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SukHo Lee

Seoul National University · Medicine

About the Lab

Professor Suk-Ho Lee's research lab specializes in skeletal muscle physiology, focusing on the mechanisms underlying muscle hypertrophy, atrophy, and regeneration. The lab investigates the effects of resistance training, growth factors such as IGF-I, and rehabilitative interventions like acupuncture and electrical stimulation on muscle mass and function in rodent models. Key research directions include understanding the interaction between anabolic signaling pathways and exercise, the long-term effects of detraining and retraining, and the clinical implications for musculoskeletal health and rehabilitation. The lab also explores inflammatory and immune-related conditions affecting the sinuses, particularly those involving eosinophils and fungal sensitivity.

muscle hypertrophyresistance trainingdetraining and retrainingskeletal muscle atrophyIGF-I signaling

Research Overview

Papers
193
Total Citations
1,650
Papers (5y)
33
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
33total
2022
2023
2024
2025
2026
Citations per year (5y)
60total
20222023202420252026

Selected Papers

15
1
Article|195 citations·2004
Viral expression of insulin-like growth factor-I enhances muscle hypertrophy in resistance-trained rats
Sukho Lee, Elisabeth R. Barton, H. Lee Sweeney, Roger P. Farrar
SJR Q1Journal of Applied Physiology

Muscle hypertrophy is the product of increased drive through protein synthetic pathways and the incorporation of newly divided satellite cells. Gains in muscle mass and strength can be achieved through exercise regimens that include resistance training. Increased insulin-like growth factor-I (IGF-I) can also promote hypertrophy through increased protein synthesis and satellite cell proliferation. However, it is not known whether the combined effect of IGF-I and resistance training results in an

Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
Article|50 citations·2003
Resistance training induces muscle-specific changes in muscle mass andfunction in rat
Sukho Lee, Roger P. Farrar

RESISTANCE TRAINING INDUCES MUSCLE -SPECIFIC CHANGES IN MUSCLE MASS AND FUNCTION IN RAT. Sukho Lee, Roger P. Farrar. JEPonline. 2003;6(2):80-87. Resistance exercise is frequently used to induce hypertrophy in animal model. T his study examined the effects of 8 weeks of resistance training followed by 4 to 8 weeks of detraining on muscle mass and function. The resistance training consisted of climbing (5 reps/3 sets) a ladder carrying a load suspended from the tail. The weights were increased gra

Orthopedics and Sports MedicineMedicine
3
Article|22 citations·2012
Swimming exercise during pregnancy alleviates pregnancy-associated long-term memory impairment
Ki-Jeong Kim, Eunhee Chung, Chang‐Ju Kim, Sukho Lee
SJR Q2Physiology & Behavior
Developmental NeuroscienceNeuroscience
4
Review|22 citations·2016
Sport-based physical activity intervention on body weight in children and adolescents: a meta-analysis
Kyungun Kim, Gina Ok, Soeun Jeon, Minsoo Kang, Sukho Lee
SJR Q1Journal of Sports Sciences

Controversial results reported in past research pertaining to the effectiveness of sport-based physical activity interventions on weight loss. The purpose of this study was to assess the impact of sport-based physical activity intervention on body weight in children and adolescents using a meta-analysis. Academic Search Complete, Education Source, ERIC, Medline, ProQuest, PsycINFO and SportDiscus databases were searched from January 2000 to April 2015. Eighteen studies met following inclusion cr

Public Health, Environmental and Occupational HealthMedicine
5
Article|21 citations·2015
Categorization and Clinicopathological Features of Chronic Rhinosinusitis With Eosinophilic Mucin in a Korean Population
Sukho Lee, Hak Jun Kim, Jin Woo Lee, Young Hoon Yoon, Yong Min Kim, Ki‐Sang Rha
SJR Q1Clinical and Experimental OtorhinolaryngologyOA

OBJECTIVES: Chronic rhinosinusitis (CRS) with eosinophilic mucin is relatively rare in Korea. We categorized CRS patients with characteristic eosinophilic mucin into several groups and compared the groups based on their clinicopathological features. METHODS: In total, 52 CRS patients with eosinophilic mucin were enrolled. Based on the presence or absence of an allergy (A) to a fungus or fungal element (F) in the mucin, the patients were divided into four groups: allergic fungal rhinosinusitis (A

OtorhinolaryngologyMedicine
6
Article|19 citations·2016
Effect of previous strength training episode and retraining on facilitation of skeletal muscle hypertrophy and contractile properties after long-term detraining in rats
Sukho Lee, Kwangseok Hong, Kijeong Kim
SJR Q2Journal of Exercise RehabilitationOA

In the present study, we investigated the effects of previous strength training and retraining following long-term cessation of exercise on muscle mass and contractile properties. Female Sprague-Dawley rats (n=24) aged eight weeks were randomly assigned one of the four groups: control (CON), detraining (DT), training (TR), and retraining (RT). The training regimen consisted of climbing ladder 5×3 sets, once every third day for eight weeks with weight attached to the tail. The weight carried duri

Molecular BiologyBiochemistry, Genetics and Molecular Biology
7
Article|18 citations·2023
Attenuation of skeletal muscle atrophy via acupuncture, electro-acupuncture, and electrical stimulation
T. Brock Symons, Jinho Park, Joo Hyun Kim, Eun Hye Kwon, Jesse Delacruz, Junghoon Lee, Yoonjung Park, Eunhee Chung, Sukho Lee
SJR Q2Integrative Medicine ResearchOA

Skeletal muscle atrophy, induced by 14 days of cast-immobilization, was significantly attenuated by acupuncture, electro-acupuncture, or electrical stimulation.

