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Won June Lee

Hanyang University · Medicine

About the Lab

Professor Won June Lee's research lab specializes in retinal and anterior segment imaging, with a focus on diabetic retinopathy, glaucoma, and choroidal diseases. The lab employs advanced imaging technologies such as swept-source OCT (SS-OCT) and angiography to investigate early structural and biochemical changes in the retina and choroid. Key research directions include the detection of early glaucomatous progression using wide-field RNFL and GCIPL mapping, the role of inflammatory cytokines in diabetic macular edema and retinal vein occlusion, and the pathophysiology of central serous chorioretinopathy through en face choroidal imaging. The lab integrates clinical ophthalmology with cutting-edge imaging and biomarker analysis to improve early diagnosis and understanding of ocular microvascular and neurodegenerative diseases.

diabetic retinopathyglaucoma imagingswept-source OCTcytokine profilingchoroidal imaging

Research Overview

Papers
146
Total Citations
1,420
Papers (5y)
46
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
46total
2021
2022
2023
2024
2025
Citations per year (5y)
269total
20212022202320242025

Selected Papers

15
1
Article|113 citations·2014
The Relationship Between Diabetic Retinopathy and Diabetic Nephropathy in a Population-Based Study in Korea (KNHANES V-2, 3)
Won June Lee, Lucia Sobrin, Min Jeong Lee, Min Ho Kang, Mincheol Seong, Hee-Yoon Cho
SJR Q1Investigative Ophthalmology & Visual Science

In DM patients, we observed a prevalence of 20.0% for any DR and 3.8% for proliferative diabetic retinopathy (PDR). Microalbuminuria prevalence was 19.3% and overt nephropathy prevalence was 5.5%. The risk factors of microalbuminuria were presence of hypertension; higher systolic blood pressure, serum hemoglobin A1c (HbA1c), and serum blood urea nitrogen level; as well as the presence of PDR. The risk factors of overt nephropathy were long duration of DM; high levels of HbA1c, systolic blood pre

OphthalmologyMedicine
2
Article|98 citations·2012
Comparison of aqueous concentrations of angiogenic and inflammatory cytokines in diabetic macular oedema and macular oedema due to branch retinal vein occlusion
Won June Lee, Min Ho Kang, Mincheol Seong, Hee Yoon Cho
SJR Q1British Journal of Ophthalmology

AIMS: The involvement of cytokines in the aqueous humour is important in the development and progression of diabetic macular oedema (DMO) and macular oedema (MO) due to branch retinal vein occlusion (BRVO-MO). In this study, the concentrations of cytokines in the aqueous humour of eyes with DMO and BRVO-MO were measured and compared. METHODS: Prospective, observational case series. Aqueous samples were obtained from 18 eyes with DMO (DMO group), 12 eyes with BRVO-MO (BRVO-MO group), and 16 norma

OphthalmologyMedicine
3
Article|85 citations·2017
Trend-based Analysis of Ganglion Cell–Inner Plexiform Layer Thickness Changes on Optical Coherence Tomography in Glaucoma Progression
Won June Lee, Young Kook Kim, Ki Ho Park, Jin Wook Jeoung
SJR Q1Ophthalmology
OphthalmologyMedicine
4
Article|72 citations·2019
Differences in eye movement range based on age and gaze direction
Won June Lee, Ji Hong Kim, Yong Un Shin, Sunjin Hwang, Han Woong Lim
SJR Q1EyeOA
EpidemiologyMedicine
5
Article|56 citations·2017
Diagnostic Ability of Wide-field Retinal Nerve Fiber Layer Maps Using Swept-Source Optical Coherence Tomography for Detection of Preperimetric and Early Perimetric Glaucoma
Won June Lee, Kyeong Ik Na, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
SJR Q1Journal of Glaucoma

PURPOSE: To evaluate the diagnostic ability of wide-field retinal nerve fiber layer (RNFL) maps with swept-source optical coherence tomography (SS-OCT) for detection of preperimetric (PPG) and early perimetric glaucoma (EG). METHODS: One hundred eighty-four eyes, including 67 healthy eyes, 43 eyes with PPG, and 74 eyes with EG, were analyzed. Patients underwent a comprehensive ocular examination including red-free RNFL photography, visual field testing and wide-field SS-OCT scanning (DRI-OCT-1 A

OphthalmologyMedicine
6
Article|48 citations·2018
Comparison of glaucoma-diagnostic ability between wide-field swept-source OCT retinal nerve fiber layer maps and spectral-domain OCT
Won June Lee, Sohee Oh, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
SJR Q1Eye
OphthalmologyMedicine
7
Article|36 citations·2016
En face choroidal vascular feature imaging in acute and chronic central serous chorioretinopathy using swept source optical coherence tomography
Won June Lee, Jung Wook Lee, Seung Hun Park, Byung Ro Lee
SJR Q1British Journal of Ophthalmology

En face imaging of SS-OCT is useful when combined with angiography in CSC for evaluating choroidal vessel dilatation at Haller's layer and to identify obscured upper layers. We identified different choroidal vessel dilatation patterns between acute and chronic CSC. These findings might be useful for pathophysiological understanding of CSC.

