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Sang-gil Lee

Yonsei University · Medicine

About the Lab

Professor Sang-gil Lee's research lab focuses on advancing personalized and precision medicine through innovative pharmaceutical technologies and microbiome research. Key research directions include the application of 3D printing in pharmaceutical formulation for on-demand, patient-specific drug delivery systems, particularly sustained-release and floating tablets. The lab also investigates the role of the gastric microbiome—especially non-H. pylori species—in gastric diseases and carcinogenesis, aiming to uncover microbial signatures and functional pathways linked to intestinal metaplasia and cancer. Additionally, the lab explores the impact of medical interventions, such as proton pump inhibitor use, on systemic and gastrointestinal health markers like magnesium homeostasis.

3D printingpersonalized medicinegastric microbiomepharmaceutical formulationmicrobiome and disease

Research Overview

Papers
500
Total Citations
13,064
Papers (5y)
45
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
45total
2022
2023
2024
2025
2026
Citations per year (5y)
592total
20222023202420252026

Selected Papers

15
1
Article|138 citations·2017
The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma
Jung-Ho Yoon, Bohyeon Yu, Chan Hyuk Park, Yeong Jin Kim, Jin‐Wu Nam, Sang Kil Lee
SJR Q1Cancer LettersOA
Cancer ResearchBiochemistry, Genetics and Molecular Biology
2
Review|137 citations·2014
The Association between the Use of Proton Pump Inhibitors and the Risk of Hypomagnesemia: A Systematic Review and Meta-Analysis
Chan Hyuk Park, Eun Hye Kim, Yun Ho Roh, Ha Yan Kim, Sang Kil Lee
SJR Q1PLoS ONEOA

PPI use may increase the risk of hypomagnesemia. However, significant heterogeneity among the included studies prevented us from reaching a definitive conclusion.

Nutrition and DieteticsNursing
3
Article|124 citations·2009
Differential diagnosis of intestinal Behçet’s disease and Crohn’s disease by colonoscopic findings
Sang Kil Lee, Beom Kyung Kim, Tae Il Kim, Won Ho Kim
SJR Q1EndoscopyOA

BACKGROUND AND STUDY AIMS: Intestinal Behçet's disease and Crohn's disease are chronic inflammatory bowel diseases that are difficult to distinguish from each other. We investigated their colonoscopic features and identified simple and valuable strategies for differential diagnosis. PATIENTS AND METHODS: Between 1995 and 2006, 250 consecutive patients with ulcers on colonoscopy (115 Behçet's, 135 Crohn's cases) were reviewed. All patients with Behçet's fulfilled the criteria of the International

OphthalmologyMedicine
4
Review|118 citations·2022
Recent progresses in exosome-based systems for targeted drug delivery to the brain
Santosh Bashyal, Thapa Chhitij, Sang Kil Lee
SJR Q1Journal of Controlled Release
Molecular BiologyBiochemistry, Genetics and Molecular Biology
5
Article|101 citations·2017
Comparative study between endoscopic submucosal dissection and surgery in patients with early gastric cancer
Kyu Yeon Hahn, Chan Hyuk Park, Yong Kang Lee, Hyunsoo Chung, Jun Chul Park, Sung Kwan Shin, Yong Chan Lee, Hyoung‐Il Kim, Jae‐Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, Sang Kil Lee
SJR Q1Surgical EndoscopyOA
Pulmonary and Respiratory MedicineMedicine
6
Article|98 citations·2007
다문화주의와 미디어/문화연구: 국내 연구동향의 검토와 새로운 전망의 모색
이상길, 안지현

이 논문의 목적은 다문화주의와 관련해 미디어/문화연구의 분야에서 이루어진 기존 논의들을 비판적으로 검토하고 앞으로의 연구 방향성을 모색해 보려는 데 있다. 이를 위해 우리는 다음과 같은 세 가지 주제를 중점적으로 다루고자 한다. 먼저 서구에서 1970년대 이후부터 본격적으로 일어난 다문화주의 논쟁을 개관하고 국내에서 다문화주의가 부상하게 된 과정을 비판적으로 검토한다. 이와 더불어 국내에서는 다문화주의와 관련해 어떠한 연구들이 진행되어 왔고 거기에는 또 어떠한 특징이 있는지 미디어/문화연구 분야의 작업들을 중심으로 살펴보고자 한다. 이러한 논의를 바탕으로 다문화주의와 관련해 미디어/문화연구 분야에서는 현재 어떠한 연구가 시급하게 요청되는지, 우리의 사회문화적 맥락 속에서 장기적으로는 어떠한 연구가 필요한지 그 방향성을 가늠해보고자 한다.

