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Won-Seok Kim

Seoul National University · Medicine

About the Lab

Professor Won-Seok Kim's research lab specializes in neurorehabilitation and stroke recovery, with a strong focus on leveraging advanced technologies such as virtual reality (VR) and motion-sensing systems like Kinect to enhance upper limb motor function in stroke patients. The lab investigates innovative, cost-effective, and home-based rehabilitation solutions, integrating biomedical informatics, neuroplasticity, and functional assessment tools to improve patient outcomes. Additionally, the lab explores neuromodulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), for treating neurological deficits in stroke survivors. The research also extends to improving the nutritional quality of staple crops, particularly soybeans, through biotechnological approaches.

stroke rehabilitationvirtual reality therapymotion analysisneuroplasticityfunctional assessment

Research Overview

Papers
373
Total Citations
5,386
Papers (5y)
115
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
115total
2022
2023
2024
2025
2026
Citations per year (5y)
681total
20222023202420252026

Selected Papers

15
1
Review|223 citations·2020
Clinical Application of Virtual Reality for Upper Limb Motor Rehabilitation in Stroke: Review of Technologies and Clinical Evidence
Won‐Seok Kim, Sungmin Cho, Jeonghun Ku, Yuhee Kim, Kiwon Lee, Han-Jeong Hwang, Nam‐Jong Paik
SJR Q1Journal of Clinical MedicineOA

Neurorehabilitation for stroke is important for upper limb motor recovery. Conventional rehabilitation such as occupational therapy has been used, but novel technologies are expected to open new opportunities for better recovery. Virtual reality (VR) is a technology with a set of informatics that provides interactive environments to patients. VR can enhance neuroplasticity and recovery after a stroke by providing more intensive, repetitive, and engaging training due to several advantages, includ

RehabilitationMedicine
2
Article|131 citations·2016
Upper Extremity Functional Evaluation by Fugl-Meyer Assessment Scoring Using Depth-Sensing Camera in Hemiplegic Stroke Patients
Won‐Seok Kim, Sung‐Min Cho, Dongyoub Baek, Hyunwoo Bang, Nam‐Jong Paik
SJR Q1PLoS ONEOA

Virtual home-based rehabilitation is an emerging area in stroke rehabilitation. Functional assessment tools are essential to monitor recovery and provide current function-based rehabilitation. We developed the Fugl-Meyer Assessment (FMA) tool using Kinect (Microsoft, USA) and validated it for hemiplegic stroke patients. Forty-one patients with hemiplegic stroke were enrolled. Thirteen of 33 items were selected for upper extremity motor FMA. One occupational therapist assessed the motor FMA while

RehabilitationMedicine
3
Article|97 citations·2014
Effect of repetitive transcranial magnetic stimulation over the cerebellum on patients with ataxia after posterior circulation stroke: A pilot study
Won‐Seok Kim, So‐Young Jung, Moo-Kyung Oh, Young Gi Min, Jong Youb Lim, Nam‐Jong Paik
SJR Q1Journal of Rehabilitation MedicineOA

This study demonstrated that 1 Hz rTMS over the cerebellum is safe, feasible and may have a beneficial effect in ataxic patients with posterior circulation stroke.

NeurologyNeuroscience
4
Article|78 citations·2018
Health-related quality of life and related factors in stroke survivors: Data from Korea National Health and Nutrition Examination Survey (KNHANES) 2008 to 2014
SuYeon Kwon, Ji-Hong Park, Won‐Seok Kim, Kyungdo Han, Yookyung Lee, Nam‐Jong Paik
SJR Q1PLoS ONEOA

As persons with stroke are surviving longer, monitoring and managing their quality of life is becoming important. We reviewed the Korea National Health and Nutrition Examination Survey (KNHANES) in order to evaluate the health-related quality of life (HRQoL) in stroke survivors as measured by the Euro Quality of Life-5D (EQ-5D), and to find out influencing factors. A total of 42,500 subjects were enrolled in the KNHANES, and 575 of them were persons with stroke. The EQ-5D index was lower in pers

