Sae Hee Ra
Yonsei University · Medicine
About the Lab
Professor Sae Hee Ra's research lab specializes in critical care and perioperative medicine, with a focus on optimizing sedation strategies in pediatric and adult patients, particularly through pharmacodynamic modeling of anesthetics like propofol. The lab investigates postoperative complications such as nausea and vomiting, exploring non-pharmacological interventions like P6 acupressure, and examines long-term outcomes following intensive care unit (ICU) discharge. Additionally, the lab addresses quality improvement in ICU practices, including head-of-bed elevation protocols to prevent ventilator-associated pneumonia and the impact of delirium on patient mortality and recovery. Their work bridges clinical anesthesiology, critical care, and patient-centered outcomes research in diverse inpatient populations.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
11Purpose: We aimed to establish the propofol effect-site concentration (Ce) for appropriate sedation by pharmacodynamic analysis and to determine the propofol Ce during occurrence of sedation-related side effects in pediatric patients undergoing brain magneticresonance imaging (MRI). Materials and Methods: In 50 pediatric patients scheduled for brain MRI, sedation was induced with 2.0 mg/kg propofol; additionalpropofol doses were 0.5−1 mg/kg. Propofol Ce was simulated by inputting the propofol ad
중환자실 재실 중 섬망을 경험하는 환자는 다른 인자들의영향을 통제한 후에도 퇴원시 사망률이 높고, 재실 기간 및입원 기간이 더 길어 본 연구의 가설과 일치하는 결과를 보였다. 이 결과는 국외 연구들에서 보고되어 온 바와 일치하며, 국내 종합병원 중환자실 환경의 환자군을 대상으로 하여그 상관관계를 처음으로 확인하였다는 의의가 있다. 이러한결과는 향후 국내 의료 환경에서 발생하는 섬망에 대한 탐색과 이에 대한 적절한 중재를 연구하는 데 기초 자료로서 활용될 것으로 기대한다.
Background: Postoperative nausea and vomiting (PONV) is a common problem in patients recovering from anesthesia and surgery. P6 point is the acupressure point for prevention of postoperative nausea and vomiting. We evaluated the efficacy of acupressure at the P6 point in 94 patients undergoing thyroidectomy in a randomized, prospective and placebo-controlled study. Methods: Ninety-four female patients, aged 18 to 60, scheduled for elective thyroidectomy, were randomized to have either placebo
Background: Although head of bed (HOB) elevation is an important strategy to prevent ventilator associated pneumonia (VAP), some observational studies have reported that the application of the semi-recumbent position was lower in patients receiving mechanical ventilator support. We performed this study to assess the effect of implementation of the HOB elevation protocol in the intensive care unit (ICU) on clinical and nutritional outcomes. Methods: We developed a HOB elevation protocol including
Background: The long-term outcomes of patients discharged from the hospital after successful care in intensive care unit (ICU) are not briskly evaluated in Korea. The aim of this study was to assess long-term mortality of patients treated in the ICU and discharged alive from the hospital and to identify predictive factors of mortality. Methods: In 3,679 adult patients discharged alive from the hospital after ICU care between 2006 and 2011, the 1-year mortality rate (primary outcome measure) was
Background: Greater occipital nerve block is used in the treatment of headaches and neuralgia in the occipital area. We evaluated the efficacy of ultrasonic doppler flowmeter-guided occipital nerve block in patients experiencing headache in the occipital region in a randomized, prospective, placebo-controlled study. Methods: Twenty-six patients, aged 18 to 70, with headache in the occipital region, were included in the study. Patients received a greater occipital nerve block performed either und
Light chain systemic amyloidosis is rare but may accompany laryngeal or pulmonary involvement, which may increase the risk in airway management. We present a case of a patient planned for resection of cervical epidural mass. The patient had face and neck ecchymoses and purpuras with an unknown cause. Mask ventilation and intubation were successful, but the operation was cancelled to evaluate bleeding from facial skin lesions. A diagnosis of light chain systemic amyloidosis prompted evaluation of
Background: Malnutrition is common in hospitalized patients, especially in critically ill patients and affects their mortality and morbidity. However, the correlation between malnutrition and poor outcome is not fully understood. Our hypothesis is that the nutritional effect on the patient`s prognosis would differ depending on the severity of the disease. Methods: 3,758 patients admitted to the intensive care unit (ICU) were observed retrospectively. Patients were divided into well, moderate and
Research Areas
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