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Sang Il Choi

Seoul National University · Medicine

About the Lab

Professor Sang Il Choi's research lab specializes in molecular imaging and cancer biology, with a focus on developing and applying advanced magnetic resonance imaging techniques to assess myocardial viability and tumor progression. The lab investigates the pathogenic mechanisms of gastric cancer, particularly the role of *Helicobacter pylori* infection and host factors like CagA and CDX1 in intestinal metaplasia and carcinogenesis. Additionally, the lab explores the prognostic and functional significance of endogenous proteins such as galectin-9 in gastric and hepatocellular carcinomas, aiming to identify biomarkers and therapeutic targets. Their work bridges clinical imaging, molecular oncology, and translational research to improve early detection and outcomes in gastrointestinal cancers.

molecular imaginggastric cancerhepatocellular carcinomamyocardial viabilitygalectin-9

Research Overview

Papers
233
Total Citations
3,945
Papers (5y)
33
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
33total
2021
2022
2023
2024
2025
Citations per year (5y)
114total
20212022202320242025

Selected Papers

15
1
Review|56 citations·2009
Recent developments in wide-detector cardiac computed tomography
Sang Il Choi, Richard T. George, Karl H. Schuleri, Eun Ju Chun, João A.C. Lima, Albert C. Lardo
International journal of cardiac imaging
Biomedical EngineeringEngineering
2
Article|54 citations·2000
Application of breath-hold T2-weighted, first-pass perfusion and gadolinium-enhanced T1-weighted MR imaging for assessment of myocardial viability in a pig model
Sang Il Choi, Chun Zi Jiang, Keun Ho Lim, Sang Tae Kim, Chung Hwan Lim, Gyung Yub Gong, Tae‐Hwan Lim
SJR Q1Journal of Magnetic Resonance ImagingOA

The purpose of this study was to correlate the abnormal signal area on various magnetic resonance (MR) images to the infarct area on pathologic examination and to assess the myocardial viability on the basis of MR images. T2-weighted, first-pass perfusion, and delayed gadolinium-enhanced T1-weighted images were used as "one-stop examinations" in a pig model of reperfused myocardial infarction. The results of each MR image were compared with those of 2,3, 5-triphenyltetrazolium chloride (TTC) sta

Radiology, Nuclear Medicine and ImagingMedicine
3
Article|42 citations·2000
Irreversibly Damaged Myocardium at MR Imaging with a Necrotic Tissue-Specific Contrast Agent in a Cat Model
Sang Il Choi, Seong Hoon Choi, Sang‐Tae Kim, Keun Ho Lim, Chung Hwan Lim, Gyung Yub Gong, Hyae Young Kim, Hanns‐Joachim Weinmann, Tae‐Hwan Lim
SJR Q1Radiology

MR images enhanced with bis-gadolinium mesoporphyrins provide accurate sizing of irreversibly damaged myocardium with a strong and persistent signal enhancement in the reperfused myocardium.

Radiology, Nuclear Medicine and ImagingMedicine
4
Article|37 citations·2019
RETRACTED: CDX1 Expression Induced by CagA-Expressing Helicobacter pylori Promotes Gastric Tumorigenesis
Sang Il Choi, Changhwan Yoon, Mi Ree Park, DaHyung Lee, Myeong‐Cherl Kook, Jian-Xian Lin, Jun Hyuk Kang, Hassan Ashktorab, Duane T. Smoot, Sam S. Yoon, Soo‐Jeong Cho
SJR Q1Molecular Cancer Research

Abstract Intestinal-type gastric cancer often results from Helicobacter pylori infection through intestinal metaplasia, a transdifferentiated premalignant phenotype. Because H. pylori virulence factor CagA has been associated with aberrant expression of the transcription factor CDX1, which regulates intestinal differentiation, we explored its relationship with H. pylori infection and function during gastric carcinogenesis in normal gastric epithelial cells and gastric cancer cell lines. Infectio

GeneticsBiochemistry, Genetics and Molecular Biology
5
Article|33 citations·2013
The prevalence and characteristics of coronary atherosclerosis in asymptomatic subjects classified as low risk based on traditional risk stratification algorithm: assessment with coronary CT angiography
Kil Joong Kim, Sang Il Choi, Min Su Lee, Jeong‐Ah Kim, Eun Ju Chun, Chang Ho Jeon
SJR Q1Heart

Although an asymptomatic population classified as low risk by the NCEP guideline has been regarded as a minimal risk group, the prevalence of atherosclerosis plaques and significant stenosis were not negligible. However, considering very low event rate for those patients, CCTA should not be performed in low-risk asymptomatic subjects, although CCTA might have the potential for identification of high-risk groups in the selected subjects regarded as a minimal-risk group by NCEP guideline.