7
Review|94 citations·2019
Complex formulations, simple techniques: Can 3D printing technology be the Midas touch in pharmaceutical industry?
Shrawani Lamichhane, Santosh Bashyal, Taekwang Keum, Gyubin Noh, Jo Eun Seo, Rakesh Bastola, Jae‐Woong Choi, Dong Hwan Sohn, Sang Kil Lee
SJR Q1Asian Journal of Pharmaceutical SciencesOA

3D printing is a method of rapid prototyping and manufacturing in which materials are deposited onto one another in layers to produce a three-dimensional object. Although 3D printing was developed in the 1980s and the technology has found widespread industrial applications for production from automotive parts to machine tools, its application in pharmaceutical area is still limited. However, the potential of 3D printing in the pharmaceutical industry is now being recognized. The ability of 3D pr

Biomedical EngineeringEngineering
8
Article|89 citations·2019
Customized Novel Design of 3D Printed Pregabalin Tablets for Intra-Gastric Floating and Controlled Release Using Fused Deposition Modeling
Shrawani Lamichhane, Jun-Bom Park, Dong Hwan Sohn, Sang Kil Lee
SJR Q1PharmaceuticsOA

Three-dimensional (3D) printing has been recently employed in the design and formulation of various dosage forms with the aim of on-demand manufacturing and personalized medicine. In this study, we formulated a floating sustained release system using fused deposition modeling (FDM). Filaments were prepared using hypromellose acetate succinate (HPMCAS), polyethylene glycol (PEG 400) and pregabalin as the active ingredient. Cylindrical tablets with infill percentages of 25%, 50% and 75% were desig

Biomedical EngineeringEngineering
9
Article|88 citations·2013
A retinyl palmitate-loaded solid lipid nanoparticle system: Effect of surface modification with dicetyl phosphate on skin permeation in vitro and anti-wrinkle effect in vivo
Ho Seong Jeon, Jo Eun Seo, Min Soo Kim, Mean Hyung Kang, Dong Ho Oh, Sang Ok Jeon, Seong Hoon Jeong, Young Wook Choi, Sang Kil Lee
SJR Q1International Journal of Pharmaceutics
Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics
10
Article|88 citations·2018
Evaluation of gastric microbiome and metagenomic function in patients with intestinal metaplasia using 16S rRNA gene sequencing
Chan Hyuk Park, A‐reum Lee, Yu‐ra Lee, Chang Soo Eun, Sang Kil Lee, Dong Soo Han
SJR Q1HelicobacterOA

BACKGROUND: Despite recent advances in studies on the gastric microbiome, the role of the non-Helicobacter pylori gastric microbiome in gastric carcinogenesis remains unclear. We evaluated the characteristics of the gastric microbiome and metagenomic functions in patients with IM. METHODS: Participants were classified into six groups according to disease status (chronic superficial gastritis [CSG], intestinal metaplasia [IM], and cancer) and H. pylori- infection status (H. pylori-positive and H.

SurgeryMedicine
11
Article|85 citations·2010
Predictive factors for local recurrence after endoscopic resection for early gastric cancer: long-term clinical outcome in a single-center experience
Jun Chul Park, Sang Kil Lee, Ju Hee Seo, Yu Jin Kim, Hyunsoo Chung, Sung Kwan Shin, Yong Chan Lee
SJR Q1Surgical EndoscopyOA
Pulmonary and Respiratory MedicineMedicine
12
Article|80 citations·2014
Long non-coding RNA HOTAIR promotes carcinogenesis and invasion of gastric adenocarcinoma
Na Keum Lee, Jung Hwa Lee, Chan Hyuk Park, Dayeon Yu, Yong Chan Lee, Jae‐Ho Cheong, Sung Hoon Noh, Sang Kil Lee
SJR Q2Biochemical and Biophysical Research CommunicationsOA
Cancer ResearchBiochemistry, Genetics and Molecular Biology
13
Article|66 citations·2016
Promoter methylation of PCDH10 by HOTAIR regulates the progression of gastrointestinal stromal tumors
Na Keum Lee, Jung Hwa Lee, Won Kyu Kim, SeongJu Yun, Young Hoon Youn, Chan Hyuk Park, Yun Young Choi, Hogeun Kim, Sang Kil Lee
SJR Q2OncotargetOA

HOTAIR, a long non-coding RNA (lncRNA), plays a crucial role in tumor initiation and metastasis by interacting with the PRC2 complex and the modulation of its target genes. The role of HOTAIR in gastrointestinal stromal tumors (GISTs) is remains unclear. Herein we investigate the mechanism of HOTAIR in the genesis and promotion of GISTs. The expression of HOTAIR was found to be higher in surgically resected high-risk GISTs than that in low- and intermediate-risk GISTs. Using GIST-T1 and GIST882

Cancer ResearchBiochemistry, Genetics and Molecular Biology
14
Article|66 citations·2017
MALAT1 promoted invasiveness of gastric adenocarcinoma
Na Keum Lee, Jung Hwa Lee, Cristina Ivan, Hui Ling, Xinna Zhang, Chan Hyuk Park, George A. Călin, Sang Kil Lee
SJR Q2BMC CancerOA

BACKGROUND: Gastric cancer is the second leading cause of cancer globally, and the mechanism of its pathogenesis is still largely unknown. Recently, non-coding RNAs have been recognized to promote metastasis in various cancers, including gastric cancer. METHODS: We found that metastasis associated lung adenocarcinoma transcript-1 (MALAT1) is upregulated in gastric cancer tissue compared to adjacent normal tissue, as determined by microarray and subsequent qRT-PCR, then investigated the impact of

Cancer ResearchBiochemistry, Genetics and Molecular Biology
15
Article|60 citations·2005
Cellular differentiation-induced attenuation of LPS response in HT-29 cells is related to the down-regulation of TLR4 expression
Sang Kil Lee, Tae Il Kim, Yun Kyung Kim, Chang Hwan Choi, Kyung Min Yang, Boah Chae, Won Ho Kim
SJR Q2Biochemical and Biophysical Research Communications
ImmunologyImmunology and Microbiology

Research Areas

Pulmonary and Respiratory MedicineSurgeryPharmaceutical ScienceGastroenterologyOncologyCancer Research

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