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Yoo-bong Hyun

Seoul National University · Agricultural and Biological Sciences

About the Lab

Professor Yoo-bong Hyun's research lab focuses on animal production systems and molecular plant biology, with a dual emphasis on optimizing swine welfare and productivity under commercial conditions and advancing precision genome editing in plants. The lab investigates the physiological and behavioral responses of pigs to combined environmental and management stressors—such as temperature, stocking density, and regrouping—while also pioneering CRISPR/Cas9-based site-directed mutagenesis for heritable genome modification in Arabidopsis. A key research direction involves understanding the regulatory roles of miR156/SPL transcription factors in plant flowering competence and the evolutionary divergence of flowering pathways between annuals and perennials. The lab integrates physiological, nutritional, and molecular approaches to improve livestock production efficiency and develop next-generation plant biotechnologies.

swine productionCRISPR/Cas9flowering regulationmiR156/SPLanimal welfare

Research Overview

Papers
84
Total Citations
3,504
Papers (5y)
19
Primary Field
Agricultural and Biological Sciences

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
19total
2021
2023
2024
2025
2026
Citations per year (5y)
55total
20212023202420252026

Selected Papers

15
1
Article|258 citations·2016
Multi-layered Regulation of SPL15 and Cooperation with SOC1 Integrate Endogenous Flowering Pathways at the Arabidopsis Shoot Meristem
Y. Hyun, René Richter, Coral Vincent, Rafael Martínez-Gallegos, Aimone Porri, George Coupland
SJR Q1Developmental CellOA
Plant ScienceAgricultural and Biological Sciences
2
Article|184 citations·1998
Growth performance of pigs subjected to multiple concurrent environmental stressors.
Y. Hyun, M. Ellis, G. L. Riskowski, Rodney W. Johnson
SJR Q1Journal of Animal Science

The effects of many single stressors have been reported, but how pigs perform when subjected to more than one or two stressors at a time, as is common in commercial swine production, has not. To study this, 256 Yorkshire x Hampshire or purebred Duroc pigs (34.7+/-.5 kg) were subjected to one of the eight treatment combinations (2 x 2 x 2 factorial) of ambient temperature (constant thermoneutral [24 degrees C] or high cycling temperature [28 to 34 degrees C]), stocking density (.56 or .25 m2/pig)

Animal Science and ZoologyAgricultural and Biological Sciences
3
Article|173 citations·2008
Cooperation and Functional Diversification of Two Closely Related Galactolipase Genes for Jasmonate Biosynthesis
Y. Hyun, Sungwook Choi, Hyun-Ju Hwang, Jihyeon Yu, Sang‐Jip Nam, Jaeyoung Ko, Ju-Young Park, Young Sam Seo, Eun Yu Kim, Stephen I. Ryu, Woo Taek Kim, Yong‐Hwan Lee
SJR Q1Developmental CellOA
Insect ScienceAgricultural and Biological Sciences
4
Article|169 citations·2014
Site-directed mutagenesis in Arabidopsis thaliana using dividing tissue-targeted RGEN of the CRISPR/Cas system to generate heritable null alleles
Y. Hyun, Jung‐Eun Kim, Seung Woo Cho, Yeonhee Choi, Jin‐Soo Kim, George Coupland
SJR Q1PlantaOA

Dividing tissue-targeted site-directed mutagenesis using RGEN of CRISPR/Cas system produces heritable mutations in Arabidopsis thaliana. Site-directed genome engineering in higher plants has great potential for basic research and molecular breeding. Here, we describe a method for site-directed mutagenesis of the Arabidopsis nuclear genome that efficiently generates heritable mutations using the RNA-guided endonuclease (RGEN) derived from bacterial clustered regularly interspaced short palindromi

Molecular BiologyBiochemistry, Genetics and Molecular Biology
5
Review|150 citations·2016
Competence to Flower: Age-Controlled Sensitivity to Environmental Cues
Y. Hyun, René Richter, George Coupland
SJR Q1PLANT PHYSIOLOGYOA

miR156 and SPL transcription factors play various roles in conferring competence to flower in plants.