Radiology, Nuclear Medicine and ImagingMedicine
6
Article|31 citations·2013
Relationship between amount of cigarette smoking and coronary atherosclerosis on coronary CTA in asymptomatic individuals
Jeong A. Kim, Eun Ju Chun, Min Su Lee, Kil Joong Kim, Sang Il Choi
International journal of cardiac imaging
Radiology, Nuclear Medicine and ImagingMedicine
7
Article|28 citations·2012
Subclinical coronary atherosclerosis in young adults: prevalence, characteristics, predictors with coronary computed tomography angiography
Kwang Nam Jin, Eun Ju Chun, Chang‐Hoon Lee, Jeong A. Kim, Min Su Lee, Sang Il Choi
International journal of cardiac imaging
Radiology, Nuclear Medicine and ImagingMedicine
8
Article|24 citations·2013
Asymptomatic subjects with zero coronary calcium score: coronary CT angiographic features of plaques in event-prone patients
Min Su Lee, Eun Ju Chun, Kil Joong Kim, Jeong A. Kim, Jin Young Yoo, Sang Il Choi
International journal of cardiac imaging
Radiology, Nuclear Medicine and ImagingMedicine
9
Article|21 citations·2017
Prognostic value of tumoral expression of galectin-9 in gastric cancer
Sang Il Choi, Ki Woo Seo, Myeong‐Cherl Kook, Chan Gyoo Kim, Young‐Woo Kim, Soo‐Jeong Cho
SJR Q3The Turkish Journal of GastroenterologyOA

BACKGROUND/AIMS: Galectin-9 (Gal-9) is a member of the β-galactoside-binding lectin family. Our previous study revealed that Gal-9 suppresses migration, invasion, and epithelial-mesenchymal transition in gastric cancer cells. Gal-9 was reported to have anti-metastatic activity in patients with malignant melanoma, breast cancer, and hepatocellular carcinoma. Therefore, we aimed to evaluate the prognostic significance of Gal-9 in patients with gastric cancer. MATERIALS AND METHODS: The clinical si

ImmunologyImmunology and Microbiology
10
Article|17 citations·2022
Better survival of patients with hepatitis B virus-related hepatocellular carcinoma in South Korea: Changes in 16-years cohorts
Sang Il Choi, Yuri Cho, Moran Ki, Bo Hyun Kim, In Joon Lee, Tae Hyun Kim, Seong Hoon Kim, Young Hwan Koh, Hyun Beom Kim, Eun Kyung Hong, Chang‐Min Kim, Joong‐Won Park
SJR Q1PLoS ONEOA

AIMS: The incidence and mortality of hepatocellular carcinoma (HCC) have decreased over time in South Korea, where hepatitis B virus (HBV) in endemic. This study investigated the changes in the characteristics and clinical outcomes of HCC patients in Korea. METHODS: Patients initially diagnosed with HCC and treated at the National Cancer Center, Korea between 2000 and 2015 (n = 4,291) were followed up until February 2017. Differences in patient characteristics and outcomes were compared between

EpidemiologyMedicine
11
Article|16 citations·2018
Prevalence and Implications of Bone Marrow Involvement in Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
Sang Il Choi, Myeong‐Cherl Kook, Sang‐Hyun Hwang, Young‐Il Kim, Jong Yeul Lee, Chan Gyoo Kim, Il Ju Choi, Hye Won Lee, Hyeon Seok Eom, Soo‐Jeong Cho
SJR Q1Gut and LiverOA

Bone marrow involvement was found in 4.3% of the patients with gastric MALT lymphoma. Bone marrow examination may be deferred because marrow involvement does not change the treatment options or outcome in gastric MALT lymphoma confined to the stomach wall.

Pathology and Forensic MedicineMedicine
12
Article|13 citations·2010
Pattern Recognition Using Feature Feedback: Application to Face Recognition
최상일, 정구민, 안현식, 곽노준, 문찬우

In this paper, we propose a new pattern recognition method using feature feedback and present its application to face recognition. Conventional pattern recognition methods extract the features employed for classification using PCA, LDA and so on. On the other hand, in the proposed method, the extracted features are analyzed in the original space using feature feedback. Using reverse mapping from the extracted features to the original space, we can identify the important part of the original data

13
Article|9 citations·2018
Three-year interval for endoscopic screening may reduce the mortality in patients with gastric cancer
Sang Il Choi, Boram Park, Jungnam Joo, Young‐Il Kim, Jong Yeul Lee, Chan Gyoo Kim, Il Ju Choi, Myeong‐Cherl Kook, Soo‐Jeong Cho
SJR Q1Surgical Endoscopy
Pulmonary and Respiratory MedicineMedicine
14
Article|7 citations·2015
LIPSCHITZ AND ASYMPTOTIC STABILITY OF NONLINEAR SYSTEMS OF PERTURBED DIFFERENTIAL EQUATIONS
Sang Il Choi, Yoon Hoe Goo
SJR Q3Korean Journal of Mathematics

Abstract. In this paper, we investigate Lipschitz and asymptotic stability for perturbed nonlinear differential systems. 1.

Numerical AnalysisMathematics
15
Article|7 citations·2015
BOUNDEDNESS IN PERTURBED NONLINEAR FUNCTIONAL DIFFERENTIAL SYSTEMS
Sang Il Choi, Yoon Hoe Goo
Journal of the Chungcheng Mathematical SocietyOA

In this paper, we investigate bounds for solutions of the perturbed nonlinear functional differential systems with a -similarity condition using the notion of h-stability.

Numerical AnalysisMathematics

Research Areas

Radiology, Nuclear Medicine and ImagingSurgeryCardiology and Cardiovascular MedicinePulmonary and Respiratory MedicineEndocrinology, Diabetes and MetabolismControl and Systems Engineering

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