OphthalmologyMedicine
8
Article|32 citations·2019
Rates of Ganglion Cell-Inner Plexiform Layer Thinning in Normal, Open-Angle Glaucoma and Pseudoexfoliation Glaucoma Eyes: A Trend-Based Analysis
Won June Lee, Sung Uk Baek, Young Kook Kim, Ki Ho Park, Jin Wook Jeoung
SJR Q1Investigative Ophthalmology & Visual ScienceOA

We determined the GCIPL thinning rates for normal and undertreated OAG and PXG eyes. Differences existed among the normal eyes and glaucoma types, with PXG progressing significantly faster than OAG.

OphthalmologyMedicine
9
Article|31 citations·2018
Combined Use of Retinal Nerve Fiber Layer and Ganglion Cell–Inner Plexiform Layer Event-based Progression Analysis
Won June Lee, Kyeong Ik Na, Ahnul Ha, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
SJR Q1American Journal of Ophthalmology
OphthalmologyMedicine
10
Article|29 citations·2018
Serial Combined Wide-Field Optical Coherence Tomography Maps for Detection of Early Glaucomatous Structural Progression
Won June Lee, Tai Jun Kim, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
SJR Q1JAMA OphthalmologyOA

The serial combined wide-field OCT maps integrating RNFL and GCIPL maps performed well in detecting structural progression in early glaucomatous eyes. Confirmation in an independent prospective study might provide greater confidence in this conclusion.

OphthalmologyMedicine
11
Article|28 citations·2017
Rate of Macular Ganglion Cell-inner Plexiform Layer Thinning in Glaucomatous Eyes With Vascular Endothelial Growth Factor Inhibition
Won June Lee, Young Kook Kim, Yong Woo Kim, Jin Wook Jeoung, Seok Hwan Kim, Jang Won Heo, Hyeong Gon Yu, Ki Ho Park
SJR Q1Journal of Glaucoma

PURPOSE: To evaluate the rate of progressive macular ganglion cell-inner plexiform layer (GCIPL) thinning in patients with open-angle glaucoma (OAG) who had been treated with intravitreal antivascular endothelial growth factor (VEGF) injection for wet age-related macular degeneration (AMD). METHODS: This study was a retrospective modified case control study with fellow eye comparison. We enrolled bilateral OAG patients who had been treated with repeated anti-VEGF injections for unilateral wet AM

OphthalmologyMedicine
12
Article|25 citations·2018
Changes in the optic nerve head induced by horizontal eye movements
Won June Lee, Kwang Gi Kim, Suk‐Woo Hong, Sunjin Hwang, Seung Hak Shin, Han Woong Lim
SJR Q1PLoS ONEOA

We found significant morphologic changes in the ONH in both abduction and adduction and these changes were associated with AXL. Considering these morphologic changes as physical properties, it allows a better understanding of the biomechanical characteristics of the ONH.

OphthalmologyMedicine
13
Article|22 citations·2014
Retromode imaging: Review and perspectives
Won June Lee, Byung Ro Lee, Yong Un Shin
SJR Q3Saudi Journal of OphthalmologyOA

Retromode imaging with infrared lasers is a novel imaging method which has been made possible by the newly introduced confocal scanning laser ophthalmoscope. Retromode imaging uses a laterally deviated confocal aperture with a central stop, which creates a shadow and allows deep retinal and retinal pigment epithelium changes to be visualized as pseudo-3-dimensional images. Its clinical value coupled with its simple, rapid, and noninvasive nature is increasingly appreciated. The combination of re

OphthalmologyMedicine
14
Article|18 citations·2011
Intravitreal bevacizumab for severe vaso-occlusive retinopathy in systemic lupus erythematosus
Won June Lee, Hee Yoon Cho, Yoon Jung Lee, Byung Ro Lee, Jae Pil Shin
SJR Q2Rheumatology International
RheumatologyMedicine
15
Article|17 citations·2020
Vulnerability Zone of Glaucoma Progression in Combined Wide-field Optical Coherence Tomography Event-based Progression Analysis
Won June Lee, Ki Ho Park, Mincheol Seong
SJR Q1Investigative Ophthalmology & Visual ScienceOA

The patterns of progressive glaucomatous structural changes in both the peripapillary and macular areas were confirmed on the combined wide-field GPA map (GPA PanoMap). An analysis of the progression pattern using the GPA PanoMap facilitates the understanding of the spatial relation between the peripapillary and macular areas in glaucoma.

OphthalmologyMedicine

Research Areas

OphthalmologyComputational MechanicsRadiology, Nuclear Medicine and ImagingPathology and Forensic MedicineMolecular BiologySociology and Political Science

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