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Sanghun Han

Korea University · Medicine

About the Lab

Professor Sanghun Han's research lab focuses on translational and clinical studies in surgical disorders, particularly in plastic and reconstructive surgery, with a strong emphasis on functional outcomes and patient-specific factors. The lab investigates the pathophysiology and treatment of conditions such as inverted nipples and neurofibromatosis-associated tumors, integrating molecular mechanisms with clinical applications. Research also extends into oncology, particularly the role of HER2 and signaling pathways like AKT/ERK in early gastric cancer, highlighting a multidisciplinary approach combining molecular biology with surgical outcomes. Additionally, the lab explores rehabilitation metrics, such as fat-mass percentage, in spinal cord injury patients to improve clinical assessment and patient management.

surgical outcomesplastic surgerygastric cancerneurofibromatosisspinal cord injury

Research Overview

Papers
111
Total Citations
1,608
Papers (5y)
21
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
21total
2021
2022
2023
2024
2025
Citations per year (5y)
44total
20212022202320242025

Selected Papers

15
1
Article|128 citations·2004
Visual Search Does Not Remain Efficient When Executive Working Memory Is Working
Sang Hoon Han, Min‐Shik Kim
SJR Q1Psychological Science

Working memory (WM) has been thought to include not only short-term memory stores but also executive processes that operate on the contents of memory. The present study examined the involvement of WM in search using a dual-task paradigm in which participants performed visual search while manipulating or simply maintaining information held in WM. Experiments 1a and 2a involved executive WM tasks that required counting backward from a target digit and sorting a string of letters alphabetically, re

Cognitive NeuroscienceNeuroscience
2
Article|106 citations·1999
The Inverted Nipple: Its Grading and Surgical Correction
Sang Hoon Han, Yoon Gi Hong
SJR Q1Plastic & Reconstructive Surgery

Inverted nipples have been treated by various methods by many authors, but the relationship between the grade of the deformity and the appropriate surgical procedure is not clearly described. One hundred seven inverted nipples in 60 patients were treated from 1993 to 1997. They were divided into three groups by the authors' system of grading. The grade was made by preoperative evaluation of severity of inversion and was confirmed by the surgical findings. In grade I, the nipple is easily pulled

GeneticsBiochemistry, Genetics and Molecular Biology
3
Article|40 citations·2015
Dexamethasone Inhibits TGF-β1–Induced Cell Migration by Regulating the ERK and AKT Pathways in Human Colon Cancer Cells Via CYR61
Sang Hoon Han, Ngoc Thuy Bui, Manh Tin Ho, Youngmee Kim, Moonjae Cho, Dong Bok Shin
SJR Q1Cancer Research and TreatmentOA

These findings suggested that dexamethasone inhibits AKT and ERK phosphorylation, leading to decreased CYR61 expression, which in turn blocks TGF-β1-induced migration.

Molecular BiologyBiochemistry, Genetics and Molecular Biology
4
Article|15 citations·2007
Malignant Gastrointestinal Stromal Tumor in a Patient with Neurofibromatosis type 1
Sang Hoon Han, Se Hoon Park, Gwon Hyun Cho, Na Rae Kim, Jae Hwan Oh, Eunmi Nam, Dong Bok Shin
SJR Q2The Korean Journal of Internal MedicineOA

Neurofibromatosis type 1 (von Recklinghausen's disease, NF-1) is an autosomal-dominant neurocutaneous disorder characterized by abnormal skin pigmentation (café au lait spots and axillary freckling), cutaneous and plexiform neurofibromas, skeletal dysplasias, and Lisch nodules (pigmented iris hamartomas). Gastrointestinal stromal tumors (GISTs) are the most common tumors of mesenchymal origin in the gastrointestinal tract, mesentery, omentum, and retroperitoneum. Here, we report a case of GIST i

NeurologyMedicine
5
Article|14 citations·2020
HER2 as a potential biomarker of lymph node metastasis in undifferentiated early gastric cancer
Sang Hoon Han, Sungjin Park, Jungsuk An, Jun-Young Yang, Jun‐Won Chung, Yoon Jae Kim, Kyoung Oh Kim, Dong Kyun Park, Kwang An Kwon, Woon Kee Lee, Seungyoon Nam, Jung Ho Kim
SJR Q1Scientific ReportsOA

