Yong-Sup Lee
Kyung Hee University · Medicine
About the Lab
Professor Yong-Sup Lee's research lab specializes in natural product chemistry and medicinal chemistry, with a focus on the isolation, structural elucidation, and synthesis of bioactive natural compounds—particularly lignans and kojic acid derivatives—targeting cancer chemotherapy, antioxidant, antimicrobial, and anti-inflammatory activities. The lab also investigates enzyme inhibitors, such as tyrosinase and COX-2, through rational drug design and synthetic methodology development, including asymmetric synthesis and reactive intermediates like N-acyliminium ions. Their work bridges organic synthesis with biological evaluation to develop novel therapeutic agents with improved selectivity and reduced side effects.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Lignans are a class of secondary plant metabolites produced by oxidative dimerization of two phenylpropanoid units. Although their molecular backbone consists only of two phenylpropane (C6-C3) units, lignans show an enormous structural diversity. There is a growing interest in lignans and their synthetic derivatives due to applications in cancer chemotherapy and various other pharmacological effects. This review deals with lignans possessing anticancer, antioxidant, antimicrobial, anti-inflammat
Kojic acid derivative 2 was synthesized by joining two pyrone rings through an ethylene linkage by Horner-Emmons reaction of phosphonate 6 with aldehyde 7. The intermediates 6 and 7 were derived from kojic acid. The tyrosinase inhibitory activity of 2 was about 8 times more potent (IC(50) = 3.63 microM) than that of kojic acid (IC(50) = 30.61 microM). Compound 2 also exhibited potent melanin synthesis inhibitory activity (19.53% inhibition at 5 mug) indicating that the connection of two pyrone r
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric Synthesis of Both Enantiomers of Pyrrolidinoisoquinoline Derivatives from L-Malic Acid and L-Tartaric AcidYong Sup Lee, Dong Wook Kang, Sook Ja Lee, and Hokoon ParkCite this: J. Org. Chem. 1995, 60, 22, 7149–7152Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/jo00127a019https://doi.org/10.1021/jo00127a019research-articleACS PublicationsRe
The traditional nonsteroidal anti-inflammatory drugs (NSAIDs) exert their effect by inhibition of cyclooxygenase-1 (COX-1) as well as COX-2 enzymes. As COX-1 is responsible for maintaining normal biological functions, the nonselective inhibition of these enzymes caused side effects including gastrointestinal (GI) problems. Recently developed selective COX-2 inhibitors could reduce these adverse effects, but the evidence of cardiovascular side effects including an increased risk of myocardial inf
N-acyliminium ions are reactive intermediates that can act as electron-deficient electrophiles toward weak or soft nucleophiles, thereby providing useful methods for both intermolecular- and intramolecular carbon-carbon and carbon-heteroatom bond formation. Nucleophilic additions to N-acyliminium ions constitute an important method for providing α-functionalized amino compounds and many other biologically active nitrogen-containing heterocycles. The development of efficient catalytic asymmetric
Research Areas
Dive deeper into Yong-Sup Lee's research on Nubint
Open this lab's papers in the app to read with AI, summarize, and cite in your writing.