Skip to main content

Sung Hyun Lee

Seoul National University · Medicine

About the Lab

Professor Sung Hyun Lee's research lab specializes in radiation biology and microdosimetry, focusing on the biological effects of heavy-ion radiation using advanced microdosimetric techniques. The lab applies the microdosimetric kinetic (MK) model to predict relative biological effectiveness (RBE) and cell survival in cancer cells exposed to various ion beams, such as helium, carbon, oxygen, and neon. Additionally, the lab investigates radioprotective agents and natural compounds—like Cirsium setidens—for their hepatoprotective and antioxidant properties, and explores the application of ionizing radiation in parasitic disease control. The integration of silicon-based microdosimeters and in vitro biological assays enables precise radiation risk assessment and therapeutic optimization.

microdosimetryradiation biologyheavy-ion therapyradioprotectionradiation therapy

Research Overview

Papers
116
Total Citations
753
Papers (5y)
52
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
52total
2022
2023
2024
2025
2026
Citations per year (5y)
146total
20222023202420252026

Selected Papers

15
1
Article|48 citations·2017
Wastewater treatment and electricity generation from a sunlight-powered single chamber microbial fuel cell
Sung Hyun Lee, Kyeong-Seok Lee, Saurav Sorcar, Abdul Razzaq, Craig A. Grimes, Su‐Il In
SJR Q2Journal of Photochemistry and Photobiology A Chemistry
Environmental EngineeringEnvironmental Science
2
Article|35 citations·2008
Antioxidant and Hepatoprotective Activities of Cirsium setidens NAKAI against CCl4-Induced Liver Damage
Sung Hyun Lee, Seong-Il Heo, Lan Li, Min Jie Lee, Myeong‐Hyeon Wang
SJR Q1The American Journal of Chinese Medicine

The antioxidant activity and hepatoprotective potential of Cirsium setidens Nakai, a widely used medicinal plant, were investigated. The n-butanol (n-BuOH) fraction of leaves and roots of C. setidens had a higher 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity than the other soluble fractions. The n-BuOH fraction of roots of C. setidens had a significant hepatoprotective activity at a dose of 500 mg/kg compared to that of a standard agent. The biochemical results were confirmed

Pulmonary and Respiratory MedicineMedicine
3
Article|23 citations·2020
Estimating the biological effects of helium, carbon, oxygen, and neon ion beams using 3D silicon microdosimeters
Sung Hyun Lee, Kota Mizushima, Ryosuke Kohno, Y. Iwata, Shunsuke Yonai, Toshiyuki Shirai, Vladimir Pan, David Bolst, Linh T. Tran, Anatoly Rosenfeld, Masao Suzuki, Taku Inaniwa
SJR Q1Physics in Medicine and BiologyOA

Abstract In this study, the survival fraction (SF) and relative biological effectiveness (RBE) of pancreatic cancer cells exposed to spread-out Bragg peak helium, carbon, oxygen, and neon ion beams are estimated from the measured microdosimetric spectra using a microdosimeter and the application of the microdosimetric kinetic (MK) model. To measure the microdosimetric spectra, a 3D mushroom silicon-on-insulator microdosimeter connected to low noise readout electronics (MicroPlus probe) was used.

Pulmonary and Respiratory MedicineMedicine
4
Article|19 citations·2004
Polycrystalline sputtered Cd(Zn, Mn)Te films for top cells in PV tandem structures
Sung Hyun Lee, Akhlesh Gupta, A. Compaan
Physica status solidi. C, Conferences and critical reviews/Physica status solidi. C, Current topics in solid state physics

The CdTe-ZnTe or CdTe–MnTe alloy system is evaluated for application in high efficiency polycrystalline thin film multijunction solar cells. CdZnTe alloy films with 1.6 and 1.7 eV band gap and CdMnTe with 1.6 and 1.8 eV were deposited by RF magnetron sputtering from targets made of mixed powders of CdTe and ZnTe (25% and 40%) or MnTe (13% and 25%), respectively. Without postdeposition treatment, however, both of these alloy films exhibit quite low photovoltaic performance when used to make cells

Electrical and Electronic EngineeringEngineering
5
Article|18 citations·1989
The effects of gamma irradiation on the survival and development of Clonorchis sinensis metacercariae
Sung Hyun Lee, Yeoung‐Hyun Park, W M Sohn, Sung‐Tae Hong, J Y Chai
Korean Journal of ParasitologyOA

