Yoo-bong Hyun
Seoul National University · Agricultural and Biological Sciences
About the Lab
Professor Yoo-bong Hyun's research lab focuses on animal production systems and molecular plant biology, with a dual emphasis on optimizing swine welfare and productivity under commercial conditions and advancing precision genome editing in plants. The lab investigates the physiological and behavioral responses of pigs to combined environmental and management stressors—such as temperature, stocking density, and regrouping—while also pioneering CRISPR/Cas9-based site-directed mutagenesis for heritable genome modification in Arabidopsis. A key research direction involves understanding the regulatory roles of miR156/SPL transcription factors in plant flowering competence and the evolutionary divergence of flowering pathways between annuals and perennials. The lab integrates physiological, nutritional, and molecular approaches to improve livestock production efficiency and develop next-generation plant biotechnologies.
Research Overview
Research Output Trend
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Selected Papers
15The effects of many single stressors have been reported, but how pigs perform when subjected to more than one or two stressors at a time, as is common in commercial swine production, has not. To study this, 256 Yorkshire x Hampshire or purebred Duroc pigs (34.7+/-.5 kg) were subjected to one of the eight treatment combinations (2 x 2 x 2 factorial) of ambient temperature (constant thermoneutral [24 degrees C] or high cycling temperature [28 to 34 degrees C]), stocking density (.56 or .25 m2/pig)
Dividing tissue-targeted site-directed mutagenesis using RGEN of CRISPR/Cas system produces heritable mutations in Arabidopsis thaliana. Site-directed genome engineering in higher plants has great potential for basic research and molecular breeding. Here, we describe a method for site-directed mutagenesis of the Arabidopsis nuclear genome that efficiently generates heritable mutations using the RNA-guided endonuclease (RGEN) derived from bacterial clustered regularly interspaced short palindromi
miR156 and SPL transcription factors play various roles in conferring competence to flower in plants.
The feed intake pattern and growth performance of boars, barrows, and gilts fed diets differing in lysine and protein content were measured on 120 crossbred pigs from 27 (SD 3.7) to 81.5 (SD 9.2) kg live weight. The pigs were housed in eight mixed-sex groups with five pigs of each sex in each group. They were fed from an electronic feed station that recorded individual meal sizes and the time and duration of visits to the feeder for each animal in the group. Four dietary treatments were compared
The effects of four group sizes (2, 4, 8, and 12 pigs per pen) and two single-space feeder types (conventional and electronic feed intake recording equipment [FIRE]) on feed intake, growth performance, and feeding patterns were determined in 208 crossbred finishing pigs (equal numbers of barrows and gilts) between 84.4 (SD = 0.81) to 112.8 (SD = 1.08) kg BW over a 4-wk period. Pigs were given ad libitum access to a corn-soybean meal-based diet (15.9% CP; 0.79% lysine; 3,328 kcal ME/kg). The floo
, flowering in response to winter cold depends on the floral integrator SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 15 (SPL15), whose activity is limited to older shoots and branches during cold exposure. In annuals, this regulatory system is conserved, but cold-induced flowering occurs in young shoots, without requirement for SPL15, through the photoperiodic pathway when plants return to warm. By reconstructing the annual response in perennials, we conclude that characteristic patterns of reproducti
The effect of crowding and mixing on growth performance and feed intake pattern were investigated in growing pigs in a 4-wk study. Feeding pattern was monitored using automated feed intake recording equipment (F.I.R.E.). A total of 256 Yorkshire x Hampshire and purebred Duroc pigs (initial weight 35.8+/-.86 kg) were allocated to one of the eight treatment combinations in a 2x2x2 factorial arrangement (feeder type [conventional feeder vs F.I.R.E. feeder], space allowance [.56 vs .25 m2/pig], and
The effects of four group sizes (2, 4, 8, and 12 pigs per pen) and two single-space feeder types (conventional and electronic feed intake recording equipment [FIRE]) on feed intake, growth performance, and feeding patterns were determined in 208 crossbred finishing pigs (equal numbers of barrows and gilts) between 84.4 (SD = 0.81) to 112.8 (SD = 1.08) kg BW over a 4-wk period. Pigs were given ad libitum access to a corn-soybean meal-based diet (15.9% CP; 0.79% lysine; 3,328 kcal ME/kg). The floo
Mitotic inheritance of identical cellular memory is crucial for development in multicellular organisms. The cell type-specific epigenetic state should be correctly duplicated upon DNA replication to maintain cellular memory during tissue and organ development. Although a role of DNA replication machinery in maintenance of epigenetic memory has been proposed, technical limitations have prevented characterization of the process in detail. Here, we show that INCURVATA2 (ICU2), the catalytic subunit
Two studies were conducted at two locations to evaluate growth performance and carcass characteristics of growing-finishing pigs fed diets containing either glyphosate-tolerant Roundup Ready (event nk603) corn, a nontransgenic genetically similar control corn (RX670), or two conventional sources of nontransgenic corn (RX740 and DK647). A randomized complete block design (three and four blocks in Studies 1 and 2, respectively) with a 2 x 4 factorial arrangement of treatments (two genders and four
Objective: To determine the effects of multiple concurrent stressors on hematologic and behavioral measurements in growing pigs. Materials and methods: Two hundred and fifty-six growing pigs (Yorkshire x Hampshire or purebred Duroc barrows and gilts, initial body weight 34.7 +/- 0.5 kg) were used in a randomized block design with a 2 x 2 x 2 factorial arrangement of treatments to determine effects on hematologic and behavioral measures of environmental temperature (constant-thermoneutral at 24°C
The effect of feeding corn-soybean meal-based diets with two levels of supplemental leucine (0 vs. 2%) on growth, carcass, and pork quality characteristics was evaluated in 40 individually fed finishing pigs over a 39-d feeding period (78.4 ± 3.46 to 114.8 ± 7.30 kg liveweight). Supplemental dietary leucine reduced weight gain (8.7%; P < 0.05), but had no effect (P > 0.05) on feed intake or gain:feed ratio. Feeding diets with 2% supplemental leucine increased (P < 0.05) longissimus fat
Research Areas
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