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Sang In Khwarg

Seoul National University · Medicine

About the Lab

Professor Sang In Khwarg's research lab specializes in oculoplastic and reconstructive surgery, with a strong focus on orbital and facial reconstruction, eyelid disorders, and ocular surface diseases. The lab investigates innovative surgical techniques for midfacial support, including ligamentous anatomy and its role in midfacial ptosis, as well as advanced treatments for conditions like epiblepharon and ocular adnexal lymphoma. A key emphasis is placed on minimally invasive and biomaterial-free regenerative approaches, such as cultured oral mucosal epithelial cell sheets for limbal stem cell deficiency. The lab also explores medical and surgical interventions in lacrimal drainage disorders and refractive complications.

oculoplastic surgerylimbal stem cell deficiencyeyelid reconstructionorbital ligamentsregenerative ophthalmology

Research Overview

Papers
217
Total Citations
2,514
Papers (5y)
15
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
15total
2021
2022
2023
2024
2025
Citations per year (5y)
75total
20212022202320242025

Selected Papers

15
1
Article|89 citations·2008
Frontalis Sling Operation Using Silicone Rod Compared with Preserved Fascia Lata for Congenital Ptosis
Min Joung Lee, Joo Youn Oh, Ho-Kyung Choung, Nam Ju Kim, Mi Sun Sung, Sang In Khwarg
SJR Q1Ophthalmology
DermatologyMedicine
2
Article|84 citations·2000
The Anatomy of Midfacial Ptosis
Mark J. Lucarelli, Sang In Khwarg, Bradley N. Lemke, J Kozel, Richard K. Dortzbach
SJR Q2Ophthalmic Plastic and Reconstructive Surgery

The lateral component of the orbitomalar ligament provides major osteocutaneous midfacial support. Subcutaneous attenuation of the orbitomalar, masseteric cutaneous, and zygomatic ligaments was associated with midfacial ptosis.

DermatologyMedicine
3
Article|77 citations·1999
Management of moderate-to-severe marcus-gunn jaw-winking ptosis
Sang In Khwarg, Kristin J. Tarbet, Richard K. Dortzbach, Mark J. Lucarelli
SJR Q1Ophthalmology
DermatologyMedicine
4
Article|62 citations·1997
Epiblepharon of the lower eyelid: classification and association with astigmatism
Sang In Khwarg, Yong J. Lee
SJR Q2Korean Journal of Ophthalmology

To determine a classification system for epiblepharon of the lower eyelid and to evaluate a possible correlation between lower lid epiblepharon and astigmatism. Three morphologic characteristics (skin fold, cilia touching the cornea and corneal erosion) were observed by slit-lamp biomicroscopic examination and Polaroid pictures in 186 eyes of 102 patients with epiblepharon of the lower lid. In 112 eyes, cycloplegic refractions performed. A classification system reflecting the severity of epiblep

DermatologyMedicine
5
Article|53 citations·2009
One-Snip Punctoplasty and Canalicular Curettage Through the PunctumA Minimally Invasive Surgical Procedure for Primary Canaliculitis
Min Joung Lee, Ho-Kyung Choung, Nam Ju Kim, Sang In Khwarg
SJR Q1Ophthalmology
OphthalmologyMedicine
6
Article|49 citations·2010
First‐line therapy with doxycycline in ocular adnexal mucosa‐associated lymphoid tissue lymphoma: A retrospective analysis of clinical predictors
Tae Min Kim, Ki Hwan Kim, Min Joung Lee, Yoon Kyung Jeon, Se‐Hoon Lee, Dong‐Wan Kim, Chul Woo Kim, Il Han Kim, Sang In Khwarg, Dae Seog Heo
SJR Q1Cancer ScienceOA

This retrospective study was launched to evaluate the efficacy of doxycycline and to find independent predictors of a clinical response in patients with ocular adnexal lymphoma of mucosa-associated lymphoid tissue (OAML). Thirty-eight patients with newly diagnosed, localized OAML received doxycycline for 3 weeks (12 patients) or 6 weeks (26 patients). Clinical factors including absolute lymphocyte count (ALC) and neutrophil count (ANC) were compared between responders and non-responders. After a

Pathology and Forensic MedicineMedicine
7
Article|45 citations·2008
Bicanalicular double silicone intubation in external dacryocystorhinostomy and canaliculoplasty for distal canalicular obstruction
Sang Won Hwang, Sang In Khwarg, Jong Hyun Kim, Ho Kyung Choung, Nam Ju Kim
SJR Q1Acta OphthalmologicaOA

PURPOSE: We aimed to evaluate the effectiveness of bicanalicular double silicone intubation in dacryocystorhinostomy (DCR) and canaliculoplasty for distal or common canalicular obstruction. METHODS: We reviewed the medical records of patients with distal or common canalicular obstruction who had undergone bicanalicular double silicone intubation (insertion of two tubes into each canaliculus) during external DCR and canaliculoplasty. We reviewed the records of subjects who had undergone the same

