Comparison of Serial 5-Year Followup Data between High Performance System Photoselective Vaporization and Holmium Laser Enucleation of the Prostate
Min Chul Cho, Won Hoon Song, Juhyun Park, Sung Yong Cho, Hyeon Jeong, Seung‐June Oh, Jae‐Seung Paick, Hwancheol Son
SJR Q1The Journal of Urology

Our serial followup data suggest that storage symptom improvement was maintained throughout the long-term postoperative period for prostate photoselective laser vaporization with a 120 W high performance system and holmium laser enucleation without any difference between the 2 surgeries. Also, more severe storage symptoms at baseline and a more severe BOOI predicted improved storage symptoms in the long term after each surgery.

UrologyMedicine
12
Article|11 citations·2021
Platelet-to-lymphocyte ratio is not a predictor of clinically significant prostate cancer at the prostate biopsy: A large cohort study
Jeong Woo Lee, Hyeon Jeong, Hwancheol Son, Min Chul Cho
SJR Q1Scientific ReportsOA

Previous studies have reported conflicting results on the predictive role of the platelet-to-lymphocyte ratio (PLR) in detecting clinically significant prostate cancer (CSPCa) at the time of prostate biopsies. We explored the predictive value of pre-biopsy PLRs for CSPCa using our large-cohort database. Consecutive men with serum prostate-specific antigen (PSA) levels of ≥ 3.0 ng/mL or abnormal digital rectal examination (DRE) findings and who underwent prostate biopsies were included in the stu

OncologyMedicine
13
Review|11 citations·2016
A review of the efficacy and safety of mirodenafil in the management of erectile dysfunction
Min Chul Cho, Jae‐Seung Paick
SJR Q1Therapeutic Advances in Urology

Erectile dysfunction (ED) is a common disorder that can jeopardize quality of life and the partnership of patients and their sexual partners. The advent of oral phosphodiesterase type 5 inhibitors (PDE5Is) has revolutionized a treatment for ED, and they are recognized as the first-line therapy for ED, regardless of its etiology. Mirodenafil, a second-generation PDE5I, has biochemical profiles such as high affinity for PDE5 and high selectivity for PDE5 over other PDE isoforms, compared to other

Psychiatry and Mental healthMedicine
14
Article|11 citations·2019
Chronic administration of LIMK2 inhibitors alleviates cavernosal veno-occlusive dysfunction through suppression of cavernosal fibrosis in a rat model of erectile dysfunction after cavernosal nerve injury
Juhyun Park, Hwancheol Son, Ji Sun Chai, Soo Woong Kim, Jae‐Seung Paick, Min Chul Cho
SJR Q1PLoS ONEOA

We evaluated whether chronic administration of LIMK2-inhibitors could improve erectile function by alleviating CVOD through suppressing cavernosal fibrosis in a rat model of cavernosal nerve crush-injury (CNCI). Forty-two 12-week-old rats were equally categorized into the three groups: sham-surgery (S), CNCI (I), and CNCI treated with LIMK2-inhibitors (L). The L-group was treated with daily intraperitoneal injection of LIMK2-inhibitors (10.0 mg/kg) for 30-days after surgery. Erectile function wa

Psychiatry and Mental healthMedicine
15
Article|9 citations·2021
Lymphocyte‐to‐monocyte ratio is a predictor of clinically significant prostate cancer at prostate biopsy
Min Chul Cho, Sangjun Yoo, Min Soo Choo, Hwancheol Son, Hyeon Jeong
SJR Q1The Prostate

BACKGROUND: Inflammation plays critical roles at different stages of carcinogenesis and cancer progression. Several previous studies showed conflicting results for the predictive role of systemic inflammation markers in the detection of clinically significant prostate cancers (CSPCs). We aimed to determine the predictive roles of lymphocyte-to-monocyte (LMR) and eosinophil-to-lymphocyte ratios (ELR) in the detection of CSPC at standard 12-core transrectal ultrasound-guided prostate biopsy (12-co

OncologyMedicine

Research Areas

UrologyPulmonary and Respiratory MedicinePsychiatry and Mental healthOncologyRheumatologySurgery

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