Plant ScienceAgricultural and Biological Sciences
6
Article|132 citations·2006
KIDARI, Encoding a Non-DNA Binding bHLH Protein, Represses Light Signal Transduction in Arabidopsis thaliana
Y. Hyun, Ilha Lee
SJR Q1Plant Molecular Biology
Plant ScienceAgricultural and Biological Sciences
7
Article|106 citations·1997
Feed intake pattern of group-housed growing-finishing pigs monitored using a computerized feed intake recording system.
Y. Hyun, M. Ellis, F. K. McKeith, E. R. Wilson
SJR Q1Journal of Animal Science

The feed intake pattern and growth performance of boars, barrows, and gilts fed diets differing in lysine and protein content were measured on 120 crossbred pigs from 27 (SD 3.7) to 81.5 (SD 9.2) kg live weight. The pigs were housed in eight mixed-sex groups with five pigs of each sex in each group. They were fed from an electronic feed station that recorded individual meal sizes and the time and duration of visits to the feeder for each animal in the group. Four dietary treatments were compared

Small AnimalsVeterinary
8
Article|106 citations·2001
Effect of group size and feeder type on growth performance and feeding patterns in growing pigs.
Y. Hyun, M. Ellis
SJR Q1Journal of Animal Science

The effects of four group sizes (2, 4, 8, and 12 pigs per pen) and two single-space feeder types (conventional and electronic feed intake recording equipment [FIRE]) on feed intake, growth performance, and feeding patterns were determined in 208 crossbred finishing pigs (equal numbers of barrows and gilts) between 84.4 (SD = 0.81) to 112.8 (SD = 1.08) kg BW over a 4-wk period. Pigs were given ad libitum access to a corn-soybean meal-based diet (15.9% CP; 0.79% lysine; 3,328 kcal ME/kg). The floo

Animal Science and ZoologyAgricultural and Biological Sciences
9
Article|92 citations·2019
A regulatory circuit conferring varied flowering response to cold in annual and perennial plants
Y. Hyun, Coral Vincent, Vicky Tilmes, Sara Bergonzi, Christiane Kiefer, René Richter, Rafael Martínez-Gallegos, Edouard Severing, George Coupland
SJR Q1ScienceOA

, flowering in response to winter cold depends on the floral integrator SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 15 (SPL15), whose activity is limited to older shoots and branches during cold exposure. In annuals, this regulatory system is conserved, but cold-induced flowering occurs in young shoots, without requirement for SPL15, through the photoperiodic pathway when plants return to warm. By reconstructing the annual response in perennials, we conclude that characteristic patterns of reproducti

Plant ScienceAgricultural and Biological Sciences
10
Article|90 citations·1998
Effects of feeder type, space allowance, and mixing on the growth performance and feed intake pattern of growing pigs.
Y. Hyun, M. Ellis, Rodney W. Johnson
SJR Q1Journal of Animal Science

The effect of crowding and mixing on growth performance and feed intake pattern were investigated in growing pigs in a 4-wk study. Feeding pattern was monitored using automated feed intake recording equipment (F.I.R.E.). A total of 256 Yorkshire x Hampshire and purebred Duroc pigs (initial weight 35.8+/-.86 kg) were allocated to one of the eight treatment combinations in a 2x2x2 factorial arrangement (feeder type [conventional feeder vs F.I.R.E. feeder], space allowance [.56 vs .25 m2/pig], and

Animal Science and ZoologyAgricultural and Biological Sciences
11
Article|70 citations·2002
Effect of group size and feeder type on growth performance and feeding patterns in finishing pigs
Y. Hyun, M. Ellis
SJR Q1Journal of Animal Science

