Woon-Hyung Ryu
Yonsei University · Medicine
About the Lab
Professor Woon-Hyung Ryu's research lab specializes in integrative and regenerative medicine, focusing on the clinical application of Korean medicine for musculoskeletal and neurological disorders. The lab investigates innovative treatments such as motion style acupuncture and pharmacopuncture for conditions like whiplash-associated disorders, shoulder injuries, and Parkinson’s disease-related pain. It also explores bio-hybrid systems, including photosynthetic energy harvesting and nanofabricated polymeric scaffolds for tissue engineering, demonstrating a strong interdisciplinary approach combining traditional medicine with modern biomedical engineering.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15In this single-center, parallel, randomized controlled trial, we aim to examine the effects and safety of motion style acupuncture treatment (MSAT; a combination of acupuncture and Doin therapy) on pain reduction and functional improvement in patients with whiplash-associated disorders (WADs). Ninety-seven patients with cervical pain admitted to the Bucheon Jaseng Hospital of Korean Medicine, South Korea, due to acute whiplash injury were treated with integrative Korean medicine (IKM) with (MSAT
The purpose of this study is to report the improved case of superior labrum from anterior to posterior tear patient treated with Shinbaro pharmacopuncture and motion style acupuncture treatment. We used Shinbaro pharmacopucture, motion style acupuncture treatment and other korean medicine treatment for this patient. This case is measured and assessed by visual analogue scale (VAS), shoulder range of motion (ROM) and shoulder physical examination (Neer test, O'Brien test). After treatment, VAS de
Extraction of photosynthetic currents from thylakoids was studied using micro pillar structured electrode. Thylakoids were isolated from spinach leaves, and the size and shape of thylakoids were estimated from scanning electron microscopy images. Based on the geometry information of thylakoids, micro pillar shaped electrode was designed and fabricated using metal-assisted chemical etching of silicon wafers. Influence of photovoltaic effect on the silicon-based micro pillar electrode was confirme
The purpose of the study is to explore the possibility of Korean medicine treatment on back pain of Parkinson's disease patient through a case study. A Parkinson's disease patient suffering from back pain and both limbs pain was hospitalized and treated with acupuncture and traditional medicine. We evaluated the treatment effect with Numerial Rate Scale (NRS), Oswestry low back pain disability questionnaire (ODI), EuroQol-Five Dimensions (EQ-5D), and Unified Parkinson's Disease Rating Scale (UPD
A simple patterning process combining near-field electrospinning (NFE) and template lithography, callednear-field electrospinning-assisted lithography (NFEAL), was developed to preparepolymeric scaffolds withmicrogroove patterns for potential use in biomedical applications. NFE enabled the deposition of poly(ethylene oxide) (PEO)fibers at a desired position. The diameters of the deposited PEOfibers could becontrolled over a range of 0.5–20 mm by adjusting the NFE parameters such as voltage, dist
