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Si Un Lee

Seoul National University · Medicine

About the Lab

Professor Si Un Lee's research lab specializes in neurocritical care and interventional neuroradiology, with a primary focus on intracranial hemorrhage and intracranial pressure management. The lab investigates innovative endovascular interventions such as middle meningeal artery embolization for chronic subdural hematoma and evaluates non-invasive monitoring techniques like optic nerve sheath diameter ultrasonography for detecting increased intracranial pressure. Their work emphasizes translational research, integrating clinical imaging, hemodynamic monitoring, and patient outcomes to improve diagnosis and treatment strategies in cerebrovascular diseases.

intracranial pressurehemorrhagic strokeultrasonographyembolizationneurocritical care

Research Overview

Papers
77
Total Citations
1,253
Papers (5y)
41
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
41total
2022
2023
2024
2025
2026
Citations per year (5y)
98total
20222023202420252026

Selected Papers

15
1
Article|424 citations·2017
Middle Meningeal Artery Embolization for Chronic Subdural Hematoma
Seung Pil Ban, Gyojun Hwang, Hyoung Soo Byoun, Tackeun Kim, Si Un Lee, Jae Seung Bang, Jung Ho Han, Chae‐Yong Kim, O-Ki Kwon, Chang Wan Oh
SJR Q1Radiology

Purpose To evaluate the effect of middle meningeal artery (MMA) embolization on chronic subdural hematoma (CSDH) and compare the treatment outcomes of MMA embolization and conventional treatment. Materials and Methods All consecutive patients 20 years or older with CSDH were assessed for eligibility. CSDHs with a focal location, a thickness of 10 mm or less, no mass effect, or underlying conditions were excluded. Seventy-two prospectively enrolled patients with CSDH underwent MMA embolization (e

NeurologyMedicine
2
Article|101 citations·2017
Correlation of optic nerve sheath diameter with directly measured intracranial pressure in Korean adults using bedside ultrasonography
Jin Pyeong Jeon, Si Un Lee, Sung‐Eun Kim, Suk Hyung Kang, Jin Seo Yang, Hyuk Jai Choi, Yong Jun Cho, Seung Pil Ban, Hyoung Soo Byoun, Young Soo Kim
SJR Q1PLoS ONEOA

ONSD as seen on bedside US correlated well with directly measured ICP in Korean adults with brain lesions. The optimal cut-off point of ONSD for detecting IICP was 5.6 mm.

NeurologyMedicine
3
Review|55 citations·2018
Ultrasonographic optic nerve sheath diameter to detect increased intracranial pressure in adults: a meta-analysis
Sung‐Eun Kim, Eun Pyo Hong, Heung Cheol Kim, Si Un Lee, Jin Pyeong Jeon
SJR Q3Acta Radiologica

BACKGROUND: The optimal optic nerve sheath diameter (ONSD) cut-off for identifying increased intracranial pressure (IICP) remains unclear in adult patients. PURPOSE: To validate the diagnostic accuracy of ultrasonographic (US) ONSD > 5.0 mm as a cut-off for detecting IICP by computed tomographic (CT) through a meta-analysis. MATERIAL AND METHODS: A systemic literature review was performed of online databases from January 1990 to September 2017. A bivariate random-effects model was used to estima

NeurologyMedicine
4
Article|51 citations·2016
The incidence of and risk factors for ischemic complications after microsurgical clipping of unruptured middle cerebral artery aneurysms and the efficacy of intraoperative monitoring of somatosensory evoked potentials: A retrospective study
Hyoung Soo Byoun, Jae Seung Bang, Chang Wan Oh, O-Ki Kwon, Gyojun Hwang, Jung Ho Han, Tackeun Kim, Si Un Lee, Seong-Rae Jo, Dong‐Gun Kim, Kyung Seok Park
SJR Q2Clinical Neurology and Neurosurgery
NeurologyMedicine
5
Article|51 citations·2021
Reactive Oxygen Species Scavenger in Acute Intracerebral Hemorrhage Patients
Moinay Kim, Joonho Byun, Yeongu Chung, Si Un Lee, Ji Eun Park, Wonhyoung Park, Jung Cheol Park, Jae Sung Ahn, Seungjoo Lee
SJR Q1Stroke

