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Sung-sin Shim

Ewha Womans University · Medicine

About the Lab

Professor Sung-sin Shim's research lab specializes in maternal-fetal medicine and diagnostic imaging, with a focus on improving prenatal diagnosis and maternal-fetal outcomes. The lab investigates biomarkers such as PAPP-A, sFlt-1/PlGF ratio, and AMH to predict fetal chromosomal abnormalities and preeclampsia, particularly in high-risk pregnancies. It also explores advanced imaging techniques, including cone beam CT-guided biopsies and fluoroscopy, to enhance diagnostic accuracy in pulmonary and oncological conditions. Additionally, the lab contributes to laryngeal interventions, evaluating alternative approaches for vocal fold paralysis in patients with prior neck surgeries.

prenatal diagnosispreeclampsia predictionbiomarkers in pregnancymedical imagingmaternal-fetal health

Research Overview

Papers
68
Total Citations
511
Papers (5y)
11
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
11total
2020
2021
2023
2024
2025
Citations per year (5y)
45total
20202021202320242025

Selected Papers

15
1
Article|70 citations·2013
Maternal age-specific rates of fetal chromosomal abnormalities in Korean pregnant women of advanced maternal age
Young Joo Kim, Jee Eun Lee, Soo Hyun Kim, Sung Shin Shim, Dong Hyun
SJR Q2Obstetrics & Gynecology ScienceOA

This study demonstrates that AMA is no longer used as a threshold for determination of who is offered prenatal diagnosis, but is a common risk factor for fetal chromosomal abnormalities.

Pediatrics, Perinatology and Child HealthMedicine
2
Article|55 citations·2018
High blood neutrophil-lymphocyte ratio associated with poor outcomes in miliary tuberculosis
Yeji Han, Soo Jung Kim, Su Hwan Lee, Yun Su Sim, Yon Ju Ryu, Jung Hyun Chang, Sung Shin Shim, Yookyung Kim, Jin Hwa Lee
SJR Q2Journal of Thoracic DiseaseOA

Pre-treatment NLR at admission may be a useful biomarker for mortality and development of ARDS in patients with miliary TB.

OncologyMedicine
3
Article|54 citations·2014
Screening models using multiple markers for early detection of late-onset preeclampsia in low-risk pregnancy
Hee Jin Park, Soo Hyun Kim, Yong Wook Jung, Sung Shin Shim, Ji Yeon Kim, Yeon Kyung Cho, Antonio Farina, Margherita Zanello, Kyoung Jin Lee, Dong Hyun
SJR Q1BMC Pregnancy and ChildbirthOA

The combination of the PAPP-A level and the second trimester sFlt-1/PlGF ratio, and the combination of the second trimester sFlt-1 level with body mass index, were better predictors of late-onset preeclampsia than any individual marker.

Obstetrics and GynecologyMedicine
4
Article|44 citations·2010
Global Gene Expression Changes Induced in the Human Placenta during Labor
K.J. Lee, Sang‐Hee Shim, Kyung Min Kang, Jung Hoon Kang, D.Y. Park, S.H. Kim, Antonio Farina, Sung Shin Shim, D.H. Cha
SJR Q1Placenta
EpidemiologyMedicine
5
Article|39 citations·2000
US and CT findings of tuberculosis of the thyroid: three case reports
Byung Chul Kang, Sun-Wha Lee, Sung Shin Shim, Hye-Young Choi, Seung-Yon Baek, Young Koog Cheon
SJR Q2Clinical Imaging
SurgeryMedicine
6
Article|27 citations·2011
Combined Fluoroscopy- and CT-Guided Transthoracic Needle Biopsy Using a C-Arm Cone-Beam CT System: Comparison with Fluoroscopy-Guided Biopsy
정주연, 김유경, 심성신, 임수미

Objective: The aim of this study was to evaluate the usefulness of combined fl uoroscopy- and CT-guided transthoracic needle biopsy (FC-TNB) using a cone beam CT system in comparison to fl uoroscopy-guided TNB (F-TNB). Materials and Methods: We retrospectively evaluated 74 FC-TNB cases (group A) and 97 F-TNB cases (group B) to compare their respective diagnostic accuracies according to the size and depth of the lesion, as well as complications, procedure time, and radiation dose. Results: The se

7
Article|23 citations·2010
Comparative Analysis of Efficiency of Injection Laryngoplasty Technique for with or without Neck Treatment Patients: A Transcartilaginous Approach Versus the Cricothyroid Approach
이승원, 김재욱, 고윤우, 심성신, 손영익

Objectives. These days, the main injection laryngoplasty technique is cricothyroid (CT) approach. However, patients who have previously undergone other neck treatments, such as thyroidectomy or neck dissection have distorted anatomical landmark makes this approach more difficult. The aim of this study is to determined the efficiency of transcartilaginous (TC) approah as compared with CT approach for unilateral vocal fold paralysis patients, especially for previously neck treated patients. Method

8
Article|23 citations·2010
Novel influenza A (H1N1) infection: chest CT findings from 21 cases in Seoul, Korea
Sung Shin Shim, Yujeong Kim, Yon Ju Ryu
SJR Q2Clinical Radiology
EpidemiologyMedicine
9
Article|18 citations·2008
Intima-Media Thickness and Pulse Wave Velocity in Hypertensive Adolescents
Tae Young Gil, Choi Youn Sung, 심성신, 홍영미
http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0191120080230010035