RehabilitationMedicine
5
Article|72 citations·2011
Transgenic soybean plants overexpressing O-acetylserine sulfhydrylase accumulate enhanced levels of cysteine and Bowman–Birk protease inhibitor in seeds
Won‐Seok Kim, Demosthenis Chronis, Matthew Juergens, Amy C. Schroeder, Seung Won Hyun, Joseph M. Jez, Hari B. Krishnan
SJR Q1Planta
Molecular BiologyBiochemistry, Genetics and Molecular Biology
6
Article|60 citations·2004
Expression of an 11 kDa methionine‐rich delta‐zein in transgenic soybean results in the formation of two types of novel protein bodies in transitional cells situated between the vascular tissue and storage parenchyma cells
Won‐Seok Kim, Hari B. Krishnan
SJR Q1Plant Biotechnology JournalOA

Soybean (Glycine max (L.) Merr.) is an important protein source in human diets and animal feeds. The sulphur content of soybean seed proteins, however, is not optimal for ration formulations. Thus, increasing the methionine and cysteine content of soybean seed proteins would enhance the nutritional quality of this widely utilized legume. We have earlier reported the isolation of an 11 kDa delta-zein protein rich in methionine from the endosperm of the maize (Zea mays L.) inbred line W23a1 [Kim,

BiotechnologyBiochemistry, Genetics and Molecular Biology
7
Article|56 citations·2018
A low cost kinect-based virtual rehabilitation system for inpatient rehabilitation of the upper limb in patients with subacute stroke
Won‐Seok Kim, Sung Min Cho, Seo Hyun Park, Ji-Young Lee, SuYeon Kwon, Nam‐Jong Paik
SJR Q3MedicineOA

BACKGROUND: We designed this study to prove the efficacy of the low-cost Kinect-based virtual rehabilitation (VR) system for upper limb recovery among patients with subacute stroke. METHODS: A double-blind, randomized, sham-controlled trial was performed. A total of 23 subjects with subacute stroke (<3 months) were allocated to sham (n = 11) and real VR group (n = 12). Both groups participated in a daily 30-minute occupational therapy for upper limb recovery for 10 consecutive weekdays. Subjects

RehabilitationMedicine
8
Article|55 citations·2020
Low-Frequency Repetitive Transcranial Magnetic Stimulation Over Contralesional Motor Cortex for Motor Recovery in Subacute Ischemic Stroke: A Randomized Sham-Controlled Trial
Won‐Seok Kim, Bum Sun Kwon, Han Gil Seo, Jihong Park, Nam‐Jong Paik
SJR Q1Neurorehabilitation and neural repair

Background Low-frequency repetitive transcranial magnetic stimulation (rTMS) over the contralesional motor cortex (M1) has demonstrated beneficial effects on motor recovery, but evidence among patients with subacute stroke is lacking. We aimed to investigate whether 1-Hz rTMS over the contralesional M1 versus sham rTMS could improve arm function in patients with subacute ischemic stroke when combined with rehabilitative motor training. Methods In total, 77 patients who were within 90 days after

NeurologyNeuroscience
9
Article|51 citations·2013
Incidence of Dysphagia and Serial Videofluoroscopic Swallow Study Findings After Anterior Cervical Discectomy and Fusion
Yu-Sun Min, Won‐Seok Kim, Sung Shik Kang, Jin Man Choi, Jin S. Yeom, Nam‐Jong Paik
SJR Q1Clinical Spine Surgery A Spine Publication

STUDY DESIGN: Prospective study. OBJECTIVE: To prospectively assess the incidence of dysphagia and to present the serial changes of each finding in the videofluoroscopic swallow study (VFSS) after anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: The reported incidence of dysphagia after ACDF has varied widely, and the serial changes of dysphagia using VFSS have not been clearly determined yet. METHODS: Data of 47 patients preoperatively and at 1 week and 1 month postop

SurgeryMedicine
10
Article|44 citations·2002
Secondary electron emission from magnesium oxide on multiwalled carbon nanotubes
Won‐Seok Kim, Whikun Yi, SeGi Yu, Jungna Heo, Taewon Jeong, Jeonghee Lee, Chang‐Soo Lee, J. M. Kim, Hee Jin Jeong, Young Min Shin, Young Hee Lee
SJR Q1Applied Physics Letters