Background and Purpose: Patients with intracerebral hemorrhage (ICH) have oxidative stress. Oxidative stress contributes to the development and progression of perihematomal edema (PHE) in brain hemorrhage patients. We hypothesized that reactive oxygen species (ROS) scavengers might have a neuroprotective role in the acute period of patients with ICH. Methods: This prospective, multicenter, single-blind, randomized study was conducted between June 2017 and October 2019. Intracranial bleeding, inc

NeurologyMedicine
6
Article|51 citations·2019
Trends in the Incidence and Treatment of Cerebrovascular Diseases in Korea : Part I. Intracranial Aneurysm, Intracerebral Hemorrhage, and Arteriovenous Malformation
Si Un Lee, Tackeun Kim, O-Ki Kwon, Jae Seung Bang, Seung Pil Ban, Hyoung Soo Byoun, Chang Wan Oh
SJR Q2Journal of Korean Neurosurgical SocietyOA

OBJECTIVE: To analyze the incidence and treatment trends of hemorrhagic stroke (HS), according to HS subtypes, using nationwide data in Korea from January 2008 to December 2016. METHODS: We used data from the national health-claim database provided by the National Health Insurance Service for 2008-2016 using the International Classification of Diseases. The crude incidence and age-standardized incidence of each disease associated with HS, which included intracranial aneurysm (IA), hypertensive i

NeurologyMedicine
7
Article|43 citations·2016
Optic nerve sheath diameter threshold by ocular ultrasonography for detection of increased intracranial pressure in Korean adult patients with brain lesions
Si Un Lee, Jin Pyeong Jeon, Lee Hannah, Jung Ho Han, Mingu Seo, Hyoung Soo Byoun, Won‐Sang Cho, Ho Geol Ryu, Hyun‐Seung Kang, Jeong Eun Kim, Heung Cheol Kim, Kyung-Sool Jang
SJR Q3MedicineOA

Optic nerve sheath diameter (ONSD) seen on ocular US has been associated with increased intracranial pressure (IICP). However, most studies have analyzed normal range of ONSD and its optimal cut-off point for IICP in Caucasian populations. Considering ONSD differences according to ethnicity, previous results may not accurately reflect the association between IICP and ONSD in Koreans. Therefore, we conducted this study to investigate normal range of ONSD and its optimal threshold for detecting II

NeurologyMedicine
8
Review|41 citations·2018
Surgical Treatment of Adult Moyamoya Disease
Si Un Lee, Chang Wan Oh, O-Ki Kwon, Jae Seung Bang, Seung Pil Ban, Hyoung Soo Byoun, Tackeun Kim
SJR Q2Current Treatment Options in Neurology
RheumatologyMedicine
9
Article|36 citations·2019
Trends in the Incidence and Treatment of Cerebrovascular Diseases in Korea : Part II. Cerebral Infarction, Cerebral Arterial Stenosis, and Moyamoya Disease
Si Un Lee, Tackeun Kim, O-Ki Kwon, Jae Seung Bang, Seung Pil Ban, Hyoung Soo Byoun, Chang Wan Oh
SJR Q2Journal of Korean Neurosurgical SocietyOA

Although the incidence of CI showed a declining trend over a 9-year period, the number and proportion of patients treated for CI increased. Meanwhile, the incidence of CASTN and the number of patients treated for CASTN have demonstrated increasing trends since 2008. On the other hand, the number of patients diagnosed with pediatric MMD decreased, despite no significant change in the incidence. In contrast, the number of patients and the incidence of adult MMD increased. These trends reflect chan

RheumatologyMedicine
10
Review|36 citations·2004
Cerebral lipiodol embolism during transcatheter arterial chemoembolization
Kweon Yoo, Bong-Goo Yoo, K. S. Kim, Si Un Lee, Bo Han
SJR Q1Neurology

Cerebral lipiodol embolism (CLE) is a rare complication that may occur during chemoembolization. The authors present three cases of CLE during transcatheter arterial chemoembolization for hepatocellular carcinoma. Multiple small nonconfluent hyperintense intracerebral lesions were found on the diffusion-weighted and fluid-attenuated inversion recovery MRI. Clinical signs completely resolved and MRI lesions markedly improved on follow-up evaluation within a 3-week period.