Human epidermal growth factor receptor 2 (HER2) is implicated in several cancers, including gastric cancer. However, limited data are available regarding its clinical significance in early gastric cancer (EGC). We evaluated the clinical significance of HER2 overexpression in patients with EGC. We retrospectively reviewed 727 patients who underwent surgical treatment for EGC between October 2010 and August 2017. HER2 expression was analysed in 680 EGC cases by immunohistochemistry and classified

Pulmonary and Respiratory MedicineMedicine
6
Article|13 citations·2015
Comparison of Fat Mass Percentage and Body Mass Index in Koreans With Spinal Cord Injury According to the Severity and Duration of Motor Paralysis
Sang Hoon Han, Bum-Suk Lee, Hyun Soo Choi, Minsoo Kang, Bo Ra Kim, Zee‐A Han, Hye Jin Lee
SJR Q1Annals of Rehabilitation MedicineOA

In Korean SCI patients, FMP showed good correlation with the duration of SCI and the extent of SCI, while BMI did not. Especially in the motor complete tetraplegia group, the diagnostic value of BMI decreased as the duration after SCI increased. This study suggested that FMP could be used complementarily when evaluating the obesity of SCI patients.

Pathology and Forensic MedicineMedicine
7
Article|12 citations·2012
Primary anaplastic large cell lymphoma of the lung presenting with acute atelectasis
Sang Hoon Han, Young Hee Maeng, Young Sill Kim, Jae Min Jo, Jung Mi Kwon, Woo Kun Kim, Mi‐Ok Kim
SJR Q2Thoracic CancerOA

Non-Hodgkin lymphoma only rarely occurs as a primary lung mass. We report a very rare case of primary pulmonary anaplastic large cell lymphoma presenting with acute atelectasis in a 55-year-old man. Chest computed tomography revealed a consolidated central mass in the left lung with obstructive pneumonia that had developed into total atelectasis. After a bronchoscopic examination failed to yield a definite diagnosis, supraclavicular lymph node biopsy was performed, revealing an anaplastic large

Pathology and Forensic MedicineMedicine
8
Article|9 citations·2003
Effects of the Abdominal Midline Incision on the Survival of the Transverse Rectus Abdominis Musculocutaneous Flap in Rat Model
Sang Hoon Han, Jin Sup Eom, Dong Ho Kim
SJR Q2Annals of Plastic Surgery

The transverse rectus abdominis musculocutaneous (TRAM) flap, as the standard for breast reconstruction, can be performed in selected patients with operation scars in the abdomen. It is questioned why the unilateral TRAM flaps raised from the abdomen with scars seem to have more blood supply to the periphery. The effect of the abdominal midline incision on the survival of the TRAM flap was studied with the rat model. The survival of the inferiorly based unilateral TRAM flap was compared between

SurgeryMedicine
9
Article|7 citations·2001
Treatment of cicatricial lagophthalmos: very small orbicularis oculi muscle pedicled skin flap
Sang Hoon Han, Jae Jin Ock
British Journal of Plastic SurgeryOA
NeurologyMedicine
10
Article|6 citations·2001
Three-Dimensional Z-Plasty in the Correction of the Unilateral Cleft Lip Nasal Deformity
Sang Hoon Han, Moon Su Choi
SJR Q1The Cleft Palate-Craniofacial Journal

OBJECTIVE: Numerous methods have been introduced for correction of the cleft lip nasal deformities, but no single procedure has given sufficiently satisfactory results to provide a surgical standard. Much effort has been put on restoring cartilaginous structures using alar cartilage modification and suspension. But even after the cartilage framework is repositioned well, redundant alar webbing is still unsightly and frequently conspicuous. This paper presents a procedure combining the usual open

SurgeryMedicine
11
Article|5 citations·2011
Solitary rectal metastasis from primary small cell lung carcinoma
Sang Hoon Han, Jeong Won Lee, Chang Lim Hyun, Soyeon Yoo, Jong Hoo Lee, Jung Mi Kwon, Woo Kun Kim
SJR Q2Thoracic CancerOA

