Yong-Je Lee

This study investigated the effects of coenzyme Q10 supplementation on metabolic parameters, inflammatory markers, arterial stiffness, and fatigue in obese subjects. We performed a randomized, double-blind, placebo-controlled, single-center study on 51 obese subjects with a body mass index (BMI) of ≥25 kg/m2. Subjects were randomized into either a coenzyme Q10 (200 mg/day) group (n = 26, BMI = 27.9 ± 2.3 kg/m2, age = 42.7 ± 11.3 years) or a placebo group (n = 25, BMI = 26.8 ± 2.8 kg/m2, age = 41

Inflammation may be linked to the pathogenesis of colorectal cancer. However, two conflicting observational results were recently reported on the relationship between the inflammatory marker C-reactive protein (CRP) and the risk of colorectal cancer. Few epidemiologic studies have examined the association between inflammatory markers and the risk of colorectal cancer. We prospectively examined the mortality and incidence risk for colon and rectal cancers among 424,419 Koreans (108,907 men and 31

연구배경: 연령, 성별, 흡연, 고지혈증, 당뇨병, 비만 등의 심혈관계 위험인자가 심박동수 변이 감소와 관련이 있다는 보고가 있다. 대사증후군은 이들 심혈관 질환의 위험인자들의 군집개념이다. 이에 저자들은 대사증후군에서 심박동수 변이의 변화를 알아보고자 하였으며, 대사증후군 기준 항목 중 심박동수 변이에 영향을 주는 항목을 알아보고자 하였다.방법: 2002년 1월과 2월 사이 일개 대학병원 건강검진센터와 비만클리닉을 내원한 178명 중 특이 병력이 없는 총 149명을 대상으로 대사증후군 집단과 비대사증후군 집단으로 구분하였고, Mean Heart Rate (MHR), Standard Deviation of N-N interval (SDNN), The Square Root of the Mean Squared Difference of successive NN intervals (RMSSD), Total Power (TP), Low Frequency (LF), High Frequency

Wheat‐rye translocations carry valuable genes for pest resistance; this has led to their incorporation into wheat varieties. To develop gene‐based 1RS specific markers, expressed sequence tags (ESTs) mapped to the short arm of wheat homoeologous group 1 were downloaded from a public database. ESTs and mature transcript sequences of nine species from the Poaceae family were BLASTed to perform comparative analysis. ESTs selected using the BLAST tool were used for primer design. The target sequence

Korean red ginseng (KRG), a heat-processed Korean ginseng (Panax ginseng C.A. Meyer), has been used as a traditional medicine for its beneficial effects on hyperglycemia. This study aimed to investigate whether the antidiabetic action of KRG in an animal model of type 2 diabetes mellitus (DM) is partly mediated by prevention of mitochondrial dysfunction and intracellular inflammation. Four-week-old C57BL/KsJ db/db mice (a genetic animal model of obese type 2 DM) and C57BL/KsJ db/+ mice were divi

‘노인 허약’은 생리학적 기전에 근거한 정상 노화와 구별된 뚜렷한 ‘임상 증후군’이다. 또한, ‘노인 허약’은 ‘정상 노화’‘전허약’‘노인 허약’‘노인병’으로 이어지는 역동성의 관점에서 이해해야 한다. ‘노인 허약’은 자신의 능동적 노력에 따라 충분히 가역적인 특징이 있다. 초기에는 증상이 뚜렷하지 않으나 점차 진행할수록 호소하는 증상이 증가한다. 체중 감소, 근육 감소(sarcopenia), 활동량 감소, 균형감각 및 보행 속도의 저하, 인지기능 저하와 영양 부족 소견들이 관찰된다. 따라서,‘노인 허약’이 있을 경우 이동 능력 등 일상생활 수행 기능이 저하되기 쉽고, 심혈관 질환, 암, 낙상의 발생 위험이 증가할 뿐아니라 사망률이 증가한다. ‘노인 허약’의 예방과 치료를 위해서는 저항 운동이 포함된 운동요법, 비타민, 미네랄, 필수아미노산, 비타민 D 등의 영양요법의 권고 근거가 높으며, 호르몬보충요법은 아직 근거가 미약하다. 향후 ‘노인 허약’에 대한 정확한 이해를 바탕으로 ‘노

