Ryu Jae-joon
Korea University · Dentistry
About the Lab
Professor Ryu Jae-joon's research lab specializes in biomaterials and tissue engineering for oral and maxillofacial applications, with a strong focus on enhancing osseointegration and bone regeneration. The lab investigates advanced implant materials, including RGD-functionalized titanium surfaces and nitric oxide-releasing scaffolds, to improve osteogenic and angiogenic responses. Key research directions include the development of bioactive materials for guided bone regeneration, optimization of dental cement polymerization under clinical conditions, and the role of systemic diseases in temporomandibular joint disorders. The lab integrates in vitro biological evaluation with translational approaches to bridge materials innovation and clinical outcomes in dentistry.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15The aim of this systematic review was to evaluate instrumentation procedures of the alveolar ridge expansion technique (ARST) with or without Guided Bone Regeneration (GBR) and to identify the most used instruments for successful outcome. An electronic as well as manual literature search was conducted in several databases including Medline, Embase, and Cochrane Central Register of Controlled Trials, for articles written in English up to September 2016. The question in focus was to identify the t
RGD-immobilized Ti substrates might be effective in improving the osseointegration of dental implants. In particular, the chemical grafting method of RGD immobilization is more favorable and is expected to provide positive outcomes with future animal and clinical studies.
ABSTRACT Objective The aim of this study was to investigate the polymerization mode of self‐adhesive, dual‐cured resin cements light‐cured through overlying materials with different degree of translucency by measuring the degree of conversion (DC). Materials and Methods Three kinds of self‐adhesive, dual‐cured resin cements (G‐CEM LinkAce TM , Maxcem Elite TM , and BisCem ® ) were light‐cured through three different restorative materials that included porcelain‐fused metal (PFM), zirconia, and l
Synthetic scaffolds, as bone grafts, provide a favorable environment for the repair and growth of new bone tissue at defect sites. However, the lack of angio- and osteo-induction limits the usefulness of artificial scaffolds for bone regeneration. Nitric oxide (NO) performs essential roles in healing processes, such as regulating inflammation and addressing incomplete revascularization. In this study, a polymer capable of controlled NO release is developed to promote the osteogenic capacity in a
The aim of this study was to evaluate the effect of rheumatic disease as a risk factor for temporomandibular disease (TMD). A total of 143 outpatients reporting symptoms indicating rheumatic disease at their first visit to the rheumatology clinic were included. We evaluated the temporomandibular joint (TMJ) with scintigraphic images, and standard questionnaires were administered for the symptomatic assessment for all patients. The patients were classified into 'healthy controls' or as per their
This study was to evaluate the effect of bone graft procedure on the primary stability of implants installed in fresh sockets and assess the vertical alteration of peri-implant bone radiographically. Twenty-three implants were inserted in 18 patients immediately after tooth extraction. The horizontal gap between the implant and bony walls of the extraction socket was grafted with xenografts. The implant stability before and after graft procedure was measured by Osstell Mentor as implant stabilit
This study describes the successful synthesis of nitric oxide (NO)-releasing compounds with biodegradable and injectable properties and demonstrates that the kinetics of NO release vary according to the type of NO donor. The antimicrobial activity of NO-releasing compounds against three common periodontal pathogens, i.e., Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Actinomyces israelii, was investigated using a susceptibility assay. Human gingival fibroblasts were treate
The aim of this study was to present a control method for modulating the translucency of lithium disilicate ceramics through thermal refinement. Identical lithium disilicate blocks were thermally refined using four different heat treatment schedules, and the microstructure, translucency, and flexural strength of the ceramics were investigated in detail by SEM, spectroscopy, and a piston-on-three-ball test. The results showed that ceramics treated under higher heat had larger grains, with an aver
This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as discs, which were treated with rhBMP-2 and collagen. Physical and biological features were investigated u
The goal of this study was to determine the effects of tobacco compounds on gene expression in a human fetal lung cell line (WI38). In the present study, we investigated the effects of tobacco compounds (nicotine, benzo(a)pyrene (B(a)P), and 2-Naphthylamine) on gene expression profiles in human fetal fibroblasts using cDNA microarray and real-time PCR. WI38 cells were cultured in Eagle's minimum essential medium (MEM) supplemented with 10% fetal bovine serum, 2% 200 mM L-glutamine, and a 2% peni
This study hypothesizes that the application of low-dose nonthermal biocompatible dielectric barrier discharge plasma (DBD-NBP) to human gingival fibroblasts (HGFs) will inhibit colony formation but not cell death and induce matrix metalloproteinase (MMP) expression, extracellular matrix (ECM) degradation, and subsequent cell migration, which can result in enhanced wound healing. HGFs treated with plasma for 3 min migrate to each other across the gap faster than those in the control and 5-min tr
This study reports the effect of light-exposure timing on the polymerization results of the dental dual-cured resin cement using multiple measurements over time. Specimens were light-polymerized at 5 different delayed time points after mixing the materials: immediate (1 min), 10 min, 30 min, 60 min, and 2 weeks. The degree of conversion (DC) measurement with infrared spectroscopy (IR) measurements and surface hardness test with Vickers diamond indenter was performed. The group that underwent imm
Research Areas
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