Lung cancer may rarely appear with a solitary rectal metastasis and no other metastases. We report the first case of primary small cell lung cancer presenting with a solitary rectal metastasis in a 62-year-old man. Chest computed tomography revealed a soft tissue lesion in the subcarinal area. Following bronchoscopic biopsy, the patient was diagnosed with small cell lung cancer. The rectal mass was incidentally found during an imaging study for staging work-up. Histological examination revealed

Pulmonary and Respiratory MedicineMedicine
12
Article|5 citations·2011
Current status of EUV mask inspection using 193nm optical inspection system in 30nm node and beyond
Sang Hoon Han, Jihoon Na, Won-Il Cho, Dong Hoon Chung, Chan-Uk Jeon, Han-Ku Cho, Dana Bernstein, Eun Young Park, Anoop Sreenath, Shmoolik Mangan
Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

Extreme Ultra Violet Lithography (EUVL) is one of the most advanced patterning technologies to overcome the critical resolution limits of current ArF lithography for 30nm generation node and beyond. Since EUVL mask manufacturing process has not been fully stabilized yet, it is still suffering from many defect issues such as blank defects, defects inside multilayer causing phase defects, CD defects, LERs (Line Edge Roughness), and so on. One of the most important roles in mask manufacturing proce

Electrical and Electronic EngineeringEngineering
13
Review|5 citations·2024
Chemoprevention of Head and Neck Cancer: A Review of Current Approaches and Future Perspectives
Sang Hoon Han, Ramireddy Bommireddy, Pauline Kim, Periasamy Selvaraj, Dong M. Shin
SJR Q1Cancer Prevention ResearchOA

Head and neck squamous cell carcinoma (HNSCC) is a spectrum of heterogeneous malignancies. A variety of genetic, environmental, and lifestyle factors contribute to the development of HNSCC. Carcinogenesis is a multistep process in which cell proliferation-associated oncogenes and cell-cycle regulation-associated tumor suppressor genes are dysregulated, resulting in premalignant lesions. Immune evasion is a critical step in the progression of benign lesions to advanced cancer. This review discuss

Psychiatry and Mental healthMedicine
14
Article|5 citations·2006
Thalidomide for Treating Metastatic Hepatocellular Carcinoma: A Pilot Study
Sang Hoon Han, Se Hoon Park, Jung Ho Kim, Jong Jun Lee, So Young Kwon, Oh Sang Kwon, Sun Suk Kim, Ju Hyun Kim, Keon Kug Kim, Yeon Ho Park, Jeong Nam Lee, Eunmi Nam
SJR Q2The Korean Journal of Internal MedicineOA

BACKGROUND: Thalidomide has been reported to have antitumor activity for treating metastatic hepatocellular carcinoma (HCC). We evaluated the safety and efficacy of using thalidomide for treating selected patients with unresectable or metastatic HCC, and their disease was refractory to systemic chemotherapy. METHODS: Eight patients with measurable and metastatic HCC that had progressed with prior systemic chemotherapy and who desired further active therapy were enrolled in this study. Thalidomid

HematologyMedicine
15
Article|3 citations·2019
ALK‐positive lung cancer diagnosed with abdominal lymph nodes in a patient receiving hemodialysis
Sung Heon Song, Ji Won Ryu, Hye Young Jwa, Chang W. Ha, Hyun Kim, Jaemin Jo, Sang Hoon Han
SJR Q2Thoracic CancerOA

There is little consensus in the literature about the administration of crizotinib in patients with end-stage renal disease undergoing hemodialysis. A 69-year-old male patient, who was receiving regular hemodialysis due to end-stage renal disease, visited the hospital with symptoms of repeated abdominal pain. There was no suspicious finding of cancer within the thorax. After biopsy, the abdominal lymph nodes were identified as adenocarcinoma originating from the lung following computed tomograph

Pulmonary and Respiratory MedicineMedicine

Research Areas

SurgeryOncologyPulmonary and Respiratory MedicineGeneticsPathology and Forensic MedicineElectrical and Electronic Engineering

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