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Se Chang Park

Seoul National University · Environmental Science

About the Lab

Professor Se Chang Park's research lab focuses on developing alternative biocontrol strategies for aquatic animal pathogens, particularly targeting antibiotic-resistant bacteria such as *Pseudomonas plecoglossicida*, *Vibrio parahaemolyticus*, and *Vibrio alginolyticus*. The lab specializes in the isolation, characterization, and application of bacteriophages as therapeutic agents in aquaculture, with an emphasis on phage therapy and biocontrol. Additionally, the lab investigates probiotic bacteria, such as *Lactobacillus reuteri* and *L. plantarum*, for their protective effects against environmental stressors like heavy metal toxicity and for enhancing fermentation processes. The overarching research direction centers on sustainable and eco-friendly solutions for disease management in aquaculture and environmental health.

bacteriophagesaquacultureantibiotic resistanceprobioticsbiocontrol agents

Research Overview

Papers
362
Total Citations
8,669
Papers (5y)
80
Primary Field
Environmental Science

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
80total
2021
2022
2023
2024
2025
Citations per year (5y)
737total
20212022202320242025

Selected Papers

15
1
Article|278 citations·2000
Isolation of Bacteriophages Specific to a Fish Pathogen, Pseudomonas plecoglossicida , as a Candidate for Disease Control
Se Chang Park, Ichiro Shimamura, Minoru Fukunaga, Koh-ichiro Mori, Toshihiro Nakai
SJR Q1Applied and Environmental MicrobiologyOA

Two types of bacteriophage specific to Pseudomonas plecoglossicida, the causative agent of bacterial hemorrhagic ascites disease in cultured ayu fish (Plecoglossus altivelis), were isolated from diseased ayu and the rearing pond water. One type of phage, which formed small plaques, was tentatively classified as a member of the family Myoviridae, and the other type, which formed large plaques, was classified as a member of the family Podoviridae. All 27 strains of P. plecoglossicida examined, whi

EcologyEnvironmental Science
2
Article|190 citations·2015
Effect of guava leaves on the growth performance and cytokine gene expression of Labeo rohita and its susceptibility to Aeromonas hydrophila infection
Sib Sankar Giri, Shib Sankar Sen, Cheng Chi, Hyoun Joong Kim, Saekil Yun, Se Chang Park, V. Sukumaran
SJR Q1Fish & Shellfish Immunology
PharmacologyPharmacology, Toxicology and Pharmaceutics
3
Article|162 citations·2003
Bacteriophage control of Pseudomonas plecoglossicida infection in ayu, Plectoglossis altivelis
Se Chang Park, Toshihiro Nakai
SJR Q3Diseases of Aquatic OrganismsOA

Two previously isolated phages were used to examine the therapeutic effects against Pseudomonas plecoglossicida infection in ayu Plecoglossus altivelis. Phage PPp-W4 (Podoviridae) inhibited the in vitro growth of P. plecoglossicida more effectively than Phage PPpW-3 (Myoviridae), and a mixture (PPpW-3/W-4) of the 2 phages exhibited the highest inhibitory activity. In phage therapy experiments, ayu were fed P. plecoglossicida-impregnated feed (10(7) CFU fish(-1)) and then fed phage-impregnated fe

EcologyEnvironmental Science
4
Article|123 citations·2019
Antioxidant, antibacterial, and anti-adhesive activities of biosurfactants isolated from Bacillus strains
Sib Sankar Giri, EunChae Ryu, V. Sukumaran, Se Chang Park
SJR Q2Microbial Pathogenesis
PollutionEnvironmental Science
5
Article|121 citations·2014
Bacteriophage Therapy of a Vibrio parahaemolyticus Infection Caused by a Multiple-Antibiotic–Resistant O3:K6 Pandemic Clinical Strain
Jin Woo Jun, Tae Hoon Shin, Ji Hyung Kim, Sang Phil Shin, Jee Eun Han, Gang Joon Heo, Mahanama De Zoysa, Gee Wook Shin, Ji Young Chai, Se Chang Park
SJR Q1The Journal of Infectious DiseasesOA

BACKGROUND: Recently isolated Vibrio parahaemolyticus strains have displayed multiple antibiotic resistance. Alternatives to conventional antibiotics are needed, especially for the multiple-antibiotic-resistant V. parahaemolyticus pandemic strain. METHODS: A bacteriophage, designated pVp-1, showed effective infectivity for multiple-antibiotic-resistant V. parahaemolyticus and V. vulnificus, including V. parahaemolyticus pandemic strains. The therapeutic potential of the phage was studied in a mo

EndocrinologyBiochemistry, Genetics and Molecular Biology
6
Article|114 citations·2016
Role of dietary ginger Zingiber officinale in improving growth performances and immune functions of Labeo rohita fingerlings
V. Sukumaran, Se Chang Park, Sib Sankar Giri
SJR Q1Fish & Shellfish Immunology
PharmacologyPharmacology, Toxicology and Pharmaceutics
7
Article|114 citations·2019
Effects of bioactive substance from turmeric on growth, skin mucosal immunity and antioxidant factors in common carp, Cyprinus carpio
Sib Sankar Giri, V. Sukumaran, Se Chang Park
SJR Q1Fish & Shellfish Immunology
ImmunologyImmunology and Microbiology
8
Article|108 citations·2019
Isolation and characterisation of pVa-21, a giant bacteriophage with anti-biofilm potential against Vibrio alginolyticus
Sang Guen Kim, Jin Woo Jun, Sib Sankar Giri, Saekil Yun, Hyoun Joong Kim, Sang Wha Kim, Jeong Woo Kang, Se Jin Han, Dalsang Jeong, Se Chang Park
SJR Q1Scientific ReportsOA

