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Myeonghee Shin

Sungkyunkwan University · Medicine

About the Lab

Professor Myeonghee Shin's research lab focuses on molecular epidemiology and thyroid endocrinology, with a strong emphasis on genetic polymorphisms—particularly in the CYP17 gene—and their association with breast cancer risk in Korean populations. The lab also investigates thyroid function and hormone reference intervals in relation to iodine nutrition, contributing critical insights into population-specific thyroid health. Additionally, the lab explores clinical predictors for laryngopharyngeal reflux (LPR), assessing the utility of symptom scores in guiding treatment response. These interdisciplinary efforts bridge molecular genetics, endocrinology, and clinical outcomes research.

thyroid functionCYP17 polymorphismbreast cancer riskmolecular epidemiologyiodine nutrition

Research Overview

Papers
120
Total Citations
2,603
Papers (5y)
25
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
25total
2020
2021
2022
2023
2024
Citations per year (5y)
361total
20202021202220232024

Selected Papers

15
1
Article|82 citations·2018
Age- and gender-specific reference intervals of TSH and free T4 in an iodine-replete area: Data from Korean National Health and Nutrition Examination Survey IV (2013–2015)
So Young Park, Hae In Kim, Hyun‐Kyung Oh, Tae Hyuk Kim, Hye Won Jang, Jae Hoon Chung, Myung‐Hee Shin, Sun Wook Kim
SJR Q1PLoS ONEOA

The reference interval of TSH in Korea, where iodine intake is above the requirement, was 0.59-7.03 mIU/L and showed U-shaped change with age, which was a similar pattern to iodine intake. The reference interval of FT4 was 0.92-1.60 ng/dL. The geometric mean and upper limit of TSH were higher than those of Western populations, reflecting the paramount importance of iodine intake on thyroid function.

Endocrinology, Diabetes and MetabolismMedicine
2
Article|37 citations·2006
Dry etching of TaN∕HfO2 gate-stack structure in BCl3∕Ar∕O2 inductively coupled plasmas
Myung‐Hee Shin, M. S. Park, Nae‐Eung Lee, Jiyoung Kim, Chung Ywong Kim, Jinho Ahn
SJR Q2Journal of Vacuum Science & Technology A Vacuum Surfaces and Films

In this work, etching characteristics of TaN(200nm)∕HfO2(80nm) gate-stack structures on Si substrate were investigated by varying the process parameters such as BCl3∕(BCl3+Ar+O2) gas mixing ratio (Q), top-electrode power, dc self-bias voltage (Vdc), and overetch time in an inductively coupled plasma etcher. To understand the role of the etch gas chemistry, we measure the relative changes in the optical emission intensity of ions and radicals in the plasma as well as in the chemical binding state

Electrical and Electronic EngineeringEngineering
3
Article|32 citations·2005
Etching characteristics of Ta and TaN using Cl2/Ar inductively coupled plasma
Myung‐Hee Shin, S.W. Na, Nae‐Eung Lee, Jinho Ahn
SJR Q2Thin Solid Films
Electrical and Electronic EngineeringEngineering
4
Article|32 citations·2006
Effect of doping elements on ZnO etching characteristics with CH4/H2/Ar plasma
Myung‐Hee Shin, Minkyung Park, Sungwook Jung, Jin‐Hyo Boo, Nae‐Eung Lee
SJR Q2Thin Solid Films
Materials ChemistryMaterials Science
5
Article|30 citations·2005
Genetic polymorphism of CYP17 and breast cancer risk in Korean women
Myung‐Hee Shin, Kyoung-Mu Lee, Jung-Hyun Yang, Seok Jin Nam, Jong‐Won Kim, Keun-Young Yoo, Sue K. Park, Dong‐Young Noh, Sei-Hyun Ahn, Bongcheol Kim, Daehee Kang
SJR Q1Experimental & Molecular MedicineOA

CYP17 gene is involved in steroidogenesis and steroid metabolism. Epidemiologic results on the association between the CYP17 polymorphism and breast cancer risk have been inconsistent. We examined the association between the MspAI polymorphism at +27 relative to the start of transcription in the 5'-untranslated region of CYP17 gene and breast cancer risk in Korean women. Four hundred and sixty-two incident cases and 337 controls were recruited from three teaching hospitals in Seoul during 1994-2

GeneticsBiochemistry, Genetics and Molecular Biology
6
Article|29 citations·2008
Ten Year Trend of Cancer Incidence in Seoul, Korea: 1993-2002
Myung‐Hee Shin, Hyun‐Kyung Oh, Yoon-Ok Ahn
SJR Q2Journal of Preventive Medicine and Public HealthOA

The cancer incidence is increasing in Seoul, Korea, especially for the colorectum and prostate for men, and for the breast, colorectum, bronchus/lung and thyroid for women.

