Subin Lee
Yonsei University · Medicine
About the Lab
Professor Subin Lee's research lab focuses on interdisciplinary biomedical and materials science research, spanning regenerative medicine, spinal surgery innovation, and functional food development. The lab investigates the biological and clinical implications of adolescent idiopathic scoliosis, including psychiatric comorbidities and advanced spinal implant technologies such as expandable interbody cages. It also explores bioactive compounds in natural products—like cinnamon powder in baked goods—for health-promoting effects, while conducting fundamental studies on fungal glycobiology and graphene-based thermal energy conversion. The lab integrates clinical data, molecular biology, and materials engineering to develop novel therapeutic and functional solutions.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15BACKGROUND: Children with adolescent idiopathic scoliosis (AIS) have reduced quality of life related to poor self-image, perhaps because of cosmetic concerns. However, there has not been a large-database epidemiologic study on the association between psychiatric disorders and scoliosis. QUESTIONS/PURPOSES: Using the Korean National Health Insurance database, we asked: (1) How common are psychiatric disorders among children with AIS? (2) After controlling for gender, age, insurance type, and resi
Graphene has been intensively studied due to its outstanding electrical and thermal properties. Recently, it was found that the heat generation by Joule heating of graphene is limited by the conductivity of graphene. Here we suggest an alternative method to generate heat on a large-area graphene film more efficiently by utilizing the unique electromagnetic (EM) wave absorption property of graphene. The EM wave induces an oscillating magnetic moment generated by the orbital motion of moving elect
Lumbar fusion surgery for treating degenerative spinal diseases has undergone significant advancements in recent years. In addition to posterior instrumentation, anterior interbody fusion techniques have been developed along with various cages for interbody fusion. Recently, expandable cages capable of altering height, lordotic angle, and footprint within the disc space have garnered significant attention. In this manuscript, we review the current status, clinical outcomes, and future prospects
계피분말의 첨가량을 0~4%로 달리하여 스펀지케이크를 제조한 후 물리화학적 품질특성 및 소비자 기호도를 조사하였다. 계피분말의 첨가비율이 증가함에 따라 케이크의 pH, 수분함량, 비체적, 굽기 손실률은 유의적으로 감소하는 경향을 나타내었다(p<0.05). 밝기를 나타내는 L<sup>*</sup>값과 황색도를 나타내는 b<sup>*</sup>값은 계피분말 첨가량이 증가할수록 유의적으로 감소하였으며(p<0.05), 적색도를 나타내는 a<sup>*</sup>값은 crust에서는 계피분말의 첨가량이 증가할수록 유의적으로 감소하여 4% 첨가군이 최소값을 나타낸 반면 crumb의 a<sup>*</sup>값은 유의적으로 증가하며 4% 대조군이 8.59로 최대값을 나타내었다. 케이크의 경도는 계피분말 첨가량에 따라 0.17~0.42 kgf로 유의적으로 증가하였고(p<0.05), 총 페놀화합물 함량은 2% 첨가군까지 단계적인 유의적 증가경향을 보였으나(p<0.05), 이후 2~4% 첨가군 사이에서
Cryptococcus neoformans is an opportunistic human fungal pathogen causing lethal meningoencephalitis. It has several cell wall mannoproteins (MPs) identified as immunoreactive antigens. To investigate the structure and function of N-glycans assembled on cryptococcal cell wall MPs in host cell interactions, we purified MP98 (Cda2) and MP84 (Cda3) expressed in wild-type (WT) and N-glycosylation-defective alg3 mutant (alg3Δ) strains. HPLC and MALDI-TOF analysis of the MP proteins from the WT reveal
Our study identified the FGF-2-derived peptide FP2 as a promising candidate peptide to improve the therapeutic potential of hWJ-MSCs, especially in bone and cartilage regeneration.
Background: There are a few biomechanical studies that describe posterior fixation methods with pedicle screws (PS) and lateral mass screws (LMS); the combination of both screw types and their effect on an allograft spacer in a surgically treated cervical segment is unknown. Methods: Finite element model (FEM) analyses were used to investigate the effects of a hybrid technique using posterior PS and LMS. Stress distribution and subsidence risk from a combination of screws under hybrid motion con
본 연구는 공황장애 말뭉치 구축과 분석을 통해 공황장애의 특성을 살펴보고 공황장애 경향 문헌을 분류할 수 있는 딥러닝 자동 분류 모델을 만들고자 하였다. 이를 위해 소셜미디어에서 수집한 공황장애 관련 문헌 5,884개를 정신 질환 진단 매뉴얼 기준으로 직접 주석 처리하여 공황장애 경향 문헌과 비 경향 문헌으로 분류하였다. 이 중 공황장애 경향 문헌에 나타난 어휘적 특성 및 어휘의 관계성을 분석하기 위해 TF-IDF값을 산출하고 단어 동시출현 분석을 실시하였다. 공황장애의 특성 및 증상 간의 관련성을 분석하기 위해 증상 빈도수와 주석 처리된 증상 번호 간의 동시출현 빈도수를 산출하였다. 또한, 구축한 말뭉치를 활용하여 딥러닝 자동 분류 모델 학습 및 성능 평가를 하였다. 이를 위하여 최신 딥러닝 언어 모델 BERT 중 세 가지 모델을 활용하였고 이 중 KcBERT가 가장 우수한 성능을 보였다. 본 연구는 공황장애 관련 증상을 겪는 사람들의 조기 진단 및 치료를 돕고 소셜미디어 말뭉치를
The purpose of our study is to compare the maternal and neonatal outcomes of induction of labor (IOL) versus expectant management at 39 weeks of gestation. We conducted a single-centered, prospective, observational study of nulliparous singleton women at 39 weeks or more. We compared the maternal and perinatal outcomes. Of 408 nulliparous women, 132 women were IOL group and 276 women were expectant management group. IOL and expectant group had similar cesarean delivery rate (18.2% vs. 15.9%, p =
High-molecular-weight glutenin subunits (HMW-GS) account for only 10% of total wheat storage proteins, but play an important role in the processing quality of wheat flour. Therefore, identifying HMW-GS alleles associated with good end-use quality provides important information for wheat breeders. To rapidly, accurately and reproducibly identify HMW-GS, we established an optimized reversed-phase ultra-performance liquid chromatography (RP-UPLC) method. Separation parameters were optimized using a
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