Psychiatry and Mental healthMedicine
11
Review|19 citations·2018
Delayed Cerebral Ischemia and Vasospasm After Spontaneous Angiogram-Negative Subarachnoid Hemorrhage: An Updated Meta-Analysis
Si Un Lee, Eun Pyo Hong, Bong Jun Kim, Sung Eun Kim, Jin Pyeong Jeon
SJR Q2World Neurosurgery
NeurologyMedicine
12
Article|15 citations·2016
Cerebrovascular Events During Pregnancy and Puerperium Resulting from Preexisting Moyamoya Disease: Determining the Risk of Ischemic Events Based on Hemodynamic Status Assessment Using Brain Perfusion Single-Photon Emission Computed Tomography
Si Un Lee, Young Seob Chung, Chang Wan Oh, O-Ki Kwon, Jae Seung Bang, Gyojun Hwang, Tackeun Kim, Seong Yeol Ahn
SJR Q2World Neurosurgery
RheumatologyMedicine
13
Article|15 citations·2018
Pathogenesis of dorsal internal carotid artery wall aneurysms based on histopathologic examination and microscopic configuration
Si Un Lee, Yoonjin Kwak, Chang Wan Oh, O-Ki Kwon, Seung Pil Ban, Tackeun Kim, Hyoung Soo Byoun, Gheeyoung Choe, Young Deok Kim, Jae Seung Bang
SJR Q2Journal of Clinical Neuroscience
NeurologyMedicine
14
Article|6 citations·2022
Quantitative radiological analysis and clinical outcomes of urgent EC-IC bypass for hemodynamic compromised patients with acute ischemic stroke
Hyunjun Jo, Dongwook Seo, Young Deok Kim, Seung Pil Ban, Tackeun Kim, O-Ki Kwon, Chang Wan Oh, Leonard Sunwoo, Beom Joon Kim, Moon‐Ku Han, Hee‐Joon Bae, Si Un Lee
SJR Q1Scientific ReportsOA

This study aimed to demonstrate the effectiveness of urgent extracranial-to-intracranial bypass (EIB) in acute ischemic stroke (AIS) through quantitative analysis of computed tomography perfusion (CTP) results using RAPID software. We retrospectively analyzed 41 patients who underwent urgent EIB for AIS under strict operation criteria. The quantitative data from CTP images were reconstructed to analyze changes in pre- and postoperative perfusion status in terms of objective numerical values usin

EpidemiologyMedicine
15
Article|6 citations·2024
Prediction of postoperative cerebral infarction after combined bypass surgery in adult moyamoya disease: combining quantitative parameters on RAPID perfusion CT with clinically related factors
Si Un Lee, Yongjae Lee, Tae Won Choi, Sang Hyo Lee, Young-Deok Kim, Seung Pil Ban, O-Ki Kwon, Chang Wan Oh, Jae Seung Bang
SJR Q1Journal of neurosurgery

OBJECTIVE: The aim of this study was to identify predictive factors of postoperative cerebral infarction (PostCI) following combined bypass (CB) surgery in adult patients with moyamoya disease (MMD) using quantitative parameters from the rapid processing of perfusion and diffusion (RAPID) perfusion CT (PCT) software. METHODS: The authors retrospectively reviewed 276 total hemispheres in patients with MMD who underwent CB. Preoperative volumes of time-to-maximum (Tmax) > 4 sec and > 6 sec were ob

RheumatologyMedicine

Research Areas

NeurologyRheumatologyPulmonary and Respiratory MedicineEpidemiologyCardiology and Cardiovascular MedicinePsychiatry and Mental health

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