OncologyMedicine
7
Article|25 citations·2005
Genetic polymorphism of CYP17 and breast cancer risk inKorean women
신명희, 이경무, 양종현, 남석진, 김종원, 유근영, 박수경, 노동영, 안세현, 김봉철, 강대희
http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0620920050370010011

CYP17 gene is involved in steroidogenesis and steroid metabolism. Epidemiologic results on the association betwen the CYP17 polymor-phism and breast cancer risk have ben incon-sistent. We examined the association between the MspAI polymorphism at +27 relative to the start of transcription in the 5-untranslated re-gion of CYP17 gene and breast cancer risk in Korean women. Four hundred and sixty-two in-cident cases and 337 controls were recruited from three teaching hospitals in Seoul during 1994-

8
Article|15 citations·2015
Vegetable Intake, but Not Fruit Intake, Is Associated with a Reduction in the Risk of Cancer Incidence and Mortality in Middle-Aged Korean Men
Yuni Choi, Jung Eun Lee, Jong-Myon Bae, Zhong-Min Li, Dong-Hyun Kim, Moo-Song Lee, Yoon-Ok Ahn, Myung‐Hee Shin
SJR Q1Journal of NutritionOA
Public Health, Environmental and Occupational HealthMedicine
9
Article|10 citations·2012
Open-Label Observational Study for Evaluating the Short-term Benefits of Rabeprazole Medication on Laryngopharyngeal Reflux
Myung‐Hee Shin, Soon Yuhl Nam, Young-Hak Park, Young-Ik Son
SJR Q1Clinical and Experimental OtorhinolaryngologyOA

Even though RSI and RFS may be used as a general guideline for LPR management, pre-treatment RSI and RFS are not useful in predicting the patients' response to short-term PPI medication in the usual pattern of practice for LPR, which is mostly based on the physical evaluation and history taking.

GastroenterologyMedicine
10
Article|7 citations·2023
Association between urinary iodine concentration and the risk of papillary thyroid cancer by sex and age: a case–control study
Yerin Hwang, Hyun‐Kyung Oh, Jae Hoon Chung, Sun Wook Kim, Jung‐Han Kim, Jee Soo Kim, Myung‐Hee Shin
SJR Q1Scientific ReportsOA

Abstract Previous studies on dietary iodine intake and the risk of papillary thyroid cancer (PTC) have demonstrated inconsistent results. We aimed to evaluate the association between urinary iodine concentration (UIC), a surrogate biomarker for dietary iodine intake, and the risk of thyroid cancer stratified by sex and age in an iodine-sufficient area. A hospital-based case–control study was conducted in Seoul, South Korea. A total of 492 cases of newly diagnosed PTC and 595 controls were includ

Endocrinology, Diabetes and MetabolismMedicine
11
Article|6 citations·2012
Open-Label Observational Study for Evaluating the Short-term Benefits of Rabeprazole Medication on Laryngopharyngeal Reflux
신명희, 남순열, 박영학, 손영익

Objectives. The aims of this study were to determine the benefits of short-term empirical proton pump inhibitor (PPI)medication on laryngopharyngeal reflux (LPR) and to determine whether scores on the reflux symptom index (RSI)and the reflux finding score (RFS) could be combined to identify subgroups of patients that will more likely to improve with this medication. Methods. Fifty-one Korean Otolaryngology Board-certified specialists joined this prospective, multi-center, and open-label observat

12
Article|4 citations·1994
Evaluation of the Completeness and Validity of the Registration in the Implementation Study of Seoul Cancer Registry (ISSCR)
Myung‐Hee Shin, Yoon‐Ok Ahn
SJR Q2Journal of Preventive Medicine and Public HealthOA

The incidence data (1991. 7. 11992. 6. 30) from the Implementation Study of Seoul Cancer Registry (ISSCR) were evaluated in terms of its completeness and validity. Two indicators for the completeness, Mortality/Incidence ratio (M/I ratio) and Age-specific Incidence Curve, showed fairy good registration throughout the age-sex specific strata, except the strata aged over 75 years old. The strata had very high M/I ratio (over 100%) and decreasing pattern of incidence, which suggested incomplete reg

General Health ProfessionsHealth Professions
13
Article|4 citations·2010
Comparison of Prevalence of Metabolic Syndrome Between Korean Emigrants and Host Country Residents in Japan and China-The Korean Emigrant Study
Myung‐Hee Shin, Mi Kyung Kim, Zhong Min Li, Hyun-Kyung Oh, Soo Ryang Kim, Miyuki Taniguchi, Jinnv Fang
SJR Q2Epidemiology and HealthOA

The prevalence of metabolic syndrome was higher in KEs than in host country residents in Japan but not in China. Abdominal obesity and triglyceride are both discriminating and influential components in metabolic syndrome.

Pathology and Forensic MedicineMedicine
14
Article|3 citations·2007
Relationship between the Source of Energy Intake and Obesity in Korean Women Using the Average of Four 3-day Dietary Records
Myung‐Hee Shin, Mi Ock Yoon, Seok Jin Nam, Yun‐Mi Song
SJR Q2Journal of Preventive Medicine and Public HealthOA

No single macronutrient was associated with BMI when all subjects were combined. However, when stratified by age, polyunsaturated fatty acid intake in younger women, and animal protein intake in older women, were positively associated with BMI. In the future, we recommend a larger study to confirm these results.

Public Health, Environmental and Occupational HealthMedicine
15
Article|2 citations·2002
Food, Nutrient, and the Risk of Breast Cancer.
Myung‐Hee Shin
Korean Journal of Epidemiology
Public Health, Environmental and Occupational HealthMedicine

Research Areas

Endocrinology, Diabetes and MetabolismPulmonary and Respiratory MedicinePathology and Forensic MedicineSurgeryPhysiologyClinical Psychology

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