Sang In Khwarg
Seoul National University · Medicine
About the Lab
Professor Sang In Khwarg's research lab specializes in oculoplastic and reconstructive surgery, with a strong focus on orbital and facial reconstruction, eyelid disorders, and ocular surface diseases. The lab investigates innovative surgical techniques for midfacial support, including ligamentous anatomy and its role in midfacial ptosis, as well as advanced treatments for conditions like epiblepharon and ocular adnexal lymphoma. A key emphasis is placed on minimally invasive and biomaterial-free regenerative approaches, such as cultured oral mucosal epithelial cell sheets for limbal stem cell deficiency. The lab also explores medical and surgical interventions in lacrimal drainage disorders and refractive complications.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15The lateral component of the orbitomalar ligament provides major osteocutaneous midfacial support. Subcutaneous attenuation of the orbitomalar, masseteric cutaneous, and zygomatic ligaments was associated with midfacial ptosis.
To determine a classification system for epiblepharon of the lower eyelid and to evaluate a possible correlation between lower lid epiblepharon and astigmatism. Three morphologic characteristics (skin fold, cilia touching the cornea and corneal erosion) were observed by slit-lamp biomicroscopic examination and Polaroid pictures in 186 eyes of 102 patients with epiblepharon of the lower lid. In 112 eyes, cycloplegic refractions performed. A classification system reflecting the severity of epiblep
This retrospective study was launched to evaluate the efficacy of doxycycline and to find independent predictors of a clinical response in patients with ocular adnexal lymphoma of mucosa-associated lymphoid tissue (OAML). Thirty-eight patients with newly diagnosed, localized OAML received doxycycline for 3 weeks (12 patients) or 6 weeks (26 patients). Clinical factors including absolute lymphocyte count (ALC) and neutrophil count (ANC) were compared between responders and non-responders. After a
PURPOSE: We aimed to evaluate the effectiveness of bicanalicular double silicone intubation in dacryocystorhinostomy (DCR) and canaliculoplasty for distal or common canalicular obstruction. METHODS: We reviewed the medical records of patients with distal or common canalicular obstruction who had undergone bicanalicular double silicone intubation (insertion of two tubes into each canaliculus) during external DCR and canaliculoplasty. We reviewed the records of subjects who had undergone the same
PURPOSE: To investigate the efficacy and safety of transplantation with biomaterial-free cultured oral mucosal epithelial cell sheets (COMECs) for ocular reconstruction in subjects with total limbal stem cell deficiency. METHODS: A prospective clinical trial (NCT02149732) was conducted in 8 subjects with total limbal stem cell deficiency after approval from the institutional review board of Seoul National University Hospital (H-0707-043-213) and the Ministry of Food and Drug Safety of Korea. COM
BACKGROUND AND OBJECTIVE: To describe our excisional technique for lower eyelid epiblepharon to reduce a medial undercorrection and to provide a guide for the excision amount using a classification system of epiblepharon according to the skin fold height. PATIENTS AND METHODS: After classification, an elliptical excision of skin and orbicularis muscle, including that below the lower canaliculus after tarsal suturing of the upper edge of the incised skin, was consecutively performed for 111 eyeli
PURPOSE: To describe the technique of splitting the lid margin combined with the excision of redundant skin and muscle during the surgical correction of epiblepharon and to report its clinical outcome. METHODS: A combined procedure that included splitting the lid margin to repair lower eyelid epiblepharon was performed on 31 eyes of 19 consecutive patients. Lid margin splitting was performed along the grey line on the medial third or half of the lower eyelid by making a 1 mm-deep incision. Havin
The ancient schwannoma is a rare variant of a neurilemoma with a course typical of a slow-growing benign neoplasm. Histologically, it can be confused with a malignant mesenchymal tumor because of increased cellularity, nuclear pleomorphism, and hyperchromatism. Despite the degree of nuclear atypia, mitotic figures are absent. We describe the clinical and histopathologic features of an ancient schwannoma of the orbit.
PURPOSE: Activation or dysregulation of the Sonic hedgehog (Shh) and Wnt signaling pathways is suggested to lead to the development of many human malignancies. In this study, we investigated Shh and Wnt signaling protein expression in eyelid sebaceous gland carcinoma, and analyzed their correlation with clinical characteristics of the tumor. METHODS: Patients who underwent surgical resection of eyelid sebaceous gland carcinoma from 1999 to 2011 were recruited for the study. Immunohistochemical s
Research Areas
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