The effects of four group sizes (2, 4, 8, and 12 pigs per pen) and two single-space feeder types (conventional and electronic feed intake recording equipment [FIRE]) on feed intake, growth performance, and feeding patterns were determined in 208 crossbred finishing pigs (equal numbers of barrows and gilts) between 84.4 (SD = 0.81) to 112.8 (SD = 1.08) kg BW over a 4-wk period. Pigs were given ad libitum access to a corn-soybean meal-based diet (15.9% CP; 0.79% lysine; 3,328 kcal ME/kg). The floo

Animal Science and ZoologyAgricultural and Biological Sciences
12
Article|70 citations·2012
The catalytic subunit ofArabidopsisDNA polymerase α ensures stable maintenance of histone modification
Y. Hyun, Hyein Yun, Kyunghyuk Park, Hyonhwa Ohr, Okchan Lee, Dong‐Hwan Kim, Sibum Sung, Yeonhee Choi
SJR Q1Development

Mitotic inheritance of identical cellular memory is crucial for development in multicellular organisms. The cell type-specific epigenetic state should be correctly duplicated upon DNA replication to maintain cellular memory during tissue and organ development. Although a role of DNA replication machinery in maintenance of epigenetic memory has been proposed, technical limitations have prevented characterization of the process in detail. Here, we show that INCURVATA2 (ICU2), the catalytic subunit

Plant ScienceAgricultural and Biological Sciences
13
Article|45 citations·2004
Performance of growing-finishing pigs fed diets containing Roundup Ready corn (event nk603), a nontransgenic genetically similar corn, or conventional corn lines
Y. Hyun, G. E. Bressner, M. Ellis, A. J. Lewis, Robert L. Fischer, E.P. Stanisiewski, G.F. Hartnell
SJR Q1Journal of Animal Science

Two studies were conducted at two locations to evaluate growth performance and carcass characteristics of growing-finishing pigs fed diets containing either glyphosate-tolerant Roundup Ready (event nk603) corn, a nontransgenic genetically similar control corn (RX670), or two conventional sources of nontransgenic corn (RX740 and DK647). A randomized complete block design (three and four blocks in Studies 1 and 2, respectively) with a 2 x 4 factorial arrangement of treatments (two genders and four

GeneticsBiochemistry, Genetics and Molecular Biology
14
Article|34 citations·2005
Environmental temperature, space allowance, and regrouping: Additive effects of multiple concurrent stressors in growing pigs
Y. Hyun, M. A. Ellis, Stan Curtis, Rodney W. Johnson
SJR Q3Journal of Swine Health and ProductionOA

Objective: To determine the effects of multiple concurrent stressors on hematologic and behavioral measurements in growing pigs. Materials and methods: Two hundred and fifty-six growing pigs (Yorkshire x Hampshire or purebred Duroc barrows and gilts, initial body weight 34.7 +/- 0.5 kg) were used in a randomized block design with a 2 x 2 x 2 factorial arrangement of treatments to determine effects on hematologic and behavioral measures of environmental temperature (constant-thermoneutral at 24°C

Animal Science and ZoologyAgricultural and Biological Sciences
15
Article|32 citations·2003
Effect of dietary leucine level on growth performance, and carcass and meat quality in finishing pigs
Y. Hyun, M. Ellis, F. K. McKeith, D. H. Baker
SJR Q2Canadian Journal of Animal ScienceOA

The effect of feeding corn-soybean meal-based diets with two levels of supplemental leucine (0 vs. 2%) on growth, carcass, and pork quality characteristics was evaluated in 40 individually fed finishing pigs over a 39-d feeding period (78.4 ± 3.46 to 114.8 ± 7.30 kg liveweight). Supplemental dietary leucine reduced weight gain (8.7%; P < 0.05), but had no effect (P > 0.05) on feed intake or gain:feed ratio. Feeding diets with 2% supplemental leucine increased (P < 0.05) longissimus fat

Animal Science and ZoologyAgricultural and Biological Sciences

Research Areas

Plant ScienceAnimal Science and ZoologyMolecular BiologyWater Science and TechnologyGeneticsInsect Science

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