Yoo Jin Park

This study was funded by Novartis Pharmaceuticals. Park and Ko are employed by Novartis Pharmaceuticals in East Hanover, New Jersey, and Ko holds stock in Novartis. Raza, George, and Agrawal are employed by Novartis Healthcare in Hyderabad, India. Study concept and design were contributed primarily by Park and Ko, along with the other authors. Raza, George, and Agrawal collected the data, along with Park and Ko. Data interpretation was performed by Agrawal, Raza, George, Park, and Ko. The manusc

Under acidic conditions, IrO2 exhibits high catalytic activity with respect to the oxygen evolution reaction (OER). However, the practical application of Ir-based catalysts is significantly limited owing to their high cost in addition to the scarcity of the metal. Therefore, it is necessary to improve the efficiency of the utilization of such catalysts. In this study, IrO2-coated Ti felt (IrO2/Ti) electrodes were prepared as high-efficiency catalysts for the OER under acidic conditions. By contr

We investigate regional features nearby the subway station using the clustering method called the funFEM and propose a two-step procedure to predict a subway passenger transport flow by incorporating the geographical information from the cluster analysis to functional time series prediction. A massive smart card transaction dataset is used to analyze the daily number of passengers for each station in Seoul Metro. First, we cluster the stations into six categories with respect to their patterns o

BACKGROUND: The in vitro production of mature human red blood cells (RBCs) from induced pluripotent stem cells (iPSCs) has been the focus of research to meet the high demand for blood transfusions. However, limitations like high costs and technological requirements restrict the use of RBCs produced by iPSC differentiation to specific circumstances, such as for patients with rare blood types or alloimmunized patients. In this study, we developed a detailed protocol for the generation of iPSC line

급속도로 활성화되고 있는 온라인 중고거래 시장은 사업자에게 새로운 분야의 사업 기회를 제공해주는 역할을 하고 있으나 급속히 성장한 이유로 아직 제도 정비나 연구가 활발히 진행되지 않아 인터넷 종합쇼핑몰 에서보다 소비자 피해가 자주, 큰 규모로 발생하고 있는 실정이다. 본 연구의 목적은 이러한 상황에서도 거래가 활발하게 이루어지고 있는 온라인 중고시장인 '중고나라' 사이트에서 플랫폼 내 구매자의 재구매의도 와 지각된 가치에 부정적, 긍정적 영향을 미치는 선행요인들의 관계를 종합적으로 고려하고 확인하는 데에 있다. 선행요인은 제품 정보 불확실성, 판매자 불확실성의 비용 측면과 상호작용성, 거래 편리성, 경제적 혜택의 혜택 측면으로 구분하였다. 연구 결과, 제품 정보 불확실성은 지각된 위험에, 상호작용성과 경제적 혜택은 지각된 가치에 유의미한 영향을 미치는 것으로 나타났다. 또한, 지각된 위험은 지각된 가치와 구매의도 에 부정적인 영향을 미치나, 지각된 가치는 구매의도에 긍정적인 영향을

Stoichiometric control of Ru, Ag, and tetrazolyl ligands resulted in the formation of different heterometallic Ru-Ag supramolecular architectures. Although the reaction of Ru and 5-(2-hydroxyphenyl)-1H-tetrazolyl (LH2) in a molar ratio of 2:1 or 6:4 resulted in the formation of dimeric or hexameric Ru complexes, Ag metal ions caused the Ru complexes to form three-dimensional cylindrical Ru6Ag6L6 and double-cone-shaped Ru6Ag8L6 complexes by occupying vacant coordination sites.

These results suggest that highly HAL-resistant cancer cells can be sensitized with cyclosporine A or elacridar, specific P-gp inhibitors that exert their effects at a low dose. These findings provide important information regarding the sensitization of highly HAL-resistant cells with selective P-gp inhibitors and indicate that elacridar may be used to treat such highly HAL-resistant cancer cells.

Our results, based on the NHID, supports the protective effect of tamoxifen against CVE in Korean breast cancer patients aged 55 and older that is not seen with AIs. Our results can guide the selection of adjuvant hormonal treatment agents for Korean breast cancer patients based on their risk of developing CVE.

Abstract Background Small colony and capnophilic variant cases have been separately reported, but there has been no reports of their simultaneous presence in one isolate. We report a case of Escherichia coli with coexpressed small colony and capnophilic phenotypes causing misidentification in automated biochemical kits and non-reactions in antimicrobial susceptibility test cards. Case presentation An 86-year-old woman developed urinary tract infection from a strain of Escherichia coli with SCV a

Antimicrobial, antifungal and anti-inflammatory effects of essential oils extracted from Chamaecyparis obtusa (EOCO) have previously been reported. In the present study, the anti-inflammatory effects of EOCO were investigated in two murine models of inflammation: Carrageenan-induced paw edema and thioglycollate-induced peritonitis, and in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The expression levels of proinflammatory cytokines were analyzed by ELISA, the expression of ni

A Gram-stain-negative, strictly aerobic bacterial strain, designated EO9T, was isolated from gasoline-contaminated soil in the Republic of Korea. Cells were non-motile short rods showing catalase- and oxidase-positive reactions. Growth was observed at 10–37 °C (optimum, 30 °C), at pH 6.0–9.0 (pH 6.5) and in the presence of 0–0.5 % (w/v) NaCl (0 %). Ubiquinone-10 (Q-10) and spermidine were identified as the predominant respiratory quinone and polyamine, respectively. Summed feature 8 (comprising

Most older persons would prefer “aging in my place,” that is, to remain in good health and live independently in their own home as long as possible. For assisting the independent living of older people, the ability to gather and analyze a user’s daily activity data would constitute a significant technical advance, enhancing their quality of life. However, the general approach based on centralized server has several problems such as the usage complexity, the high price of deployment and expansion