OphthalmologyMedicine
8
Article|44 citations·2017
Prospective Clinical Trial of Corneal Reconstruction With Biomaterial-Free Cultured Oral Mucosal Epithelial Cell Sheets
Kwang Gi Kim, Hyun Ju Lee, Jin Suk Ryu, Yun Hee Kim, Saewha Jeon, Joo Youn Oh, Ho Kyung Choung, Sang In Khwarg, Won Ryang Wee, Mee Kum Kim
SJR Q1Cornea

PURPOSE: To investigate the efficacy and safety of transplantation with biomaterial-free cultured oral mucosal epithelial cell sheets (COMECs) for ocular reconstruction in subjects with total limbal stem cell deficiency. METHODS: A prospective clinical trial (NCT02149732) was conducted in 8 subjects with total limbal stem cell deficiency after approval from the institutional review board of Seoul National University Hospital (H-0707-043-213) and the Ministry of Food and Drug Safety of Korea. COM

Radiology, Nuclear Medicine and ImagingMedicine
9
Article|42 citations·2017
Surgical outcomes of external dacryocystorhinostomy and risk factors for functional failure: a 10-year experience
Matthew J. Lee, Sang In Khwarg, I H Kim, Jun Ho Choi, Youn Joo Choi, Na Young Kim, H-K Choung
SJR Q1EyeOA
OphthalmologyMedicine
10
Article|33 citations·2002
Epiblepharon of the Lower Eyelid: Technique of Surgical Repair and Quantification of Excision According to the Skin Fold Height
Sang In Khwarg, Ho-Kyung Choung
SJR Q2Ophthalmic surgery, lasers & imaging retina

BACKGROUND AND OBJECTIVE: To describe our excisional technique for lower eyelid epiblepharon to reduce a medial undercorrection and to provide a guide for the excision amount using a classification system of epiblepharon according to the skin fold height. PATIENTS AND METHODS: After classification, an elliptical excision of skin and orbicularis muscle, including that below the lower canaliculus after tarsal suturing of the upper edge of the incised skin, was consecutively performed for 111 eyeli

DermatologyMedicine
11
Article|27 citations·2014
Prognostic value of clinical and pathologic T stages defined by the American Joint Committee on Cancer for eyelid sebaceous carcinoma in Korea
Youn Joo Choi, Hyun Chul Jin, Min Joung Lee, Namju Kim, Ho Kyung Choung, Sang In Khwarg
SJR Q2Japanese Journal of Ophthalmology
EpidemiologyMedicine
12
Article|26 citations·2007
Lid margin split in the surgical correction of epiblepharon
Sang Won Hwang, Sang In Khwarg, Jong Hyun Kim, Nam Ju Kim, Ho-Kyung Choung
SJR Q1Acta OphthalmologicaOA

PURPOSE: To describe the technique of splitting the lid margin combined with the excision of redundant skin and muscle during the surgical correction of epiblepharon and to report its clinical outcome. METHODS: A combined procedure that included splitting the lid margin to repair lower eyelid epiblepharon was performed on 31 eyes of 19 consecutive patients. Lid margin splitting was performed along the grey line on the medial third or half of the lower eyelid by making a 1 mm-deep incision. Havin

DermatologyMedicine
13
Article|25 citations·1999
Ancient Schwannoma of the Orbit
Sang In Khwarg
Archives of OphthalmologyOA

The ancient schwannoma is a rare variant of a neurilemoma with a course typical of a slow-growing benign neoplasm. Histologically, it can be confused with a malignant mesenchymal tumor because of increased cellularity, nuclear pleomorphism, and hyperchromatism. Despite the degree of nuclear atypia, mitotic figures are absent. We describe the clinical and histopathologic features of an ancient schwannoma of the orbit.

NeurologyMedicine
14
Article|24 citations·2011
Dermis-Fat Graft for Treatment of Exposed Porous Polyethylene Implants in Pediatric Postenucleation Retinoblastoma Patients
Min Joung Lee, Sang In Khwarg, Ho-Kyung Choung, Nam Ju Kim, Young Suk Yu
SJR Q1American Journal of Ophthalmology
GeneticsBiochemistry, Genetics and Molecular Biology
15
Article|20 citations·2012
Expression of Shh and Wnt Signaling Pathway Proteins in Eyelid Sebaceous Gland Carcinoma: Clinicopathologic Study
Namju Kim, Ji Eun Kim, Ho-Kyung Choung, Min Joung Lee, Sang In Khwarg
SJR Q1Investigative Ophthalmology & Visual ScienceOA

PURPOSE: Activation or dysregulation of the Sonic hedgehog (Shh) and Wnt signaling pathways is suggested to lead to the development of many human malignancies. In this study, we investigated Shh and Wnt signaling protein expression in eyelid sebaceous gland carcinoma, and analyzed their correlation with clinical characteristics of the tumor. METHODS: Patients who underwent surgical resection of eyelid sebaceous gland carcinoma from 1999 to 2011 were recruited for the study. Immunohistochemical s

Molecular BiologyBiochemistry, Genetics and Molecular Biology

Research Areas

OphthalmologyDermatologyPathology and Forensic MedicineGeneticsRadiology, Nuclear Medicine and ImagingSurgery

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