Electrical ablation (EA) is a non-thermal ablation technique that causes less damage to the tissuesurrounding the targeted area than conventional thermal ablation. EA induces immunogenic cell death(ICD) and can potentially synergize with cancer immunotherapy. In this study, the optimal voltage andpulse conditions for the induction of ICD were identified. Finite element analysis was used to estimate theablation zone under a variety of voltage and pulse conditions. Cancer cells were cultured in vi
Seung-Hyun Jeong, K.M.D., Chang-gon Kim, K.M.D., Yeong-Ung Yun, K.M.D., Won-Hyung Ryu, K.M.D., Yong-hyun Jeon, K.M.D., Young-jun Choi, K.M.D., Jae-hyun Chung, K.M.D.. J Korean Med Rehabi 2019;29:195-201. https://doi.org/10.18325/jkmr.2019.29.2.195
Techniques for the delivery foreign materials into living cells as well as for sensing have undeniable worth in cell biology research. A major barrier for intracellular delivery is to cross the cell membrane with little or no damage. Among the various intracellular delivery methods, one-dimensional nanoneedles are one of the promising methods for insertion with minimal invasiveness to a cell. Most of the previous studies have been conducted using vertical nanoneedle. Here, we synthesized new inc
FAS (fluoroalkylsilane)/Nafion® composite electrolyte membranes were successfully fabricated through a sol-gel method. The FAS consisting of a hydrophobic functional group and silanol ligands is impregnated in a Nafion® membrane. The prepared FAS/Nafion composite electrolyte membranes (FNCMs) containing hydrophobic FAS-derived silicate nano-particles in a Nafion® matrix showed a decrease in methanol crossover and a reduction in the humidity dependence without a large sacrifice of proton conducti
마이크로 유체구조를 기반으로 하는 약물전달장치는 마이크로 유체 채널형상의 간단한 변형만으로 약물분출량을 쉽게 조절할 수 있는 장점이 있다. 그러나 디바이스 제작에 사용된 생분해성 고분자 85/15poly(lactic-co-glycolic acid) (85/15PLGA)의 소수성 기질 때문에 약물전달 장치내부로의 release medium의 유입이 원활하게 이루어지지 않으며 그 결과, 디바이스의 임플랜트 후 초기의 약물 분출에 영향을 줄 것으로 예상된다. 따라서 surfactant인 polyethylene-glycol600 (PEG600)과 Tween80을 이용하여 micro-channel의 표면처리를 한 디바이스와 surfactant를 사용하지 않은 디바이스를 각각 제작하여 약물 전달 실험을 하였으며, 이를 바탕으로 마이크로 유체 채널의 기하학적 형상에 따른 국소 마취제의 일종인 bupivacaine HCl(BHCl)의 분출속도제어를 입증하였다.
3 9 6 ( 2 0 1 8 1 2 ) J .I n t .K o r e a nMe d .2 0 1 8 ; 3 9 ( 6 ) : 1 3 2 1 -1 3 2 8 h t t p : / / d x . d o i . o r g / 1 0 . 2 2 2 4 6 / j i k m. 2 0 1 8 . 3 9 . 6 . 1 3 2 1 1 3 2 1 :2 0 1 8 . 1 2 . 0 3 ,:2 0 1 8 . 1 2 . 3 1 ,:2 0 1 8 .
Objectives: This study aimed to assess the impact of traditional Korean medicine services (TKMS) on subsequent knee surgery and opioid use in patients diagnosed with knee osteoarthritis (KOA). Methods: This retrospective cohort study used National Health Insurance Review and Assessment Service claims data from 2015 to 2017 to identify patients treated for KOA (M17) in 2016. Patients with at least two Korean medicine (KM) clinic visits within 6 weeks of the initial diagnosis formed the TKMS group
Abstract not Available.
피부와 같이 체외에 적용되는 마이크로니들과 달리 혈관 약물 전달을 위한 마이크로니들은 실린더 모양의 혈관이나 혈관 분지부와 같은 복잡한 굴곡과 형상을 가진 부위에 장착되므로 보다 유연성을 갖고 쉽게 감아서 장착할 수 있어야 한다. 이전 연구에서 유연기판에 제작된 마이크로니들의 연구가 있었으나 비분해성 재료이거나 변형할 수 있는 곡율이 작은 한계를 갖고 있다. 본 연구에서는 생분해성 수술용 메쉬에 마이크로니들 어레이를 제작하는 방법을 개발하였다. 가열된 금속 필라의 끝단에 융해생분해성고분자를 액적 형태로 이송하여 몰드 내의 개별 마이크로 캐버티(cavity)에 압력을 가하여 채워넣는 방식으로 몰딩을 진행하였다. 이 후에 수술용 메쉬를 국소적으로 각각의 마이크로니들과 결합하여 마이크로니들 메쉬를 제작하였다. 토끼 복부 대동맥 혈관을 이용하여 혈관 조직 투과성을 확인하였고 모델 약물을 이용하여 두가지의 약물을 각기 다른 전달율로 방출하는 특성을 확인하였다.
Research Areas
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