The effects of gamma irradiation on the survival and development of C. sinensis metacercariae were studied to evaluate the feasibility of irradiation as a control measure for clonorchiasis. Pseudorasbora parva were collected at an endemic river of clonorchiasis and were used for irradiation of the fluke in three schemes. The first (Scheme 1) was irradiation of the isolated metacercariae from the fish followed by infection to experimental rats. The second (Scheme 2) was irradiation of the fish, a

EcologyEnvironmental Science
6
Article|9 citations·2021
Amplitude-modulated continuous wave scanning LIDAR based on parallel phase-demodulation
Sung Hyun Lee, Wook-Hyeon Kwon, Yong‐Hwa Park

Light detection and ranging (LIDAR) is one of solutions to extract 3D depth image of objects. Especially, as fabrication process of silicon image sensor has been progressed, amplitude-modulated continuous wave (AMCW) time-of-flight (ToF) cameras have been widely used due to their relatively cheap price and high measurement accuracy. However, to estimate ToF, reflected laser signal should be sequentially demodulated using optoelectronic device such as demodulation pixel, which induces relatively

InstrumentationPhysics and Astronomy
7
Article|8 citations·2022
Predicting the Biological Effects of Human Salivary Gland Tumour Cells for Scanned 4He-, 12C-, 16O-, and 20Ne-Ion Beams Using an SOI Microdosimeter
Sung Hyun Lee, Kota Mizushima, Shunsuke Yonai, Shinnosuke Matsumoto, Hideyuki Mizuno, Taku Nakaji, Ryosuke Kohno, Y. Iwata, Toshiyuki Shirai, Vladimir Pan, Angela Kok, Marco Povoli
SJR Q2Applied SciencesOA

Experimental microdosimetry along with the microdosimetric kinetic (MK) model can be utilized to predict the biological effects of ions. To predict the relative biological effectiveness (RBE) of ions and the survival fraction (SF) of human salivary gland tumour (HSGc-C5) cells, microdosimetric quantities measured by a silicon-on-insulator (SOI) MicroPlus-mushroom microdosimeter along the spread-out Bragg peak (SOBP) delivered by pencil beam scanning of 4He, 12C, 16O, and 20Ne ions were used. The

Pulmonary and Respiratory MedicineMedicine
8
Article|6 citations·2017
A carbon CT system: how to obtain accurate stopping power ratio using a Bragg peak reduction technique
Sung Hyun Lee, Naoki Sunaguchi, Yoshiyuki Hirano, Yosuke Kano, Chang Liu, M. Torikoshi, Tatsuya Ohno, Takashi Nakano, Tatsuaki Kanai
SJR Q1Physics in Medicine and Biology

In this study, we investigate the performance of the Gunma University Heavy Ion Medical Center's ion computed tomography (CT) system, which measures the residual range of a carbon-ion beam using a fluoroscopy screen, a charge-coupled-device camera, and a moving wedge absorber and collects CT reconstruction images from each projection angle. Each 2D image was obtained by changing the polymethyl methacrylate (PMMA) thickness, such that all images for one projection could be expressed as the depth

Pulmonary and Respiratory MedicineMedicine
9
Article|4 citations·2018
A Study on the Application of Coastal Disaster Prevention Considering Climate Change
Sung Hyun Lee, Bo Ram Kim, Jun Hyeok Im, Kuk Ryul Oh, Ou Bae Sim
Journal of Climate Change Research

Korea is surrounded by the West Sea, the South Sea, and the East Sea. There are various points at which large and small rivers flow into the sea, and areas where these rivers meet the coast are vulnerable to disasters. Thus, it is necessary to study disaster prevention techniques based on coastal characteristics and the pattern of disasters. In this study, we analyzed the risk factors of disaster districts analyzed in comprehensive plans for the reduction of damage to coastal cities from storms

Ocean EngineeringEngineering
10
Article|4 citations·2001
A study on new‐shaped sustaining electrode showing high luminous efficiency in AC PDPs
Sung Hyun Lee, Dong‐Hyun Kim, Jae Young Lee, Chung Hoo Park, Jae Hwa Ryu
SJR Q1Journal of Information DisplayOA

Abstract In order to improve the luminous efficiency in ac PDP(Plasma Display Panel), we have suggested a new bridge type sustaining electrode which makes it possible to have free alignment between front and rear panels. The luminous efficiency of the ac PDP with suggested new sustaining electrode is improved by about 28 % compared with that of conventional sustaining electrode. However, the luminance of the ac PDP with the suggested electrode is kept the same with the conventional ones.

