Sung Yeon Kim
Seoul National University · Neuroscience
About the Lab
Professor Sung Yeon Kim's research lab specializes in developing innovative bioengineering and analytical methodologies to address critical challenges in biomedical research and environmental science. The lab focuses on advancing nondestructive tissue processing techniques using electrokinetic principles, such as stochastic electrotransport, for rapid molecular delivery in porous biological samples. It also pioneers microfluidic and hydrogel-based platforms for 3D tissue modeling, particularly in cancer research and angiogenesis, enabling high-resolution visualization and functional assessment of tumor vasculature. Additionally, the lab investigates environmental particulate matter and its health impacts, emphasizing the chemical characterization of airborne PM10 and PM2.5 in urban settings. These interdisciplinary efforts bridge engineering, biology, and environmental science to create transformative tools for precision medicine and public health.
Research Overview
Research Output Trend
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Selected Papers
15Nondestructive chemical processing of porous samples such as fixed biological tissues typically relies on molecular diffusion. Diffusion into a porous structure is a slow process that significantly delays completion of chemical processing. Here, we present a novel electrokinetic method termed stochastic electrotransport for rapid nondestructive processing of porous samples. This method uses a rotational electric field to selectively disperse highly electromobile molecules throughout a porous sam
Abstract Tissue expansion techniques physically expand swellable gel‐embedded biological specimens to overcome the resolution limit of light microscopy. As the benefits of expansion come at the expense of signal concentration, imaging volume and time, and mechanical integrity of the sample, the optimal expansion ratio may widely differ depending on the experiment. However, existing expansion methods offer only fixed expansion ratios that cannot be easily adjusted to balance the gain and loss ass
Three-dimensional (3D) visualization of tumor vasculature is a key factor in accurate evaluation of RNA interference (RNAi)-based antiangiogenic nanomedicine, a promising approach for cancer therapeutics. However, this remains challenging because there is not a physiologically relevant in vitro model or precise analytic methodology. To address this limitation, a strategy based on 3D microfluidic angiogenesis-on-a-chip and 3D tumor vascular mapping was developed for evaluating RNAi-based antiangi
유권자들의정책에대한선호는정당에대한지지와함께가장많이연구된선거결과의결정요인이다. 특히 최근의여러경험적 연구들은미국 등의 선거에서 정책에대한선호가정당에 대한 지지와 더불어 선거결과에강력한 영향을미친다는것을밝히고 있으며, 지금에 와서는 선거결과를설명할때정당지지와함께유권자들의정책선호의영향에주목하는것이일반적이다(Miller and Shanks 1996;Adams et al. 2005; Lewis-Beck et al. 2008). 그러나우리나라의경우 최근들어경제투표, 이념투표, 세대투표 등에 대한 연구는 상당히 진행되었으나 아직까지 정책투표에 대한연구는 거의 이루어지지않았다. 이연구는 2012년2월 말실시된설문조사자료를이용하여우리나라 유권자들의 정책에 대한 선호가 대통령 후보의 선택에 영향을 미치는지 분석한다. 특히, 이 과정에서 정책이슈에대한유권자들의 선호와 아울러 후보들의정책에 대한 유권자들의 인식을 함께 고려한다. 분석결과는정책 선호가 정당지지,출신지역, 나이, 이념 등과 더불어 우리나라
The bed nucleus of the stria terminalis (BNST)-a key part of the extended amygdala-has been implicated in the regulation of diverse behavioral states, ranging from anxiety and reward processing to feeding behavior. Among the host of distinct types of neurons within the BNST, recent investigations employing cell type- and projection-specific circuit dissection techniques (such as optogenetics, chemogenetics, deep-brain calcium imaging, and the genetic and viral methods for targeting specific type
The purpose of this study was to characterize mass concentration of PM10, PM2.5 and metallic composition using Minivol Portable Sampler from May 2003 to May 2004 in metropolitan city, Seoul. Annual average concentration of PM10 were 57.67(±?28.20) mg/m3 and PM2.5 were 42.06(±20.23) mg/m3. The concentration was the highest in winter because persistent thermal inversion and in spring, particulate matter concentration was high because of yellow-sand events. The average PM2.5/PM10 ratio was 0.73. Th
Nanoparticles (NPs) are a promising carrier for cancer therapeutics. Systemically administered NPs are transported to tumor tissues via the bloodstream, extravasated from microvessels, and delivered to cancer cells. The distribution of NPs in the tumor vascular microenvironment critically determines the therapeutic efficacy of NP-delivered drugs, but its precise assessment in 3D across a large volume remains challenging. Here, an analytical platform-termed OMNIA (for Optical Mapping of Nanoparti
선거에서 후보자들의 정책 입장에 대한 유권자들의 인식은 정책 투표(issue voting) 나아가 대의민주주의 작동의 필수적인 기초이다. 그러나 이러한 중요성에도 불구하고 한국 유권자들의 후보자들의 정책 입장에 대한 인식에 관해서는 지금까지 거의 연구가 이루어지지 않았다. 이 연구는 우리나라 유권자들이 선거에서 후보자들의 정책 입장(issue stance)을 어떻게 판단하고 인식하는지 경험적으로 분석한다. 구체적으로 투영 효과(projection effects), 추론 효과(inference-making), 허구적 일치성 효과(false consensus effect) 등 지금까지 제시된 대표적인 설명들이 한국 유권자들에게도 유효한 설명력을 갖는지를 2012년 2월에 실시된 설문 조사 자료를 이용하여 검증한다. 분석 결과는 유권자들의 후보자 선호, 유권자들 자신의 정책 입장, 그리고 정당의 정책 입장에 대한 기존의 지식 등이 유권자들의 판단에 독립적이고도 강력한 영향을 끼친다는 것을
본 연구는 중등수학 강의교재를 대상으로 네트워크 텍스트 분석을 실시하여 향후 수학영재 교재개발 및 수정에 대한시사점을 제안하였다. 분석대상은 2002년부터 2014년까지 한 대학부설 과학영재교육원에서 사용한 110개의 강의교재에 제시되어 있는 학습목표를 활용하였다. 주제어 빈도 분석은 KrKwic, 행렬화 작업은 KrTitle, 사회 네트워크 분석은 NetMiner4.0 프로그램을 활용하였으며, 네트워크의 기본정보, 중심성, 중앙성, 컴포넌트, 그리고 k-코어 분석을 수행하였다. 구체적인 연구결과는 다음과 같다. 첫째, 전체 주제어 네트워크에는 ‘다양성’, ‘이해’, ‘개념’, ‘방법’, ‘적용’, ‘연결성’, ‘문제해결’, ‘기본’, ‘실생활’, 그리고 ‘사고력’ 등을 포함하는 핵심 주제어 네트워크가 형성되어 있으며, 중심성분석 결과 지식 측면이 강의교재에 잘 반영되어 있는 것으로 나타났다. 둘째, 영재교육진흥종합계획 시기별로 주제어네트워크를 분석한 결과, 시기에 상관없이 ‘이해’
The extract of Platycodi radix has long been used as an anti-inflammatory traditional medicine in Korea for the treatment of bronchitis, asthma and acute respiratory disease. In this study, the anti-inflammatory actions of the methanol extract of Platycodi radix administered via oral administration were evaluated. The results revealed that the extracts exhibited potent anti-inflammatory action. Of the hexane, chloroform, ethyl acetate, butanol and water fractions, the butanol fraction had the mo
Research Areas
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