Seo-yeon Yang
Ewha Womans University · Medicine
About the Lab
Professor Seo-yeon Yang's research lab focuses on molecular mechanisms underlying insulin secretion in pancreatic β-cells, with a central emphasis on the calcium-binding protein secretagogin (SCGN). The lab investigates how SCGN's structural dynamics, particularly its Ca²⁺-dependent dimerization and conformational changes, regulate insulin exocytosis. Additionally, the lab explores the psychological and social impacts of online gaming, especially MMORPGs, on real-life interpersonal competence in young adults. The research integrates molecular biology, mass spectrometry, and behavioral science to bridge cellular mechanisms with human behavioral outcomes.
Research Overview
Research Output Trend
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Selected Papers
5Secretagogin (SCGN), a Ca(2+)-binding protein having six EF-hands, is selectively expressed in pancreatic β-cells and neuroendocrine cells. Previous studies suggested that SCGN enhances insulin secretion by functioning as a Ca(2+)-sensor protein, but the underlying mechanism has not been elucidated. The present study explored the mechanism by which SCGN enhances glucose-induced insulin secretion in NIT-1 insulinoma cells. To determine whether SCGN influences the first or second phase of insulin
Abstract Secretagogin (SCGN), a hexa EF-hand calcium binding protein, plays key roles in insulin secretion in pancreatic β-cells. It is not yet understood how the binding of Ca 2+ to human SCGN (hSCGN) promotes secretion. Here we have addressed this question, using mass spectrometry combined with a disulfide searching algorithm DBond. We found that the binding of Ca 2+ to hSCGN promotes the dimerization of hSCGN via the formation of a Cys193-Cys193 disulfide bond. Hydrogen/deuterium exchange mas
본 연구는 MMORPG 이용동기가 MMORPG의 사회적 이용을 매개로 현실의 대인관계 유능성에 끼치는 영향에 대해 알아보았다. 이를 위해 MMORPG 커뮤니티를 대상으로 총 496부의 설문을 회수하였다. 분석 결과, MMORPG 이용동기와 대인관계 유능성 간 관계에서 MMORPG의 사회적 이용은 완전매개하였다. 이용 동기 중 사회적 관계성 이용 동기는 MMORPG의 사회적 이용을 정적으로 완전매개하여 대인관계 유능성에 영향을 주었다. 몰입/도피 이용 동기의 경우 대인관계 유능성에 직접적으로 부정적인 영향을 주었으나, MMORPG의 사회적 이용을 부분 매개하여 부정적인 영향이 다소 감소하였음을 알 수 있었다.
Purpose : This study was conducted to investigate the functions of daily living, physical and cognitive functions, and functional recovery training services of elderly residents in long-term care facilities. Method : We sent surveys to representatives of the facilities and analyzed the data for 73 care facilities that we received via email. Each facility has selected one resident for each of the eight groups. The functions of daily living, cognitive function and physical function, and functional
Purpose: This study was conducted to confirm the provision standards and appropriateness of functional recovery training services performed on residents in long-term care facilities. Methods: Twenty-eight service providers working in four long-term care facilities applied the functional recovery training services to 63 older residents for 15 days, integrating them with their existing daily tasks. The contents recorded by the service providers on checklists were analyzed, and the experiences of a
Research Areas
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