There is an increasing emergence of antibiotic-resistant Vibrio alginolyticus, a zoonotic pathogen that causes mass mortality in aquatic animals and infects humans; therefore, there is a demand for alternatives to antibiotics for the treatment and prevention of infections caused by this pathogen. One possibility is through the exploitation of bacteriophages. In the present study, the novel bacteriophage pVa-21 was classified as Myoviridae and characterised as a candidate biocontrol agent against

EcologyEnvironmental Science
9
Article|105 citations·2018
Therapeutic Effect of Intestinal Autochthonous Lactobacillus reuteri P16 Against Waterborne Lead Toxicity in Cyprinus carpio
Sib Sankar Giri, Saekil Yun, Jin Woo Jun, Hyoun Joong Kim, Sang Guen Kim, Jeong Woo Kang, Sang Wha Kim, Se Jin Han, V. Sukumaran, Se Chang Park
SJR Q1Frontiers in ImmunologyOA

Harmful effects of heavy metals are myriad. Lead (Pb) from soil and atmosphere contaminates water bodies and affects the aquatic animals. Our previous study confirmed the <i>in vitro</i> probiotic potential of <i>Lactobacillus reuteri</i> against Pb toxicity, but further investigation is necessary for gaining insights into the related protection mode. Therefore, in this study, we investigated the protective effects of the potential probiotic <i>L. reuteri</i> P16 against waterborne Pb exposure-i

ImmunologyImmunology and Microbiology
10
Article|102 citations·2018
Use of a Potential Probiotic, Lactobacillus plantarum L7, for the Preparation of a Rice-Based Fermented Beverage
Sib Sankar Giri, Shib Sankar Sen, Subrata Saha, V. Sukumaran, Se Chang Park
SJR Q1Frontiers in MicrobiologyOA

This study aimed to isolate potential probiotic lactic acid bacteria from a traditional rice-based fermented beverage "bhaati jaanr" and to evaluate their role during preparation of the beverage. Among various isolates, <i>Lactobacillus plantarum</i> strain L7 exhibited satisfactory <i>in vitro</i> probiotic characteristics such as acid resistance and bile tolerance, cell surface hydrophobicity, auto-aggregation, antibiotic susceptibility, and antimicrobial activities. Therefore, performance of

Food ScienceAgricultural and Biological Sciences
11
Article|97 citations·2013
Protective effects of the Aeromonas phages pAh1-C and pAh6-C against mass mortality of the cyprinid loach (Misgurnus anguillicaudatus) caused by Aeromonas hydrophila
Jin Woo Jun, Ji Hyung Kim, Sang Phil Shin, Jee Eun Han, Ji Young Chai, Se Chang Park
SJR Q1Aquaculture
EcologyEnvironmental Science
12
Article|83 citations·2014
Eating oysters without risk of vibriosis: Application of a bacteriophage against Vibrio parahaemolyticus in oysters
Jin Woo Jun, Hyoun Joong Kim, Sae Kil Yun, Ji Young Chai, Se Chang Park
SJR Q1International Journal of Food Microbiology
EndocrinologyBiochemistry, Genetics and Molecular Biology
13
Article|81 citations·2017
Phage Application for the Protection from Acute Hepatopancreatic Necrosis Disease (AHPND) in Penaeus vannamei
Jin Woo Jun, Jee Eun Han, Sib Sankar Giri, Kathy F.J. Tang, Xiaohui Zhou, Luis Fernando Aranguren, Hyoun Joong Kim, Saekil Yun, Cheng Chi, Sang Guen Kim, Se Chang Park
SJR Q3Indian Journal of Microbiology
ImmunologyImmunology and Microbiology
14
Article|77 citations·2015
Production and characterization of a thermostable bioflocculant from Bacillus subtilis F9, isolated from wastewater sludge
Sib Sankar Giri, Harshiny Muthukumar, Shib Sankar Sen, V. Sukumaran, Se Chang Park
SJR Q1Ecotoxicology and Environmental Safety
Water Science and TechnologyEnvironmental Science
15
Article|73 citations·2013
Isolation and characterization of a Myoviridae bacteriophage against Staphylococcus aureus isolated from dairy cows with mastitis
Jee Eun Han, Ji Hyung Kim, Sun Young Hwang, Casiano H. Choresca, Sang Phil Shin, Jin Woo Jun, Ji Young Chai, Yong Ho Park, Se Chang Park
SJR Q1Research in Veterinary Science
EcologyEnvironmental Science

Research Areas

ImmunologyEcologyMolecular BiologyEndocrinologyPharmacologyInfectious Diseases

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