Electrical and Electronic EngineeringEngineering
11
Article|4 citations·2021
Calculation of Stopping-Power Ratio from Multiple CT Numbers Using Photon-Counting CT System: Two- and Three-Parameter-Fitting Method
Sung Hyun Lee, Naoki Sunaguchi, Akie Nagao, Yoshiyuki Hirano, Hiroshi Sakurai, Yosuke Kano, M. Torikoshi, Tatsuaki Kanai, Mutsumi Tashiro
SJR Q1SensorsOA

The two-parameter-fitting method (PFM) is commonly used to calculate the stopping-power ratio (SPR). This study proposes a new formalism: a three-PFM, which can be used in multiple spectral computed tomography (CT). Using a photon-counting CT system, seven rod-shaped samples of aluminium, graphite, and poly(methyl methacrylate) (PMMA), and four types of biological phantom materials were placed in a water-filled sample holder. The X-ray tube voltage and current were set at 150 kV and 40 μA, respe

Biomedical EngineeringEngineering
12
Article|4 citations·2022
Distance measurement error compensation using machine learning for laser scanning AMCW time-of-flight sensor
Sung Hyun Lee, Wook Hyeon Kwon, Yoon-Seop Lim, Yong‐Hwa Park

Amplitude-modulated continuous wave (AMCW) time-of-flight (ToF) sensor is widely used to capture 3D information of objects due to its relatively high measurement precision in short range. However, the measurement accuracy of AMCW ToF measurement method is generally sensitive to the reflectivity of object, internal stray light, modulation instability, and external light. Consequently, distance measurement error inevitably occurs even in indoor measurement condition. To compensate such error, a po

InstrumentationPhysics and Astronomy
13
Article|3 citations·2023
Error on the stopping power ratio of ERKODENT's mouthpiece for head and neck carbon ion radiotherapy treatment
Sung Hyun Lee, Takayuki Kanai, Hikaru Souda, Yuya Miyasaka, Hongbo Chai, Takuya Ono, Yoshifumi Yamazawa, Koji Suzuki, Azusa Sato, Masashi Katsumata, Takeo Iwai
SJR Q1Journal of Applied Clinical Medical PhysicsOA

The errors on the stopping power ratio (SPR) of mouthpiece samples from ERKODENT were evaluated. Erkoflex and Erkoloc-pro from ERKODENT and samples that combined Erkoflex and Erkoloc-pro were computed tomography (CT)-scanned using head and neck (HN) protocol at the East Japan Heavy Ion Center (EJHIC), and the values were averaged to obtain the CT number. The integral depth dose of the Bragg curve with and without these samples was measured for 292.1, 180.9, and 118.8 MeV/u of the carbon-ion penc

Pulmonary and Respiratory MedicineMedicine
14
Article|3 citations·2020
Effect of general ion recombination on dose measurement for high dose rate carbon-ion scanning beam
Sung Hyun Lee, Ryohei Tansho, Kota Mizushima, T. Furukawa, Yousuke Hara, Y. Saraya, Naoya Saotome, Toshiyuki Shirai
SJR Q3Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms
Pulmonary and Respiratory MedicineMedicine
15
Article|2 citations·2013
Quantitative analysis of dose distribution to determine optimal width of respiratory gating window using Gafchromic EBT2 film
Sung Hyun Lee, Kum Bae Kim, Mi‐Sook Kim, Hyung‐Jun Yoo, Seung Woo Park, Haijo Jung, Young Hoon Ji, Chul‐Young Yi
SJR Q3Journal of the Korean Physical Society

The purpose of this study was to determine the dependence of the dose distribution on the width of the respiratory gating window by using radiochromic Gafchromic EBT2 film. An in-house three-dimensional breathing simulator was used with a 4-s cycle and a 3-cm movement. The gamma index and the 50, 95, and 20–80% dose distributions were individually analyzed with regard to static, 100 (full motion), 60, 40, 30, 20, and 15% respiratory gating windows. In addition, dose differences based on the diff

RadiationPhysics and Astronomy

Research Areas

Pulmonary and Respiratory MedicineElectrical and Electronic EngineeringRadiationInstrumentationEnvironmental EngineeringBiomedical Engineering

Dive deeper into Sung Hyun Lee's research on Nubint

Open this lab's papers in the app to read with AI, summarize, and cite in your writing.