Increased intima-media thickness (IMT) and pulse wave velocity (PWV) are noninvasive markers of early arterial wall alteration and are more widely used in adult clinical research. We investigated whether IMT and PWV are useful predictors of cardiovascular risk in hypertensive adolescents. Fifteen hypertensive adolescents (13-18 yr old, systolic BP ≥140 mmHg, diastolic BP ≥90 mmHg) and seventeen normotensive subjects were included. Height, weight, obesity index, body mass index (BMI), and fat dis

10
Article|18 citations·2015
Maternal antimullerian hormone as a predictor of fetal aneuploidy occurring in an early pregnancy loss
So Hyun Shim, Hyeong In Ha, Yong Wook Jung, Sung Shin Shim, Yeon Kyung Cho, Ji Youn Kim, Kyoung Jin Lee, Dong Hyun, Soo Hyun Kim, Hee Jin Park
SJR Q2Obstetrics & Gynecology ScienceOA

Low maternal AMH level might be a predicting marker for fetal aneuploid in early pregnancy loss.

Pediatrics, Perinatology and Child HealthMedicine
11
Article|13 citations·2016
The usefulness of low-dose CT scan in elderly patients with suspected acute lower respiratory infection in the emergency room
Ji Eun Park, Yookyung Kim, So W Lee, Sung Shin Shim, Jeong K. Lee, Jin H. Lee
SJR Q1British Journal of Radiology

OBJECTIVE: To evaluate the usefulness of low-dose CT (LDCT) for the diagnosis of acute lower respiratory infection (ALRI) in elderly patients in the emergency room (ER). METHODS: A total of 160 consecutive patients (mean age: 75.9 ± 9.2 years; range: 60-97 years), who were diagnosed to have ALRI by LDCT in the ER, were enrolled in this study. Initial chest radiograph (CR) and CT patterns of ALRI were analysed, and clinical courses of patients were assessed. RESULTS: 49 patients showed negative C

Critical Care and Intensive Care MedicineMedicine
12
Review|13 citations·2019
Spontaneous remission of advanced progressive poorly differentiated non-small cell lung cancer: a case report and review of literature
Hee‐Young Yoon, Heae Surng Park, Min Sun Cho, Sung Shin Shim, Yookyung Kim, Jin Hwa Lee
SJR Q2BMC Pulmonary MedicineOA

BACKGROUND: Spontaneous remission (SR) of cancer is a very rare phenomenon of unknown mechanism. In particular, SR of non-small cell lung cancer (NSCLC) has been scarcely reported. We present the case of a 74-year-old woman with advanced, poorly differentiated NSCLC (highly expressing programmed death ligand-1 [PD-L1]) that progressed despite multiple lines of chemotherapy but then spontaneously remitted. CASE PRESENTATION: The patient presented with hemoptysis and was diagnosed with stage IIIA

BiotechnologyBiochemistry, Genetics and Molecular Biology
13
Article|12 citations·2018
Predictive factor for volume reduction of uterine fibroids after short-term use of ulipristal acetate
Bo Seong Yun, Seok Ju Seong, Yong Wook Jung, Mi‐La Kim, Hyo Sook Bae, Mi Kyoung Kim, Sung Shin Shim
SJR Q2European Journal of Obstetrics & Gynecology and Reproductive Biology
Obstetrics and GynecologyMedicine
14
Article|11 citations·2021
The impacts of insufficient sleep and its change during pregnancy on postpartum depression: A prospective cohort study of Korean women
Bo Seong Yun, So Hyun Shim, So Hyun Shim, Hee Young Cho, Seok‐Jae Heo, Inkyung Jung, Haeng Jun Jeon, You Jung Han, Dong Wook Kwak, Min Hyung Kim, Hyojin Park, Jin Hoon Chung
SJR Q1International Journal of Gynecology & ObstetricsOA

OBJECTIVE: To determine the association between insufficient sleep in the prenatal period and postpartum depression (PPD), and whether changes in sleep patterns during pregnancy increase the risk of PPD. METHODS: A prospective cohort study was conducted between March 2013 and November 2017. Participants completed a sleep questionnaire pre-pregnancy and at 12, 24 and 36 gestational weeks (GW). Depressive symptoms were assessed by the Edinburgh Postnatal Depression Scale (EPDS) at 4 weeks postpart

Experimental and Cognitive PsychologyPsychology
15
Article|6 citations·2024
Endometrial E-cadherin and N-cadherin Expression during the Mid-Secretory Phase of Women with Ovarian Endometrioma or Uterine Fibroids
Bo Seong Yun, Na Yeon Yun, Jung Eun Lee, Minyeon Go, Hee Yeon Jang, Ji Eun Park, Ju‐Won Roh, Sung Shin Shim
SJR Q2Journal of Personalized MedicineOA

BACKGROUND: Endometriosis and uterine fibroids are benign conditions frequently linked to subfertility/infertility. Recent research has highlighted the importance of epithelial-mesenchymal transition between embryonic and endometrial cells in the context of embryo implantation. Additionally, the adverse endometrial environment during implantation has been proposed as a mechanism contributing to infertility in endometriosis. Nevertheless, the role of cadherin molecule alterations in relation to e

Reproductive MedicineMedicine

Research Areas

Pediatrics, Perinatology and Child HealthObstetrics and GynecologyEpidemiologySurgeryPulmonary and Respiratory MedicineReproductive Medicine

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