Dyslipidemia is implicated in increased cardiovascular risk associated with chronic kidney disease (CKD) and in the progression of renal damage. This study compared 4 different lipid-related ratios (total cholesterol [TC]/high-density lipoprotein cholesterol [HDL-C],triglyceride [TG]/HDL-C, calculated low-density lipoprotein cholesterol [c-LDL-C]/HDL-C,and non-HDL-C/HDL-C ratio) for prediction of CKD stage 3 or more to investigate the association between them. This cross-sectional study included

Several studies have reported that hyperuricemia is associated with the development of hypertension and cardiovascular disease. Increasing evidences also suggest that hyperuricemia may have a pathogenic role in the progression of renal disease. Paradoxically, uric acid is also widely accepted to have antioxidant activity in experimental studies. We aimed to investigate the association between glomerular filtration rate (GFR)and uric acid in healthy individuals with a normal serum level of uric a

Purpose: Sex hormone-binding globulin (SHBG) is a serum glycoprotein produced predominantly in hepatocytes. As such, the synthesis of SHBG could be associated with liver function and metabolic syndrome. Alanine aminotransferase (ALT) levels could reflect hepatocellular injury and insulin resistance; however, the relationship between hepatic steatosis and ALT with SHBG has not been investigated in humans. The objective of this study was to investigate the associations between SHBG and hepatocyte

Recent epidemiological research has indicated that men have increased health risks due to biological and social factors. Research in the area of men’s health has been focused on disease events and subsequent disabilities. In future aging societies, more attention should be paid to the importance of men’s health because a decreased quality of life and increased social burden are impending unless proper maneuvers are taken to slow the development and progression of morbidity through the use of pre

Background: This study investigated the effects of Korean red ginseng (KRG) supplementation on metabolic parameters,inflammatory markers, and arterial stiffness in subjects with metabolic syndrome. Methods: We performed a randomized, double-blind, placebo-controlled, single-center study in 60 subjects who were not taking drugs that could affect metabolic and vascular functions. Subjects were randomized into either a KRG (4.5 g/d)group or a placebo group for a 12-week study. We collected anthropo

Successful or health aging may not be enough of explaining all perspectives of aging-related consequences in the upcoming super-aged society. Korea has experienced a rapid decline in the traditional family structure and a soar in nuclear families or solitude. Korea sustains paradoxically dissociated delivery of health care and welfare despite a decade of policy implementation of long-term care insurance. On November 20th, 2018, to resolve these challenges, the Ministry of Health and Welfare proc

Either chronic inflammation or metabolic syndrome (MetS) is associated with renal impairment. This cross-sectional study was designed to investigate the relationship between elevated white blood cell (WBC) counts and chronic kidney disease (CKD) stage 3or more according to the presence of MetS in adult Koreans. In total, 5,291 subjects (≥ 20 yr-old) participating in the 2005 Korean National Health and Nutrition Examination were included. CKD stage 3 or more was defined as having an estimated glo

연구배경: 인슐린 저항성 및 제2형 당뇨병의 발생이 염증과 관련되어 있다는 보고가 있다. 저자들은 염증지표인 백혈구 수 증가와 고혈당증의 관계 및 흡연 상태별로 백혈구 수의 증가가 고혈당증에 미치는 영향에 대해 전향적 연구를 통해 알아보고자 한다. 방법: 공복혈당장애 또는 당뇨병의 기왕력이 없는 남성 건강검진 피검자 6,734명을 대상으로 백혈구를 2.9～5.9, 6.0～ 6.9, 7.0～8.1, 8.2～16.5 (×103 cells/μL)의 네 구간으로 구분하고 2.9～5.9구간을 기준집단으로 하였다. 1994년 1월 1일부터 2002년 12월 31일 사이에 당뇨병을 진단받은 경우 또는 2003년 검진 시 공복혈당이 110 mg/dL 이상의 공복혈당장애를 고혈당증으로 정의하였고, 고혈당증과 관련성이 있다고 알려진 인자들을 독립변수로 다중 로지스틱 회귀분석을 이용하여 백혈구 구간별 고혈당증의 승산비를 구하였다. 또한 흡연상태별로 백혈구 수의 증가와 고혈당증의 관계를 살펴보고자 비흡연