Sungyong Mun

A tandem simulated moving bed (SMB) was developed previously for the purification of insulin from two impurities in two sequential steps. In this study, an efficient optimization tool based on the standing wave design is developed to find the optimal tandem SMB for insulin purification. Both system parameters (total number of columns, zone configuration, column diameter, and column length for each ring) and operating parameters (zone flow rates and switching time for each ring) are optimized to

A tandem simulated moving bed (SMB) has been developed previously to purify insulin from two impurities in two sequential steps. In this study, rate-model simulations are used to investigate how variations in operating and system parameters affect the yield and purity of the SMB. The parameters include the pump outputs, step time, bed voidage, size-exclusion factor, and extra-column dead volume. The results show that a robust pump configuration can minimize the effects of pump output deviations.

One of the prerequisites to the development of a simulated moving bed (SMB) or a temperature-gradient SMB process for separation of succinic acid and lactic acid is to obtain their adsorption equilibrium data on a properly selected adsorbent. It was first found that an Amberchrom CG300C resin could function well as a qualified adsorbent for the separation processes of interest. On the basis of the selected adsorbent, the single-component adsorption equilibria of succinic acid and lactic acid wer