We have investigated effects of electric fields on the yield of secondary electron emission (SEE) from the primary electron bombardment on magnesium oxide (MgO) covering vertically grown multiwalled carbon nanotubes (MWCNTs). We observe that the yield of SEE increases up to at least 22 000 at a special condition. The strong local field generated by the sharp tip of vertically grown MWCNTs accelerates secondary electrons generated by primary electrons. This eventually gives rise to so called Town

Electrical and Electronic EngineeringEngineering
11
Article|44 citations·2005
Improved emission stability of single-walled carbon nanotube field emitters by plasma treatment
Won‐Seok Kim, Jeonghee Lee, Tae Won Jeong, Jung Na Heo, Byung Yoon Kong, Yong Jin, J. M. Kim, Sung Hee Cho, Jong Hwan Park, Duk‐Hyun Choe
SJR Q1Applied Physics Letters

We investigated the effect of plasma treatment on single-walled carbon nanotube (SWCNT) field emitters, which were fabricated by printing a photoimageable SWCNT paste, to improve emission lifetime. The treatment was performed by applying a dc pulsed voltage between two electrodes, where the cathode was the SWCNT emitter to be treated and the anode was a bare indium-doped tin oxide glass, under inert gas (Xe∕Ne) atmosphere. With increasing applied voltage and treatment time, the stability of the

Materials ChemistryMaterials Science
12
Review|42 citations·2019
Transcranial direct current stimulation for the treatment of motor impairment following traumatic brain injury
Won‐Seok Kim, Kiwon Lee, Seonghoon Kim, Sung Min Cho, Nam‐Jong Paik
SJR Q1Journal of NeuroEngineering and RehabilitationOA

After traumatic brain injury (TBI), motor impairment is less common than neurocognitive or behavioral problems. However, about 30% of TBI survivors have reported motor deficits limiting the activities of daily living or participation. After acute primary and secondary injuries, there are subsequent changes including increased GABA-mediated inhibition during the subacute stage and neuroplastic alterations that are adaptive or maladaptive during the chronic stage. Therefore, timely and appropriate

NeurologyNeuroscience
13
Article|38 citations·2014
Effects of proteome rebalancing and sulfur nutrition on the accumulation of methionine rich δ-zein in transgenic soybeans
Won‐Seok Kim, Joseph M. Jez, Hari B. Krishnan
SJR Q1Frontiers in Plant ScienceOA

Expression of heterologous methionine-rich proteins to increase the overall sulfur amino acid content of soybean seeds has been only marginally successful, presumably due to low accumulation of transgenes in soybeans or due to gene silencing. Proteome rebalancing of seed proteins has been shown to promote the accumulation of foreign proteins. In this study, we have utilized RNAi technology to suppress the expression of the β-conglycinin, the abundant 7S seed storage proteins of soybean. Western

Plant ScienceAgricultural and Biological Sciences
14
Review|37 citations·2021
Safety Review for Clinical Application of Repetitive Transcranial Magnetic Stimulation
Won‐Seok Kim, Nam‐Jong Paik
Brain & NeurorehabilitationOA

Studies using repetitive transcranial magnetic stimulation (rTMS) in healthy individuals and those with neuropsychiatric diseases have rapidly increased since the 1990s, due to the potential of rTMS to modulate the cortical excitability in the brain depending on the stimulation parameters; therefore, the safety considerations for rTMS use are expected to become more important. Wassermann published the first safety guidelines for rTMS from the consensus conference held in 1996, and Rossi and coll

NeurologyNeuroscience
15
Article|36 citations·2013
The process design and simulation for the methanol production on the FPSO (floating production, storage and off-loading) system
Won‐Seok Kim, Dae Ryook Yang, Dong Ju Moon, Byoung Sung Ahn
SJR Q2Process Safety and Environmental Protection
CatalysisChemical Engineering

Research Areas

RehabilitationPlant ScienceNeurologyCardiology and Cardiovascular MedicineCognitive NeuroscienceMolecular Biology

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