Molecular BiologyBiochemistry, Genetics and Molecular Biology
8
Article|14 citations·2017
Acute effects of Kinesio taping on muscle function and self‐perceived fatigue level in healthy adults
Nan Hee Lee, Hyun Chul Jung, Gina Ok, Sukho Lee
SJR Q1European Journal of Sport Science

This study investigated the acute effects of Kinesio taping (KT) on muscular power, strength, endurance, and self-perceived fatigue level. This is a randomized, partial double-blind, crossover trial. Eighteen healthy adults (7 males [23.86 ± 1.68 years] and 11 females [24.82 ± 3.71 years]) were enrolled in this study. All subjects underwent three different trials which included no tap (NT), placebo tap (PT), and KT. Idividuals were assessed for peak and mean power, muscular strength and enduranc

Orthopedics and Sports MedicineMedicine
9
Article|10 citations·2020
Body fat-related differences in gait parameters and physical fitness level in weight-matched male adults
Hye‐Jung Choi, Jongil Lim, Sukho Lee
SJR Q3Clinical Biomechanics
PhysiologyMedicine
10
Article|8 citations·2020
Impact of Placement of Fitbit HR under Laboratory and Free-Living Conditions
Hyun Chul Jung, Minsoo Kang, Nan Hee Lee, Soeun Jeon, Sukho Lee
SJR Q1SustainabilityOA

Wrist-worn activity monitors have become accessible for measuring physical activities, but an activity monitor’s accuracy worn at different placements is not well understood. This study aimed to examine the differences in measurements of heart rates, step counts, and calories estimated from the fitness tracker worn at different locations and the accuracy of Fitbit HR against criterion measures. Thirty-two healthy adults participated in this study. Participants wore Fitbit HR at four different lo

Complementary and alternative medicineMedicine
11
Article|7 citations·2016
Interaction of Resistance Training, Electroacupuncture and Huang Qi supplementation on skeletal muscle function and GLUT4 protein concentration in rats
Sukho Lee, Ki-Jeong Kim, Nathalie Lambrecht, Junyoung Hong, Yi‐Hung Liao, Aram Yoon, Jeffrey R. Bernard
SJR Q1Acupuncture in Medicine

OBJECTIVE: To determine the effects and potential synergy of resistance training (RT), Huang Qi (HQ) herbal supplementation, and electroacupuncture (EA) on skeletal muscle mass, contractile properties, and components of the insulin signalling pathway in healthy Sprague Dawley rats. METHODS: Female Sprague Dawley rats were randomly assigned to one of five groups (n=8 each): control (CON), RT only, RT with EA (RT-EA), RT with HQ (RT-HQ), and RT combined with both EA and HQ (RT-EA-HQ). RT was perfo

Complementary and alternative medicineMedicine
12
Article|7 citations·2020
The Effects of Wild Ginseng Extract on Psychomotor and Neuromuscular Performance Recovery Following Acute Eccentric Exercise: A Preliminary Study
Hyun Chul Jung, Nan Hee Lee, Young Chan Kim, Sukho Lee
SJR Q2Applied SciencesOA

To examine the efficacy of wild ginseng extract (WGE) on psychomotor and neuromuscular performance recovery following acute eccentric exercise. This study was a double-blind, crossover, and placebo-controlled design with a 14-day washout period. Ten male adults, aged 27.1 ± 4.33 years old, voluntarily participated in the study. Subjects were assigned to one of two parallel conditions (WGE or placebo) in a counterbalanced manner. Subjects consumed two packs of WGE (350 mg/package) or placebo drin

Molecular BiologyBiochemistry, Genetics and Molecular Biology
13
Article|5 citations·2022
Maternal low-intensity exercise and probiotic ingestion during pregnancy improve physical ability and brain function in offspring mice
June-Chul Kim, Sukho Lee
SJR Q1Journal of Functional FoodsOA

Appropriate exercise during pregnancy is known to benefit the fetus. Recently, providing probiotics during pregnancy has been shown to affect offspring positively. However, the effectiveness of exercise coupled with taking probiotics and the effects on the brain and immunity as well as the physical fitness of the offspring remains unclear. In this study, we investigate the effect of low-intensity exercise and probiotic ingestion during pregnancy on offspring mice. C57BL/6J pregnant mice were sub

Nutrition and DieteticsNursing
14
Article|5 citations·2003
Insulin-like growth factor-1 induces skeletal muscle hypertrophy
Sukho Lee

One of the primary mechanisms controlling skeletal muscle hypertrophy is satellite cell activation, proliferation and differentiation. Insulin-like growth factor-1 (IGF-1) has been shown to stimulate satellite cell proliferation and fusion in rat skeletal muscle and to increase myofiber size and myonuclei number in tissue. This brief review presents the basic information about IGF-1 itself, IGF-1 receptor, different kinds of IGF binding proteins and signaling pathway for biological action of IGF

Molecular BiologyBiochemistry, Genetics and Molecular Biology
15
Article|5 citations·2011
High Fat Caloric Consumption and Low Levels of Physical Activity May Induce Prevalence of Obesity in Hispanic American Children
Sukho Lee, Kwangseok Hong, Cordelia R. Rodriguez
IJASS(International Journal of Applied Sports Sciences)OA

The number of obese youth has increased dramatically in recent decades, yet very little data has assessed how children`s lifestyles have led to this increase in obesity. This study investigated possible factors (media viewing, dietary patterns, and levels of physical activity) contributing to the prevalence in obese Hispanic American children. Twenty-four Hispanic boysaged 6-13 years were recruited. Based on initial body mass index screenings, the subjects were assigned to either a control or ob

Public Health, Environmental and Occupational HealthMedicine

Research Areas

Molecular BiologyPublic Health, Environmental and Occupational HealthGeneral Health ProfessionsOrthopedics and Sports MedicineComplementary and alternative medicinePhysiology

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